Avobenzone suppresses proliferative activity of human trophoblast cells and induces apoptosis mediated by mitochondrial disruption

This study suggests that avobenzone induces mitochondrial dysfunction-mediated apoptosis leading to abnormal placentation during early pregnancy.
Source: Reproductive Toxicology - Category: Toxicology Source Type: research

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Conclusions: Our study demonstrates that NCH gel appears to be able to reduce the formation of IUAs in women who undergo curettage in the second trimester, although larger controlled, randomized, multicenter studies are needed to confirm these results. PMID: 30524185 [PubMed - in process]
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - Category: Surgery Tags: JSLS Source Type: research
The objective of the study was to identify microorganisms of the maternal genital tract that are associated with neonatal damage, in order to prevent future perinatal complications. Seven hundred and eleven pregnant patients attended their prenatal control during the period January 2010-July 2013. Ureaplasma urealyticum and Mycoplasma hominis presence was investigated in umbilical cord blood by metabolic substrates (Micofast-Biomerieux) and that of T.vaginalis, by PCR using specific primers. The microbiological study of the vaginal contents of 288 pregnant patients at weeks 35 to 37 was performed by conventional methods, a...
Source: Revista Argentina de Microbiologia - Category: Microbiology Tags: Rev Argent Microbiol Source Type: research
Publication date: Available online 15 December 2018Source: Molecular Aspects of MedicineAuthor(s): Denise Hoch, Martin Gauster, Sylvie Hauguel-de Mouzon, Gernot DesoyeAbstractEarly pregnancy is characterized by a series of complex and tightly regulated events to ultimately establish implantation and early placental development. One of the key events is the opening of the decidual spiral arteries into the intervillous space. It leads to a rise in oxygen tension in the intervillous space and the placenta and will induce transcriptional and translational changes of oxygen-sensitive molecules including antioxidants.Diabetes an...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
Publication date: Available online 14 December 2018Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Iwona Lewicka, Rafał Kocyłowski, Mariusz Grzesiak, Zuzanna Gaj, Adam Sajnóg, Danuta Barałkiewicz, Constantin von Kaisenberg, Joanna SuliburskaAbstractThe aim of the study was to determine the correlations between body mass index (BMI) values before pregnancy and the concentrations of selected elements (Mg, Co, Cu, Zn, Sr, Cd, Ba, Pb, U, Ca, Cr, Al, Mn, V, Fe) in blood serum and amniotic fluid (AF) in pregnant women. Elemental analysis of serum and amniotic fluid in 225 Polish women (Caucasian/whi...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Publication date: Available online 14 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Nasim Tabibnejad, Mohammad Hasan Sheikhha, Nasrin Ghasemi, Fesahat, Mehrdad Soleimani, Abbas AflatoonianAbstractResearch questionCan a combination of time-lapse morphokinetic parameters and cumulus cell gene expression in polycystic ovary syndrome (PCOS) women be used to predict assisted reproductive treatment outcome?DesignA total of 547 embryos from 100 intracytoplasmic sperm injection (ICSI) cycles were evaluated. Fifty women with PCOS and 50 women who were categorized as tubal factor infertility were recruited. Time-lap...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
ConclusionsThe trial demonstrated the low immunogenicity potential of follitropin delta in repeated ovarian stimulation, and confirmed the appropriateness of the follitropin delta dosing regimen in repeated cycles, with documented efficacy and safety.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Publication date: Available online 14 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Lingjuan Wang, Su Song, Xuemei Liu, Mengdi Zhang, Wenpei XiangAbstractResearch questionIs low MFN2 expression associated with ageing in granulosa cells as well as assisted reproductive technology (ART) outcome, and what is the underlying mechanism of action of MFN2?DesignIn a prospective study, fresh granulosa cells were obtained from 161 women aged 20–40 years who underwent IVF with embryo transfer and who were divided into two groups: the diminished ovarian reserve (DOR) group (n = 51) and the control group (n...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Publication date: January 2019Source: The Lancet Global Health, Volume 7, Issue 1Author(s): Anne CC Lee, Luke C Mullany, Mohammad Quaiyum, Dipak K Mitra, Alain Labrique, Parul Christian, Parvez Ahmed, Jamal Uddin, Iftekhar Rafiqullah, Sushil DasGupta, Mahmoodur Rahman, Emilia H Koumans, Salahuddin Ahmed, Samir K Saha, Abdullah H Baqui, Projahnmo Study Group in BangladeshSummaryBackgroundOne-third of preterm births are attributed to pregnancy infections. We implemented a community-based intervention to screen and treat maternal genitourinary tract infections, with the aim of reducing the incidence of preterm birth.MethodsWe...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Publication date: January 2019Source: The Lancet Global Health, Volume 7, Issue 1Author(s): Jean H Humphrey, Mduduzi N N Mbuya, Robert Ntozini, Lawrence H Moulton, Rebecca J Stoltzfus, Naume V Tavengwa, Kuda Mutasa, Florence Majo, Batsirai Mutasa, Goldberg Mangwadu, Cynthia M Chasokela, Ancikaria Chigumira, Bernard Chasekwa, Laura E Smith, James M Tielsch, Andrew D Jones, Amee R Manges, John A Maluccio, Andrew J Prendergast, Jean H HumphreySummaryBackgroundChild stunting reduces survival and impairs neurodevelopment. We tested the independent and combined effects of improved water, sanitation, and hygiene (WASH), and impro...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Conclusion: Our findings, which show that endothelial dysfunction occurred in uterine and renal arteries but not in the aorta, are consistent with the human findings of microvascular changes in preeclampsia. PMID: 30543088 [PubMed]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
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