Advances in nanomicelles for sustained drug delivery

Publication date: 25 November 2017 Source:Journal of Industrial and Engineering Chemistry, Volume 55 Author(s): Najmeh Amirmahani, Nosrat O. Mahmoodi, Mohsen Mohammadi Galangash, Atefeh Ghavidast The efficient direct access of therapeutic molecules to the target tissues is still a major obstacle in developing useful therapeutic interventions. Over the past decades, polymeric micelles are interesting nanocarries for drug delivery systems due to small size (10–100nm), low toxicity, capacity to solubilize lipophilic drugs in core and high drug loading. Here, the design of various nanomicelles such as amphiphilic dendrimer, boronate ester linked, X-shaped four-armed gemini-like, amphiphilic based vitamin E, styrene-maleic acid, diselenide linkages, oleic acid and natural polymeric inulin and vitamin E, siRNA and natural water soluble polysaccharides nanomicelles described and their efficacy discussed. Graphical abstract
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research