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Condition: Pregnancy
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Total 418 results found since Jan 2013.
Toxoplasma gondii induces pyroptosis in human placental trophoblast and amniotic cells by inducing ROS production and activation of cathepsin B and NLRP1/NLRP3/NLRC4/AIM2 inflammasome
Toxoplasma gondii infection in pregnant women may cause fetal anomaly; however, the underlying mechanisms remain unclear. Here, we investigated whether T. gondii induces pyroptosis in human placental cells and the underlying mechanisms. Human placental trophoblast (BeWo and HTR-8/SVneo) and amniotic (WISH) cells were infected with T. gondii, and then ROS production, cathepsin B (CatB) release, inflammasome activation, and pyroptosis induction were evaluated. Moreover, the molecular mechanisms of these effects were investigated by treating the cells with ROS scavengers, a CatB inhibitor, or inflammasome-specific siRNA.
Source: American Journal of Pathology - September 21, 2023 Category: Pathology Authors: Juan-Hua Quan, Fei Fei Gao, Tian-Zhong Ma, Wei Ye, Xiang Gao, Ming-Zhu Deng, Lan-Lan Yin, In-Wook Choi, Jae-Min Yuk, Guang-Ho Cha, Young-Ha Lee, Jia-Qi Chu Tags: Regular Article Source Type: research
The role of PGRMC2 in the trophoblast invasion
In conclusion, PGRMC2 plays a role in placentation by promoting cell proliferation, invasion, and angiogenesis in EVTs via activation of HIF1α signaling. We thus identified a new function of PGRMC2 and provide insights on understanding the mechanisms of trophoblast invasion.PMID:37665239 | DOI:10.1093/biolre/ioad109
Source: Reproductive Biology - September 4, 2023 Category: Reproduction Medicine Authors: Tae Yokouchi-Konishi Yongjie Liu Liping Feng Source Type: research
Elevated galectin-3 levels detected in women with hyperglycemia during early and mid-pregnancy antagonizes high glucose - induced trophoblast cells apoptosis via galectin-3/foxc1 pathway
CONCLUSION: Future studies were required to validate whether plasma galectin-3 might become a potential biomarker for hyperglycemia during pregnancy. Elevated galectin-3 levels might be a vital protective mechanism among those exposed to hyperglycemia during pregnancy.PMID:37626284 | DOI:10.1186/s10020-023-00707-5
Source: Molecular Medicine - August 25, 2023 Category: Molecular Biology Authors: Yu Deng Hongyan Jin Jie Ning Dong Cui Muqiu Zhang Huixia Yang Source Type: research
HMOX1 Participates in Pre-Eclampsia by Regulating the Proliferation, Apoptosis, and Angiogenesis Modulation Potential of Mesenchymal Stem Cells via VEGF
Biochem Genet. 2023 Aug 12. doi: 10.1007/s10528-023-10474-x. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) are involved in the pathogenesis of pre-eclampsia (PE). Heme oxygenase (HMOX) protects against placental cytotoxic injuries associated with PE. Here, we aimed to clarify the roles of HMOX1 in MSC proliferation and apoptosis, trophoblast cell migration, and regulation of angiogenesis, and assess its involvement in the pathogenesis of PE. HMOX1 and vascular endothelial growth factor (VEGF) expression levels in decidual tissues and decidua-derived MSCs (dMSCs) of healthy pregnant women and patients with PE ...
Source: Biochemical Genetics - August 12, 2023 Category: Genetics & Stem Cells Authors: Juan Shi Min Su Source Type: research
HIF-1 α is positively associated with endometrial receptivity by regulating PKM2
CONCLUSIONS: HIF-1α plays a crucial role in the building of ER through regulating glycolysis.PMID:37533344 | DOI:10.1111/jog.15752
Source: Cell Research - August 3, 2023 Category: Cytology Authors: Lixia Liang Yang Yang Lin Yang Xiuping Zhang Suming Xu Yanling Liu Xueqing Wu Lan Chao Source Type: research
Suppression of PGE2/EP2 signaling alleviates Hirschsprung disease by upregulating p38 mitogen-activated protein kinase activity
In this study, an Ednrb-deficient mouse model of HSCR was generated and used to investigate if PGE2/EP2 pathway could be a potential therapeutic target for HSCR. We found that downregulation of PGE2/EP2 signaling by siRNA-mediated ablation of a PGE2 synthase or pharmacologic blockage of EP2 enhanced ENCC colonization in the distal bowel of Ednrb-/- mice and alleviated their HSCR-like symptoms. Furthermore, blockage of EP2 was shown to promote ENCC migration through upregulating p38 mitogen-activated protein kinase activity, which was downregulated in the colon of Ednrb-/- mice and in the distal aganglionic bowel of HSCR pa...
Source: Molecular Medicine - July 31, 2023 Category: Molecular Biology Authors: Jiao Wang Zhengke Zhi Jie Ding Na Jia Yuqing Hu Jiali Cai Hongxing Li Jie Tang Weibing Tang Xiaohua Mao Source Type: research
Higher gestational weight gain delays wound healing and reduces expression of long non-coding RNA KLRK1-AS1 in neonatal endothelial progenitor cells
J Physiol. 2023 Jul 20. doi: 10.1113/JP284871. Online ahead of print.ABSTRACTHigh gestational weight gain (GWG) is a cardiovascular risk factor and may disturb neonatal endothelial function. Long non-coding RNAs (lncRNAs) regulate gene expression epigenetically and can modulate endothelial function. Endothelial colony forming cells (ECFCs), circulating endothelial precursors, are a recruitable source of endothelial cells and sustain endothelial function, vascular growth and repair. We here investigated whether higher GWG affects neonatal ECFC function and elucidated the role of lncRNAs herein. Wound healing of umbilical co...
Source: The Journal of Physiology - July 20, 2023 Category: Physiology Authors: Elisa Weiss Anna Schr üfer Carolina Tocantins Mariana Simoes Diniz Boris Novakovic Anke S van Bergen Azra Kulovic-Sissawo Richard Saffery Reinier A Boon Ursula Hiden Source Type: research
