Methylene tetrahydrofolate reductase and methionine synthase gene polymorphisms as genetic determinants of pre-eclampsia
This study was a hospital based study carried out in Lagos, South-western Nigeria. Two hundred pregnant women clinically diagnosed with pre-eclampsia (study group) and 200 apparently healthy non-pre-eclamptic pregnant women (control group) were recruited for the study after written informed consent. Pre-eclampsia was diagnosed based on the International Society for the Study of Hypertension in Pregnancy re-classification of 2013. MTHFR C677T and MTR A2756G polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.Statistical analyzes were performed using SPSS vers...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 11, 2020 Category: OBGYN Source Type: research

Title. Epidemiology of pre-eclampsia in the Republic of Kazakhstan: maternal and neonatal outcomes
ConclusionThe data obtained are needed to tailor public health interventions targeted on a reduction of PE problem in Kazakhstan. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 11, 2020 Category: OBGYN Source Type: research

PHLDA2 gene polymorphisms and risk of HELLP syndrome and severe preeclampsia
CONCLUSIONGenetic variation in the PHLDA2 gene is not associated with HELLP syndrome or PE with severe features. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 30, 2020 Category: OBGYN Source Type: research

Opportunities for improving hypertensive disorders of pregnancy (HDP) management in primary care settings: a review of international published guidelines in the context of pregnancy care in Indonesia
Publication date: Available online 22 January 2020Source: Pregnancy HypertensionAuthor(s): Fitriana Murriya Ekawati, Ova Emilia, Shaun Brennecke, Jane Gunn, Sharon Licqurish, Phyllis LauAbstractGlobally, almost maternal mortality caused by HDP occurs in low to middle-income countries (LMIC); yet, limited guidance is available to local primary care practitioners who are usually the main health care providers. This review examined existing international practice guidelines to identify potential practices to improve HDP management in Indonesian primary care. We performed a structured literature search strategies and snowballi...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 22, 2020 Category: OBGYN Source Type: research

The flipside of hydralazine in pregnancy: A systematic review and meta-analysis
Publication date: Available online 21 January 2020Source: Pregnancy HypertensionAuthor(s): Christina Antza, Chrisa Dimou, Ioannis Doundoulakis, Evangelos Akrivos, Stella Stabouli, Anna Bettina Haidich, Dimitrios G. Goulis, Vasilios kotsisAbstractThe present systematic review and meta-analysis investigated the effects of hydralazine compared with other antihypertensive drugs in maternal, perinatal and neonatal outcomes of pregnant women with hypertensive disorders. Twenty studies with 1283 participants were included. Of them, 626 received hydralazine and 657 other antihypertensive treatments, such as labetalol, nifedipine, ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 21, 2020 Category: OBGYN Source Type: research

Aspirin modulates STOX1 expression and reverses STOX1-induced insufficient proliferation and migration of trophoblast cells
ConclusionThe present study suggested that inhibition of the expression of STOX1 could promote the effects of aspirin in the treatment of preeclampsia. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 18, 2020 Category: OBGYN Source Type: research

Longitudinal follow-up of Kidney Function in Patients with a History of Preeclampsia: from 11 to 18 years postpartum
In conclusion, our data suggests that progression to kidney disease is not a major concern in women after preeclampsia within 18 years postpartum. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research

Maternal hypertension, preeclampsia, and risk of neonatal respiratory disorders in a large-prospective cohort study
Conclusion: Maternal hypertension and preeclampsia are risk factors for neonatal respiratory disorders in full-term and preterm newborns. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research

Identification of microRNA 210-5p in Human Placentae from Pregnancies Complicated by Preeclampsia and Intrauterine Growth Restriction, and its Potential Role in the Pregnancy Complications
Publication date: Available online 14 January 2020Source: Pregnancy HypertensionAuthor(s): Zain Awamleh, Victor K.M. HanAbstractPreeclampsia (PE) and intrauterine growth restriction (IUGR) are pregnancy complications resulting from abnormal placental development. As epigenetic regulators, microRNAs can regulate placental development and contribute to the disease pathophysiology by influencing the expression of genes involved in placental development or disease. Our previous study revealed an increase in miR-210-5p expression in placentae from patients with early-onset pregnancy complications and identified candidate gene t...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research

The relationship of a Prothrombsin G20210A mutation or a Factor V Leiden mutation and on-aspirin platelet (re-)activity
ConclusionWe feel these data are suggestive of increased on-aspirin platelet (re-)activity, as measured by the PFA-200 and the VerifyNow, in non-pregnant carriers of a FII-mutation, but not in carriers of FVL-mutation. Interestingly, this increased on-aspirin platelet (re-)activity is present in spite of low sTxB2 levels (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research

Retrospective evaluation of established cut-off values for the sFlt-1/PlGF ratio for predicting imminent delivery in preeclampsia patients
ConclusionThe sFlt-1/PlGF ratio appears to be a powerful tool for diagnosing and predicting preeclampsia. However, the data do not confirm the cut-off values described earlier, with longer pregnancy durations in this group of patients. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research

Calcium deficient placental growth restriction is mediated by an increase in non-invasive integrin α5 and β4 phenotype
ConclusionsThe in vitro trophoblast cell integration into endothelial cellular networks could be modified by altering media calcium through integrin switch away from integrins α5 and β4 and towards integrin α1 which may be required for healthy early trophoblast integration. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research

The effect of folic acid throughout pregnancy among pregnant women at high risk of pre-eclampsia: a randomized clinical trial
Publication date: Available online 14 January 2020Source: Pregnancy HypertensionAuthor(s): Lili Zheng, Jing Huang, Hongfang Kong, Fang Wang, Yuan Su, Hong XinAbstractBackgroundPre-eclampsia is a serious hypertension disease that occurs during pregnancy. Folic acid (FA) supplementation has been reported to reduce pre-eclampsia risk in pregnant women. Here, we aimed to assess whether treatment of high doses of FA in pregnant women with high pre-eclampsia risk could prevent the onset of pre-eclampsia.MethodsWe conducted a randomized clinical trial in 1576 women who had pre-eclampsia or eclampsia in their last pregnancy and ha...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research

Differences in DNA methylation of insulin-like growth factor 2 and cadherin 13 in patients with preeclampsia
ConclusionDifferences in DNA methylation were found in placental tissue, umbilical cord white blood cells and HUVEC of patients with early onset preeclampsia compared to (un)complicated controls, but not in patients with late-onset preeclampsia. The genes showing the largest differential methylation encode insulin-like growth factor 2 binding protein and receptor and cadherin 13. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 15, 2020 Category: OBGYN Source Type: research

Severe proteinuria as a parameter of worse perinatal/neonatal outcomes in women with preeclampsia
Publication date: Available online 10 January 2020Source: Pregnancy HypertensionAuthor(s): Mamoru Morikawa, Michinori Mayama, Yoshihiro Saito, Kinuko Nakagawa, Takeshi Umazume, Kentaro Chiba, Satoshi Kawaguchi, Kazutoshi Cho, Hidemichi WatariAbstractObjectivesThe present study aimed to determine the relationship between the severity of proteinuria and maternal/neonatal outcomes among women with preeclampsia.Study designProteinuria severity was measured at preeclampsia diagnosis and at delivery in 94 women with preeclampsia (among 2904 women with singleton pregnancies, who delivered after 22 gestational weeks). Preeclampsia...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 10, 2020 Category: OBGYN Source Type: research

Identifying Hypertension in Pregnancy using Electronic Medical Records: The importance of Blood Pressure Values
ConclusionIncorporating EMR BP identified many pregnant women with hypertension who would have been missed by using diagnosis codes alone. Future studies should seek to incorporate BP to study treatment and outcomes of hypertension in pregnancy. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - January 4, 2020 Category: OBGYN Source Type: research

The role of follistatin and granulocyte-colony stimulating factor in hiv-associated pre-eclampsia
Publication date: Available online 30 December 2019Source: Pregnancy HypertensionAuthor(s): Siphesihle Mdlalose, Jagidesa Moodley, Thajasvarie NaickerAbstractKwaZulu-Natal has a high burden of HIV infection and high blood pressure, specifically pre-eclampsia (PE) in pregnancy. Follistatin (FS) and granulocyte-colony stimulating factor (G-CSF) are two glycoproteins involved in PE pathogenesis. In light of the high maternal mortality and morbidity in South Africa (SA), we investigated the expression of FS and G-CSF in the duality of HIV-associated PE. Serum samples of normotensive and pre-eclamptic women were analysed using ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 31, 2019 Category: OBGYN Source Type: research

Expression profiles of candidate microRNAs in the peripheral blood leukocytes of patients with early- and late-onset preeclampsia versus normal pregnancies
Publication date: Available online 30 December 2019Source: Pregnancy HypertensionAuthor(s): Selin Demirer, Meryem Hocaoglu, Abdulkadir Turgut, Ateş Karateke, Evrim Komurcu-BayrakAbstractObjectivesMaternal leucocytes play an important role in the pathogenesis of preeclampsia (PE). Circulating microRNAs (miRNAs) are small, noncoding RNA molecules. The purpose of this study was to investigate miR-518b, miR-155-5p, and miR-21-3p in the peripheral blood leukocytes of patients with PE, compared to controls.Study designUsing real-time quantitative PCR method, the selected miRNAs which have been associated with PE were examined f...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 31, 2019 Category: OBGYN Source Type: research

Investigating the diagnostic capacity of uric acid in the occurrence of preeclampsia
ConclusionThe UA concentration in preeclamptic pregnancies is significantly increased compared to normal pregnancies and the level of UA may have diagnostic ability in the occurrence of preeclampsia. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 28, 2019 Category: OBGYN Source Type: research

Correlation of biological parameters with placental parameters and pregnancy outcomes in pre-eclamptic women
ConclusionsThere is no correlation between biological parameters and placental lesions in pre-eclamptic women. Yet, low PLR at delivery is correlated with low placental and birth weights. Moreover, low first trimester PlGF is correlated with long time from pre-eclampsia diagnosis to delivery. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 27, 2019 Category: OBGYN Source Type: research

Central hemodynamics are associated with fetal outcomes in pregnancies of advanced maternal age
Publication date: Available online 26 December 2019Source: Pregnancy HypertensionAuthor(s): Ophelia Yin, Allison Woods, Brian Koos, Greggory DeVore, Yalda AfsharAbstractObjectivesAge is a known risk factor for both maternal cardiovascular disease and adverse outcomes in pregnancy. We aimed to characterize the hemodynamic profiles in pregnancies of advanced maternal age (AMA) and correlate these with fetal outcomes.Study DesignThis was a prospective observational study of pregnancies undergoing antenatal testing. Maternal hemodynamics were measured non-invasively using an imaging probe at the descending aorta and the Uscom ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 27, 2019 Category: OBGYN Source Type: research

Meta-analysis of gene expression profiles in preeclampsia
ConclusionsThis work, combining rigorous methods of meta-analysis and the use of modern bioinformatics tools, proposes the existence of novel, overlooked so far, biochemical pathways and mechanisms to contribute to preeclampsia development such as carbohydrate, aminoacids and pyrimidine metabolism. Our findings pave the way for further investigation of the above pathways in experimental efforts to decipher the orchestrating mechanisms for preeclampsia development. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 21, 2019 Category: OBGYN Source Type: research

Postpartum hypertensive disorders in the Emergency Department – A retrospective review of local practice in Calgary, Alberta
ConclusionsPostpartum HDP is commonly under-recognized and under-treated in the ED, highlighting opportunities for interventions to improve the recognition and management of postpartum HDP. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 21, 2019 Category: OBGYN Source Type: research

Plasma ceramide is increased and associated with proteinuria in women with pre-eclampsia and HELLP syndrome
Publication date: Available online 17 December 2019Source: Pregnancy HypertensionAuthor(s): Fouad Amraoui, Hajar Hassani Lahsinoui, Leon J.A. Spijkers, Liffert Vogt, Stephan L.M. Peters, Dayanjan S. Wijesinghe, Urszula O. Warncke, Charles E. Chalfant, Carrie Ris-Stalpers, Bert-Jan H. van den Born, Gijs B. AfinkAbstractObjectivesCeramide is a sphingolipid with anti-angiogenic and pro-apoptotic properties that has shown to be increased in plasma of women with pre-eclampsia. We aimed to compare plasma and placental sphingolipid content among normotensive pregnant women and pre-eclamptic women with and without HELLP syndrome a...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 18, 2019 Category: OBGYN Source Type: research

Hippo-YAP1 signaling pathway and severe preeclampsia (sPE) in the Chinese population
Publication date: January 2020Source: Pregnancy Hypertension, Volume 19Author(s): Rui Liu, Chan Wei, Qiang Ma, Weimin WangAbstractBackgroundThe present study aims to explore the possible mechanisms of Hippo-YAP1 signaling pathway in the development of severe preeclampsia (sPE).MethodsA total of 14 pregnancies complicated with severe preeclampsia as well as 14 healthy pregnancies were involved in this research from Department of Obstetrics, the First Affiliated Hospital of Xi’An Jiaotong University, from 15th March 2016 to 15th March 2018. The mRNA levels of YAP1, TAZ, MST1 and MST2 were tested via the RT-qPCR in the ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 15, 2019 Category: OBGYN Source Type: research

Evaluation of the clinical impact of the revised ISSHP and ACOG definitions on preeclampsia
Publication date: Available online 11 December 2019Source: Pregnancy HypertensionAuthor(s): Anisha R. Bouter, Johannes J. DuvekotAbstractBackgroundIn 2018/2013 both ISSHP and ACOG revised their original statements and postulated new criteria for preeclampsia with and without severe features. Most importantly, preeclampsia can now also be established in the absence of proteinuria when other specific symptoms are present.ObjectiveWhat is the clinical impact of the use of three different new definitions for the diagnosis of preeclampsia?Study designRetrospective cohort study of all pregnant women who gave birth in the Erasmus...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 11, 2019 Category: OBGYN Source Type: research

Associations of childhood adiposity and changes in adiposity status from childhood to adulthood with pregnancy hypertension
Conclusion(s)Childhood adiposity was associated with increased risk of pregnancy hypertension, with the association of childhood abdominal obesity independent of adult abdominal obesity. Women who were persistently overweight/obese or abdominally obese since childhood had the highest risk of pregnancy hypertension. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 4, 2019 Category: OBGYN Source Type: research

17-Hydroxyprogesterone caproate improves T cells and NK cells in response to placental ischemia; new mechanisms of action for an old drug
Publication date: Available online 2 December 2019Source: Pregnancy HypertensionAuthor(s): Jamil T. Elfarra, Jesse N. Cottrell, Denise C. Cornelius, Mark W. Cunningham, Jessica L. Faulkner, Tarek Ibrahim, Babbette Lamarca, Lorena M. AmaralAbstractPreeclampsia (PE) is new onset hypertension during pregnancy associated with increased uterine artery resistance (UARI) and an imbalance among CD4 + T lymphocytes and natural killer (NK) cells. We have shown an important role for 17-hydroxyprogesterone caproate (17-OHPC) to improve hypertension and fetal demise in the RUPP rat model of PE. However we have not examined a ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 3, 2019 Category: OBGYN Source Type: research

Preeclampsia exposed offspring have greater body mass index than non-exposed offspring during peripubertal life: A meta-analysis
This study evaluates the effect of preeclampsia on body mass index (BMI) of offspring who were exposed to preeclampsia in utero.MethodsData were obtained from studies identified by a literature search in electronic databases. Random-effects metanalyses were conducted to achieve mean difference in BMI, waist circumference, gestation length, and birthweight between preeclampsia exposed (PE) and non-exposed (non-PE) offspring older than 5 years. Metaregression analyses were performed to identify factors affecting offspring BMI.ResultsSixteen studies (11639 PE offspring; age 15.5 years [14.2, 16.8]; 33.3% [32.6, 33.9] male...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 3, 2019 Category: OBGYN Source Type: research

Hyperferritinemia worsens the perinatal outcomes of conceptions of pregnancies with preeclampsia
ConclusionIn the presence of hyperferritinemia, preeclampsia patients were associated with a higher rate of unfavorable neonatal outcomes. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - November 29, 2019 Category: OBGYN Source Type: research

Editorial Board
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - November 26, 2019 Category: OBGYN Source Type: research

Acknowledgement to Reviewers 2019
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - November 26, 2019 Category: OBGYN Source Type: research

Corrigendum to “Preeclampsia postpartum: Impairment of cerebral autoregulation and reversible cerebral hyperperfusion” [Pregnancy Hypertens. 17 (2019) 121–126]
Publication date: Available online 14 November 2019Source: Pregnancy HypertensionAuthor(s): Wibke G. Janzarik, Jenny Jacob, Evi Katagis, Filiz Markfeld-Erol, Linda Sommerlade, Matthias Wuttke, Matthias Reinhard (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - November 14, 2019 Category: OBGYN Source Type: research

First-line antihypertensive treatment for severe hypertension in pregnancy: A systematic review and network meta-analysis
ConclusionsGiven the results of this systematic review and network meta-analysis, maternity care providers should feel comfortable initiating management of severe hypertension in pregnancy using oral nifedipine. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - November 1, 2019 Category: OBGYN Source Type: research

Vascular endothelial growth factor C/A 2578 gene polymorphism and umbilical artery Doppler in preeclamptic women
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): Hanan H. Mowad, Khadiga M. Abougabal, Ashraf S. Fahim, Nesreen A.A. Shehata, Hamada A.A. Ali, Mona Z. NasserAbstractIntroductionPreeclampsia is strongly associated with placental hypoperfusion. Genetic factors have an impact on the pathogenesis of preeclampsia. The aim is to assess the association of Vascular Endothelial Growth Factor (C2578A) gene polymorphism with the occurrence and severity of preeclampsia and the umbilical artery Doppler changes among preeclamptic women.Materials and methodsThis case-control study was conducted in clinica...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - November 1, 2019 Category: OBGYN Source Type: research

The Reduced Uterine Perfusion Pressure (RUPP) rat model of preeclampsia exhibits impaired systolic function and global longitudinal strain during pregnancy
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): Bhavisha A. Bakrania, Michael E. Hall, Sajid Shahul, Joey P. GrangerAbstractBackgroundPreeclampsia (PE) is a disorder prevalent in 3–8% of pregnancies, characterized by hypertension, endothelial dysfunction and cardiac dysfunction, including hypertrophy and impaired global longitudinal strain (GLS), which indicates reduced contractility and tissue injury. Despite several clinical studies highlighting impaired cardiac function in these women, the underlying mechanisms have not been studied, in part, due to lack of an appropriate animal m...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 26, 2019 Category: OBGYN Source Type: research

Pregnancy outcomes in correlation with placental histopathology in subsequent pregnancies complicated by preeclampsia
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): Michal Levy, Michal Kovo, Letizia Schreiber, Ilia Kleiner, Liron Koren, Giulia Barda, Eldar Volpert, Jacob Bar, Eran WeinerAbstractObjectiveIn attempt to deepen our understanding of the etiopathogenesis of preeclampsia we aimed to study the placental component and pregnancy outcomes in two consecutive pregnancies complicated by preeclampsia in the same patient.Study designPregnancy and placental reports of all pregnancies complicated by preeclampsia between 2008 and 2018 were reviewed. Included were only cases with recurrent preeclampsia in t...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 22, 2019 Category: OBGYN Source Type: research

The association between maternal and foetal REN gene polymorphisms and preeclampsia/eclampsia: A hybrid design study
ConclusionsFindings from this study indicate that foetal rs5707 polymorphisms may play a significant role in PE/E development, especially among overweight or obese pregnant women in China. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 15, 2019 Category: OBGYN Source Type: research

Management of non-severe pregnancy hypertension – A summary of the CHIPS Trial (Control of Hypertension in Pregnancy Study) research publications
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): Laura A. Magee, Evelyne Rey, Elizabeth Asztalos, Eileen Hutton, Joel Singer, Michael Helewa, Terry Lee, Alexander G. Logan, Wessel Ganzevoort, Ross Welch, Jim G. Thornton, Peter von DadelszenAbstractThe international CHIPS Trial (Control of Hypertension In Pregnancy Study) enrolled 987 women with chronic (75%) or gestational (25%) hypertension. Pre-eclampsia developed in 48%; women remained on their allocated BP control and delivered an average of two weeks later. ‘Less tight’ control (target diastolic BP 100 mmHg) achieved BP t...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 15, 2019 Category: OBGYN Source Type: research

A randomised controlled trial of blood pressure self-monitoring in the management of hypertensive pregnancy. OPTIMUM-BP: A feasibility trial
ConclusionsThis is the first randomised investigation of BP self-monitoring for the management of pregnancy hypertension and indicates that a large RCT would be feasible. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 14, 2019 Category: OBGYN Source Type: research

Visit-to-visit blood pressure variability is associated with gestational hypertension and pre-eclampsia
ConclusionsVVV during pregnancy, especially SBP-CV, was independently associated with GH and PE. These results suggested that VVV could provide additional information to identify pregnant women at high risk of GH or PE. Further studies exploring prospective association between VVV, GH and PE are warranted. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 12, 2019 Category: OBGYN Source Type: research

Impact of gestational hypertension and preeclampsia on fetal gender: A large prospective cohort study in China
ConclusionsOur results support a slight but significant association between gestational hypertension or preeclampsia and decreased likelihood of male delivery. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 12, 2019 Category: OBGYN Source Type: research

NAMPT levels are inversely related to nitric oxide formation and positively related to soluble fms-like tyrosine kinase-1 levels in preeclampsia
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): Daniela A. Pereira, Valéria C. Sandrim, Ana C.T. Palei, Jose E. Tanus-Santos, Vanessa A. Belo, Ricardo C. Cavalli, Marcelo R. LuizonAbstractNAMPT is a biomarker for endothelial dysfunction, but its relationship with nitrite (marker of NO formation) and soluble fms-like tyrosine kinase-1 (sFLT-1) has not been previously evaluated in preeclampsia. Therefore, we measured plasma NAMPT and sFLT-1 levels using enzyme immunoassays and plasma nitrite concentrations using an ozone-based chemiluminescence assay. NAMPT was positively correlated t...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 12, 2019 Category: OBGYN Source Type: research

Association of arginine vasopressin (AVP) promoter polymorphisms with preeclampsia
ConclusionPolymorphic variants located on the promoter region of AVP are associated with PE. Thus we hypothesize that allelic variation may have a role in increasing the risk of developing PE. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 6, 2019 Category: OBGYN Source Type: research

Levels of syndecan-1 and hyaluronan in early- and late-onset preeclampsia
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): Jakub Kornacki, Przemysław Wirstlein, Ewa Wender-OzegowskaAbstractObjectiveThe study aimed to assess serum levels of syndecan-1 (SDC-1) and hyaluronan (HA) in patients with early- and late-onset preeclampsia (PE).Study designBlood samples were collected in the third trimester of pregnancy from 20 women with early-onset PE, 20 with late-onset PE, and 20 with normal pregnancy for the assessment of serum levels of SDC-1 and HA as markers of endothelial injury. PE was categorized as early-onset when diagnosed at
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 5, 2019 Category: OBGYN Source Type: research

Combined effects of increasing maternal age and nulliparity on hypertensive disorders of pregnancy and small for gestational age
The objective was to evaluate the potential combined effects of nulliparity and increasing maternal age on small for gestational age (SGA 
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 5, 2019 Category: OBGYN Source Type: research

A randomized-controlled trial to assess the effect of ibuprofen on postpartum blood pressure in women with hypertensive disorders of pregnancy
ConclusionsAmong women with gestational hypertension and preeclampsia without severe features, ibuprofen is an equally safe option as acetaminophen with respect to postpartum blood pressure concerns. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 5, 2019 Category: OBGYN Source Type: research

Oxidative stress in early pregnancy and the risk of preeclampsia
ConclusionCAT is the only antioxidant as shown in our study to be related to the severity of the disease and may be a promising predictor for PE. Further studies are warranted to investigate the use of CAT as a novel therapeutic for PE. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 4, 2019 Category: OBGYN Source Type: research

Association of maternal Toll-like receptor-4 alleles with susceptibility to early-onset preeclampsia in central Greece
DiscussionWe recorded association between common TLR4 gene variants and early-onset preeclampsia. Our findings support the involvement of maternal innate immune system in severe hypertensive disorders of pregnancy and point to the potential value of maternal TLR4 polymorphisms as predictors-risk factors of susceptibility to early-onset preeclampsia in Central Greece. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 4, 2019 Category: OBGYN Source Type: research

Sequential profile of endothelial functions and arterial stiffness in preeclampsia during the course of pregnancy
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): Priyanka Garg, Ashok Kumar Jaryal, Garima Kachhawa, Alka Kriplani, Kishore Kumar DeepakAbstractObjectiveTo evaluate the temporal profile of arterial functions during the course of pregnancy and also to determine the predictive accuracy of vascular function indices in development of preeclampsia (PE).Study designLongitudinal study, two hundred and eight women participated in the study and vascular functions were assessed at 11–13, 20–22 and 30–32 weeks of gestation.Main outcome measuresFlow mediated dilatation (FMD), augmen...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - October 2, 2019 Category: OBGYN Source Type: research