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Nutrition: Vitamins
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Total 289 results found since Jan 2013.
Advances in nanomicelles for sustained drug delivery
Publication date: 25 November 2017 Source:Journal of Industrial and Engineering Chemistry, Volume 55 Author(s): Najmeh Amirmahani, Nosrat O. Mahmoodi, Mohsen Mohammadi Galangash, Atefeh Ghavidast The efficient direct access of therapeutic molecules to the target tissues is still a major obstacle in developing useful therapeutic interventions. Over the past decades, polymeric micelles are interesting nanocarries for drug delivery systems due to small size (10–100nm), low toxicity, capacity to solubilize lipophilic drugs in core and high drug loading. Here, the design of various nanomicelles such as amphiphilic dendrimer,...
Source: Journal of Industrial and Engineering Chemistry - August 5, 2017 Category: Chemistry Source Type: research
Calcitriol-mediated reduction in IFN- γ output in T cell large granular lymphocytic leukemia requires vitamin D receptor upregulation
Publication date: Available online 20 July 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): M. Paige Kulling, C. Kristine Olson, L. Thomas Olson, E. Cait Hamele, N. Kathryn Carter, J. David Feith, P. Thomas Loughran Constitutively activated STAT1 and elevated IFN-γ are both characteristic of T cell large granular lymphocytic leukemia (T-LGLL), a rare incurable leukemia with clonal expansion of cytotoxic T cells due to defective apoptosis. Interferon gamma (IFN-γ) is an inflammatory cytokine that correlates with worse progression and symptomology in multiple autoimmune diseases and cancers...
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 21, 2017 Category: Biochemistry Source Type: research
1,25-Dihydroxyvitamin D3 suppresses gastric cancer cell growth through VDR- and mutant p53-mediated induction of p21
Publication date: Available online 29 April 2017 Source:Life Sciences Author(s): Mingxing Li, Longfei Li, Lin Zhang, Wei Hu, Jing Shen, Zhangang Xiao, Xu Wu, Franky Leung Chan, Chi Hin Cho Aims Previous studies have indicated that vitamin D deficiency correlates with cancer risk and vitamin D potentiates antitumor effects in a variety of cancers. The antitumor effect of vitamin D on gastric cancer was rarely studied. We aimed to investigate the antitumor effect of vitamin D on gastric cancer and underlying mechanisms. Main methods We investigated the antitumor activity of the active form of vitamin D, 1α,25-dihydroxyvita...
Source: Life Sciences - April 30, 2017 Category: Biology Source Type: research
MAPK Signaling has Stage-dependent Osteogenic Effects on Human Adipose-derived Stem Cells in vitro.
CONCLUSIONS: It is likely that MAPK signaling plays a significant role in ASC osteogenesis, affecting differentiation in kinase- and stage-specific manners.
PMID: 28398098 [PubMed - as supplied by publisher]
Source: Connective Tissue Research - April 13, 2017 Category: Research Tags: Connect Tissue Res Source Type: research
MicroRNA-125b inhibits AML cells differentiation by directly targeting Fes.
In this study, it was shown that miR-125b expression level decreased in response to 1α, 25-dihydroxy-vitamin D3 (1,25D3) in a dose- and time-dependent manner and miR-125b blocked 1,25D3-induced monocytic differentiation of U937 cells. In addition, miR-125b decreased mRNA expression of myelomonocytic differentiation markers, including CD11c, CD18 and CD64 and arrested the cell cycle at the S phase in U937 and HL60 cells. Fes was identified as a novel direct target of miR-125b and miR-125b could also reduce the expression levels of PU.1 and macrophage colony-stimulating factor receptor (MCSFR). Furthermore, Fes was found to...
Source: Gene - April 4, 2017 Category: Genetics & Stem Cells Authors: Hu J, Zheng L, Shen X, Zhang Y, Li C, Xi T Tags: Gene Source Type: research
Activation of Nrf2-Antioxidant Signaling by 1,25-Dihydroxycholecalciferol Prevents Leptin-Induced Oxidative Stress and Inflammation in Human Endothelial Cells Biochemical, Molecular, and Genetic Mechanisms
Conclusion: Pretreatment with 1,25(OH)2D3 in the presence of a high concentration of leptin has a beneficial effect on HUVECs through the regulation of mediators of antioxidant activity and inflammation.
Source: Journal of Nutrition - April 3, 2017 Category: Nutrition Authors: Teixeira, T. M., da Costa, D. C., Resende, A. C., Soulage, C. O., Bezerra, F. F., Daleprane, J. B. Tags: Obesity and Metabolism Research Articles Biochemical, Molecular, and Genetic Mechanisms Source Type: research
Autocrine and Paracrine Interactions between Multiple Myeloma Cells and Bone Marrow Stromal Cells by Growth Arrest-specific Gene 6 Cross-talk with Interleukin-6 Signal Transduction
The pathogenesis of multiple myeloma (MM) has not yet been fully elucidated. Our microarray analysis and immunohistochemistry revealed significant up-regulation of growth arrest-specific gene 6 (Gas6), a vitamin K-dependent protein with a structural homology with protein S, in bone marrow (BM) cells of MM patients. ELISA showed that the serum levels of soluble Gas6 were significantly increased in the MM patients when compared with healthy controls. Gas6 was overexpressed in the human CD138-positive MM cell line RPMI-8226. Exogenous Gas6 suppressed apoptosis induced by serum deprivation and enhanced cell proliferation of th...
Source: Journal of Biological Chemistry - March 9, 2017 Category: Chemistry Authors: Miki Furukawa, Hiroshi Ohkawara, Kazuei Ogawa, Kazuhiko Ikeda, Koki Ueda, Akiko Shichishima-Nakamura, Emi Ito, Jun-ichi Imai, Yuka Yanagisawa, Reiko Honma, Shinya Watanabe, Satoshi Waguri, Takayuki Ikezoe, Yasuchika Takeishi Tags: Cell Biology Source Type: research
Experimental Study on 1,25(OH)2D3 Amelioration of Oral Lichen Planus through Regulating NF ‐κB Signaling Pathway
ConclusionThese results suggest that 1,25(OH)2D3 plays an anti‐inflammatory role in OLP by mediating NF‐κB signaling pathway but not AP‐1 signaling pathway with a VDR‐dependent manner, predicting vitamin D supplement may be a potential strategy for the OLP management.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - February 22, 2017 Category: ENT & OMF Authors: Jie Du, Ran Li, Feiyan Yu, Fang Yang, Jinhua Wang, Qingyong Chen, Xiangyu Wang, Bin Zhao, Fang Zhang Tags: Original Article Source Type: research
Calcipotriol inhibits α‐synuclein aggregation in SH‐SY5Y neuroblastoma cells by a Calbindin‐D28K‐dependent mechanism
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - February 5, 2017 Category: Neuroscience Authors: Alexandre N. Rcom ‐H'cheo‐Gauthier, Adrian C. B. Meedeniya, Dean L. Pountney Tags: Original Article Source Type: research
1,25(OH)2 D3 attenuates hepatic steatosis by inducing autophagy in mice.
CONCLUSIONS: The data suggest that 1,25(OH)2 D3 may ameliorate hepatic steatosis by inducing autophagy by upregulating ATG16L1.
PMID: 28145056 [PubMed - as supplied by publisher]
Source: Obesity - January 31, 2017 Category: Eating Disorders and Weight Management Authors: Li R, Guo E, Yang J, Li A, Yang Y, Liu S, Liu A, Jiang X Tags: Obesity (Silver Spring) Source Type: research
Vitamin D differentially regulates Salmonella-induced intestine epithelial autophagy and interleukin-1 β expression.
CONCLUSION: Active vitamin D might enhance autophagic clearance of Salmonella infection, while modulation of inflammatory responses prevents the host from detrimental effects of overwhelming inflammation.
PMID: 28058015 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 20, 2016 Category: Gastroenterology Authors: Huang FC Tags: World J Gastroenterol Source Type: research
Maternal 25 ‐hydroxyvitamin D is inversely correlated with foetal serotonin
ConclusionsThese observations provide the first evidence of an inverse relationship between maternal 25(OH)D and foetal serotonin concentrations. We propose that maternal vitamin D deficiency increases foetal serotonin concentrations and thereby contributes to longer‐term neurocognitive impairment in infants and children.
Source: Clinical Endocrinology - December 18, 2016 Category: Endocrinology Authors: Padma Murthi, Miranda Davies ‐Tuck, Martha Lappas, Harmeet Singh, Joanne Mockler, Rahana Rahman, Rebecca Lim, Bryan Leaw, James Doery, Euan M. Wallace, Peter R. Ebeling Tags: Original Article Source Type: research
1,25-Dihydroxy vitamin D3 stimulates system A amino acid transport in primary human trophoblast cells
In conclusion, 1,25-dihydroxy vitamin D3 regulates System A activity through increased mRNA expression of SNAT2 transporters. Effects on placental amino acid transport may be the mechanism underlying the association between maternal vitamin D status and fetal growth.
Source: Molecular and Cellular Endocrinology - December 15, 2016 Category: Endocrinology Source Type: research
Roles of 1,25(OH) < sub > 2 < /sub > D < sub > 3 < /sub > and Vitamin D Receptor in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus by Regulating the Activation of CD4 < sup > + < /sup > T Cells and the PKC δ/ERK Signaling Pathway
Conclusion:Our study provide evidence that 1,25(OH)2D3 and VDR could inhibit the activation of CD4+ T cells and suppress the immune response of SLE and RA through inhibiting PKC δ/ERK pathway and promoting DNA methylation of CD11a, CD70 and CD40L.Cell Physiol Biochem 2016;40:743-756
Source: Cellular Physiology and Biochemistry - December 2, 2016 Category: Cytology Source Type: research
Role of GPx4 in human vascular endothelial cells, and the compensatory activity of brown rice on GPx4 ablation condition
In conclusion, our data demonstrated that GPx4 is an essential antioxidant enzyme for protecting lipid peroxidation, and is a regulator of ferroptosis in vascular endothelial cells. Furthermore, vitamin E rich food, such as brown rice, can compensate for GPx4 loss by protecting cells against lipid peroxidation.
Source: Pathophysiology - November 30, 2016 Category: Pathology Source Type: research
