Dysregulation of VEGF-dependent angiogenesis in cavernous lung tuberculosis
ConclusionsTaking into account the absolute prevalence of proangiogenic factors in FCT in all patients, the use of targeted therapy aimed at VEGF-A blockade is pathogenetically justified. (Source: Pathophysiology)
Source: Pathophysiology - November 23, 2019 Category: Pathology Source Type: research
Wi-Fi decreases melatonin protective effect and increases hippocampal neuronal damage in pentylenetetrazole induced model seizures in rats
ConclusionWi-Fi did not directly affect epileptic seizures. Nevertheless, it inhibits the positive effects of melatonin on epilepsy and it also has negative effects on hippocampal neuronal damage. These effects of Wi-Fi may occur via oxidative pathways. (Source: Pathophysiology)
Source: Pathophysiology - November 22, 2019 Category: Pathology Source Type: research
Polyphenol rich fruit attenuates genomic instability, modulates inflammation and cell cycle progression of offspring from fatty acid intake maternal
Publication date: Available online 22 November 2019Source: PathophysiologyAuthor(s): Perla Pizzi Argentato, Luciana Pellegrini Pisani, Veridiana Vera De Rosso, Glaucia Resende Soares, Marcelo Jose Dias Silva, Wagner Vilegas, Daniel Araki RibeiroAbstractThe aim of this study was to investigate the effect of juçara (Euterpe edulis Mart.) supplementation on the maternal trans fatty acids intake in the livers of 21-day-old offspring. In order for this to happen, histopathological analysis, cytogenetic status, inflammation (COX-2 and TNF-alpha) and cell cycle progression were investigated in this setting. On the first day of p...
Source: Pathophysiology - November 22, 2019 Category: Pathology Source Type: research
Hypoglycemic and antioxidant effect of Juniperus procera extract on rats with streptozotocin-induced diabetes
This study examined the anti-hyperglycemic action of Juniperus procera extract (JPE) on diabetic rats. Sixty male rats were divided into 6 equal groups: control, control treated with JPE (200 mg/kg), diabetic, diabetic treated with insulin (1 U/kg), diabetic treated with JPE (200 mg/kg), and diabetic treated with both insulin and JPE. Blood and tissue samples were collected for serum chemistry, gene expression, and immunohistochemistry analyses, the results of which revealed hyperglycemia and inflammation following diabetes induction. Administration of JPE alone or with insulin reduced the hyperglycemia reported in dia...
Source: Pathophysiology - November 12, 2019 Category: Pathology Source Type: research
Vitamin C Suppresses Ovarian Pathophysiology in Experimental Polycystic Ovarian Syndrome
ConclusionThis study shows that Vitamin C plays a protective role against DHEA-Induced Polycystic Ovary in Wistar rats via its antioxidant and anti-apoptotic mechanisms. (Source: Pathophysiology)
Source: Pathophysiology - September 20, 2019 Category: Pathology Source Type: research
Gastrointestinal effects of standardized Brazilian phytomedicine (Arthur de Carvalho Drops®) containing Matricaria recutita, Gentiana lutea and Foeniculum vulgare
Publication date: Available online 8 September 2019Source: PathophysiologyAuthor(s): Elizama S. Silveira, Suzana B. Bezerra, Kalyane S. Ávila, Talita M. Rocha, Pedro Jorge Caldas Magalhães, Flávia Almeida Santos, Luzia Kalyne A.M. LealAbstractArthur de Carvalho Drops® (ACD) is a traditional Brazilian herbal medicine used to treat functional gastrointestinal disorders (FGIDs). ACD is a formulation of herbal extracts from Matricaria recutita (chamomile), Foeniculum vulgare (fennel) and Gentiana lutea L. (gentian). Considering the popular use for FGIDs, the aim of this work was to investigate the ACD effect on gastric and...
Source: Pathophysiology - September 9, 2019 Category: Pathology Source Type: research
Vanillylmandelic acid protects against reperfusion injury in an experimental animal model of myocardial infarction
In conclusion, reperfusion injury was blunted through vanillylmandelic acid administration, which seems to be mediated by parasympathetic activation. (Source: Pathophysiology)
Source: Pathophysiology - September 6, 2019 Category: Pathology Source Type: research
The protective effect of grape skin or purple carrot extracts against cadmium intoxication in kidney of rats
Publication date: Available online 12 August 2019Source: PathophysiologyAuthor(s): Samuel Rangel Claudio, Flavia Andressa Pidone Ribeiro, Eliene Cezario De Lima, Aline Boveto Santamarina, Luciana Pellegrini Pisani, Camilo Seabra Dias Pereira, Celina Tizuko Fujiyama Oshima, Daniel Araki RibeiroAbstractThe aim of this study was to evaluate the protective effect of grape skin or purple carrot extracts against cadmium-induced intoxication in rats’ kidneys. For this purpose, 30 male Wistar rats were distributed into six groups (n = 5), as follows: control group; cadmium group and groups treated with grape skin at 175 or 3...
Source: Pathophysiology - August 13, 2019 Category: Pathology Source Type: research
Anti-inflammatory efficacy of Methanolic extract of Muntingia calabura L. leaves in Carrageenan induced paw edema model
Publication date: Available online 10 August 2019Source: PathophysiologyAuthor(s): Ninan Jisha, A. Vysakh, V. Vijeesh, M.S. LathaAbstractThe plant Muntingia calabura L. is a well-known herb which gained attention due to its pharmacological value. The necessity of this plant in human ailments is illustrious in old medical practices. Muntingia calabura L. leaves were therapeutically used for ulcer, fever, headache etc. The study was designed to assess the acute toxicity and anti-inflammatory potential of methanolic extract of Muntingia calabura L. (MEMC) in in vivo models. Two different doses (550, 2000 mg/kg body weight) ...
Source: Pathophysiology - August 11, 2019 Category: Pathology Source Type: research
Quantity not composition of dietary fats represents the dominant contributor to experimental obesity: relevance to human pathophysiology
This study compared the obesogenic effects of plant and animal derived fatty diets in Wistar rats. Rats of each gender were divided into three dietary (standard chow (SC), high fat diet rich in animal fat (HFDaf) and a high fat diet rich in plant fat (HFDpf)) groups of ten each and fed for 17 weeks. Anthropometric, Adiposity and nutritive variables were assessed using standard methods. Comparing HFDpf to HFDaf: Abdominal circumference (AC),initial feed intaken (IFI), final feed intake(FFI), final body weight (FBW), white adipose tissue (WAT) were increased but brown adipose tissue (BAT) decreased in male rats fed with HFDp...
Source: Pathophysiology - August 9, 2019 Category: Pathology Source Type: research
Experimental dapsone administration induces infertility in male Wistar rats: mechanisms and clinical implications
This study investigated the effect of the administration of dapsone on the reproductive activities of male rats using in vivo and in vitro techniques. In the in vivo study, dapsone was administered orally to male Wistar rats for 5 days or 6 weeks after which their body weight, relative reproductive organ weights, sperm parameters and reproductive hormones were determined while testicular and epididymal histology were also assessed. Data were compared using analysis of variance and Students-Newman-Keuls multiple comparison test. For the in vitro study, Sertoli cells were cultured and treated with varying doses of dapsone at...
Source: Pathophysiology - August 1, 2019 Category: Pathology Source Type: research
Camphor elicits up-regulation of hepatic and pulmonary pro-inflammatory cytokines and chemokines via activation of NF-kB in rats
Publication date: Available online 29 July 2019Source: PathophysiologyAuthor(s): Oluwatobi T. Somade, Babajide O. Ajayi, Nurudeen O. Tajudeen, Eniola M. Atunlute, Adewale S. James, Samuel A. KehindeAbstractConsumption of camphor infusions is widely used as an aphrodisiac in preparation for sexual intercourse, to boost performance. There is dearth of information associating or relating its consumption to liver or lung inflammation. Therefore, we investigated the effect of various doses of camphor in an acute study, on hepatic and pulmonary levels of some pro-inflammatory cytokines and chemokines in male wistar rats. Followi...
Source: Pathophysiology - July 30, 2019 Category: Pathology Source Type: research
Aqueous garlic extract supresses experimental gentamicin induced renal pathophysiology mediated by oxidative stress, inflammation and Kim-1
ConclusionAGE normalizes Gent-induced renal dysfunction. Their co-administration is a plausible advice, although the therapeutic efficiency of Gent was not investigated. (Source: Pathophysiology)
Source: Pathophysiology - July 30, 2019 Category: Pathology Source Type: research
Effects of experimental intracerebral ventricular injection of amyloid beta peptide (1-42) aggregates on daily rhythms of Aβ-degrading enzymes in the hippocampus: Relevance to Alzheimer's disease pathophysiology
Publication date: Available online 29 July 2019Source: PathophysiologyAuthor(s): Andrea Castro, Cinthia Coria-Lucero, Ana Anzulovich, Lorena Navigatore-FonzoAbstractOne of the main pathological features in the Alzheimer disease (AD) is the presence of senile plaques, primarily composed of Aβ peptide aggregates, in cortex and hippocampus. AD late onset, which constitutes 90% of cases, could be mainly attributable to deficiencies in the clearance of the Aß peptide. Here we show that expression of Aβ-degrading enzymes varies on a daily basis in the hippocampus. Interestingly, an intracerebroventricular injection of Aβ agg...
Source: Pathophysiology - July 30, 2019 Category: Pathology Source Type: research
Dynamic Gut Microbiome Changes Following Regional Intestinal Lymphatic Obstruction in Primates
Publication date: Available online 28 June 2019Source: PathophysiologyAuthor(s): F. Becker, F.N.E. Gavins, J. Fontenot, P. Jordan, J.Y. Yun, R. Scott, P.R. Polk, R.E. Friday, M. Boktor, M. Musso, E. Romero, S. Boudreaux, J. Simmons, D.L. Hasselschwert, J.E. Goetzmann, J. Vanchiere, U. Cvek, M. Trutschl, P. Kilgore, J.S. AlexanderAbstractThe pathogenesis of inflammatory bowel disease (IBD) has been linked with lymphostasis, but whether and how lymphatic obstruction might disturb the intestinal microbiome in the setting of Crohn’s Disease (CD) is currently unknown. We employed a new model of CD in African Green monkeys, te...
Source: Pathophysiology - June 29, 2019 Category: Pathology Source Type: research
