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Acetyl-l-carnitine attenuates arsenic-induced liver injury by abrogation of mitochondrial dysfunction, inflammation, and apoptosis in rats
Publication date: Available online 12 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Vida Bodaghi-Namileh, Mohammad Reza Sepand, Ameneh Omidi, Mehdi Aghsami, Seyed Afshin Seyednejad, Sara Kasirzadeh, Omid Sabzevari Industrial and agricultural developments in recent years have resulted in the excessive discharge of arsenic into the environment, making arsenic toxicity a major worldwide concern. Oxidative stress is considered the primary mechanism for arsenic toxicity. The main objective of this study was to evaluate acetyl-l-carnitine’s (ALC) protective ability against the arsenic-induced h...
Source: Environmental Toxicology and Pharmacology - December 13, 2017 Category: Environmental Health Source Type: research

Activation of human eosinophils with palladium nanoparticles (Pd NPs): importance of the actin cytoskeleton in Pd NPs-induced cellular adhesion
Publication date: Available online 11 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): P. Chhay, M. Murphy-Marion, Y. Samson, D. Girard Palladium (Pd) is known to be released into the environment in the fine and ultrafine (at the nanoscale) airborne particle fractions mainly from automobile catalytic converters leading to an increase human exposure to this noble metal. It was reported that Pd can induce allergic reactions in individuals exposed to it via different ways. Some studies reported an increased number of eosinophils into airways following NP exposure in vivo in rodent models of allergies...
Source: Environmental Toxicology and Pharmacology - December 12, 2017 Category: Environmental Health Source Type: research

Antifouling processes and toxicity effects of antifouling paints on marine environment. A review
Publication date: Available online 8 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Intissar Amara, Wafa Miled, Rihab Ben Slama, Neji Ladhari The production infrastructure in aquaculture invariably is a complex assortment of submerged components with cages, nets, floats and ropes. Cages are generally made from polyamide or high density polyethylene (PEHD). All of these structures serve as surfaces for biofouling. However, cage nets and supporting infrastructure offer fouling organisms thousands of square meters of multifilament netting. That's why, before immersing them in seawater, they should ...
Source: Environmental Toxicology and Pharmacology - December 9, 2017 Category: Environmental Health Source Type: research

The Selectivity of Artemisinin-Based Drugs on Human Lung Normal and Cancer Cells
Publication date: Available online 7 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xinyang Li, Shiyan Gu, Donglei Sun, Huangmei Dai, Hongyu Chen, Zunzhen Zhang Artemisinin-based drugs are documented to possess anticancer potential that is selectively effective to cancer cells. However, this selectivity is disputable in different studies and the mechanism is still unclear. To clarify this discrepancy, this study employed five assays to evaluate the cytotoxic effects of artemisinin and artesunate on normal human bronchial epithelial (HBE) cells and lung adenocarcinoma A549 cells. The results of f...
Source: Environmental Toxicology and Pharmacology - December 8, 2017 Category: Environmental Health Source Type: research

Physiologically-based pharmacokinetic and toxicokinetic models for estimating human exposure to five toxic elements through oral ingestion
Publication date: Available online 7 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Eric Dede, Marcus J. Tindall, John W. Cherrie, Steve Hankin, Chris Collins Biological monitoring and physiologically-based pharmacokinetic (PBPK) modelling are useful complementary tools in quantifying human exposure to elements in the environment. In this work, we used PBPK models to determine the optimal time for collecting biological samples in a longitudinal study to determine if participants who consumed allotment produce had been exposed to arsenic, cadmium, chromium, nickel or lead. There are a number of P...
Source: Environmental Toxicology and Pharmacology - December 8, 2017 Category: Environmental Health Source Type: research

N-acetyl-l-cysteine ameliorates the PM2.5-induced oxidative stress by regulating SIRT-1 in rats
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Lu Yang, Zheng Duan, Xin Liu, Yadong Yuan Silent information regulator 1 (SIRT1), a class III histone deacetylase, plays a major role in combating cellular oxidative stress injury. However, the role of SIRT1 in oxidative stress induced by particulate matter remains unclear. A total of 32 healthy male Sprague–Dawley rats were divided into PM2.5, PM2.5 +NAC, filtered air (control), and filtered air+NAC (NAC control) groups. The expressions of MnSOD, SIRT1, and FOXO3a were examined at both transcriptional and protein l...
Source: Environmental Toxicology and Pharmacology - December 7, 2017 Category: Environmental Health Source Type: research

In vitro study on the joint hepatoxicity upon combined exposure of cadmium and BDE-209
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Lixin Wang, Miaomiao Zheng, Yu Gao, Jiansheng Cui Joint toxicity is an important issue during the risk assessment of environmental pollutants. Contamination of heavy metals and persistent organic pollutants (POPs) under the environmental and biological settings poses substantial health risk to humans. Although previous studies demonstrated the co-occurrence of cadmium and decabrominated diphenyl ether (BDE-209) in environmental mediums, food chains and even human body, their potentially joint toxicities remain elusive thu...
Source: Environmental Toxicology and Pharmacology - December 6, 2017 Category: Environmental Health Source Type: research

The Ascidian Embryo Teratogenicity assay in Ciona intestinalis as a new teratological screening to test the mixture effect of the co-exposure to ethanol and fluconazole.
Publication date: Available online 2 December 2017 Source:Environmental Toxicology and Pharmacology Author(s): Maria Battistoni, Silvia Mercurio, Gentile Francesco Ficetola, Francesca Cristiana Metruccio, Elena Menegola, Roberta Pennati The aim of this work was to evaluate the Ascidian Embryo Teratogenicity assay (AET) as new alternative invertebrate model to test the developmental effects of the co-exposure to ethanol and fluconazole. Ciona intestinalis embryos were exposed to the azolic fungicide fluconazole, (FLUCO, 7.8–250μM), to ethanol (Eth, 0.01–0.5%) and to their mixture (0.01% Eth+FLUCO 7.8–2...
Source: Environmental Toxicology and Pharmacology - December 3, 2017 Category: Environmental Health Source Type: research

Fabrication of capsaicin functionalized reduced graphene oxide and its effect on proliferation and differentiation of osteoblasts
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Liansuo Zhai, Lin Li, Qi Zhang Herein, we report a new simple and biological approach for the preparation of capsaicin adsorbed reduced graphene oxide (RGO), where capsaicin acts as a stabilizing and deoxygenating agent. The capsaicin that is decorated on graphene surface plays an important role as a capping agent to avoid the aggregation of graphene sheets. The capsaicin functionalized RGO stimulated the differentiation and proliferation of osteoblasts to a larger extent, which is a significant feature for the use of bio...
Source: Environmental Toxicology and Pharmacology - November 30, 2017 Category: Environmental Health Source Type: research

Evidence for estrogeno-mimetic effects of a mixture of low-dose pollutants in a model of ovariectomized mice
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Benoit Julien, Claudie Pinteur, Nathalie Vega, Emmanuel Labaronne, Hubert Vidal, Danielle Naville, Brigitte Le Magueresse-Battistoni We recently hypothesized that a mixture of low-dosed dioxin, polychlorobiphenyl, phthalate and bisphenol may induce estrogeno-mimetic activities in a model of lifelong-exposed female mice. Herein, we evaluated the impact of this mixture in estrogen deficiency conditions. Based on the protective effects of estrogens against metabolic disorders, we reasoned that exposure to pollutants should a...
Source: Environmental Toxicology and Pharmacology - November 30, 2017 Category: Environmental Health Source Type: research

Antimutagenic action of the live yeast can be transmitted to the offspring of Drosophila melanogaster. A genetic study using the wing spot assay
Publication date: January 2018 Source:Environmental Toxicology and Pharmacology, Volume 57 Author(s): Emilio Pimentel, Martha P. Cruces The present study evaluates whether the protective effect of live yeast (LY) against direct and indirect mutagenic agents, persists in the offspring from individuals fed with LY. The wing-spot test in Drosophila was used; four different mates were performed: a) neither females nor males were fed with LY-enriched food (NLYxNLY); b) only females were fed (LYxNLY); c) males were fed (NLYxLY) or d) both progenitors were fed (LYxLY). Results confirm that LY strongly stimulates fecundity in fem...
Source: Environmental Toxicology and Pharmacology - November 30, 2017 Category: Environmental Health Source Type: research

Hypolipidemic activity of P-methoxycinnamic diester (PCO-C) isolated from Copernicia prun ífera against Triton WR-1339 and hyperlipidemic diet in mice
Publication date: December 2017 Source:Environmental Toxicology and Pharmacology, Volume 56 Author(s): A.C.V.A. Filho, P.A.S. Rodrigues, S.R. Benjamin, R.T.T. Paim, M.O. Holanda, J.Y.G. Silva, T.S. Milo, I.G.P. Vieira, M.G.R. Queiroz, M.I.F. Guedes Carnauba wax is extracted from the leaves of the Copernicia prunífera and contains approximately 80% of esters in its composition. The purpose of the present study was evaluate the hypolipidemic effect of p-methoxycinnamic diesters (PCO-C) extracted from Copernicia prunífera in a model of acute and chronic dyslipidemia in mice. The levels of total cholesterol and ...
Source: Environmental Toxicology and Pharmacology - November 17, 2017 Category: Environmental Health Source Type: research

Protective effects of proanthocyanidins against cadmium-induced testicular injury through the modification of Nrf2-Keap1 signal path in rats
In conclusion, PAs exhibited a significant chemopreventive potential against Cd-induced testicular oxidative damage in rats, possibly through the modification of Nrf2-Keap1 signal path. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 15, 2017 Category: Environmental Health Source Type: research

Pesticides contaminated dust exposure, risk diagnosis and exposure markers in occupational and residential settings of Lahore, Pakistan
Publication date: Available online 7 November 2017 Source:Environmental Toxicology and Pharmacology Author(s): Sidra Waheed, Crispin Halsall, Andrew J. Sweetman, Kevin C. Jones, Riffat Naseem Malik There are few studies documenting the dust loaded with pesticides as a potential non-dietary exposure source for occupational worker and populations living near agricultural farms and pesticides formulation plants. In present study we have evaluated the pesticide concentration in dust from potential sites and relevant health risk from dust ingestion. Furthermore, the effect of currently used pesticides was investigated on blood...
Source: Environmental Toxicology and Pharmacology - November 8, 2017 Category: Environmental Health Source Type: research

A Zinc Schiff base complex inhibits cancer progression both in vivo and in vitro by inducing apoptosis
In conclusion, the synthesized Zn-complex may be developed for efficacious, multidrug resistance reversal, non-toxic chemotherapeutic agents in future. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 7, 2017 Category: Environmental Health Source Type: research

Trans-generational transmission of altered phenotype resulting from flubendiamide-induced changes in apoptosis in larval imaginal discs of Drosophila melanogaster
This study further demonstrated trans-generational transmission of altered phenotype in three subsequent generations of a non-target insect model, D. melanogaster. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 7, 2017 Category: Environmental Health Source Type: research

The effect of elemental content on the risk of dental fluorosis and the exposure of the environment and population to fluoride produced by coal-burning
This study can provide a scientific basis for a further understanding of the causes of health damage caused by fluoride and the improvement of targeted prevention strategies. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 6, 2017 Category: Environmental Health Source Type: research

Protective effect of proanthocyanidins against cadmium-induced testicular injury through the modification of Nrf2-Keap1 signal path in rats
In conclusion, PAs exhibited a significant chemopreventive potential against Cd-induced testicular oxidative damage in rats, possibly through the modification of Nrf2-Keap1 signal path. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 4, 2017 Category: Environmental Health Source Type: research

Sensitive biomarkers identification for differentiating Cd and Pb induced toxicity on zebrafish embryos
Publication date: Available online 31 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jian Yin, Ai-Ping Wang, Wan-Fang Li, Rui Shi, Hong-Tao Jin, Jin-Feng Wei Cadmium (Cd) and lead (Pb) are naturally existing heavy metals that pose significant health risks. The present study aims to identify sensitive biomarkers for differentiating the toxicities induced by Cd and Pb and for providing clues for the early prediction of toxicity and environmental risk assessment. Indicators related to oxidative stress and inflammatory responses in zebrafish treated with Cd and Pb over time (from 24hpf to 96hpf) were...
Source: Environmental Toxicology and Pharmacology - November 1, 2017 Category: Environmental Health Source Type: research

Estrogen-responsive gene networks in the teleost liver: What are the key molecular indicators?
The objective of this study was to identify core groups of transcripts and molecular signaling pathways that respond to 17alpha-ethylinestadiol (EE2), a ubiquitous estrogenic contaminant, using transcriptome datasets generated from six independent laboratories. We sought to determine which biomarkers and gene networks were those most robust and reliably detected in multiple laboratories. Six laboratories conducted microarray analysis in pieces of the same liver from male fathead minnows exposed to ∼15ng/L EE2 for 96hours. There were common transcriptional networks identified in every dataset. These included a down-regu...
Source: Environmental Toxicology and Pharmacology - November 1, 2017 Category: Environmental Health Source Type: research

Oxidative stress-elicited autophagosome accumulation contributes to human neuroblastoma SH-SY5Y cell death induced by PBDE-47
In this study, we used human neuroblastoma SH-SY5Y cells to explore the effects of PBDE-47 on autophagy and investigate the role of autophagy in PBDE-47-induced cell death. Results showed PBDE-47 could increase autophagic level (performation of cell ultrastructure with double membrane formation, MDC-positive cells raised, autophagy-related proteins LC3-II, Beclin1 and P62 increased) after cells exposed to PBDE-47. Then cells were exposed to PBDE-47 (1, 5, 10μmol/L) respectively for 1, 3, 6, 9, 12, 18, 24h, and the results showed that PBDE-47 increased the levels of LC3-II, Beclin1 and P62 in 5, 10μmol/L (9, 12, 18, 2...
Source: Environmental Toxicology and Pharmacology - October 30, 2017 Category: Environmental Health Source Type: research

Fluoride: A Review of Pre-clinical and Clinical Studies
Publication date: Available online 24 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Divya Sharma, Aarti Singh, Kanika Verma, Sarvesh Paliwal, Swapnil Sharma, Jaya Dwivedi Fluoride is ubiquitous in environment and profound in bones, teeth and calcified tissues of human body. Fluoride have been the topic of regular discussion and investigations. Besides its toxicity, fluoride have also been examined for its beneficial effects like prevention and treatment of tooth decay, microbial infection, inflammation, cancer, occurrence of renal stone and many more. Since last many decades, several efforts hav...
Source: Environmental Toxicology and Pharmacology - October 30, 2017 Category: Environmental Health Source Type: research

A study of genotoxicity and oxidative stress induced by mercuric chloride in the marine polychaete Perinereis aibuhitensis
Publication date: Available online 28 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Lai Jun Zhang, Yao Li, Pan Chen, Xiao Mei Li, Yong Gan Chen, Yu Yu Hang, Wei Jie Gong The marine polychaete worm Perinereis aibuhitensis was used to study the genotoxic effects of mercuric chloride by means of the comet assay and micronucleus (MN) test. P. aibuhitensis was subjected in vivo to two different concentrations of mercuric chloride (0.05mgL−1 and 0.5mgL−1) for 96h. The comet assay of coelomocytes demonstrated that TailDNA% values increased with extended exposure to or increased concentratio...
Source: Environmental Toxicology and Pharmacology - October 30, 2017 Category: Environmental Health Source Type: research

Prediction of aquatic toxicity of benzene derivatives using molecular descriptor from atomic weighted vectors.
Publication date: Available online 13 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Yoan Martínez-López, Stephen J. Barigye, Oscar Martínez-Santiago, Yovani Marrero-Ponce, James Green, Juan A. Castillo-Garit Several descriptors from atom weighted vectors are used in the prediction of aquatic toxicity of set of organic compounds of 392 benzene derivatives to the protozoo ciliate Tetrahymena pyriformis (log(IGC50)−1). These descriptors are calculated using the MD-LOVIs software and various Aggregation Operators are examined with the aim comparing their performances in pr...
Source: Environmental Toxicology and Pharmacology - October 14, 2017 Category: Environmental Health Source Type: research

T-2 toxin induces cytotoxicity and disrupts tight junction barrier in SerW3 cells
This study focused on revealing the cytotoxic effects of T-2 on Sertoli cells associated with cell junctional barriers. In the present study, SerW3 cells were exposed to T-2 toxin at 12, 120 and 1200ng/ml doses for 24 and 48hours. Cytotoxicity tests including cell viability (MTT), lactate dehydrogenase (LDH) cytotoxicity test and trypan blue exclusion assay were performed. Occludin, ZO-1, N-cadherin and β-catenin were immunolabelled, expressions of occludin and N-cadherin were determined by western blotting. SerW3 cell barrier integrity was measured by transepithelial electrical resistance (TEER). Cytotoxicity caused ...
Source: Environmental Toxicology and Pharmacology - October 13, 2017 Category: Environmental Health Source Type: research

Effects of glyphosate-based herbicide on pintado da Amaz ônia: Hematology, histological aspects, metabolic parameters and genotoxic potential
This study investigated the effects on the hybrid fish jundiara (Leiarius marmoratus×Pseudoplatystoma reticulatum) of an environmentally relevant exposure to this herbicide. Glucose levels in liver, muscle and plasma decreased after exposure to 1.357mgL−1 of Roundup Original® (glyphosate nominal concentration), while glycogen levels reduced in liver and muscle for different times. Elevated cholesterol and triglycerides revealed an adaptive response. Protein and lactate levels also increased during the experiment, however no changes were observed for muscle lactate. Increment of the transaminases suggests da...
Source: Environmental Toxicology and Pharmacology - October 12, 2017 Category: Environmental Health Source Type: research

Effect of repeated administration of 4-methylpyrazole on renal function and lipid peroxidation products in rat kidney after ethylene glycol poisoning
Publication date: Available online 10 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Karina Sommerfeld-Klatta, Jędrzej Przystanowicz, Joanna Kowalówka-Zawieja, Barbara Zielińska-Psuja Toxic effects of ethylene glycol (EG) and its metabolites are mainly related to metabolic acidosis and kidney damage. EG biotransformation involving CYP2E1 affects the oxidant-antioxidant balance. The study assessed the effect of repeated administration of 4-methylpyrazole (4MP, 15mg/kg b.w. after 2hours, followed by 10mg/kg b.w. every 12hours) on renal function (creatinine, urea and urinary protein levels)...
Source: Environmental Toxicology and Pharmacology - October 11, 2017 Category: Environmental Health Source Type: research

CYP2C9 and VKORC1 in therapeutic dosing and safety of acenocoumarol treatment: implication for clinical practice in Hungary
Publication date: Available online 8 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Reka Varnai, Csilla Sipeky, Lajos Nagy, Sandor Balogh, Bela Melegh The purpose of this work was to investigate the contribution of CYP2C9 and VKORC1 to acenocoumarol (AC) dose variability, bleeding events in Hungary. The study recruited 117 patients on long-term AC therapy (INR 2-3), and 510 healthy individuals to model the findings. Patients were genotyped for alleles proved to affect lower AC overdose CYP2C9*2, CYP2C9*3, VKORC1*2. Additionally, we tested VKORC1*3, VKORC1*4 to examine their effect in patients wit...
Source: Environmental Toxicology and Pharmacology - October 9, 2017 Category: Environmental Health Source Type: research

Effects of particulate matter from straw burning on lung fibrosis in mice
Conclusion Exposure of mice with BLM-induced IPF to PM2.5 from straw burning exacerbated lung inflammation and fibrosis and increased mortality; NAC increased the mouse survival, indicating protective effects. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - October 8, 2017 Category: Environmental Health Source Type: research

Toxicity of ZnO nanoparticles (NPs) to A549 cells and A549 epithelium in vitro: interactions with dipalmitoyl phosphatidylcholine (DPPC)
In this study, we investigated the effects of dipalmitoyl phosphatidylcholine (DPPC), the major component in lung surfactant, on stability and toxicity of ZnO NPs. The presence of DPPC increased the UV–vis spectra, hydrodynamic size, Zeta potential and dissolution rate of ZnO NPs, which indicates that DPPC might interact with NPs and affect the colloidal stability of NPs. Exposure to ZnO NPs induced cytotoxicity associated with increased intracellular Zn ions but not superoxide in A549 cells. In A549 epithelium model, exposure to ZnO NPs induced cytotoxicity and decreased the release of interleukin 6 (IL-6) without a...
Source: Environmental Toxicology and Pharmacology - October 8, 2017 Category: Environmental Health Source Type: research

The α-lipoic acid improves high-fat diet-induced cerebral damage through inhibition of oxidative stress and inflammatory reaction
This study is to clarify the protective role of α-lipoic acid in high-fat diet-induced cerebral damage mice. The mice were divided into 5 groups: normal control group, high-fat diet (HFD) group, low-dose α-lipoic acid group for prevention, high-dose α-lipoic acid group for prevention, and high-dose α-lipoic acid group for treatment. The groups’ weights and blood glucose changes were monitored. We used HE staining to observe morphological changes in the cerebral cortex. The expression levels of the oxidative stress proteins SOD2, catalase, and the inflammatory pathway proteins p-JNK, p-ERK were...
Source: Environmental Toxicology and Pharmacology - October 4, 2017 Category: Environmental Health Source Type: research

The potential effects of efavirenz on Oreochromis mossambicus after acute exposure
Publication date: Available online 2 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): L Robson, IEJ Barnhoorn, GM Wagenaar Antiretroviral drugs (ARVs) are hazardous therapeutic pharmaceuticals present in South African surface water. Efavirenz is an ARV commonly used in human immunodeficiency virus (HIV) treatment in South Africa. Although little is known about the toxic effects of efavirenz on fish health, threats of toxicity to the aquatic environment have been reported. Oreochromis mossambicus were exposed under controlled conditions to environmentally-relevant efavirenz concentrations (10.3ng/L)...
Source: Environmental Toxicology and Pharmacology - October 3, 2017 Category: Environmental Health Source Type: research

Low cytotoxicity of anisotropic gold nanoparticles coated with lysine on peripheral blood mononuclear cells “in vitro”
Publication date: December 2017 Source:Environmental Toxicology and Pharmacology, Volume 56 Author(s): Jorge O. Avila-Alejo, Ana K. González-Palomo, Germán Plascencia-Villa, Miguel José-Yacamán, Hugo R. Navarro-Contreras, Iván N. Pérez-Maldonado The aim of this study was to evaluate the cytotoxic effects of anisotropic (non spherical morphologies) gold nanoparticles coated with the amino acid Lysine (Lys) on peripheral blood mononuclear cells (PBMC) “in vitro”. Gold (Au) nanoparticles tested in this study were synthesized by a seed-mediated growth using Lys as a struct...
Source: Environmental Toxicology and Pharmacology - October 1, 2017 Category: Environmental Health Source Type: research

The ameliorating effects of selenium and vitamin C against fenitrothion-induced blood toxicity in Wistar rats
Publication date: December 2017 Source:Environmental Toxicology and Pharmacology, Volume 56 Author(s): Marija D. Milošević, Milica G. Paunović, Miloš M. Matić, Branka I. Ognjanović, Zorica S. Saičić Fenitrothion is widely used organophosphate pesticide in agriculture and health programs, but besides, it causes several toxic effects. The present study was designed to evaluate the possible protective effects of selenium (0.5mg/kg b.w.) and vitamin C (100mg/kg b.w) on altered haematological, biochemical and oxidative stress parameters in the blood of rats orally treated with fenitrothion (20mg/kg b.w) for...
Source: Environmental Toxicology and Pharmacology - September 28, 2017 Category: Environmental Health Source Type: research

Cellular pathways involved in silica nanoparticles induced apoptosis: A systematic review of in vitro studies
Publication date: December 2017 Source:Environmental Toxicology and Pharmacology, Volume 56 Author(s): Collins Otieno Asweto, Jing Wu, Mohamed Ali Alzain, Hejing Hu, Sebastian Andrea, Lin Feng, Xiaozhe Yang, Junchao Duan, Zhiwei Sun Silica nanoparticles (SiNPs) have been found to pass through biological barriers and get distributed in the human body. They induce cell apoptosis via various mechanisms in body organs. To understand these mechanisms, we carried out systematic review of in vitro studies on SiNPs-induced cell apoptosis. Office of Health Assessment and Translation approach for Systematic Review and Evidence Inte...
Source: Environmental Toxicology and Pharmacology - September 28, 2017 Category: Environmental Health Source Type: research

Selection of reference genes for quantitative real-time PCR analysis in chicken ovary following silver nanoparticle treatment
In conclusion, the results obtained depend on the algorithm used and it arises from the diverse calculation strategies used in these programs. The outcome from the NormFinder is considered to be the most trustworthy and used in further qPCR analysis. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 23, 2017 Category: Environmental Health Source Type: research

Elucidation of protective efficacy of Pentahydroxy flavone isolated from Madhuca indica against arsenite-induced cardiomyopathy: Role of Nrf-2, PPAR- γ, c-fos and c-jun
Conclusion Administration of 3,5,7,3′,4′- Pentahydroxy flavone (i.e. Quercetin (QTN)) isolated from MI-ALC showed significant protection against arsenic-induced oxido-nitrosative stress and myocardial injury via modulation of Nrf2, PPAR-γ, and apoptosis. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 22, 2017 Category: Environmental Health Source Type: research

Sulforaphane mitigates cadmium-induced toxicity pattern in human peripheral blood lymphocytes and monocytes
In this study, we investigated the protective role of sulforaphane on Cd-induced toxicity in human peripheral blood lymphocytes and monocytes. Sulforaphane did not show any major reduction in the viability of lymphocytes and monocytes. However, Cd treatment at a concentration of 50μM induced around 69% cell death. Treatment of IC10-Cd and 100μM sulforaphane combination for 24 and 48h increased viability by 2 and 9% in cells subjected to Cd toxicity, respectively. In addition, IC25 of Cd and 100μM sulforaphane combination recovered 17–20% of cell viability. Cd induced apoptotic and necrotic cell death. Sulfor...
Source: Environmental Toxicology and Pharmacology - September 21, 2017 Category: Environmental Health Source Type: research

Intestinal epithelial cell injury induced by copper containing nanoparticles in piglets
Publication date: Available online 17 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Hui Zhang, Xiaoxing Wu, Khalid Mehmood, Zhenyu Chang, Kun Li, Xiong Jiang, Fazul Nabi, Muhammad Ijaz, Mujeeb Ur Rehman, Muhammad Tariq Javed, Donghai Zhou The nano copper has been widely used in modern clinical medicine practice. However, it has been noticed that nano copper particles induce cell injury and toxicity. The present study was designed to determine the effect of nano copper particles on cell injury of intestinal epithelial cells (IECs) in piglets. The IECs were treated with different doses of nano c...
Source: Environmental Toxicology and Pharmacology - September 19, 2017 Category: Environmental Health Source Type: research

Butyl Benzyl Phthalate (BBP) Induces Caudal Defects During Embryonic Development
Publication date: Available online 17 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Nicole M. Roy, Ewelina Zambrzycka, Jenna Santangelo Butyl benzyl phthalate (BBP) is commonly added during the manufacturing of plastics to increase flexibility and elasticity. However, BBP leaches off of plastic and environment presence has been detected in soil, groundwater and sediment potentially effecting organisms in the environment. Given the widespread uses of BBP in household, consumer goods and the presence of BBP in the environment, studies on developmental toxicity are needed. Here, we use a zebrafis...
Source: Environmental Toxicology and Pharmacology - September 19, 2017 Category: Environmental Health Source Type: research

Distribution of chromosome breakpoints in benzene-exposed and unexposed AML patients
Publication date: October 2017 Source:Environmental Toxicology and Pharmacology, Volume 55 Author(s): Patrick J. Kerzic, Richard D. Irons Results of laboratory studies and investigations of occupationally exposed healthy individuals have been used to develop a mode of action for benzene-induced leukemia that mirrors disease following treatment with chemotherapeutic agents. Recently we have described series of AML and MDS cases with benzene exposure history, and have provided cytogenetic, molecular, and pathologic evidence that these cases differ significantly in many features from therapy-related disease. Here we have ext...
Source: Environmental Toxicology and Pharmacology - September 19, 2017 Category: Environmental Health Source Type: research

The genetic influence in fluorosis
Publication date: Available online 15 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Sreemanta Pramanik, Depanwita Saha Fluorosis, caused by ingestion of excess fluoride, is endemic in at least 25 countries across the globe, China and India being the worst affected among them. Dental, skeletal and non-skeletal are the major types of fluorosis affecting millions of people in these countries. A number of genetic epidemiological studies carried out by investigators have shown the evidence for association between genetic polymorphisms in candidate genes and differences in the susceptibility pattern...
Source: Environmental Toxicology and Pharmacology - September 16, 2017 Category: Environmental Health Source Type: research

The Role of PPAR alpha in Perfluorooctanoic Acid Induced Developmental Cardiotoxicity and L-carnitine Mediated Protection –Results of in ovo Gene Silencing
In conclusion, PFOA-induced heart rate elevation is likely PPAR alpha independent, while the right ventricular wall thinning seems to be PPAR alpha dependent. The protective effects of L-carnitine do not require PPAR alpha. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 15, 2017 Category: Environmental Health Source Type: research

Identification of key genes and pathways and therapeutic agents in Cadmium-treated liver cells: a bioinformatics study
Publication date: Available online 14 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Liang Zhang, Yi Huang, Zhen Yu, Mengmeng Shao, Yunbo Luo, Yi Zhu Evidence indicates that Cadmium (Cd) can accumulate in liver, which results in acute or chronic cell damage with unclear complex mechanisms. Thus, we aimed to explore the possible molecules and pathways by using bioinformatics methods Consequently, two datasets (GSE8865 and GSE31286) were retrieved and the differentially expressed genes (DEGs) were screened out. The intersection of the DEGs included seven up-regulated and forty-three down-regulate...
Source: Environmental Toxicology and Pharmacology - September 15, 2017 Category: Environmental Health Source Type: research

Hesperidin, a citrus bioflavonoid, alleviates trichloroethylene-induced oxidative stress in Drosophila melanogaster
Publication date: October 2017 Source:Environmental Toxicology and Pharmacology, Volume 55 Author(s): Amos Olalekan Abolaji, Oluwatoyin Victoria Babalola, Abimbola Kehinde Adegoke, Ebenezer Olatunde Farombi Trichloroethylene (TCE) is a chlorinated organic pollutant of groundwater with diverse toxic effects in animals and humans. Here, we investigated the ameliorative role of hesperidin, a citrus bioflavonoid on TCE-induced toxicity in Drosophila melanogaster. Four groups of D. melanogaster (50 flies/vial, with 5 vials/group) were exposed to ethanol (2.5%, control), HSP (400mg/10g diet), TCE (10μM/10g diet) and TCE (10&...
Source: Environmental Toxicology and Pharmacology - September 12, 2017 Category: Environmental Health Source Type: research

Wildfire smoke exposure and human health: Significant gaps in research for a growing public health issue
Publication date: October 2017 Source:Environmental Toxicology and Pharmacology, Volume 55 Author(s): Carolyn Black, Yohannes Tesfaigzi, Jed A. Bassein, Lisa A. Miller Understanding the effect of wildfire smoke exposure on human health represents a unique interdisciplinary challenge to the scientific community. Population health studies indicate that wildfire smoke is a risk to human health and increases the healthcare burden of smoke-impacted areas. However, wildfire smoke composition is complex and dynamic, making characterization and modeling difficult. Furthermore, current efforts to study the effect of wildfire smoke...
Source: Environmental Toxicology and Pharmacology - September 10, 2017 Category: Environmental Health Source Type: research

The risk of coronary artery disease estimated non-invasively in patients with essential hypertension environmentally exposed to cigarette smoke
Conclusions In patients with essential hypertension environmental exposure to cigarette smoke may result in elevated risk of coronary artery disease estimated non-invasively through measurement of coronary artery calcium score by computed tomography. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 9, 2017 Category: Environmental Health Source Type: research

Genetic susceptibility to breast cancer risk associated with inorganic arsenic exposure
Conclusion MTR c.2756A>G polymorphism may confer protection for BC associated with iAs exposure. Further research is warranted to elucidate the potential involvement of other polymorphisms in iAs-related BC. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 9, 2017 Category: Environmental Health Source Type: research

In vitro assessment of neurotoxicity and neuroinflammation of homemade MWCNTs
Publication date: Available online 7 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Giuseppa Visalli, Monica Currò, Daniela Iannazzo, Alessandro Pistone, Marianna Pruiti Ciarello, Giuseppe Acri, Barbara Testagrossa, Maria Paola Bertuccio, Raffaele Squeri, Angela Di Pietro Multi walled carbon nanotubes (MWCNTs) activate pathways involved in cytotoxicity, genotoxicity and inflammation. Inhaled MWCNTs are translocated to extra pulmonary organs and their hydrophobicity allows them to cross the blood–brain barrier (BBB). Further exposure of central nervous system (CNS) occurs via olfact...
Source: Environmental Toxicology and Pharmacology - September 8, 2017 Category: Environmental Health Source Type: research

Protective Effect of Thymoquinone against Diazinon-Induced Hematotoxicity, Genotoxicity and Immunotoxicity in Rats
This study showed that Thy (without the significant effect on genotoxicity) decreased the hematological toxicity, immunotoxicity and butyrl and acetyl cholinesterase activity induced by DZN. The success of Thy supplementation against DZN toxicity can be attributed to the antioxidant effects of its constituents. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 8, 2017 Category: Environmental Health Source Type: research