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Condition: Pregnancy

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Total 418 results found since Jan 2013.

GSE95666 The Epidermal Growth Factor Receptor Critically Regulates Endometrial Function during Early Pregnancy
Contributor : Francesco DeMayoSeries Type : Expression profiling by arrayOrganism : Mus musculusInfertility and adverse gynecological outcomes such as preeclampsia and miscarriage represent significant female reproductive health concerns. The spatiotemporal expression of growth factors indicates that they play an important role in pregnancy. The goal of this study is to define the role of the ERBB family of growth factor receptors in endometrial function. Using conditional ablation in mice and siRNA in primary human endometrial stromal cells, we identified the epidermal growth factor receptor (Egfr) to be critical for endo...
Source: GEO: Gene Expression Omnibus - March 4, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

Chinese 1 strain of Toxoplasma gondii excreted –secreted antigens negatively modulate Foxp3 via inhibition of the TGFßRII/Smad2/Smad3/Smad4 pathway
This study was designed to investigate the effect of excreted–secreted antigens (ESA) of Chinese 1 strain of T. gondii on the expression of forkhead box transcription factor (Foxp3) as it pertains to early pregnancy and abortion. ESA caused a marked inhibition in the expression of Foxp3 both in vivo and in vitro. In addition, ESA negatively modulated Smad2 and Smad3 at the posttranslational level. Smad2 siRNA cooperated with ESA to further suppress the level of Foxp3. This inhibitory effect on Foxp3 expression was partially abrogated by overexpression of Smad2, Smad3 and Smad4. Additionally, ESA attenuated the expression...
Source: Journal of Cellular and Molecular Medicine - March 15, 2017 Category: Molecular Biology Authors: Jinling Chen, Caiqun Huang, Dandan Zhu, Pei Shen, Yinong Duan, Jianxin Wang, Chunzhao Yang, Liting Wu Tags: Original Article Source Type: research

Chinese 1 strain of Toxoplasma gondii excreted-secreted antigens negatively modulate Foxp3 via inhibition of the TGF ßRII/Smad2/Smad3/Smad4 pathway.
This study was designed to investigate the effect of excreted-secreted antigens (ESA) of Chinese 1 strain of T. gondii on the expression of forkhead box transcription factor (Foxp3) as it pertains to early pregnancy and abortion. ESA caused a marked inhibition in the expression of Foxp3 both in vivo and in vitro. In addition, ESA negatively modulated Smad2 and Smad3 at the posttranslational level. Smad2 siRNA cooperated with ESA to further suppress the level of Foxp3. This inhibitory effect on Foxp3 expression was partially abrogated by overexpression of Smad2, Smad3 and Smad4. Additionally, ESA attenuated the expression o...
Source: J Cell Mol Med - March 15, 2017 Category: Molecular Biology Authors: Chen J, Huang C, Zhu D, Shen P, Duan Y, Wang J, Yang C, Wu L Tags: J Cell Mol Med Source Type: research

The adequate corpus luteum: miR-96 promotes luteal cell survival and progesterone production.
Conclusions: miR-96 targets FOXO1 to regulate luteal development through effects on cell survival and steroid production. The miR-183-96-182 cluster could provide a novel target for the manipulation of luteal function. PMID: 28368475 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - March 20, 2017 Category: Endocrinology Authors: Mohammed BT, Sontakke SD, Ioannidis J, Duncan WC, Donadeu FX Tags: J Clin Endocrinol Metab Source Type: research

ITGAV (alpha v integrins) bind SPP1 (osteopontin) to support trophoblast cell adhesion
This study determined whether alpha v (av) integrins (ITGAV) directly mediate porcine trophoblast cell adhesion to secreted phosphoprotein 1 (SPP1, also known as osteopontin (OPN)) and examined the temporal/spatial expression of ITGAV, beta 3 (b3, ITGB3) and beta 6 (b6, ITGB6) integrin subunits, and SPP1, at the uterine–placental interface of pigs. Knockdown of ITGAV in porcine Tr (pTr2) cells by siRNA reduced pTr2 attachment to SPP1. In situ hybridization confirmed the presence of ITGAV, ITGB3 and ITGB6 mRNAs in uterine LE and conceptus Tr between Days 9 and 60 of gestation, with no change in the magnitude of expres...
Source: Reproduction - April 6, 2017 Category: Reproduction Medicine Authors: Frank, J. W., Seo, H., Burghardt, R. C., Bayless, K. J., Johnson, G. A. Tags: Research Source Type: research

Human chorionic gonadotropin  β regulates epithelial-mesenchymal transition and metastasis in human ovarian cancer.
Human chorionic gonadotropin β regulates epithelial-mesenchymal transition and metastasis in human ovarian cancer. Oncol Rep. 2017 Jul 14;: Authors: Liu N, Peng SM, Zhan GX, Yu J, Wu WM, Gao H, Li XF, Guo XQ Abstract Human chorionic gonadotropin β (β-hCG) is a well-known and accurate marker for the diagnosis and monitoring of pregnancy, trophoblastic tumors and ovarian germ cell tumors. Recently, β-hCG has been found to be closely related to poor prognosis and metastasis in various other malignant tumors, while its role and mechanism in ovarian cancer is still unclear. In the present study, lenti...
Source: Oncology Reports - July 18, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications.
Authors: Cai M, Kolluru GK, Ahmed A Abstract MicroRNAs are small, noncoding RNA molecules that regulate target gene expression in the posttranscriptional level. Unlike siRNA, microRNAs are "fine-tuners" rather than "switches" in the regulation of gene expression; thus they play key roles in maintaining tissue homeostasis. The aberrant microRNA expression is implicated in the disease process. To date, numerous studies have demonstrated the regulatory roles of microRNAs in various pathophysiological conditions. In contrast, the study of microRNA in pregnancy and its associated complications, such as preeclampsia (PE)...
Source: Journal of Pregnancy - July 19, 2017 Category: OBGYN Tags: J Pregnancy Source Type: research

The transcriptional repressor GATAD2B mediates progesterone receptor suppression of myometrial contractile gene expression Gene Regulation
The mechanisms whereby progesterone (P4), acting via the progesterone receptor (PR), inhibits proinflammatory/contractile gene expression during pregnancy are incompletely defined. Using immortalized human myometrial (hTERT-HM) cells stably expressing wild-type PR-A or PR-B (PRWT), we found that P4 significantly inhibited IL-1β induction of the NF-κB target genes, COX-2 and IL-8. P4–PRWT transrepression occurred at the level of transcription initiation and was mediated by decreased recruitment of NF-κB p65 and RNA polymerase II to COX-2 and IL-8 promoters. However, in cells stably expressing a PR-A or PR-B DNA-binding...
Source: Journal of Biological Chemistry - July 28, 2017 Category: Chemistry Authors: Chien-Cheng Chen, Alina P. Montalbano, Imran Hussain, Wan-Ru Lee, Carole R. Mendelson Tags: Gene Regulation Source Type: research

HB-EGF regulates Prss56 expression during mouse decidualization via EGFR/ERK/EGR2 signaling pathway
Embryo implantation and decidualization are key steps for successful reproduction. Although numerous factors have been identified to be involved in embryo implantation and decidualization, the mechanisms underlying these processes are still unclear. Based on our preliminary data, Prss56, a trypsin-like serine protease, is strongly expressed at implantation site in mouse uterus. However, the expression, regulation and function of Prss56 during early pregnancy are still unknown. In mouse uterus, Prss56 is strongly expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy compared to inter-implantat...
Source: Journal of Endocrinology - August 2, 2017 Category: Endocrinology Authors: Liu, J., Gao, F., Liu, Y.-F., Dou, H.-T., Yan, J.-Q., Fan, Z.-M., Yang, Z.-M. Tags: Research Source Type: research

NLRP7 contributes to in vitro decidualization of endometrial stromal cells.
CONCLUSIONS: NLRP7 was upregulated and translocated to the nucleus of the endometrial stromal cells in an in vitro decidualization model. Overexpressed NLRP7 promoted the IGFBP-1 expression and PR reporter activation. IGFBP-1 expression decreased with the knockdown of NLRP7. Therefore, we suggest that NLRP7 contributes to in vitro decidualization of endometrial stromal cells. PMID: 28810880 [PubMed - in process]
Source: Reproductive Biology - August 15, 2017 Category: Reproduction Medicine Authors: Huang JY, Yu PH, Li YC, Kuo PL Tags: Reprod Biol Endocrinol Source Type: research

Molecular mechanism of miR-181b in heart disease due to pregnancy-induced hypertension syndrome.
Authors: Gao Z, Wang L, Wang J, Yang F, Qu J Abstract The present study aimed to investigate the molecular mechanisms of microRNA (miR)-181b in heart disease due to hypertensive disorders complicating pregnancy (HDCP) through regulating the expression of metallopeptidase inhibitor 3 (TIMP3). miR-181b expression was detected by reverse transcription-quantitative polymerase chain reaction in peripheral blood samples from patients with HDCP. These samples were analyzed for clinical pathological characteristics. The primary cardiomyocytes of rats were cultured in hypoxic conditions for 24 h, in which miR-181b expressio...
Source: Experimental and Therapeutic Medicine - September 17, 2017 Category: General Medicine Tags: Exp Ther Med Source Type: research

Abstract 036: Regulation of sFlt-1 Splicing by U2AF and JMJD Session Title: Pregnancy and Preeclampsia
Preeclampsia (PE) is a gestational disorder defined by new-onset hypertension and maternal endothelial dysfunction. Though its origins are unclear, placental ischemia is thought to be the central cause. In response, the placenta releases pathogenic factors, such as the anti-angiogenic soluble form of the VEGF receptor Flt-1 (sFlt-1), into the maternal circulation. sFlt-1 is a soluble splice variant of the VEGF receptor Flt-1, acting as a VEGF sink in the circulation. The regulation of sFlt-1 splicing is not completely understood, but it is proposed that the splicing factor U2AF65 promotes splicing, while JMJD6 opposes it b...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Adrian C Eddy, Heather Chapman, Eric M George Tags: Oral Abstract Presentations Source Type: research

Abstract 146: MicroRNA-216a Promotes M1 Macrophages Polarization Through the Activation of Telomerase Session Title: Developmental Programming and Pregnancy Induced Hypertension
Conclusions: Our data indicated that miR-216a promotes M1 macrophages polarization through the activation of telomerase and reduces collagen III in mice carotid lesions, and ultimately accelerates the development of atherosclerosis.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Shujun Yang, Jian Li, Yu Chen, Rutai Hui, Weili Zhang Tags: Oral Abstract Presentations Source Type: research

Human Endometrial Stromal Cell Decidualization Requires Transcriptional Reprogramming by PLZF.
Abstract Infertility and early embryo-miscarriage is linked to inadequate endometrial decidualization. Although transcriptional reprogramming is known to drive decidualization in response to progesterone, the key signaling effectors that directly mediate this hormone response are not fully known. This knowledge-gap is clinically significant because identifying the early signals that directly mediate progesterone-driven decidualization will address some of the current limitations in diagnosing and therapeutically treating patients at most risk for early pregnancy loss. We recently revealed that the promyelocytic le...
Source: Biology of Reproduction - November 25, 2017 Category: Reproduction Medicine Authors: Szwarc MM, Hai L, Gibbons WE, Peavey MC, White LD, Mo Q, Lonard DM, Kommagani R, Lanz RB, DeMayo FJ, Lydon JP Tags: Biol Reprod Source Type: research

Effects of THC on human amniotic epithelial cell proliferation and migration.
CONCLUSION: These results suggested that THC inhibited the migration of human amniotic epithelial cell through the regulation of MMP2 and MMP9, which in turn altered the development of the amnion during the gestation and partially resulted in preterm labor and other adverse pregnancy outcomes. PMID: 29191629 [PubMed - as supplied by publisher]
Source: Toxicology - November 27, 2017 Category: Toxicology Authors: Yao JL, He QZ, Liu M, Chang XW, Wu JT, Duan T, Wang K Tags: Toxicology Source Type: research