Cardiac Remodeling in Morbidly Obese Women and its Association with Adverse Perinatal Outcomes
Publication date: Available online 23 May 2019Source: Pregnancy HypertensionAuthor(s): Jourdan E. Triebwasser, Nayla G. Kazzi, Melinda B. Davis, Emily K. Kobernik, Lisa D. Levine, Elizabeth S. LangenAbstractObjectivesTo determine the association of cardiac remodeling in early pregnancy and adverse perinatal outcomes among women with BMI ≥ 40 kg/m2.Study designWe performed a retrospective cohort study including women with BMI ≥ 40 kg/m2 without known cardiac disease. Women who underwent screening transthoracic echocardiography prior to gestational age 24 weeks were included. Women were analyzed by group with normal or...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 24, 2019 Category: OBGYN Source Type: research

Downregulation of miR-424 in placenta is associated with severe preeclampsia
Publication date: Available online 23 May 2019Source: Pregnancy HypertensionAuthor(s): Qiuqin Tang, Jing Gui, Xian Wu, Wei WuAbstractPrevious studies have suggested that altered miRNA expression in the placenta is associated with preeclampsia. The aim of this study was to investigate the expression of miR-424 in placental samples of severe preeclampsia (sPE) and uncomplicated pregnancy patients. miRNA was isolated from placentas obtained from 30 sPE patients and 30 healthy women. Quantitative real-time polymerase chain reaction was used to analyze the expression of miR-424. The prediction of target genes of miR-424 was per...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 24, 2019 Category: OBGYN Source Type: research

Self-reported maternal morbidity: results from the Community Level Interventions for Pre-eclampsia (CLIP) baseline survey in Sindh, Pakistan
ConclusionThis study estimated population-level mortality ratios that can be used for the planning of health interventions in these regions. Self-reported pregnancy hypertension and seizures was inaccurate, reflecting limited community understanding of these disorders. Mortality estimates are comparable to those reported by the World Health Organization for maternal mortality ratio and neonatal mortality rate of 170/100,000 and 36/1000 live births, respectively.Graphical abstract (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 19, 2019 Category: OBGYN Source Type: research

Combined antiretroviral therapy for HIV and the risk of hypertensive disorders of pregnancy: A systematic review
ConclusionDespite all studies indicating a higher frequency of HDP among pregnant women living with HIV using combined antiretroviral therapy when compared with seropositive pregnant women not using antiretroviral therapy, the quality of the studies is mixed, necessitating further research. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 19, 2019 Category: OBGYN Source Type: research

Changes over-time in blood pressure of women with preeclampsia compared to those with normotensive pregnancies: A 15 year population-based cohort study
Publication date: Available online 16 May 2019Source: Pregnancy HypertensionAuthor(s): Mina Amiri, Fahimeh Ramezani Tehrani, Maryam Rahmati, Samira Behboudi-Gandevani, Fereidoun AziziAbstractObjectivesTo estimate the incidence of hypertension and the trend of systolic and diastolic blood pressure changes and relating factors influencing women with and without prior PE.Study designThis prospective population based study included a total of 3022 eligible women (355 with PE and 2667 non-PE) recruited from participants of the Tehran Lipid and Glucose Study (TLGS) who were assessed for progression to subsequent hypertension ove...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 17, 2019 Category: OBGYN Source Type: research

Downregulations of circulating miR-31 and miR-21 are associated with preeclampsia
Publication date: Available online 15 May 2019Source: Pregnancy HypertensionAuthor(s): Kun Dong, Xiangli Zhang, Lijuan Ma, Na Gao, Haiyang Tang, Feng Jian, Yuyan MaAbstractMicroRNAs (miRs) are highly stable in circulating, which suppress target gene expression by base-pairing to the 3’-untranslated region. We compared the expressions of 3 circulating miRs (miR-31, miR-21, and miR-16), which are related to the control of cell apoptosis, invasion, angiogenesis and immune tolerance in non-pregnancy (n=10), 20-34 gestational weeks normal pregnancy (20-34GW NP, n=20), early onset preeclampsia (EOPE, n=20), 34-41 gestation...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 16, 2019 Category: OBGYN Source Type: research

External validation of the Fetal Medicine Foundation algorithm for the prediction of preeclampsia in a Brazilian population
Publication date: Available online 10 May 2019Source: Pregnancy HypertensionAuthor(s): Karina Bilda de Castro Rezende, Antônio José Ledo Alves da Cunha, Joffre Amim Junior, Rita Guérios Bornia (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 11, 2019 Category: OBGYN Source Type: research

Association of MicroRNA-210 and MicroRNA-155 with severity of preeclampsia
ConclusionsMicroRNA-210 may be the noncoding RNA at the molecular level in which the increase in its level accompanies the progression of PE; and is closely associated with the severity of Preeclampsia. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 11, 2019 Category: OBGYN Source Type: research

A Clinical evaluation of blood pressure measurement by iHealth BP5 in pregnancy
ConclusionThe iHealth BP5 is as good as the frequently used Omron M6 Comfort and can be used for blood pressure measurement during pregnancy.Condensed abstractIn 45 women the mean blood pressure differences between the Omron M6 Comfort, iHealth BP5 and the aneroid manometer were less dan ± 5 mmHg. These differences did not relate to gestational age, BMI or arm circumference. Bland-Altman plots showed good agreement of both iHealth BP5 and Omron M6 Comfort, without any systematic effects, as compared to the aneroid manometer.The iHealth BP5 is as good as the frequently used Omron M6 Comfort and can be used for blood ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 11, 2019 Category: OBGYN Source Type: research

Peripartum cardiomyopathy with co-incident preeclampsia: a cohort study of clinical risk factors and outcomes among commercially insured women
ConclusionPreeclamptic women with risk factors for PPCM and women with pePPCM at increased risk of MACE should be followed closely. Further studies are required to determine whether preeclampsia affects the long-term prognosis of women with PPCM. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 11, 2019 Category: OBGYN Source Type: research

Significance of pre-hospital care to reduce the morbidity of eclampsia in rural Zambia
ConclusionThe Pritchard regimen is considered to be suitable in the setting. However, the morbidity of eclampsia was high out of hospital. We have to educate pregnant women about the risks of PE and encourage the measurement of blood pressure at health facilities. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 11, 2019 Category: OBGYN Source Type: research

Vascular endothelial growth factor gene polymorphisms and hypertensive disorder of pregnancy: a meta-analysis
ConclusionsIn summary, our findings indicated that rs2010963 and rs3025039 polymorphisms were both significantly associated with the susceptibility to hypertensive disorder of pregnancy in certain populations. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 11, 2019 Category: OBGYN Source Type: research

Methyldopa versus Nifedipine or no medication for treatment of chronic hypertension during pregnancy: a multicenter randomized clinical trial
Publication date: Available online 9 May 2019Source: Pregnancy HypertensionAuthor(s): Mohamed Salama, Mohamed Rezk, Wael Gaber, Haitham Hamza, Hala Marawan, Awni Gamal, Sameh AbdallahAbstractObjectiveTo assess the maternal and fetal outcome in women with mild to moderate chronic hypertension on antihypertensive drug (methyldopa or nifedipine) therapy compared to no medication.MethodsThis multicenter randomized clinical trial was conducted at Menoufia University hospital, Shibin El-kom Teaching hospital and 11 Central hospitals at Menoufia governorate, Egypt.490 pregnant women with mild to moderate chronic hypertension were...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 11, 2019 Category: OBGYN Source Type: research

Prediction of preeclampsia using combination of biomarkers at 18–23 weeks of gestation: A nested case-control study
Publication date: July 2019Source: Pregnancy Hypertension, Volume 17Author(s): Anshul Jadli, Kanjaksha Ghosh, Kaizad Damania, Purnima Satoskar, Vandana Bansal, Shrimati ShettyAbstractObjectiveTo evaluate the combination of plasma activated endothelial microparticles (CD62e), serum Copeptin (CPP) and placental growth factor (PlGF) levels at 18–23 weeks of gestation for prediction of preeclampsia (PE) in primigravid women.MethodsThis was a nested case-control study from a prospective cohort of 1115 primigravid women attending antenatal care clinic. Plasma levels of CD62e and serum Copeptin, PlGF levels were measured ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 11, 2019 Category: OBGYN Source Type: research

Agreement of aneroid and oscillometric blood pressure devices used in pregnancy
ConclusionAccurate automated devices may ensure consistent assessment of blood pressure in the antenatal setting. Our results suggest that Microlife VSA and Uscom BP+ may be suitable alternatives to the aneroid device for use in the antenatal setting. Further studies assessing both auscultatory and oscillometric blood pressure devices in pregnancy, and especially in hypertensive cohorts, are required. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 10, 2019 Category: OBGYN Source Type: research

CXCL9/CXCL10 angiostasis CXC-chemokines in parallel with the CXCL12 as an angiogenesis CXC-chemokine are variously expressed in pre-eclamptic-women and their neonates
ConclusionAccording to the results, the CXC chemokines are involved in pathogenesis of pre-eclampsia and play important roles in several processes such as neovascularization, embryonic development and inflammatory responses that are mediated by pre-ecalmpsia. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 5, 2019 Category: OBGYN Source Type: research

Prediction of preeclampsia using combination of biomarkers at 18-23 weeks of gestation: A nested case-control study
Publication date: Available online 3 May 2019Source: Pregnancy HypertensionAuthor(s): Anshul Jadli, Kanjaksha Ghosh, Kaizad Damania, Purnima Satoskar, Vandana Bansal, Shrimati ShettyAbstractObjectiveTo evaluate combination of plasma activated endothelial microparticles (CD62e), serum Copeptin (CPP) and placental growth factor (PlGF) levels at 18-23 weeks of gestation for prediction of preeclampsia (PE) in primigravid women.MethodsThis was a nested case control study from a prospective cohort of 1115 primigravid women attending antenatal care clinic. Plasma levels of CD62e and serum Copeptin, PlGF levels were measured by fl...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 5, 2019 Category: OBGYN Source Type: research

Editorial Board
Publication date: April 2019Source: Pregnancy Hypertension, Volume 16Author(s): (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 3, 2019 Category: OBGYN Source Type: research

Liver enzyme patterns in maternal deaths due to Eclampsia: A South African cohort
Publication date: Available online 3 May 2019Source: Pregnancy HypertensionAuthor(s): Olutayo Margaret Alese, Thajasvarie Naicker, Jagidesa MoodleyAbstractEclampsia is an obstetric emergency and a major cause of maternal mortality in low and middle-income countries such as South Africa. Despite years of research, there is no single test for the prediction of eclampsia, however liver function tests have been effective in monitoring the prognosis of this disorder.This was a retrospective study of patients in whom the final cause of death was eclampsia in South Africa between the years 2014-2016.Of 109 cases who died from ecl...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 3, 2019 Category: OBGYN Source Type: research

Association of plasma lactate concentration at admission of severe preeclampsia to maternal complications
ConclusionIncreased plasma lactate concentrations at admission in women with severe preeclampsia are independently associated to maternal complications. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 3, 2019 Category: OBGYN Source Type: research

Quantifying adherence to antihypertensive medication for chronic hypertension during pregnancy
This study aimed to evaluate adherence to antihypertensive treatment amongst pregnant women with chronic hypertension using high-performance liquid chromatography-tandem mass spectrometry instrumentation. Spot urine samples collected from women who were randomised to labetalol or nifedipine were assessed. Samples from 74 women were included; documented prescribing and urine metabolite detection were concordant in 88% (n=65). Evidence of self-administration of alternative treatment was observed in 8% (n=6). Measurement of urinary antihypertensive metabolites in pregnancy provides insight into treatment adherence. (Source: P...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 3, 2019 Category: OBGYN Source Type: research

Soluble E-selectin, platelet count and mean platelet volume as biomarkers for pre-eclampsia
Publication date: Available online 26 April 2019Source: Pregnancy HypertensionAuthor(s): Hend El-Sayed Hassan, Hanan Azzam, Maha Othman, Mohammad Hassan, Tarek SelimAbstractObjectivesPreeclampsia remains a major cause of maternal mortality and morbidity worldwide with increased risk for cardiovascular disease later in life. Many previous studies have examined several biomarkers including E-selectin. We aimed to assess the role of sE-selectin together with platelet count and mean platelet volume (MPV) as biomarkers for the prediction of preeclampsia.Study design and major outcome measuresThis case-control study included 85 ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - April 26, 2019 Category: OBGYN Source Type: research

Maternal and Perinatal Outcome Related to Severity of Chronic Hypertension in Pregnancy
This study was performed in Dr Soetomo General Hospital, a tertiary center in East – Java, Indonesia over the period of 2013-2017. Chronic hypertension (CH) was divided using JNC VII criteria, as stage 1 (Blood pressure ≥140/90 mmHg) and Stage 2 (BP>160/110 mmHg) hypertension.Main Outcome Measures:The primary outcomes were maternal and perinatal outcome. Data was statistically analyzed using Chi-square, Fischer exact test, and Mann-Whitney test (program: SPSS ®23)ResultsOver these 5 years, 352 patients were diagnosed with CH. The stage 2 of CH was associated with worse maternal outcome: maternal death (5.6%...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - April 23, 2019 Category: OBGYN Source Type: research

Differential expression of candidate circulating microRNAs in maternal blood leukocytes of the patients with preeclampsia and gestational diabetes mellitus
ConclusionsOur findings indicated that decreased miR-21-3p and miR-155-5p expression levels are associated with PE and miR-21-3p levels are associated with GDM. Our study for the first time revealed that miR-21-3p, miR-16-5p and miR155-5p are not related to PE-GDM group. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - April 20, 2019 Category: OBGYN Source Type: research

Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy: First in vivo evidence
Publication date: April 2019Source: Pregnancy Hypertension, Volume 16Author(s): Ana Sofia Cerdeira, Neva Kandzija, Pille Pargmae, William Cooke, Tim James, Christopher Redman, Manu VatishAbstractCirculating sFlt-1 increases significantly in pregnancy compared to the non-pregnant state and even more so in the event of preeclampsia. We set out to determine if circulating sFlt-1 is placentally derived in normal pregnancy. Paired uterine and peripheral vein samples were collected at time of caesarean section. A follow up peripheral sample was collected in the postpartum period. There was a significant sFlt-1 gradient between u...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - April 18, 2019 Category: OBGYN Source Type: research

Accuracy and precision of USCOM versus transthoracic echocardiography before and during pregnancy
ConclusionDue to its safe and feasible use, USCOM could be used to determine CO in pregnant women. However, absolute values of USCOM and TTE cannot be used interchangeably. Future research could focus on the agreement of USCOM and TTE in clinical decision-making. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - April 16, 2019 Category: OBGYN Source Type: research

Genetic variants in DICER1, DROSHA, RAN, and XPO5 genes and risk of Pregnancy-induced Hypertension
Publication date: Available online 16 April 2019Source: Pregnancy HypertensionAuthor(s): Xin Huang, Yuhui An, Xun Li, Dapeng Wang, Hongzhuan Tan, Jun LeiAbstractObjectiveTo evaluate the impact of microRNA (miRNA) machinery gene polymorphisms on the risk of gestational hypertension (GH) and preeclampsia (PE).Study design: A case-control study among Han Chinese with a total of 143 patients diagnosed with PE, 79 with GH, and 330 healthy controls was conducted. Nine candidate SNPs in 4 selected miRNA biogenesis genes were genotyped, including three DICER1 SNPs (rs3742330, rs1057035 and rs13078), two DROSHA SNPs (rs17409893 and...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - April 16, 2019 Category: OBGYN Source Type: research

Low fetal fraction of cell-free DNA predicts placental dysfunction and hypertensive disease in pregnancy
CONCLUSIONSLow fetal fraction of cfDNA among asymptomatic women may serve as a predictor of subsequent placental dysfunction and hypertensive disease. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - April 13, 2019 Category: OBGYN Source Type: research

Vegetable dietary pattern associated with low risk of preeclampsia possibly through reducing proteinuria
ConclusionsAdherence to vegetable dietary pattern may be associated with the lower risk of preeclampsia, possibly through reducing development of proteinuria. The original full study was registered at clinicaltrials.gov as NCT02537392. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - April 8, 2019 Category: OBGYN Source Type: research

Title: Circulating soluble fms-like tyrosine kinase-1 is placentally derived in normal pregnancy : First in vivo evidence
Publication date: Available online 30 March 2019Source: Pregnancy HypertensionAuthor(s): Ana Sofia Cerdeira, Neva Kandzija, Pille Pargmae, William Cooke, Tim JAMES, Christopher Redman, Manu VatishAbstractCirculating sFlt-1 increases significantly in pregnancy compared to the non-pregnant state and even more so in the event of preeclampsia. We set out to determine if circulating sFlt-1 is placentally derived in normal pregnancy. Paired uterine and peripheral vein samples were collected at time of caesarean section. A follow up peripheral sample was collected in the postpartum period. There was a significant sFlt-1 gradient ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 31, 2019 Category: OBGYN Source Type: research

Differences in the prognosis of preeclampsia according to the initial symptoms: a single-center retrospective report
Publication date: Available online 30 March 2019Source: Pregnancy HypertensionAuthor(s): Eishin Nakamura, Yukiko Mikami, Sumiko Era, Yoshihisa Ono, Shigetaka Matsunaga, Tomonori Nagai, Yasushi Takai, Masahiro Saitoh, Kazunori Baba, Hiroyuki Seki (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 31, 2019 Category: OBGYN Source Type: research

Serum levels of miR-628-3p and miR-628-5p during the early pregnancy are increased in women who subsequently develop preeclampsia
ConclusionsSerum hsa-miR-628-3p and hsa-miR-628-5p were differentially expressed between WWD-PE and controls, suggesting a participation of these miRNAs in the development of preeclampsia. Future studies are needed to validate hsa-miR628-3p and -5p as early predictors of preeclampsia. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 29, 2019 Category: OBGYN Source Type: research

Role of plasma PlGF, PDGF-AA, ANG-1, ANG-2, and the ANG-1/ANG-2 ratio as predictors of preeclampsia in a cohort of pregnant women
ConclusionIn pregnant women, with gestational ages between 20-25 weeks significant differences in biomarker concentrations between groups PE and HP were not observed. The ROC curves showed that the biomarkers were ineffective as preeclampsia predictors in the analyzed cohort. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 24, 2019 Category: OBGYN Source Type: research

Midpregnancy prediction of pre-eclampsia using serum biomarkers sFlt-1 and PlGF
Publication date: Available online 21 March 2019Source: Pregnancy HypertensionAuthor(s): Carin Black, Ahmed Al-Amin, Caroline Stolarek, Stefan C. Kane, Daniel Lorber Rolnik, Adrienne White, Fabricio da Silva Costa, Shaun BrenneckeAbstractObjectivesPre-eclampsia remains a significant cause of morbidity and mortality. Placental biomarkers soluble Fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) have been investigated previously for their ability to predict pre-eclampsia. We compared the performance of these biomarkers for midpregnancy pre-eclampsia prediction using three different immunoassay platforms....
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 22, 2019 Category: OBGYN Source Type: research

Critical barriers for preeclampsia diagnosis and treatment in low-resource settings: an example from Bolivia
Publication date: Available online 14 March 2019Source: Pregnancy HypertensionAuthor(s): Lilian Toledo-Jaldin, Sheana Bull, Stephen Contag, Carlos Escudero, Patricio Gutierrez, Alexandra Heath, James M. Roberts, Jean Scandlyn, Colleen G. Julian, Lorna G. MooreAbstractThe goals of the United Nation’s Millennium Summit for reducing maternal mortality have proven difficult to achieve. In Bolivia, where maternal mortality is twice the South American average, improving the diagnosis, treatment and ultimately prevention of preeclampsia is key for achieving targeted reductions. We held a workshop in La Paz, Bolivia to revie...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 16, 2019 Category: OBGYN Source Type: research

Hypertensive disorder of pregnancy prevalence and associated factors among pregnant women attending ante natal care at Gondar Town Health Institutions, North West Ethiopia 2017
ConclusionThe finding of this study showed that there were a considerable proportion of women had hypertensive disorder of pregnancy. Therefore, it is important to give health education to develop health seeking behavior of pregnant women. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 13, 2019 Category: OBGYN Source Type: research

Pregnancy Hypertension and its Associations with Pre-pregnancy Depression, Anxiety, Antidepressants, and Anxiolytics
ConclusionWhile anti-depressants/anxiolytics may be useful indicators in risk stratification for pregnancy hypertension, the same does not appear to be true for depression/anxiety without related medication use. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 13, 2019 Category: OBGYN Source Type: research

Prediction models for preeclampsia: a systematic review
ConclusionsTo date, multiple and widely varying models for preeclampsia prediction have been developed, some yielding promising results. The high degree of between-study heterogeneity impedes selection of the best model, or an aggregated analysis of prognostic models. Before multivariable preeclampsia prediction can be clinically implemented universally, further validation and calibration of well-performing prediction models is needed. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 13, 2019 Category: OBGYN Source Type: research

Diagnostic utility of angiogenic biomarkers in pregnant women with suspected preeclampsia: a health economics review
Publication date: Available online 11 March 2019Source: Pregnancy HypertensionAuthor(s): Dietmar Schlembach, Martin Hund, Cyrill Wolf, Manu VatishAbstractPreeclampsia is a major cause of morbidity and mortality, can be difficult to diagnose, and is associated with significant healthcare costs. The prediction, diagnosis and prognosis of preeclampsia have depended on repeated assessment of women with known risk factors, including intensive monitoring and hospitalization. Many of these women may never go on to develop preeclampsia. Recent developments in the pathogenesis of preeclampsia have shown that maternal serum biomarke...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 13, 2019 Category: OBGYN Source Type: research

Serum Cystatin-C as predictive factor of preeclampsia: a meta-analysis of 27 observational studies
ConclusionsAccording to the findings of our study serum cystatin-c seems to be a promising biomarker for the detection of preeclampsia during the third trimester of pregnancy. Therefore, its implementation in future predictive models in the field is recommended. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 13, 2019 Category: OBGYN Source Type: research

Quantification of circulating miR-517c-3p and miR-210-3p levels in preeclampsia
This study can lead to new opportunities for research about the roles of miRNAs in preeclampsia etiology or new biomarkers. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 13, 2019 Category: OBGYN Source Type: research

The importance and safety of calcium antagonists in the treatment of hypertension in pregnant women
Publication date: Available online 6 March 2019Source: Pregnancy HypertensionAuthor(s): Grzegorz Grześk, Łukasz Wołowiec, Marcin Walukiewicz, Daniel Rogowicz, Wojciech Gilewski, Joanna BanachAbstractThe use of CCBs, including newer dihydropyridine derivatives like felodipine and amlodipine, seems to be an effective, safe and more modern option in HDP therapy and during breast-feeding. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 6, 2019 Category: OBGYN Source Type: research

Editorial Board
Publication date: January 2019Source: Pregnancy Hypertension, Volume 15Author(s): (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 28, 2019 Category: OBGYN Source Type: research

Re-evaluation of abruptio placentae and other maternal complications during expectant management of early onset pre-eclampsia
Publication date: Available online 27 February 2019Source: Pregnancy HypertensionAuthor(s): Helvi M. Shoopala, David R. HallAbstractObjectiveExpectant management of appropriately selected cases of early pre-eclampsia in a dedicated, tertiary in-patient setting with frequent non-invasive maternal and fetal surveillance, prolongs pregnancy, improves perinatal outcome and mitigates the impact of maternal complications. As the rate of abruptio placentae in a large descriptive study performed nearly 20 years ago was 20%, a study to re-evaluate the rate of abruptio placentae and other maternal complications was performed.Study d...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 27, 2019 Category: OBGYN Source Type: research

Considering parents as a unit: Associations of gestational diabetes and gestational hypertension with postpartum diabetes and hypertension in couples
ConclusionsGDM/GH predict diabetes and hypertension in couples as a unit underscoring the concept of shared couple risk. These findings may help foster couple collaboration for cardiovascular risk reduction in the household. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 27, 2019 Category: OBGYN Source Type: research

Corrigendum to “The feasibility and acceptability of self-testing for proteinuria during pregnancy: A mixed methods approach” [Pregn. Hypertens. 12 (2018) 161–168]
Publication date: April 2019Source: Pregnancy Hypertension, Volume 16Author(s): Katherine L. Tucker, Liza Bowen, Carole Crawford, Philippa Mallon, Lisa Hinton, Mei-Man Lee, Jason Oke, Kathryn S. Taylor, Carl Heneghan, Clare Bankhead, Lucy Mackillop, Tim James, Pippa Oakeshott, Lucy C. Chappell, Richard J. McManus (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 27, 2019 Category: OBGYN Source Type: research

Peripheral maternal haemodynamics across pregnancy in hypertensive disorders of pregnancy
ConclusionWomen who develop preeclampsia show an altered, while those who develop GH or IH demonstrate a comparable haemodynamic adaptation compared to uncomplicated pregnancies. Monitoring central blood pressure and AIx in pregnancy provides additional value. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 25, 2019 Category: OBGYN Source Type: research

CD-34+ and VE-cadherin+ endothelial progenitor cells in preeclampsia and normotensive pregnancies
ConclusionAlthough widely used in cardiovascular disease other than preeclampsia, this is the first study using VE-cadherin as a marker of endothelial lineage to define EPCs in preeclampsia. Our results suggest the higher number of EPCs in preeclampsia may be a response of the bone marrow to endothelial injury. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 25, 2019 Category: OBGYN Source Type: research

Considering Parents as a Unit: Associations of Gestational Diabetes and GestationalHypertension with Postpartum Diabetes and Hypertension in Couples
ConclusionsGDM/GH predict diabetes and hypertension in couples as a unit underscoring the concept of shared couple risk. These findings may help foster couple collaboration for cardiovascular risk reduction in the household (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 18, 2019 Category: OBGYN Source Type: research

Angiogenic factors and uterine artery Doppler in predicting preeclampsia and associated adverse outcomes in a tertiary hospital in south India
Publication date: April 2019Source: Pregnancy Hypertension, Volume 16Author(s): Ajit Sebastian, T.J. Simi Raj, Hilda Yenuberi, Victoria Job, Santosh Varuhghese, Jayaseelan L., Annie Regi (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 16, 2019 Category: OBGYN Source Type: research