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Total 193 results found since Jan 2013.

TGF- β1-induced cell migration in pancreatic carcinoma cells is RAC1 and NOX4-dependent and requires RAC1 and NOX4-dependent activation of p38 MAPK.
TGF-β1-induced cell migration in pancreatic carcinoma cells is RAC1 and NOX4-dependent and requires RAC1 and NOX4-dependent activation of p38 MAPK. Oncol Rep. 2017 Oct 12;: Authors: Witte D, Bartscht T, Kaufmann R, Pries R, Settmacher U, Lehnert H, Ungefroren H Abstract Transforming growth factor (TGF)-β promotes epithelial-mesenchymal transition and cell invasion of cancer cells in part through the small GTPase RAC1. Since RAC1 can signal through reactive oxygen species (ROS), we probed the role of the ROS-producing NADPH oxidase (NOX) and p38 mitogen-activated protein kinase (MAPK) in mediating TG...
Source: Oncology Reports - October 20, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis
Cysteine is an essential amino acid for infants, aged people as well as patients with metabolic disorders. Although the thiol group of cysteine side chain is active in oxidative reactions, the role of cysteine in cancer remains largely unknown. Here, we report that the expression level of the solute carrier family 3, member 1 (SLC3A1), the cysteine carrier, tightly correlated with clinical stages and patients' survival. Elevated SLC3A1 expression accelerated the cysteine uptake and the accumulation of reductive glutathione (GSH), leading to reduced reactive oxygen species (ROS). ROS increased the stability and activity of ...
Source: Theranostics - September 12, 2017 Category: Molecular Biology Authors: Yang Jiang, Yuan Cao, Yongbin Wang, Wei Li, Xinyi Liu, Yixuan Lv, Xiaoling Li, Jun Mi Tags: Research Paper Source Type: research

Mono-(2-ethylhexyl) phthalate induced ROS-dependent autophagic cell death in human vascular endothelial cells.
In conclusion, it is possible that ROS elicited autophagy through Akt1 pathway in the MEHP-treated EA.hy926 cells. PMID: 28655635 [PubMed - as supplied by publisher]
Source: Toxicology in Vitro - June 24, 2017 Category: Toxicology Authors: Liu N, Jiang L, Sun X, Yao X, Zhai X, Liu X, Wu X, Bai Y, Wang S, Yang G Tags: Toxicol In Vitro Source Type: research

Molecules, Vol. 22, Pages 969: Docosahexaenoic Acid Induces Expression of Heme Oxygenase-1 and NAD(P)H:quinone Oxidoreductase through Activation of Nrf2 in Human Mammary Epithelial Cells
In conclusion, DHA activates Nrf2, possibly through modification of critical Keap1 cysteine 288 residue and PKCδ-mediated phosphorylation of Nrf2, leading to upregulation of HO-1 and NQO1 expression.
Source: Molecules - June 10, 2017 Category: Chemistry Authors: Hye-Yoon Bang Sin-Aye Park Soma Saeidi Hye-Kyung Na Young-Joon Surh Tags: Article Source Type: research

7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells
Publication date: Available online 8 May 2017 Source:Life Sciences Author(s): En-Xia Wang, Bo-Yang Zou, Lei Shi, Lin-Ying Du, Yan-Yan Zhu, Ya-Meng Jiang, Xiao-Dong Ma, Xiao-Hui Kang, Chang-Yuan Wang, Yu-Hong Zhen, Li-Dan Sun Aims To investigate the antitumor effects of 7-O-geranylquercetin (GQ), a novel O-alkylated derivative of quercetin, against non-small cell lung cancer (NSCLC) cell lines A549 and NCI-H1975 and the corresponding mechanisms. Main methods Cell viability was assessed using MTT assay. The expression of proteins involved in apoptosis and autophagy was measured using western blotting. Besides, apoptosis was...
Source: Life Sciences - May 9, 2017 Category: Biology Source Type: research

SIRT6 inhibits TNF- α-induced inflammation of vascular adventitial fibroblasts through ROS and Akt signaling pathway.
This study aims to investigate the role of SIRT6 in vascular inflammation and it molecular mechanism. We found that tumor necrosis factor-α (TNF-α) did not alter the localization of SIRT6 in vascular adventitial fibroblasts (VAFs), vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs). The expression of SIRT1, SIRT6 was decreased in TNF-α-treated VAFs. In contrast, TNF-α significantly increased the expression of monocyte chemotactic protein 1 (MCP-1) and interleukin (IL) -6. Knockdown of SIRT1 and SIRT6 by siRNA significantly enhanced TNF-α-induced expression of MCP-1 and IL-6, respectively. Overe...
Source: Experimental Cell Research - May 4, 2017 Category: Cytology Authors: He Y, Xiao Y, Yang X, Li Y, Wang B, Yao F, Shang C, Jin Z, Wang W, Lin R Tags: Exp Cell Res Source Type: research

NLRP3 inflammasome activation contributes to aldosterone-induced podocyte injury
Aldosterone (Aldo) has been shown as an important contributor of podocyte injury. However, the underlying molecular mechanisms are still elusive. Recently, the pathogenic role of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in mediating renal tubular damage was identified while its role in podocyte injury still needs evidence. Thus the present study was undertaken to investigate the role of NLRP3 inflammasome in Aldo-induced podocyte damage. In vitro, exposure of podocytes to Aldo enhanced NLRP3, caspase-1, and IL-18 expressions in dose- and time-dependent manners, indicating an activation of NL...
Source: AJP: Renal Physiology - April 1, 2017 Category: Urology & Nephrology Authors: Bai, M., Chen, Y., Zhao, M., Zhang, Y., He, J. C.-J., Huang, S., Jia, Z., Zhang, A. Tags: RESEARCH ARTICLE Source Type: research

Cr(VI) induces cytotoxicity in vitro through activation of ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction via the PI3K/Akt signaling pathway.
This study provides novel insights into the molecular mechanisms of Cr(VI)-induced cytotoxicity. PMID: 28323103 [PubMed - as supplied by publisher]
Source: Toxicology in Vitro - March 17, 2017 Category: Toxicology Authors: Zhang Y, Xiao F, Liu X, Liu K, Zhou X, Zhong C Tags: Toxicol In Vitro Source Type: research

Sulfiredoxin involved in the protection of peroxiredoxins against hyperoxidation in the early hyperglycaemia.
Abstract As a direct consequence of hyperglycaemia, the excessive generation of ROS is central to the pathogenesis of diabetic cardiomyopathy. We hypothesize that stimulation of high glucose (HG) results in an increased sulfiredoxin (Srx) expression, which regulates ROS signaling through reducing the hyperoxidized peroxiredoxins (Prxs). We show that hyperoxidized Prxs were initially reduced in the preliminary stage but then dramatically increased in advanced stage and these changes corresponded to a significant increase of Srx expression in the heart of diabetic rats. These time-dependent changes were also confirm...
Source: Experimental Cell Research - February 11, 2017 Category: Cytology Authors: Shi S, Guo Y, Lou Y, Li Q, Cai X, Zhong X, Li H Tags: Exp Cell Res Source Type: research

Inhibition of c-Src protects paraquat induced microvascular endothelial injury by modulating caveolin-1 phosphorylation and caveolae mediated transcellular permeability
Publication date: Available online 2 February 2017 Source:Environmental Toxicology and Pharmacology Author(s): Yu Huang, Qing He The mechanisms underlying paraquat induced acute lung injury (ALI) is still not clear. C-Src plays an important role in the regulation of microvascular endothelial barrier function and the pathogenesis of ALI. In the present study, we found that paraquat induced cell toxicity and an increase of reactive oxygen species (ROS) in endothelium. Paraquat exposure also induced significant increase of caveolin-1 phosphorylation, caveolae trafficking and albumin permeability in endothelial monolayers. C-...
Source: Environmental Toxicology and Pharmacology - February 2, 2017 Category: Environmental Health Source Type: research

20S-Protopanaxadiol, an aglycosylated ginsenoside metabolite, induces hepatic stellate cell apoptosis through LKB1-AMPK activation
Publication date: Available online 25 January 2017 Source:Journal of Ginseng Research Author(s): Sang Mi Park, Eun Hye Jung, Jae Kwang Kim, Kyung Hwan Jegal, Chung A. Park, Il Je Cho, Sang Chan Kim Background Previously, we reported Korean Red Ginseng inhibited liver fibrosis in mice and reduced the expressions of fibrogenic genes in hepatic stellate cells (HSCs). The present study was undertaken to identify the major ginsenoside responsible for reducing numbers of HSCs and the underlying mechanism involved. Methods Using LX-2 cells (a human immortalized HSC line) and primary activated HSCs, MTT assays were conducted to e...
Source: Journal of Ginseng Research - January 24, 2017 Category: Complementary Medicine Source Type: research

Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: roles of NOX4 and mitochondrion
Publication date: Available online 5 January 2017 Source:Redox Biology Author(s): Wenwen Zhao, Haitao Feng, Wen Sun, Kang Liu, Jin-Jian Lu, Xiuping Chen Oxidative stress causes endothelial death while underlying mechanisms remain elusive. Herein, the pro-death effect of tert-butyl hydroperoxide (t-BHP) was investigated with low concentration (50μM) of t-BHP (t-BHPL) and high concentration (500μM) of t-BHP (t-BHPH). Both t-BHPL and t-BHPH induced endothelial cell death was determined. T-BHPL induced caspase-dependent apoptosis and reactive oxygen species (ROS) generation, which was inhibited by N-acetyl-L-cysteine (NAC)....
Source: Redox Biology - January 5, 2017 Category: Biology Source Type: research

TRPM2 Promotes Neurotoxin MPP + /MPTP-Induced Cell Death
AbstractIn neurons, Ca2+ is essential for a variety of physiological processes that regulate gene transcription to neuronal growth and their survival. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium ions (MPP+) are potent neurotoxins that selectively destroys the dopaminergic (DA) neurons and mimics Parkinson ’s disease (PD) like symptoms, but the mechanism as how MPP+/MPTP effects DA neuron survival is not well-understood. In the present study, we found that MPP+ treatment increased the level of reactive oxygen species (ROS) that activates and upregulates the expression and function o...
Source: Molecular Neurobiology - December 11, 2016 Category: Neurology Source Type: research

Advanced Oxidation Protein Products Sensitized the Transient Receptor Potential Vanilloid 1 via NADPH Oxidase 1 and 4 to Cause Mechanical Hyperalgesia
In conclusion, AOPPs increased significantly in CFA-induced hyperalgesia rats and they activated Nox1/Nox4-ROS to sensitize TRPV1-dependent Ca2+ influx and CGRP release which led to inducing mechanical hyperalgesia. Graphical abstract
Source: Redox Biology - September 17, 2016 Category: Biology Source Type: research

Heme oxygenase-1-mediated apoptosis under cadmium-induced oxidative stress is regulated by autophagy, which is sensitized by tumor suppressor p53.
Abstract Heme oxygenase-1 (HO-1) is a stress-inducible cytoprotective enzyme. It is often overexpressed in different types of cancers and promotes cell survival. However, the role of HO-1 and the underlying molecular mechanism of cadmium (Cd)-induced oxidative stress in cancer cells remain undefined. Here we show that the role of HO-1 under Cd-induced oxidative stress is dependent upon autophagy, which is sensitized by the tumor suppressor p53. The sensitivity to Cd was 3.5- and 14-fold higher in p53-expressing YD8 and H460 cells than in p53-null YD10B and H1299 cells, respectively. The levels of p53 in YD8 and ...
Source: Biochemical and Biophysical Research communications - September 8, 2016 Category: Biochemistry Authors: So KY, Oh SH Tags: Biochem Biophys Res Commun Source Type: research