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Condition: Pregnancy

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Total 418 results found since Jan 2013.

The involvement of hormone-sensitive lipase in all-trans retinoic acid induced cleft palate
Int J Dev Biol. 2023 Jan 20. doi: 10.1387/ijdb.220137kz. Online ahead of print.ABSTRACTAbnormally high concentrations of all-trans retinoic acid (atRA) induce cleft palate, which is accompanied by abnormal migration and proliferation of mouse embryonic palatal mesenchyme (MEPM) cells. Hormone-sensitive lipase (HSL) is involved in many embryonic development processes. The current study was designed to elucidate the mechanism of HSL in cleft palate induced by atRA. To establish a cleft palate model in Kunming mice, pregnant mice were administered atRA (70 mg/kg) by gavage at embryonic Day 10.5 (E10.5). Embryonic palates were...
Source: International Journal of Developmental Biology - January 23, 2023 Category: Biology Authors: K Zheng Q N Ye Source Type: research

Uterine histotroph and conceptus development: III. Adrenomedullin stimulates proliferation, migration and adhesion of porcine trophectoderm cells via AKT-TSC2-MTOR cell signaling pathway
Amino Acids. 2023 Apr 10. doi: 10.1007/s00726-023-03265-6. Online ahead of print.ABSTRACTAdrenomedullin (ADM) as a highly conserved peptide hormone has been reported to increase significantly in the uterine lumen during the peri-implantation period of pregnancy in pigs, but its functional roles in growth and development of porcine conceptus (embryonic/fetus and its extra-embryonic membranes) as well as underlying mechanisms remain largely unknown. Therefore, we conducted in vitro experiments using our established porcine trophectoderm cell line (pTr2) isolated from Day-12 porcine conceptuses to test the hypothesis that por...
Source: Amino Acids - April 10, 2023 Category: Biochemistry Authors: Bangmin Liu Sudikshya Paudel William L Flowers Jorge A Piedrahita Xiaoqiu Wang Source Type: research

Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4 Research Articles
Obese women have an increased risk to deliver large babies. However, the mechanisms underlying fetal overgrowth in these pregnancies are not well understood. Obese pregnant women typically have elevated circulating lipid levels. We tested the hypothesis that fatty acids stimulate placental amino acid transport, mediated via toll-like receptor 4 (TLR4) and mammalian target of rapamycin (mTOR) signaling pathways. Circulating NEFA levels and placental TLR4 expression were assessed in women with varying prepregnancy body mass index (BMI). The effects of oleic acid on system A and system L amino acid transport, and on the activ...
Source: The Journal of Lipid Research - February 12, 2013 Category: Lipidology Authors: Lager, S., Gaccioli, F., Ramirez, V. I., Jones, H. N., Jansson, T., Powell, T. L. Tags: Research Articles Source Type: research

A Novel Role for FOXO3 in Human Labor: Increased Expression in Laboring Myometrium, and Regulation of Pro-Inflammatory and Pro-Labor Mediators in Pregnant Human Myometrial Cells.
Abstract Preterm birth is the leading factor causing neonatal mortality and morbidity. Inflammation plays a central role in stimulating uterine contractility, which is responsible for approximately one-third of all preterm births. Recent studies have shown that the transcription factor Forkhead box O3 (FOXO3) regulates inflammation in non-gestational tissues such as adipocytes and hepatocytes. Thus, in this study, we sought to determine the effect of (i) human term labor on myometrial FOXO3 expression, and (ii) FOXO3 inhibition and FOXO3 overexpression on pro-inflammatory and pro-labor mediators in human myometria...
Source: Biology of Reproduction - May 1, 2013 Category: Reproduction Medicine Authors: Lim R, Barker G, Lappas M Tags: Biol Reprod Source Type: research