Episodes of hypovolemia/dehydration in baboons with pig kidney transplants: A new syndrome of clinical importance?
Xenotransplantation, EarlyView. (Source: Xenotransplantation)
Source: Xenotransplantation - November 28, 2018 Category: Transplant Surgery Authors: Hayato Iwase,
Takayuki Yamamoto,
David K. C. Cooper Tags: LETTER TO THE EDITOR Source Type: research
Circulating miRNA ‐150‐5p is associated with immune‐mediated early β‐cell loss in a humanized mouse model
ConclusionsOur data demonstrated that immune ‐related miRNAs are associated with human islet xenograft rejection in mice. miR‐150‐5p is increased in human islet graft and in the circulation during islet xenograft rejection and β‐cell destruction prior to hyperglycemia and may be an early biomarker for islet xenograft rejection. (Source: Xenotransplantation)
Source: Xenotransplantation - November 21, 2018 Category: Transplant Surgery Authors: Regan Roat,
Md Munir Hossain,
Jenica Christopherson,
Colette Free,
Claudiane Guay,
Romano Regazzi,
Zhiguang Guo Tags: ORIGINAL ARTICLE Source Type: research
Chronic dialysis in patients with end ‐stage renal disease: Relevance to kidney xenotransplantation
AbstractRenal allotransplantation clearly offers better survival and quality of life for end ‐stage renal disease (ESRD) patients than chronic dialysis. The median waiting time for a deceased donor kidney in a suitable ESRD patient is 3.9 years. The initial candidates for pig kidney xenotransplantation will be those with ESRD unlikely to receive an allograft within a reasonable period of time. It is thus reasonable to ascertain whether clinical trials of xenotransplantation might likewise offer superior outcomes. Chronic dialysis in patients with ESRD is associated with poor quality of life, significant morbidity, and r...
Source: Xenotransplantation - November 20, 2018 Category: Transplant Surgery Authors: Abhijit Jagdale,
David K. C. Cooper,
Hayato Iwase,
Robert S. Gaston Tags: COMMENTARY Source Type: research
Amino acid and lipid profiles following pig ‐to‐primate liver xenotransplantation
This report aims to further investigate the post‐LXT lipid and amino acid metabolism profile in our longest surviving recipients (25 and 29 da ys). Experimental samples and control samples, consisting of pre‐transplant porcine and baboon serum and plasma, were analyzed for standard lipid profiles and for amino acid levels. Lipid profiles of LXT recipients remained stable following xenotransplantation compared to donor porcine baseline le vels. Amino acid concentrations also remained similar to baseline controls, with the exception of a 3‐foldincrease inl‐ornithine and more than a 10‐folddecrease inl‐arginine p...
Source: Xenotransplantation - November 16, 2018 Category: Transplant Surgery Authors: Jigesh A. Shah,
Madhukar S. Patel,
Nathan Louras,
David H. Sachs,
Parsia A. Vagefi Tags: BRIEF COMMUNICATION Source Type: research
Comparative evaluation of decellularized porcine liver matrices crosslinked with different chemical and natural crosslinking agents
The objective of this study was to compare the scaffold properties of porcine liver ECM crosslinked with different agents (glutaraldehyde, genipin, and quercetin) to find the best strategy for producing a decellularized matrix with optimal and stable characteristics for transplantation and regeneration. The properties examined include mechanical properties, material stability, immunogenicity, and angiogenic capacity. Scaffolds were implanted into the greater omentum of rats, and their abilities to induce immune cell subpopulation invasion and neovascularization were evaluated. The results show that genipin crosslinking of ...
Source: Xenotransplantation - November 10, 2018 Category: Transplant Surgery Authors: Mengyu Gao,
Yujia Wang,
Yuting He,
Yi Li,
Qiong Wu,
Guang Yang,
Yanyan Zhou,
Diwei Wu,
Ji Bao,
Hong Bu Tags: ORIGINAL ARTICLE Source Type: research
Will donor ‐derived neoplasia be problematic after clinical pig organ or cell xenotransplantation?
AbstractThere is an increased incidence of certain tumors and other neoplastic disease in organ allotransplant recipients receiving immunosuppressive therapy. Following clinical pig organ xenotransplantation, will there be a risk of the development of neoplasia in the pig graft or in other tissues transplanted with it, eg, lymph nodes? The incidence of neoplasia in young slaughterhouse pigs is very low (<0.005%), but in older pigs is largely unknown (as most pigs are killed within the first six months of life). However, lymphosarcoma, nephroblastoma, and melanoma have been reported in pigs. These tumors should be readil...
Source: Xenotransplantation - November 9, 2018 Category: Transplant Surgery Authors: Abhijit Jagdale,
Hayato Iwase,
Edwin Klein,
David K. C. Cooper Tags: COMMENTARY Source Type: research
Contribution of rat embryonic stem cells to xenogeneic chimeras in blastocyst or 8 ‐cell embryo injection and aggregation
Xenotransplantation, EarlyView. (Source: Xenotransplantation)
Source: Xenotransplantation - October 30, 2018 Category: Transplant Surgery Authors: Hiroki Okumura,
Anna Nakanishi,
Satoshi Toyama,
Mai Yamanoue,
Kana Yamada,
Akane Ukai,
Tadahiro Hashita,
Takahiro Iwao,
Tomomi Miyamoto,
Yoh ‐ichi Tagawa,
Masumi Hirabayashi,
Ichiro Miyoshi,
Tamihide Matsunaga Source Type: research
Porcine signal regulatory protein alpha binds to human CD47 to inhibit phagocytosis: Implications for human hematopoietic stem cell transplantation into severe combined immunodeficient pigs
Xenotransplantation, EarlyView. (Source: Xenotransplantation)
Source: Xenotransplantation - October 12, 2018 Category: Transplant Surgery Authors: Adeline N. Boettcher,
Joan E. Cunnick,
Ellis J. Powell,
Timothy K. Egner,
Sara E. Charley,
Crystal L. Loving,
Christopher K. Tuggle Source Type: research
Cardiac xenografts show reduced survival in the absence of transgenic human thrombomodulin expression in donor pigs
Xenotransplantation, EarlyView. (Source: Xenotransplantation)
Source: Xenotransplantation - October 5, 2018 Category: Transplant Surgery Authors: Avneesh K. Singh,
Joshua L. Chan,
Laura DiChiacchio,
Naomi L. Hardy,
Philip C. Corcoran,
Billeta G. T. Lewis,
Marvin L. Thomas,
Allen P. Burke,
David Ayares,
Keith A. Horvath,
Muhammad M. Mohiuddin Source Type: research
In vitro evaluation of bovine pericardium after a soft decellularization approach for use in tissue engineering
Xenotransplantation, EarlyView. (Source: Xenotransplantation)
Source: Xenotransplantation - September 28, 2018 Category: Transplant Surgery Authors: Marina Augusto Heuschkel,
Amanda Leitolis,
Jo ão Gabriel Roderjan,
Paula Hansen Suss,
César Augusto Oleinik Luzia,
Francisco Diniz Affonso Costa, `
Alejandro Correa,
Marco Augusto Stimamiglio Source Type: research
Cover Image, Volume 25, Issue 5
Xenotransplantation,Volume 25, Issue 5, September/October 2018. (Source: Xenotransplantation)
Source: Xenotransplantation - September 26, 2018 Category: Transplant Surgery Authors: Han ‐Tang Wang,
Akira Maeda,
Rieko Sakai,
Pei‐Chi Lo,
Chihiro Takakura,
Patmika Jiaravuthisan,
Afifah Mod Shabri,
Rei Matsuura,
Tasuku Kodama,
Shohei Hiwatashi,
Hiroshi Eguchi,
Hiroomi Okuyama,
Shuji Miyagawa Source Type: research
Issue Information
Xenotransplantation,Volume 25, Issue 5, September/October 2018. (Source: Xenotransplantation)
Source: Xenotransplantation - September 26, 2018 Category: Transplant Surgery Source Type: research
Long ‐term culture and in vitro maturation of macroencapsulated adult and neonatal porcine islets
Xenotransplantation, EarlyView. (Source: Xenotransplantation)
Source: Xenotransplantation - September 19, 2018 Category: Transplant Surgery Authors: Nizar I.
Mourad
,
Pierre
Gianello Source Type: research
Xenotransplantation literature update, July/August 2018
Xenotransplantation, EarlyView. (Source: Xenotransplantation)
Source: Xenotransplantation - September 17, 2018 Category: Transplant Surgery Authors: Heather E. Levy
,
Christopher Burlak Source Type: research
Circulating miRNA or circulating DNA —Potential biomarkers for organ transplant rejection
Xenotransplantation, EarlyView. (Source: Xenotransplantation)
Source: Xenotransplantation - September 11, 2018 Category: Transplant Surgery Authors: Qin
Huo
,
Ming
Zhou
,
David K. C.
Cooper
,
Yifan
Dai
,
Ni
Xie
,
Lisha
Mou Source Type: research
