Cadmium-resistant rhizobacterium Bacillus cereus M4 promotes the growth and reduces cadmium accumulation in rice (Oryza sativa L.)
Publication date: Available online 19 September 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Changrong Wang, Zhongqi Liu, Yongchun Huang, Yeni Zhang, Xiaohan Wang, Zhouyue HuAbstractRice farmland cadmium pollution is an increasing problem for food safety. Cd-resistant bacterial strain was isolated from rice rhizosphere soil and identified as Bacillus cereus M4. Treatment with M4 fermentation broth increased rice seedlings growth in vermiculite, while reduced Cd accumulation in grains of rice grown in Cd-contaminated potted soil from 0.309 to 0.186 mg/kg. Indoleacetic acid (IAA) was detected in M4 ...
Source: Environmental Toxicology and Pharmacology - September 21, 2019 Category: Environmental Health Source Type: research

Assessing the toxicant effect of spontaneously volatilized 4-vinylcyclohexane exposure in nymphs of the lobster cockroach Nauphoeta cinerea
Publication date: Available online 16 September 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Emily Pansera Waczuk, Roger Wagner, Bruna Klein, João Batista Teixeira da Rocha, Daniel M.P. Ardisson-Araújo, Nilda Vargas BarbosaAbstractVinylcyclohexene (VCH) is an environmental contaminant well known for its ovotoxicant effects in several organisms. However, the mechanisms underlying the toxicity of VCH as well as its harmful effects toward other organs are until unclear. In this work, we assess some endpoint signals of toxicity induced by volatilized VCH exposure using nymphs of the lobster coc...
Source: Environmental Toxicology and Pharmacology - September 18, 2019 Category: Environmental Health Source Type: research

The Organochlorine Pesticides Pentachlorophenol and Dichlorodiphenyltrichloroethane Increase Secretion and Production of Interleukin 6 by Human Immune Cells
Publication date: Available online 12 September 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Tamara J. Martin, Sahra Gabure, JaQuel Maise, Sequena Snipes, Margarita Peete, Margaret M. WhalenABSTRACTThe environmental contaminants pentachlorophenol (PCP) and 4, 4′-dichlorodiphenyltrichloroethane (DDT) are detected in some human blood samples at levels as high as 5 µM (PCP) and 260 nM (DDT). Several cancers are associated with exposures to these contaminants. IL-6 is a pro-inflammatory cytokine that when dysregulated stimulates inflammatory diseases and tumor progression. Immune cells exp...
Source: Environmental Toxicology and Pharmacology - September 13, 2019 Category: Environmental Health Source Type: research

Editorial Board
Publication date: October 2019Source: Environmental Toxicology and Pharmacology, Volume 71Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 8, 2019 Category: Environmental Health Source Type: research

Impairments of bone marrow hematopoietic cells followed by the sever erythrocyte damage and necrotic liver as the outcome of chronic in vivo exposure to cadmium: Novel insights from quails
Publication date: Available online 4 September 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Damir Suljevic, Anida Corbic, Erna Islamagic, Muhamed Focak, Filip Filipic, Andi AlijagicAbstractCadmium is a heavy metal classified as an environmental hazard, and its toxicity is subject to extensive research. Japanese quails were exposed to cadmium chloride (CdCl2) ad libitum for 20 days. Bone marrow, peripheral blood and liver were analyzed following the exposure. Moreover, we have provided the very first explanation of hematopoietic lines in Japanese quail. Following CdCl2 exposure, changes in the number, siz...
Source: Environmental Toxicology and Pharmacology - September 5, 2019 Category: Environmental Health Source Type: research

Stress-related over-enhancement of the hypothalamic-pituitary-adrenal axis causes experimental neurolathyrism in rats
Publication date: Available online 31 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Kimino Minagawa, Shin-ichi Yamada, Ayano Suzuki, Saeko Ta, Toshio Kumai, Fernand Lambein, Kuniko Kusama-EguchiAbstractNeurolathyrism is a motor neuron disease that is caused by the overconsumption of grass peas (Lathyrus sativus L.) under stressful conditions. The neuro-excitatory β-N-oxalyl-L-α,β-diaminopropionic acid present in grass peas was proposed the causative agent of spastic paraparesis of the legs. Historical reports of neurolathyrism epidemics, studies of neurolathyrism animal models, and ...
Source: Environmental Toxicology and Pharmacology - September 1, 2019 Category: Environmental Health Source Type: research

Characterization of the PM2.5 concentration in surgical smoke in different tissues during hemihepatectomy and protective measures
Publication date: Available online 29 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Wenjun Tan, Haoyang Zhu, Nana Zhang, Dinghui Dong, Shanpei Wang, Fenggang Ren, Junxi Xiang, Rongqian Wu, Yi LvAbstractThe characteristics of the PM2.5 concentration in surgical smoke produced by operating on different human tissues during hemihepatectomy were explored to provide a reference for protective measures. Our results showed that the highest concentration of PM2.5 produced by the electrosurgical knife was the liver tissue, followed by muscle, adipose, and vascular tissue. When the single-layer disposable me...
Source: Environmental Toxicology and Pharmacology - August 30, 2019 Category: Environmental Health Source Type: research

Effects of the organochlorine p,p’-DDT on MCF-7 cells: investigating metabolic and immune modulatory transcriptomic changes
The objectives of this study were to investigate DDT-induced transcriptomic alterations in enzymes and transporters involved in xenobiotic metabolism, immune responses, oxidative stress markers, and cell growth in a human breast cancer cell line. MCF-7 cells were exposed to both environmentally-relevant and previously-tested concentrations of p,p’-DDT in a short-term experiment. Significant up-regulation of metabolizing enzymes and transporters (ACHE, GSTO1, NQO1 and ABCC2) and oxidative stress markers (CXCL8, HMOX-1, NFE2L2 and TNF) was clearly observed. Conversely, UGT1A6, AHR and cell growth genes (FGF2 and VEGFA)...
Source: Environmental Toxicology and Pharmacology - August 30, 2019 Category: Environmental Health Source Type: research

Dose-specific Biochemical and Erythrocytic Alterations of Anthracene Exposure on Blood of Anabas testudineus (Bloch)
Publication date: Available online 25 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Sukhendu Dey, Apurba Ratan GhoshAbstractThe present work is designed to compare the chronic toxicity of anthracene [one of the major constituents of polycyclic aromatic hydrocarbons (PAHs)] on Anabas testudineus (Bloch), in an air-breathing carnivorous fish, in laboratory condition under the exposure of two doses of LC50 value, i.e., 0.0075 mg/l (T1), i.e., 25% and 0.015 mg/l (T2) i.e., 50% for 21 days. A comprehensive comparison was recorded based on biochemical parameters and evaluated the erythrocyt...
Source: Environmental Toxicology and Pharmacology - August 26, 2019 Category: Environmental Health Source Type: research

Protective effect of Vitamin D3 against lead induced hepatotoxicity, oxidative stress, immunosuppressive and calcium homeostasis disorders in rat
Publication date: Available online 23 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Hussain Almasmoum, Bassem Refaat, Mazen M. Ghaith, Riyad A. Almaimani, Shakir Idris, Jawwad Ahmad, Abdelghany H. Abdelghany, Mohammad A. BaSalamah, Mohamed El-BoshyAbstractLead (Pb) is an extremely poisonous, non-essential trace element and toxicity develops in humans following frequent exposure to the heavy metal in polluted environmental and occupational settings. Pb induces hepatic damage through the depletion of the antioxidant system, enhancing cellular oxidative stress and stimulation of proinflammatory cytoki...
Source: Environmental Toxicology and Pharmacology - August 25, 2019 Category: Environmental Health Source Type: research

Soil copper uptake by land snails: a semi-field experiment with juvenile Cantareus aspersus snails
Publication date: Available online 16 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): George Andrei Drăghici, Cristina Dehelean, Iulia Pinzaru, Despina Maria Bordean, Aurica Borozan, Aristides Michael Tsatsakis, Leda Kovatsi, Dragos NicaAbstractThere is currently limited scientific evidence linking soil copper and land snails, although these invertebrates are important players in terrestrial ecosystems. In the present study, Cantareus aspersus juveniles, were exposed in two successive phases of 30 days each, to soil spiked with increasing concentrations of copper sulfate. Copper concentrated prefere...
Source: Environmental Toxicology and Pharmacology - August 17, 2019 Category: Environmental Health Source Type: research

Inhibition Effects of Some Antidepressant Drugs on Pentose Phosphate Pathway Enzymes
Publication date: Available online 16 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Muhammet Serhat Özaslan, Neslihan Balcı, Yeliz Demir, Mahmut Gürbüz, Ömer İrfan KüfrevioğluAbstractThe glucose metabolism in the pentose cycle is essential to the source of NADPH. Deficiency of these enzymes have been linked to depression and psychotic disorders. Depression is an increasingly prevalent mental disorder which may cause loss of labor. Antidepressant drugs are commonly employed in treatments of mood disorders and anxiety treatment. The purpose of this study is to investigate ...
Source: Environmental Toxicology and Pharmacology - August 17, 2019 Category: Environmental Health Source Type: research

Toxicity of cadmium in musculoskeletal diseases
The objective of this review is to summarize the molecular mechanisms of inflammation and oxidative stress activated by Cd at the bone level, particularly in osteoporosis, RA, and OA. Cadmium can increase bone resorption, affect the activity of osteoclasts and calcium (Ca) absorption, and impair kidney function, which favors the development of osteoporosis. In the case of RA, Cd interferes with the activity of antioxidant proteins, like superoxide dismutase (SOD) and catalase (CAT). It also promotes an inflammatory state, inducing the process of citrullination, which affects the proteins of immune response. On the other ha...
Source: Environmental Toxicology and Pharmacology - August 17, 2019 Category: Environmental Health Source Type: research

Evaluation of physiological changes induced by the fluoroquinolone antibiotic ciprofloxacin in the freshwater macrophyte species Lemna minor and Lemna gibba
In this study we selected two species of aquatic macrophytes, Lemna minor and Lemna gibba, which are standard plant species inscribed in ecotoxicological testing guidelines. In this work we characterized the toxic effects of the quinolone antibiotic ciprofloxacin (in levels of 0.005, 0.013, 0.031, 0.078, and 0.195 mg/L), focusing on its potential toxicity towards photosynthetic mechanisms, and pro-oxidant effects. These objectives were attained by measuring the concentrations of chlorophyll a and b, and carotenoids levels. The determination of the quantum yield allowed assessing the effects of ciprofloxacin on the p...
Source: Environmental Toxicology and Pharmacology - August 16, 2019 Category: Environmental Health Source Type: research

Targeting p53/TRAIL/caspase-8 signaling by adiponectin reverses thioacetamide-induced hepatocellular carcinoma in rats
In conclusion; Adiponectin can be proposed as a promising therapy for HCC. Adiponectin's tumoricidal activity can be partially mediated by blocking HCC-induced reduction in p53 expression as well as reactivation of TRAIL signaling and induction of apoptotic pathway providing more protection for the body against the tumor.Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 16, 2019 Category: Environmental Health Source Type: research

DNA damage and adverse neurological outcomes among garlic farmers exposed to organophosphate pesticides
Publication date: Available online 12 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Ratana Sapbamrer, Surat Hongsibsong, Nalin Sittitoon, Patchareeya AmputAbstractGarlic farmers used organophosphate pesticides to control insects, resulting in an increased risk for adverse health outcomes. Thus, we investigated exposure to organophosphate pesticides, DNA damage, nerve conduction, and neurological symptoms among 134 garlic farmers. They were interviewed, measured nerve conduction, and collected blood and urine for determining DNA damage and dialkylphosphate metabolites. Total dialkylphosphate levels ...
Source: Environmental Toxicology and Pharmacology - August 13, 2019 Category: Environmental Health Source Type: research

Impacts of plastic products used in daily life on the environment and human health: what is known?
Publication date: Available online 7 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): M.O. Rodrigues, N. Abrantes, F.J.M. Gonçalves, H. Nogueira, J.C. Marques, A.M.M. GonçalvesAbstractPlastics are indispensable and persistent materials used in daily life that can be fragmented into micro- or nanoplastics. They are long polymer chains mixed with additives that can be toxic when in contact with distinct species. The toxicity can result from polymer matrix, additives, degradation products and adsorbed contaminants. Notwithstanding, there is still an immense gap of information concerning the...
Source: Environmental Toxicology and Pharmacology - August 8, 2019 Category: Environmental Health Source Type: research

Targetingp53/TRAIL/caspase-8 signaling by adiponectin reverses thioacetamide-induced hepatocellular carcinoma in rats
In conclusion; Adiponectin can be proposed as a promising therapy for HCC. Adiponectin's tumoricidal activity can be partially mediated by blocking HCC-induced reduction in p53 expression as well as reactivation of TRAIL signaling and induction of apoptotic pathway providing more protection for the body against the tumor.Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 8, 2019 Category: Environmental Health Source Type: research

The role of ANXA5 in DBP-induced oxidative stress through ERK/Nrf2 pathway
Publication date: Available online 1 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Lei Zhang, Zhiqiang Qin, Ran Li, Shangqian Wang, Wei Wang, Min Tang, Wei ZhangAbstractDi-N-butylphthalate (DBP) have given rise to more and more attention due to its unique endocrine toxicity to male reproductive system. Our previous studies have demonstrated antioxidative Nrf2 (nuclear factor erythroid related factor 2) pathway play a vital role in DBP induced oxidative stress injury. ANXA5 (annexin A5), which is highly expressed in testicular Leydig and Sertoli cells, was found upregulated after DBP stimulation. Mo...
Source: Environmental Toxicology and Pharmacology - August 3, 2019 Category: Environmental Health Source Type: research

Association of blood chromium and rare earth elements with the risk of DNA damage in chromate exposed population
Publication date: Available online 1 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Yi Bai, Changmao Long, Guiping Hu, Di Zhou, Xiaoying Gao, Zhangjian Chen, Tiancheng Wang, Shanfa Yu, Youli Han, Lailai YanAbstractPollution of heavy metals often occurs in combination with multiple metal ions. Whether the genetic damage among chromate exposed population correlated with rare earth elements (REEs) was still not well elucidated. A total of 291 participants from a chromate production plant were recruited in the present study. The DNA oxidative damage was evaluated by urinary 8-hydroxydeoxyguanosine (8-OH...
Source: Environmental Toxicology and Pharmacology - August 3, 2019 Category: Environmental Health Source Type: research

A comparative study of the role of crocin and sitagliptin in attenuation of STZ-induced diabetes mellitus and the associated inflammatory and apoptotic changes in pancreatic β-islets
In conclusion, crocin reduced blood glucose level mainly via reduction of oxidative burden, modulation of apoptotic pathway and attenuation of pancreatic inflammation. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 1, 2019 Category: Environmental Health Source Type: research

Quantification of microcystins in natural waters by HPLC-UV after a pre-concentration step: validation of the analytical performances and study of the interferences
Publication date: Available online 29 July 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Hélène Thuret-Benoist, Virginie Pallier, Geneviève Feuillade-CathalifaudAbstractA method for the determination of microcystins concentrations (MC-LR, MC-RR, MC-YR) in natural water samples was optimized using High Performance Liquid Chromatography with UV/PDA detection after Solid Phase Extraction. Solid Phase Extraction is needed to clean natural sample and concentrate pollutant. The method was validated by evaluation of specificity and repeatability. Average recoveries in ultra-pure grade water ...
Source: Environmental Toxicology and Pharmacology - July 30, 2019 Category: Environmental Health Source Type: research

Editorial Board
Publication date: August 2019Source: Environmental Toxicology and Pharmacology, Volume 70Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 28, 2019 Category: Environmental Health Source Type: research

Clinical features of aflatoxin B1-exposed patients with liver cancer and the molecular mechanism of aflatoxin B1 on liver cancer cells
This study was, therefore, designed to investigate the potent bioeffect of AKR7A on the lipid metabolism in AFB1-exposed hepatocellular carcinoma cells through assaying human cancerous samples and cell culture. In the baseline data, the HCC patients showed increased contents of AFB1 in sera and cancerous samples. In the clinical parameters, the HCC patients demonstrated changed lipid settings in sera. As revealed by immunostaining and immunoblotting, AFB1-elevated HCC sections showed marked down-regulation of AKR7A expression, accompanied with reduced ApoB expression and increased CD36, S6K1 expressions in the HCC. Studies...
Source: Environmental Toxicology and Pharmacology - July 26, 2019 Category: Environmental Health Source Type: research

Neuroprotective Role of Naringenin against Methylmercury Induced Cognitive Impairment and Mitochondrial Damage in a Mouse Model
Publication date: Available online 23 July 2019Source: Environmental Toxicology and PharmacologyAuthor(s): K. Adwaid Manu, Hannah Christina, Shubhankar Das, Kamalesh D. Mumbrekar, B.S. Satish RaoAbstractHuman exposure to organomercurials like methylmercury (MeHg) may occur by consumption of contaminated seafood, affecting various vital organs especially, brain contributing to neuro disorders. The citrus flavanone, naringenin (NAR) has shown strong antioxidant and anti-inflammatory effects and therefore may exert cytoprotective effect against xenobiotic agents. Herein, we investigated the neuroprotective role of NAR against...
Source: Environmental Toxicology and Pharmacology - July 24, 2019 Category: Environmental Health Source Type: research

Efficacy of methylprednisolone on T-2 toxin-induced cardiotoxicity in vivo: a pathohistological study
Publication date: Available online 19 July 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Vesna Jaćević, Wu Qinghua, Eugenie Nepovimova, Kamil KučaAbstractOur aim was to compare the protective efficacy of two different formulations of methylprednisolone in T-2 toxin-induced cardiomyopathy. Methylprednisolone (soluble form, Lemod-solu® and/or depot form, Lemod-depo®, a total single dose of 40 mg/kg im) was given immediately after T-2 toxin (1 LD50 0.23 mg/kg sc). The myocardial tissue samples were examinated by using histopathology, semiquantitative and imaging analyses on day 1, 7,...
Source: Environmental Toxicology and Pharmacology - July 21, 2019 Category: Environmental Health Source Type: research

Microcystin concentrations and liver histopathology in Clarias gariepinus and Oreochromis mossambicus from three impacted rivers flowing into a hyper-eutrophic freshwater system: A pilot study
Publication date: Available online 17 July 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Lee-Ann S. Modley, Isaac T. Rampedi, Annemariè Avenant-Oldewage, Vimbai Mhuka, Mathew Nindi, Cobus Van DykAbstractThe Roodeplaat Dam and its three inflowing rivers are highly impacted by surrounding anthropogenic activities. The system is hyper-eutrophic and characterized by seasonal algal blooms and previous studies have reported levels of the hepatotoxin microcystin in the water of the impoundment. Limited information is available on the microcystin concentrations in the inflowing rivers and no information is...
Source: Environmental Toxicology and Pharmacology - July 18, 2019 Category: Environmental Health Source Type: research

Transcriptomic profiling of Hydra magnipapillata after exposure to naproxen
Publication date: Available online 5 July 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Ade Yamindago, Nayun Lee, Seonock Woo, Seungshic YumAbstractThe extensive use in humans and animals of nonsteroidal anti-inflammatory drugs (NSAIDs) increases their possible impact on aquatic organisms. In the present study, we investigated acute toxicity, morphological responses, and potential physiological and metabolic impacts of naproxen exposure on Hydra magnipapillata. The median lethal concentrations (LC50) of naproxen in H. magnipapillata were 51.999 mg/L, 44.935 mg/L, and 42.500 mg/L after...
Source: Environmental Toxicology and Pharmacology - July 7, 2019 Category: Environmental Health Source Type: research

Comparison of the reactivation rates of acetylcholinesterase modified by structurally different organophosphates using novel pyridinium oximes
Publication date: Available online 5 July 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Sandip B. Bharate, Chih-Kai Chao, Charles M. ThompsonAbstractA novel panel of oximes were synthesized, which have displayed varying degree of reactivation ability towards different organophosphorus (OP) modified cholinesterases following insecticide exposures. In the present article, we report a comparative reactivation profile of a series of quaternary pyridinium-oximes for electric eel acetylcholinesterase (EEAChE) inhibited by the organophosphorus (OP) inhibitors methyl paraoxon (MePOX), ethyl paraoxon (POX; paraoxo...
Source: Environmental Toxicology and Pharmacology - July 7, 2019 Category: Environmental Health Source Type: research

The Potential Exposure and Hazards of Copper Nanoparticles: A Review
Publication date: Available online 5 July 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Thelma Ameh, Christie M. SayesABSTRACTCopper is an essential element for metabolism in plants and animals. In its nanoform, copper has found various applications, thus increasing potential environmental exposure. Released nanoparticles in the environment undergo various transformation processes while bioaccumulation and toxicity of copper nanoparticles have been demonstrated in plants and animals. This toxicity is thought to be a combined effect of intracellular particles and the release of dissolved copper ions. Oxida...
Source: Environmental Toxicology and Pharmacology - July 6, 2019 Category: Environmental Health Source Type: research

N-acetylcysteine dual and antagonistic effect on cadmium cytotoxicity in human leukemia cells
In conclusion, NAC exhibits dual and antagonistic effects on Cd2+ cytotoxicity in human leukemia cells.Graphical Abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - June 27, 2019 Category: Environmental Health Source Type: research

The Histopathological, Cytopathological and Ultrastructural Effects of Carbaryl on Gills of Oreochromis niloticus (Linnaeus, 1758)
Publication date: Available online 25 June 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Pelin Uğurlu, Elif İpek Satar, Tarık ÇiçekAbastractUltrastructural and histopathological reponses in the organs of living organisms are important and useful tools to determine the health condition and the effects of pollutants, such as pesticides, on the organisms. The aim of this study is to determine possible histopathological, cytopathological and ultrastructural alterations in gills of Oreochromis niloticus individuals exposed to 850 µg/L Carbaryl standart at 7th, 14th and 21 s...
Source: Environmental Toxicology and Pharmacology - June 27, 2019 Category: Environmental Health Source Type: research

Induction of chemokine CCL3 by NF-κB reduces methylmercury toxicity in C17.2 mouse neural stem cells
Publication date: Available online 24 June 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Tsutomu Takahashi, Min-Seok Kim, Miyuki Iwai-Shimada, Takayuki Hoshi, Masatake Fujimura, Takashi Toyama, Yasuyuki Fujiwara, Akira Naganuma, Gi-Wook HwangAbstractMethylmercury is an environmental pollutant that shows selective toxicity to the central nervous system. We previously reported that brain-specific expression of chemokine CCL3 increases in mice administered methylmercury. However, the relationship between CCL3 and methylmercury toxicity has not been elucidated. Here, we confirmed that induction of CCL3 expres...
Source: Environmental Toxicology and Pharmacology - June 25, 2019 Category: Environmental Health Source Type: research

Effects of lipopolysaccharide on T lymphocyte cell subsets and cytokine secretion in Mesenteric lymph nodes of mice: histological and molecular study
Publication date: Available online 22 June 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Chao Li, Hong-chao Zhou, Yi-Lin Nie, Bao-Yu Zhao, Chen-Chen WuAbstractLipololysaccharides (LPS) can disrupt the gut barrier. How dose LPS affects the immune performance of mesenteric lymph nodes? The results showed the hematological parameters significantly changed after LPS treatment. The length of intestinal villus was shortened and the depth of crypts was deepened, especially on the ileum. After LPS treatment 6 h, 12 h, the number of CD3+ T cells and CD4/CD8 in the mesenteric lymph nodes of ileum were...
Source: Environmental Toxicology and Pharmacology - June 24, 2019 Category: Environmental Health Source Type: research

Biomarker-based assessment of the toxicity of the antifungal clotrimazol to the microcrustacean Daphnia magna
Publication date: Available online 21 June 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Madalena Vieira, Amadeu M.V.M. Soares, Bruno NunesAbstractAmong the vast list of xenobiotics that may promote harmful effects in aquatic ecosystems, pharmaceuticals are currently a prominent class due to their ability to persist in these environments and also due to the lack of information regarding their effects on the different components of the aquatic biota. Antifungals in particular, despite their massive use, are not extensively studied in environbmental terms. The main objective of this study was to characteriz...
Source: Environmental Toxicology and Pharmacology - June 22, 2019 Category: Environmental Health Source Type: research

Expression of serine proteases in neutrophils from women and men: regulation by endocrine disruptor bisphenol A
Publication date: Available online 18 June 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Wioletta Ratajczak-Wrona, Karolina Nowak, Marzena Garley, Kamil Grubczak, Dorota Dabrowska, Agnieszka Iwaniuk, Sara Wilk, Marcin Moniuszko, Jan Czerniecki, Slawomir Wolczynski, Ewa JablonskaAbstractBisphenol A (BPA) is a well-known endocrine disruptor. However, little information is available about its immunological effects. In the present study, we aimed to evaluate cytotoxic activity of BPA on human polymorphonuclear neutrophils (PMNs) according to gender and examine its effect on the expression of neutrophil serine...
Source: Environmental Toxicology and Pharmacology - June 19, 2019 Category: Environmental Health Source Type: research

A protective study of Curcumin associated with Cr6+ induced oxidative stress, genetic damage, transcription of genes related to apoptosis and histopathology of fish, Channa punctatus (Bloch, 1793)
Publication date: Available online 11 June 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Yashika Awasthi, Arun Ratn, Rajesh Prasad, Manoj Kumar, Abha Trivedi, J.P. Shukla, Sunil P. TrivediAbstractAmeliorative potential of curcumin against Cr6+-induced eco-toxicological manifestations was assessed in liver of exposed Channa punctatus (Actinopterygii) in six groups for 45 d; Group I as control. Group II with 3 mg/L of curcumin; group III with 7.89 mg/L of Cr6+. Groups IV, V and VI were simultaneously co-exposed with 7.89 mg/L of Cr6+ and three different curcumin concentrations, 1, 2, an...
Source: Environmental Toxicology and Pharmacology - June 12, 2019 Category: Environmental Health Source Type: research

A pilot study to assess peripheral blood TCR β-chain CDR3 repertoire in occupational medicamentosa-like dermatitis due to trichloroethylene using high-throughput sequencing
Publication date: Available online 12 June 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Dafeng Lin, Dianpeng Wang, Peimao Li, Yanhua Yang, Wei Liu, Liuzhuo Zhang, Zhimin Zhang, Yanfang Zhang, Xianqing HuangAbstractWe exploratively characterized T cell receptor (TCR) repertoires from occupational medicamentosa-like dermatitis due to trichloroethylene (OMDT) patients to better understand the underlying pathological mechanism. We used a combination of multiplex-PCR, Illumina sequencing and IMGT/High V-QUEST to analyze the characteristics and polymorphisms of the TCR β-chain complementarity-determining ...
Source: Environmental Toxicology and Pharmacology - June 12, 2019 Category: Environmental Health Source Type: research

Responses of Chlorella vulgaris exposed to boron: Mechanisms of toxicity assessed by multiple endpoints
This study aimed to assess SPP toxicity using multiple endpoints, specially detecting the intracellular metal ion concentrations, malondialdehyde (MDA) content and extracellular polymeric substance (EPS) classes for the very first time during SPP exposure to Chlorella vulgaris (C. vulgaris). Our findings indicated that the inhibitory effects of SPP on C. vulgaris may be related to nutrient absorption and utilization. The changes in intracellular starch grains, MDA and the protein-like substances in EPS probably acted as a defense mechanism, helping to alleviate the toxic effects. This work may contribute to the understandi...
Source: Environmental Toxicology and Pharmacology - June 11, 2019 Category: Environmental Health Source Type: research

Effects of cyclophosphamide on the phenotypes and functions of THP-1 cells
In this study, effects of immunosuppressant cyclophosphamide (CY) on THP-1 cells were observed while 2, 4-Dinitrochlorobenzene (DNCB) was used as a control. The phenotypes of THP-1 cells, the ability to activate naïve T cells, intracellular reactive oxygen species (ROS) level, gene markers, phagocytic ability and cell apoptosis were detected after THP-1 cells being exposed to different concentrations of CY and DNCB. Both CY and DNCB were able to activate THP-1 cells, but there were a lot of differences in their effects on THP-1 cells, such as the changes in phenotypes, in the ability to activate naïve T cells, in...
Source: Environmental Toxicology and Pharmacology - June 9, 2019 Category: Environmental Health Source Type: research

Investigating the inotropic effect of pyruvic acid on the isolated rat heart and its underlying mechanism
This study sought to explore the inotropic effects of pyruvic acid on the function of the isolated rat hearts and investigate its underlying mechanism. Pyruvic acid produced a greater negative inotropic effect compared to HCl and sodium pyruvate in a concentration-dependent pattern in the hearts. The role of low dose of pyruvic acid on heart function was regulated by pyruvic acid molecules and high dose pyruvic acid may be influenced by pyruvic acid molecules and pH. Kv channels may be involved in the pyruvic acid-induced negative inotropic effect. Finally, pyruvic acid markedly increased the level of LDH and CK and reduce...
Source: Environmental Toxicology and Pharmacology - June 9, 2019 Category: Environmental Health Source Type: research

Indole-3-carbinol inhibits lipid deposition and promotes autophagy in hyperlipidemia zebrafish larvae
This study investigated the protective effect of I3C in hyperlipidemia zebrafish larvae and early life stage toxicity of I3C on zebrafish embryos/larvae. Zebrafish larvae were fed with 4% high-cholesterol diet (HCD) and treated with I3C 2.5μmol/L and 5μmol/L for two weeks. Confocal image analysis, oil Red O staining were used to analysis vascular lipid accumulation and western blotting was used to evaluate possible mechanics. In addition, zebrafish embryos were treated with I3C for 96 hours to assess the general toxicity and cardiotoxicity. We found that lipid deposition on vasculature was dose-dependently decreased ...
Source: Environmental Toxicology and Pharmacology - June 9, 2019 Category: Environmental Health Source Type: research

Evaluation of Lapatinib Cytotoxicity and Genotoxicity on MDA-MB-231 Breast Cancer Cell line
In conclusion, lapatinib induced cytotoxic and genotoxic effects on MDA-MB-231 cell line. However, laptinib reduced the EGFR protein expression and EGFR signals, it raised the apoptotic cells and TP53 gene signals, which triggered extensive DNA damage. Therefore, lapatinib is an effective TKI in triple negative breast cancer cells as elucidated by its mode of cell death. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - June 9, 2019 Category: Environmental Health Source Type: research

Evaluation of cytogenotoxicity and oxidative stress parameters in male Swiss mice co-exposed to titanium dioxide and zinc oxide nanoparticles
Publication date: Available online 5 June 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Opeoluwa Fadoju, Olusegun Ogunsuyi, Olubukola Akanni, Okunola Alabi, Chibuisi Alimba, Oluwatosin Adaramoye, Sebastien Cambier, Santhana Eswara, Arno C. Gutleb, Adekunle BakareAbstractA number of studies have investigated the adverse toxic effects of titanium dioxide (TiO2) nanoparticles (NPs) or zinc oxide (ZnO) NPs. Information on the potential genotoxic effects of the interactions of TiO2 NPs and ZnO NPs in vivo is lacking. Therefore, this study was designed to investigate the cytogenotoxicity of TiO2 NPs or ZnO NPs ...
Source: Environmental Toxicology and Pharmacology - June 6, 2019 Category: Environmental Health Source Type: research

Editorial Board
Publication date: July 2019Source: Environmental Toxicology and Pharmacology, Volume 69Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - June 6, 2019 Category: Environmental Health Source Type: research

Species-specific models in toxicology: in vitro epithelial barriers
Publication date: Available online 1 June 2019Source: Environmental Toxicology and PharmacologyAuthor(s): A. Bertero, J. Augustyniak, L. Buzanska, F. CaloniAbstractSpecies-specific in vitro epithelial barriers represent interesting predictive tools for risk assessment evaluation in toxicological studies. Moreover, these models could be applied either as stand-alone methods for the study of absorption, bioavailability, excretion, transport, effects of xenobiotics, or through an Integrated Testing Strategy.The aim of this review is to give a comprehensive overview of in vitro species-specific epithelial barrier models from b...
Source: Environmental Toxicology and Pharmacology - June 1, 2019 Category: Environmental Health Source Type: research

Pharmacokinetics of oral and intravenous cannabidiol and its antidepressant-like effects in chronic mild stress mouse model
Publication date: Available online 30 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Chen Xu, Tanran Chang, Yaqi Du, Chaohui Yu, Xin Tan, Xiangdong LiAbstractCannabidiol (CBD) exhibits significant efficacy in mental and inflammatory diseases. Several studies have recently reported on the rapid antidepressant-like effects of CBD, suggesting that CBD is a potential anti-depressant or anti-stress drug. However, CBD is mainly administered orally or by inhalation with poor bioavailability, resulting in high costs. We aim to explore the efficacy of long-term periodic administration of CBD in chronic mild str...
Source: Environmental Toxicology and Pharmacology - May 31, 2019 Category: Environmental Health Source Type: research

Prediction and risk assessment of five heavy metals in maize and peanut: a case study of Guangxi, China
Publication date: Available online 27 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Qiubei Gu, Tao Yu, Zhongfang Yang, Junfeng Ji, Qingye Hou, Lei Wang, Xueji Wei, Qizuan ZhangAbstractTo assess the contamination levels and health risk of cadmium (Cd), copper (Cu), mercury (Hg), lead (Pb), and zinc (Zn) to human beings, the concentrations of these heavy metals in soil were surveyed and the concentrations in maize and peanut grains were estimated by models. The geo-accumulation index (I geo) was calculated, and chronic daily intake (CDI), hazard quotient (HQ) and hazard index (HI) were estimated. Result...
Source: Environmental Toxicology and Pharmacology - May 28, 2019 Category: Environmental Health Source Type: research

Bioinformatic and experimental data decipher the pharmacological targets and mechanisms of plumbagin against hepatocellular carcinoma
ConclusionCollectively, the pharmacological targets and mechanisms of plumbagin-treating HCC were predicted and integrated through the method of network pharmacology, followed by some investigative validations. Interestingly, these 5 predominant biomolecules may be the potential targets for screening and treating HCC.Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - May 28, 2019 Category: Environmental Health Source Type: research

Mechanisms mediating the cardioprotective effect of carvedilol in cadmium induced cardiotoxicity. Role of eNOS and HO1/Nrf2 pathway
Publication date: Available online 28 May 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Marwa M.M. Refaie, Maram El-Hussieny, Asmaa M.A. Bayoumi, Sayed ShehataAbstractCadmium (Cd) is a highly toxic heavy metal with several harmful effects including cardiotoxicity. For the first time, we aimed to evaluate the possible cardioprotective effect of carvedilol (CAR) in Cd induced cardiotoxicity and study the mechanisms involved in such protection including endothelial nitric oxide synthase (eNOS) and HO1/Nrf2 pathway. CAR (1,10 mg/kg/d) was administered orally for 4 weeks with Cd induced cardiac injury (...
Source: Environmental Toxicology and Pharmacology - May 28, 2019 Category: Environmental Health Source Type: research