Journal of Cell Communication and Signaling This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Proteome-wide assessment of human interactome as a source of capturing domain-motif and domain-domain interactions
In conclusion, all PPI datasets demonstrated significant enrichment in DMIs and DDIs (p-value <0.001), establishing Y2H and AP-MS as reliable methods for predicting these interactions. This study provides valuable insights for biologists in selecting appropriate methods for predicting DMIs, ultimately aiding in SLiM discovery.PMID:38545252 | PMC:PMC10964934 | DOI:10.1002/ccs3.12014 (Source: Journal of Cell Communication and Signaling)
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Sobia Idrees Keshav Raj Paudel Source Type: research

Role for CCN1 in lysophosphatidic acid response in PC-3 human prostate cancer cells
We examined the role of CCN1/CYR61, an inducible matricellular protein, in LPA-induced signal transduction in PC-3 human prostate cancer cells. We found that both LPA and S1P induced expression of CCN1 and CCN2 within 2-4 h. CCN1 was induced by 18:1-LPA, but not by 18:0-, 18:2-, or 18:3-LPAs. A free fatty acid receptor-4 agonist inhibited LPA-induced CCN1 induction. CCN1 appeared in the ECM within 2 h after LPA addition. LPA caused biphasic activation of Erk MAPK, with an initial peak at 10-20 min followed by a later phase after 6 h. LPA increased adhesion of PC-3 cells to culture substrates (standard culture plates, fibro...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Pravita Balijepalli Brianna K Knode Samuel A Nahulu Emily L Abrahamson Mary P Nivison Kathryn E Meier Source Type: research

LncRNA HOTTIP promotes LPS-induced lung epithelial cell injury by recruiting DNMT1 to epigenetically regulate SP-C
The objective of this study was to elucidate the involvement of the long noncoding RNA (lncRNA) HOTTIP in acute lung injury and understand the underlying mechanisms. Relevant expression of mRNAs and proteins were assessed by qRT-PCR and western blot assays. Cell viability was determined by employing the CCK-8 assay, and apoptosis was quantified through TUNEL staining. The concentration of inflammatory factors was measured by ELISA. The degree of DNA methylation was quantified through MSP assay. The interaction between HOTTIP and DNA methyltransferase 1 (DNMT1) was examined by RIP assay. LPS upregulated HOTTIP, whereas down...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Shuang Li Shuangjia Li Zhanqun Gao Yang Liu Source Type: research

Survivin inhibition ameliorates liver fibrosis by inducing hepatic stellate cell senescence and depleting hepatic macrophage population
In conclusion, downregulation of survivin in the fibrotic liver decreases HSC activation by inducing cellular senescence and modulating macrophage cytokine expression that collectively ameliorates liver fibrosis.PMID:38545255 | PMC:PMC10964939 | DOI:10.1002/ccs3.12015 (Source: Journal of Cell Communication and Signaling)
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Sachin Sharma Shaikh Maryam Ghufran Mehreen Aftab Chhagan Bihari Sampa Ghose Subhrajit Biswas Source Type: research

JAK3/STAT5 signaling-triggered upregulation of PIK3CD contributes to gastric carcinoma development
J Cell Commun Signal. 2024 Feb 7;18(1):e12017. doi: 10.1002/ccs3.12017. eCollection 2024 Mar.ABSTRACTGastric cancer (GC) is one of the most common solid cancers with high incidence and mortality worldwide. Chronic gastritis and consequent inflammatory microenvironment is known as a major cause leading to gastric carcinogenesis. Here we report that PIK3CD that encodes p110δ, a catalytic subunit of the class IA PI3Ks, is overexpressed and tumorigenic in GC and associated with tumor inflammatory microenvironment. By investigating the data from TCGA database and our immunohistochemical staining and quantitative real-time PCR ...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Qingqing Hu Ning Dou Qiong Wu Yong Gao Yandong Li Jingde Chen Source Type: research

Lactate drives CD38 signaling to promote Epithelial-Mesenchymal Transition through Snail induction in non-small cell lung cancer cells
J Cell Commun Signal. 2024 Feb 14;18(1):e12018. doi: 10.1002/ccs3.12018. eCollection 2024 Mar.ABSTRACTCD38 is the main NADase in mammalian cells. It regulates the homeostasis of nicotinamide adenine dinucleotide (NAD+) and extracellular nucleotides. Its function plays an important role in infection and aging. However, its potential functions in tumor cells have not been fully elucidated. In the present study, we demonstrated that lactate, which is derived from tumor metabolism remodeling, upregulates the expression of CD38 through OXPHOS-driven Hippo-TAZ pathway. The highly expressed CD38 converts NAD + to adenosine throug...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Yating Lu Yang Yang Tao Chang Qiyun Jiang Chenfeng Yang Chunzhe Fu Huijun Wei Yuanpeng He Zhihao Wu Source Type: research

IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research