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Nutrition: Vitamins

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Total 289 results found since Jan 2013.

15-Deoxy- Δ(12,14)-prostaglandin J2 stabilizes hypoxia inducible factor-1α through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2.
15-Deoxy-Δ(12,14)-prostaglandin J2 stabilizes hypoxia inducible factor-1α through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2. Free Radic Res. 2016 Oct;50(10):1140-1152 Authors: Choi JE, Kim JH, Song NY, Suh J, Kim DH, Kim SJ, Na HK, Nadas J, Dong Z, Cha YN, Surh YJ Abstract 15-Deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2), a representative J-series cyclopentenone prostaglandin, has biphasic roles in cell proliferation and apoptosis. Hypoxia inducible factor-1 (HIF-1) regulates expression of various genes involved in tumor growth and angiogenesis. In the present study...
Source: Free Radical Research - November 6, 2016 Category: Research Tags: Free Radic Res Source Type: research

Maternal 25 ‐hydroxyvitamin D is inversely correlated with fetal serotonin
ConclusionsThese observations provide the first evidence of an inverse relationship between maternal 25(OH)D and fetal serotonin concentrations. We propose that maternal vitamin D deficiency increases fetal serotonin concentrations and thereby contributes to longer‐term neurocognitive impairment in infants and children.This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - October 31, 2016 Category: Endocrinology Authors: Padma Murthi, Miranda Davies ‐Tuck, Martha Lappas, Harmeet Singh, Joanne Mockler, Rahana Rahman, Rebecca Lim, Bryan Leaw, James Doery, Euan M Wallace, Peter R Ebeling Tags: Original Article Source Type: research

Akt/AMPK/mTOR pathway was involved in the autophagy induced by vitamin E succinate in human gastric cancer SGC-7901 cells.
Abstract Vitamin E succinate (VES), a derivative of vitamin E, is a promising cancer chemopreventive agent that inhibits tumor promotion by inducing apoptotic cell death. The effects of VES on autophagy, an intricate programmed process which helps cells survive in some stressed situations by degrading some cytoplasmic material, are unclear. When human gastric cancer cells SCG-7901 were exposed to VES, both the level of microtubule-associated protein 1 light chain 3 and the yeast ATG6 homolog Beclin-1 increased, and related autophagy genes were activated, thereby suggesting that autophagy was induced by VES. We als...
Source: Molecular and Cellular Biochemistry - October 27, 2016 Category: Biochemistry Authors: Yu Y, Hou L, Song H, Xu P, Sun Y, Wu K Tags: Mol Cell Biochem Source Type: research

15-Deoxy- Δ(12,14)-prostaglandin J2 stabilizes hypoxia inducible factor-1α through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2.
15-Deoxy-Δ(12,14)-prostaglandin J2 stabilizes hypoxia inducible factor-1α through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2. Free Radic Res. 2016 Sep 6;:1-13 Authors: Choi JE, Kim JH, Song NY, Suh J, Kim DH, Kim SJ, Na HK, Nadas J, Dong Z, Cha YN, Surh YJ Abstract 15-Deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2), a representative J-series cyclopentenone prostaglandin, has biphasic roles in cell proliferation and apoptosis. Hypoxia inducible factor-1 (HIF-1) regulates expression of various genes involved in tumor growth and angiogenesis. In the present study, treatme...
Source: Free Radical Research - September 8, 2016 Category: Research Tags: Free Radic Res Source Type: research

MXRA5 is a TGF- β1-regulated human protein with anti-inflammatory and anti-fibrotic properties.
In conclusion, MXRA5 is a TGFβ1- and VHL-regulated protein and, for the first time, we identify MXRA5 functions as an anti-inflammatory and anti-fibrotic molecule. This information may yield clues to design novel therapeutic strategies in diseases characterized by inflammation and fibrosis. PMID: 27599751 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - September 5, 2016 Category: Molecular Biology Authors: Poveda J, Sanz AB, Fernandez-Fernandez B, Carrasco S, Ruiz-Ortega M, Cannata-Ortiz P, Ortiz A, Sanchez-Niño MD Tags: J Cell Mol Med Source Type: research

Vitamin D Enhances the Efficacy of Irinotecan through miR-627-Mediated Inhibition of Intratumoral Drug Metabolism
Cytochrome P450 enzyme CYP3A4 is an important drug-metabolizing enzyme, and high levels of tumoral expression of CYP3A4 are linked to drug resistance. We investigated the function of vitamin D–regulated miR-627 in intratumoral CYP3A4 suppression and its role in enhancing the efficacy of chemotherapy. We found that miR-627 targets CYP3A4 and suppresses CYP3A4 expression in colon cancer cell lines. Furthermore, calcitriol (the active form of vitamin D) suppressed CYP3A4 expression by activating miR-627. As a result, calcitriol inhibited CYP3A4-mediated metabolism of irinotecan (a topoisomerase I inhibitor) in cancer ce...
Source: Molecular Cancer Therapeutics - August 31, 2016 Category: Cancer & Oncology Authors: Sun, M., Zhang, Q., Yang, X., Qian, S. Y., Guo, B. Tags: Small Molecule Therapeutics Source Type: research

Vitamin D Inhibits Intratumoral Drug Metabolism
Cytochrome P450 enzyme CYP3A4 is an important drug-metabolizing enzyme, and high levels of tumoral expression of CYP3A4 are linked to drug resistance. We investigated the function of vitamin D–regulated miR-627 in intratumoral CYP3A4 suppression and its role in enhancing the efficacy of chemotherapy. We found that miR-627 targets CYP3A4 and suppresses CYP3A4 expression in colon cancer cell lines. Furthermore, calcitriol (the active form of vitamin D) suppressed CYP3A4 expression by activating miR-627. As a result, calcitriol inhibited CYP3A4-mediated metabolism of irinotecan (a topoisomerase I inhibitor) in cancer ce...
Source: Molecular Cancer Therapeutics - August 31, 2016 Category: Cancer & Oncology Authors: Sun, M., Zhang, Q., Yang, X., Qian, S. Y., Guo, B. Tags: Small Molecule Therapeutics Source Type: research

Upregulation of nuclear factor ‐κB activity mediates CYP24 expression and reactive oxygen species production in indoxyl sulfate‐induced chronic kidney disease
ConclusionsThese results provide evidence that administration of IS in human renal tubular epithelial cells upregulates NF‐κB, which leads to increase CYP24 expression and ROS production. They also suggest that suppressing NF‐κB signalling is promising for the development into a strategy for CKD treatment.
Source: Nephrology - August 21, 2016 Category: Urology & Nephrology Authors: Lihua Wang, Zhiying Gao, Lili Wang, Yongning Gao Tags: Original Article Source Type: research

Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress by Vitamin D in Endothelial Cells.
Abstract Endoplasmic reticulum (ER) stress and oxidative stress promote endothelial dysfunction and atherosclerosis. Since vitamin D has been shown in several studies to lower the risk of cardiovascular disease, we examined the effects of vitamin D on ER stress and oxidative stress in endothelial cells. ER stress was measured using the placental secreted alkaline phosphatase assay and oxidative stress was measured by hydroethidine fluorescence. Expression of ER stress markers, including glucose-regulated protein 78, c-jun N-terminal kinase 1 phosphorylation, and eukaryotic initiation factor 2α phosphorylation, as...
Source: Free Radical Biology and Medicine - July 21, 2016 Category: Biology Authors: Haas MJ, Jafri M, Wehmeier KR, Onstead-Haas LM, Mooradian AD Tags: Free Radic Biol Med Source Type: research

Vitamin E promotes breast cancer cell proliferation by reducing ROS production and p53 expression.
CONCLUSIONS: Vitamin E accelerated breast cancer growth by reducing ROS production and p53 expression. PMID: 27383327 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 9, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Inborn Error of Cobalamin Metabolism Associated with the Intracellular Accumulation of Transcobalamin‐Bound Cobalamin and Mutations in ZNF143, Which Codes for a Transcriptional Activator
This article is protected by copyright. All rights reserved
Source: Human Mutation - June 28, 2016 Category: Genetics & Stem Cells Authors: Mihaela Pupavac, David Watkins, Francis Petrella, Somayyeh Fahiminiya, Alexandre Janer, Warren Cheung, Anne‐Claude Gingras, Tomi Pastinen, Joseph Muenzer, Jacek Majewski, Eric A. Shoubridge, David S. Rosenblatt Tags: Research Article Source Type: research

New Preparative Approaches for Micro and Nano Drug Delivery Carriers.
Abstract The full success of pharmacological therapies is strongly depending from the use of suitable, efficient and smart drug delivery systems (DDSs). Thus DDSs development is one of the main challenges in pharmaceutical industry both to achieve tailored carrier systems based on drug features and to promote manufacturing innovations to reduce energetic resources, emissions, wastes and risks. Main functions of an ideal DDS are: to protect loaded active molecules from degradation in physiological environments; to deliver them in a controlled manner and towards a specific organ or tissue, to allow the maintenance o...
Source: Current Drug Delivery - June 26, 2016 Category: Drugs & Pharmacology Authors: Lamberti G, Barba AA, Bochicchio S, Dalmoro A, d'Amore M Tags: Curr Drug Deliv Source Type: research

Combined treatment with vitamin C and sulindac synergistically induces p53- and ROS-dependent apoptosis in human colon cancer cells.
In this study, we evaluated a combinatorial strategy utilizing sulindac and vitamin C. The death of HCT116 cells upon combination therapy occurred via a p53-mediated mechanism. The combination therapeutic resistance developed in isogenic p53 null HCT116 cells and siRNA-mediated p53 knockdown HCT116 cells, but the exogenous expression of p53 in p53 null isogenic cells resulted in the induction of cell death. In addition, we investigated an increased level of intracellular ROS (reactive oxygen species), which was preceded by p53 activation. The expression level of PUMA (p53-upregulated modulator of apoptosis), but not Bim, w...
Source: Toxicology Letters - June 19, 2016 Category: Toxicology Authors: Gong EY, Shin YJ, Hwang IY, Kim JH, Kim SM, Moon JH, Shin JS, Lee DH, Hur DY, Jin DH, Hong SW, Lee WK, Lee WJ Tags: Toxicol Lett Source Type: research

MCL1 has a vital role in retinoic acid-mediated protection of TLR9-stimulated B-cells from spontaneous and DNA damage-induced apoptosis.
This article is protected by copyright. All rights reserved. PMID: 27278254 [PubMed - as supplied by publisher]
Source: Immunology - June 8, 2016 Category: Allergy & Immunology Authors: Holm KL, Indrevaer RL, Myklebust JH, Kolstad A, Moskaug JØ, Naderi EH, Blomhoff HK Tags: Immunology Source Type: research

1,25-Dihydroxyvitamin D inhibits glutamine metabolism in Harvey-ras transformed MCF10A human breast epithelial cell
Publication date: Available online 3 May 2016 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Xuanzhu Zhou, Wei Zheng, G.A. Nagana Gowda, Daniel Raftery, Shawn S. Donkin, Brian Bequette, Dorothy Teegarden Breast cancer is the second most common cancer among women in the US. The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), is proposed to inhibit cellular processes and to prevent breast cancer. The current studies investigated the effect of 1,25(OH)2D on glutamine metabolism during cancer progression employing Harvey-ras oncogene transformed MCF10A human breast epitheli...
Source: The Journal of Steroid Biochemistry and Molecular Biology - May 5, 2016 Category: Biochemistry Source Type: research