Filtered By:
Condition: Pregnancy
This page shows you your search results in order of relevance.
Order by Relevance | Date
Total 418 results found since Jan 2013.
Generation of transgenic pigs carrying siRNA vector directed against human tissue factor expression
ConclusionsThe AVR is currently the bottleneck in porcine‐to‐primate organ xenotransplantation. Controlling TF‐induced coagulation might provide protective effects for porcine xenografts. Thus, TF knockdown pigs could be critical in producing the ultimate multi‐transgenic pig as organ donor for human patients.
References[1] Toomey J, Kratzer K, Lasky N, Stanton J, Broze GJ. Targeted disruption of the murine tissue factor gene results in embryonic lethality. Blood. 1996; 88(5): 1583–1587.
Source: Xenotransplantation - April 19, 2014 Category: Transplant Surgery Authors: Hellen Ahrens, Björn Petersen, Doris Herrmann, Andrea Lucas‐Hahn, Petra Hassel, Maren Ziegler, Wilfried Kues, Heiner Niemann Tags: Program and Abstracts Source Type: research
Efficient siRNA transfer to knockdown a placenta specific lncRNA using RGD-modified nano-liposome: A new preeclampsia-like mouse model
Publication date: 30 July 2018 Source:International Journal of Pharmaceutics, Volume 546, Issues 1–2 Author(s): Qianwen Yu, Yue Qiu, Xuhui Wang, Jiajing Tang, Yayuan Liu, Ling Mei, Man Li, Ming Yang, Li Tang, Huile Gao, Zhirong Zhang, Wenming Xu, Qin He Preeclampsia is one of the most serious pregnancy complications. Many animal models have already been developed by researchers to study the pathogenesis and treatment of preeclampsia. However, most of these animal models were established by systemic administration or by surgery in the uterine cavity, which could lead to unwanted systemic toxicity or operative wounds and ...
Source: International Journal of Pharmaceutics - May 17, 2018 Category: Drugs & Pharmacology Source Type: research
Title: Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells
Conclusions: Using Ishikawa cells, we observed that exposure to genistein resulted in distinct changes in gene expression and unique differences in the GR transcriptome.
Citation: Whirledge S, Senbanjo LT, Cidlowski JA. 2015. Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect 123:80–87; http://dx.doi.org/10.1289/ehp.1408437
Address correspondence to J.A. Cidlowski, NIH/NIEHS, MD F3-07, P.O. Box 12233, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-1564. E-mail: cidlows1@niehs.nih.gov
We thank X. Xu (Integrative Bioinformatic...
Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Research Article January 2015 Source Type: research
Abstract P310: Atuplex Formulated With Small Interfering RNA For Soluble Fms-like Tyrosine Kinase-1 (sFLT1) Selectively Silences Maternal And Placental sFLT1 In A Preeclamptic Rat Model Session Title: Pregnancy and Preeclampsia and Developmental Programming of Cardiovascular Disease
Preeclampsia is a pregnancy-related disorder characterized by hypertension and proteinuria, affecting about 5-8% of pregnancies. It is a major cause of fetal and maternal morbidity/mortality. The disease is most probably multifactorial and caused by several placental dysfunctions. As an important mediator, sFLT1 is induced in the placenta and in the serum of preeclamptic women, acting as a decoy receptor for placenta like growth factors (PLGF) and inducing an antiangiogenic balance. RNAi mediated gene specific silencing could represent a new therapeutic option in preeclampsia management. We tested sFLT1-specific small inte...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Nadine Haase, Kristin Kraker, Ute Schaeper, Jens Endruschat, Dominik N Muller, Ralf Dechend Tags: Poster Abstract Presentations Source Type: research
Periostin acts as a bridge between gestational diabetes mellitus (GDM) and chronic inflammation to modulate insulin resistance by modulating PPAR α/NF-κB/TNF-α signaling pathway
CONCLUSION: POSTN levels were significantly higher in pregnant women with GDM and were associated with chronic inflammation and PPARα expression. POSTN may act as a bridge between GDM and chronic inflammation to modulate insulin resistance by modulating PPARα/NF-κB/TNF-α signaling pathway.PMID:37106515 | DOI:10.2174/1871530323666230427104724
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 28, 2023 Category: Drugs & Pharmacology Authors: Qun Ji Xinying Li Yan Wang Haiwei Liu Kaining Chen Huibiao Quan Huachuan Zhang Jianmin Ran Source Type: research
Abstract 275: Tissue Transglutaminase Stabilizes Placental AT1 Receptor and Contributes to Pathophysiology in Preeclampsia Poster Session I
Preeclampsia (PE) is a serious hypertensive disease of pregnancy associated with the presence of the major angiotensin receptor AT1-agnostic autoantibodies (AT1-AAs) that cause the defining PE features when introduced into pregnant mice. To understand AT1-AA-mediated receptor activation in PE, we explored the role of tissue transglutaminases (TG2), the most ubiquitous member of a group of enzymes modifying proteins by catalyzing the formation of -(-glutamyl)-lysine isopeptide bonds. TG2, a versatile protein that can also function as a G protein, is enriched in the syncytiotrophoblasts of placenta, the key organ in PE patho...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Liu, C., Wang, W., Parchim, N., Irani, R., Ning, C., Sun, K., Zhao, S., Zhao, C., Song, A., Zhang, Y., Blackwell, S., Sibai, B., Jin, J., Kellems, R., Xia, Y. Tags: Poster Session I Source Type: research
Abstract 280: Sflt-1 is Regulated via Both Transcriptional and Post-transcriptional Modification in Preeclampsia Poster Session I
Preeclampsia (PE) is a life-threatening hypertensive renal disorder of pregnancy. Soluble fms-like tyrosine kinase 1 (sFlt-1), an anti-angiogenic factor, is elevated and contributes to PE. However, molecular basis underlying its up-regulation in PE remains unclear. Here we report that hypoxia inducible factor-1α (HIF-1α), an important transcriptional factor, and U2AF65, a key molecule involved in alternative splicing, are significantly increased in the placentasof PE patients compared to the controls. Using two animal models of PE including angiotensin receptor type 1 receptor agonistic autoantibody (AT1-AA) an...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Wang, W., Parchim, N., Iriyama, T., Luo, R., Zhao, C., Zhang, Y., Blackwell, S., Sabai, B., Tao, L., Kellems, R., Xia, Y. Tags: Poster Session I Source Type: research
