HGF regulate HTR-8/SVneo trophoblastic cells migration/invasion under hypoxic conditions through increased HIF-1 α expression via MAPK and PI3K pathways.

In conclusion, HGF facilitates HTR-8/SVneo cell migration/invasion by activation of MAPK/PI3K signaling pathways and increased expression of MMPs. HIF-1α has a role in HGF-mediated increase in migration under hypoxic conditions. PMID: 30684191 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30684191?dopt=Abstract

Source: Journal of Cell Communication and Signaling - January 26, 2019 Category: Molecular Biology Authors: Chaudhary P, Babu GS, Sobti RC, Gupta SK Tags: J Cell Commun Signal Source Type: research

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