Anxiety-associated behavior and genotoxicity found in adult Danio rerio exposed to tebuconazole-based commercial product
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Tássia Flávia Dias Castro, José Gilmar da Silva Souza, Aline Ferreira Souza de Carvalho, Isadora de Lima Assis, Marcel José Palmieri, Larissa Fonseca Andrade Vieira, Silvana Marcussi, Monica Rodrigues Ferreira Machado, Luis David Solis MurgasAbstractThe effects of different concentrations of commercial product based on tebuconazole, on adults of Danio rerio, were evaluated through novel tank diving test and micronucleus and comet assay tests. A total of 320 adult D. rerio were divided into eigh...
Source: Environmental Toxicology and Pharmacology - July 13, 2018 Category: Environmental Health Source Type: research

Effects of diesel exhaust particles on the expression of tau and autophagy proteins in human neuroblastoma cells
The objective of the present study was to evaluate the neurotoxic effects caused by diesel exhaust particles (DEPs). We determined the ability of DEPs and carbon black (CB) to induce neurotoxicity, oxidative stress and inflammation, and to disrupt the expression of tau and autophagy proteins in human neuroblastoma IMR-32 cells. Spherical CB (dominated by C, N, and S) and DEPs (dominated by C, N, and O) in aggregates were observed using a field emission-scanning electron microscope (FE-SEM) equipped with energy-dispersive x-ray (EDX) microanalysis. Cell viability was significantly decreased by CB and DEPs in IMR-32 cells, b...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Corrigendum to “Effect of probiotic supplement on aflatoxicosis and gene expression in the liver of broiler chicken” [Environ. Toxicol. Pharmacol. 60 (2018) 118–127]
Publication date: Available online 29 June 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ramadan Salem, Nagwan El-Habashi, Sabreen E. Fadl, Osama A. Sakr, Zizy I. Elbialy (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Anxiety- associated behavior and genotoxicity found in adult Danio rerio exposed to tebuconazole-based commercial product
Publication date: Available online 30 June 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Tássia Flávia Dias Castro, José Gilmar da Silva Souza, Aline Ferreira Souza de Carvalho, Isadora de Lima Assis, Marcel José Palmieri, Larissa Fonseca Andrade Vieira, Silvana Marcussi, Monica Rodrigues Ferreira Machado, Luis David Solis MurgasAbstractThe effects of different concentrations of commercial product based on tebuconazole, on adults of Danio rerio, were evaluated through novel tank diving test and micronucleus and comet assay tests. A total of 320 adult D. rerio were divided into ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Corrigendum to “The research of genetic toxicity of β-phellandrene” [Environ. Toxicol. Pharmacol. 54 (2017) 28–33]
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Zhiyuan Cheng, Jianjun Jiang, Xiaohua Yang, Hongqian Chu, Ming Jin, Yuan Li, Tao Xi, Siqi Wang, Yao Huang, Lanqin Shang, Shuang Wu, Weidong Hao, Yueying Qian, Xuetao Wei (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Editorial Board
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Diabetes escalates knee osteoarthritis in rats: Evidence of adaptive mechanism
In conclusion, diabetic-osteoarthritic state is characterised by more altered biochemical profile, relative to what is probable in either disease condition. Nevertheless, this situation remains subject to the influence of endogenous homeostatic mechanisms. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Inter-individual and inter-organ variability in the bioactivation of paracetamol by human liver and kidney tissues
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Ege Arzuk, Burak Turna, Murat Sözbilen, Hilmi OrhanAbstractParacetamol (PAR) overdose is associated with massive hepatic injury; it may induce kidney toxicity as well. It is essential to measure organ-specific activities of related CYPs for evaluating the overdose cases. Available HPLC-based methods require high amounts of tissue samples. In order to develop liquid chromatography mass spectrometry (LC–MS)-based methods to process small amounts of human tissues, liver and kidney samples were obtained. Individual micr...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Assessment of the inhibitory activity of the pyrethroid pesticide deltamethrin against human placental glutathione transferase P1-1: A combined kinetic and docking study
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Victor Markus, Kerem Teralı, Ozlem Dalmizrak, Nazmi OzerAbstractDeltamethrin (DEL), which is a synthetic pyrethroid insecticide, has been used successfully all over the world to treat mosquito nets for the control of malaria. Glutathione S-transferases (GSTs; EC 2.5.1.18) catalyze the conjugation of reduced glutathione (GSH) to a variety of xenobiotics and are normally recognized as detoxification enzymes. Here, we used a colorimetric assay based on the human placental GSTP1-1 (hpGSTP1-1)-catalyzed reaction between GSH and th...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Prenatal alcohol exposure reduces 5-HT concentration in mouse intestinal muscle and mucosa
In conclusion, prenatal alcohol exposure causes a decrease in conversion of tryptophan to 5-HT in both muscle and mucosa although the effect is more pronounced in females. The observed sex difference may be related to changes associated with the estrous cycle. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Expression of cyp1a induced by benzo(A)pyrene and related biochemical and genotoxic biomarkers in the neotropical freshwater fish Prochilodus lineatus
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Caroline Santos, Marcelo Tempesta de Oliveira, Ilce Mara de Syllos Cólus, Silvia Helena Sofia, Claudia Bueno dos Reis MartinezAbstractThe goal of this work was to design specific cyp1a primers for the fish Prochilodus lineatus to study the expression of this gene and its relation to the activity of biotransformation phase I enzyme (ethoxyresorufin O-deethylase - EROD) and genotoxic damage after 6 and 24 h of benzo(a)pyrene (B(a)P) intraperitoneal injection. In comparison to fish injected only with canola oil (vehicle)...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Clinical and radiographic periodontal status and whole salivary cotinine, IL-1β and IL-6 levels in cigarette- and waterpipe-smokers and E-cig users
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Sameer A. Mokeem, Mohammed N. Alasqah, Dimitrios Michelogiannakis, Abdulaziz A. Al-Kheraif, Georgios E. Romanos, Fawad JavedAbstractThe aim was to compare the clinical (plaque index [PI], bleeding on probing [BOP], probing pocket depth [PPD] and clinical attachment loss [CAL]) and radiographic (marginal bone loss [MBL]) periodontal parameters and whole salivary cotinine, interleukin (IL)-1β and IL-6 levels among cigarette-smokers, waterpipe-smokers, E-cig users and never-smokers. In total, 154 male individuals (39 cigaret...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Deciphering the toxic effects of iprodione, a fungicide and malathion, an insecticide on thiol protease inhibitor isolated from yellow Indian mustard seeds
This study was carried out to see the effect of commercially used pesticides on a specific plant protein viz. phytocystatin isolated from yellow mustard seeds (YMP). Phytocystatin is a thiol proteinase inhibitor, which regulates endogenous and exogenous cysteine proteinases and plays a vital physiological role in plants. Different classes of pesticides like fungicide (iprodione) of dicarboximide class and an insecticide (malathion) of class organophosphate are retorted for our study. In the presence of these pesticides, biophysical and biochemical changes were observed in phytocystatin. These changes were evaluated making ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Risk assessment of exposure to aflatoxin B1 and ochratoxin A through consumption of different Pistachio (Pistacia vera L.) cultivars collected from four geographical regions of Iran
In this study, aflatoxin B1 (AFB1) and ochratoxin A (OTA) levels in five pistachio cultivars collected from four sites of Iran, were measured by HPLC. Based on the results, risk assessment for AFB1 and OTA residues was done. The highest mean concentrations of AFB1 and OTA were found in Ahmad-aghaei (4.33 and 2.19 ng/g, respectively) and Akbari (4.08 and 1.943 ng/g, respectively) cultivars from Rafsanjan, Iran. Even the highest concentrations of AFB1 and OTA in analyzed samples were lower than the corresponding maximum limits set by EU authorities. The hazard index (HI) value for consumers of Iranian pistachio is below ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Adapting and applying common methods used in pharmacovigilance to the environment: A possible starting point for the implementation  of eco-pharmacovigilance
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Jun Wang, Mengya Zhang, Shulan Li, Bingshu HeAbstractNow, the occurrence of pharmaceuticals in natural environment has been frequently reported around the world. As a kind of biologically active compounds specially designed to be effective even at very low concentration levels, pharmaceuticals in the environment could have adverse impacts to the health of human beings or other non-targeted organisms due to long-term exposures. To minimize the pharmaceutical pollution from the perspective of drug administration, a new concept c...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Dietary supplementation of Spirulina ameliorates iron-induced oxidative stress in Indian knife fish Notopterus Notopterus
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Deepali Mohanty, Luna SamantaAbstractIron though an essential cofactor for many proteins including haemoglobin and cytochromes, when in excess (>1 ppm in water and 100 ppm in fish tissue) elicits toxicity via Fenton reaction inducing oxidative stress. The present study aimed to evaluate the efficacy of dietary Spirulina (Arthrospira platensis) supplementation on waterborne-iron induced oxidative stress in the tissues of Notopterus notopterus. Juvenile fishes were divided randomly into 4 groups, namely, Group-I: control ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Lithium entrapped chitosan nanoparticles to reduce toxicity and increase cellular uptake of lithium
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Geeva, Shoba NarayanAbstractLithium carbonate is an effective drug against bipolar disorders. Direct use of lithium carbonate has been reported to result in lithium toxication and pulmonary complications. With chitosan micro and nanoparticles gaining attention for their protein absorption, drug targeting and improved dissolution rate of sparingly water-soluble drugs, this work has focused on chitosan loaded Li as a possible alternative to Li alone for cellular uptake. Well standardized ionic gelation technique employed in this...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Hepatoprotective effect of lawsone on rifampicin-isoniazid induced hepatotoxicity in in vitro and in vivo models
This study documented the hepatoprotective efficacy of lawsone, the major bioactive naphthoquinone present in Lawsonia inermis L. (Lythraceae) using in vitro and in vivo models. Lawsone was isolated from the leaves of L. inermis and its structure was confirmed using spectroscopic data. In-vitro antioxidant effect of lawsone was evaluated using ABTS assay. Hepatoprotective effect of lawsone was determined with RIF-INH treated HepG2 cells and Wistar rats. Administration of RIF-INH reduced the viability of the HepG2 cells and the treatment with lawsone significantly restored the viability of the cells even at lower concentrat...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Phenol and chlorinated phenols exhibit different apoptotic potential in human red blood cells (in vitro study)
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Jaromir Michałowicz, Anna Włuka, Monika Cyrkler, Aneta Maćczak, Paulina Sicińska, Katarzyna MokraAbstractPhenol and chlorinated phenols are widely spread in the environment and human surrounding, which leads to a common environmental and occupational exposure of humans to these substances. The aim of this study was to assess eryptotic changes in human red blood cells treated with phenol, 2,4-dichlorophenol (2,4-DCP), 2,4,6-trichlorophenol (2,4,6-TCP) and pentachlorophenol (PCP). The erythrocytes were incubated with phenols...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis
In this study, the biological effects of one of the most abundant OPFRs, tris (1-chloro-2-propyl) phosphate (TCPP), on the immunity in mussel Mytilus galloprovincialis were characterized by testing the reactive oxygen species, apoptosis, antioxidant system and immunity related gene expressions. Results indicated that both TCPP exposures (10 and 100 nmol L−1) significantly (p
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

In vivo investigation on the chronic hepatotoxicity induced by sertraline
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Mansour I. Almansour, Yazun B. Jarrar, Bashir M. JarrarAbstractAlthough sertraline is widely prescribed as relatively safe antidepressant drug, hepatic toxicity was reported in some patients with sertraline treatment. The present study was conducted to investigate the morphometric, hepatotoxicity, and change in gene expression of drug metabolizing enzymes. Male healthy adult rabbits (Oryctolagus cuniculus) ranging from 1050 to 1100 g were exposed to oral daily doses of sertraline (0, 1, 2, 4, 8 mg/kg) for 9 weeks. The anim...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

CLZ-8, a potent small-molecular compound, protects radiation-induced damages both in vitro and in vivo
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Tian Feng, Jiyuan Liu, Nan Zhou, Libin Wang, Xueying Liu, Shengyong Zhang, Siwang Wang, Hui ChenAbstractPUMA (p53 up-regulated mediator of apoptosis) is particularly important in initiating radiation-induced damage and apoptosis. It has been shown that inhibition of PUMA can provide a profound benefit for the long-term survival of the mice, without an increased risk of malignancies after irradiation. It becomes to be a potential target for developing an effective treatment aimed to protect cells from lethal radiation. CLZ-8, a...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

The use of liver slices from the Cape vulture (Gyps coprotheres) to better understand the role of liver toxicity of Non-steroidal anti-inflammatory drugs (NSAIDs) in vultures
Publication date: Available online 4 July 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Emmanuel Oluwasegun Adawaren, Lilian Mukandiwa, Emmanuel Mfotie Njoya, Lizette Bekker, Neil Duncan, Vinny NaidooAbstractDiclofenac, a non-steroidal anti-inflammatory drug (NSAID) was responsible for the death of millions of vultures on the Asian subcontinent, following the consumption of diclofenac contaminated carcasses. The aim of this research was to establish if liver slices could serve as an alternate means of predicting the toxicity of NSAIDs in Gyps vultures. The Cape vulture liver slices was prepared and incuba...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Reversal of behavioral decline and neuropathology by a complex vitamin supplement involves modulation of key neurochemical stressors
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Olayemi Joseph Olajide, John Oluwasegun Fatoye, Oluwakunmi Folashade Idowu, Damilola Ilekoya, Ismail Temitayo Gbadamosi, Monsurat Titi Gbadamosi, Nnaemeka Tobechukwu AsogwaAbstractMetal ions are crucial for normal neurochemical signaling and perturbations in their homeostasis have been associated with neurodegenerative processes. Hypothesizing that in vivo modulation of key neurochemical processes including metal ion regulation (by transferrin receptor-1: TfR-1) in cells can improve disease outcome, we investigated the ef...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Toxicity of environmentally-relevant concentrations of arsenic on developing T lymphocyte
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Huan Xu, Xiaolei Wang, Scott W. BurchielAbstractArsenic is a ubiquitous environmental contaminant that exists in many inorganic and organic forms. In particular, arsenite is known to induce immunotoxicity in humans and animals. There are still major gaps in our understanding of the mechanism(s) of the immunotoxicity induced by arsenic at environmentally-relevant concentrations. T cells are an essential part of the immune system required for host resistance to infections and protection from cancer. Developing T cells in th...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Neochlorogenic acid inhibits against LPS-activated inflammatory responses through up-regulation of Nrf2/HO-1 and involving AMPK pathway
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Sun Young Park, Mei Ling Jin, Eun Hye Yi, Yoon Kim, Geuntae ParkAbstractAcute and chronic inflammatory diseases are associated with excessive inflammation due to the accumulation of pro-inflammatory mediators and cytokines produced by macrophages. In the present study, we investigated the anti-inflammatory properties of neochlorogenic acid (nCGA) from Lonicera japonica on lipopolysaccharide (LPS)-activated inflammation in macrophages and participation of the AMPK/Nrf2 pathway. nCGA pretreatment significantly reduced the p...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

The in vitro toxicity analysis of titanium dioxide (TiO2) nanoparticles on kinematics and biochemical quality of rainbow trout sperm cells
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Mustafa Erkan Özgür, Sevgi Balcıoğlu, Ahmet Ulu, İmren Özcan, Fatih Okumuş, Süleyman Köytepe, Burhan AteşAbstractIn recent years, titanium dioxide (TiO2) nanoparticles (NPs) as metal oxide nanoparticles are widely used in industry, agriculture, personal care products, cosmetics, sun protection and toothpaste, electronics, foodstuffs and food packaging. This use of nano-TiO2 has been associated with environmental toxicity concerns. Therefore, the aim of this study was to evaluate the in vitro ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Physiological and anthocyanin biosynthesis genes response induced by vanadium stress in mustard genotypes with distinct photosynthetic activity
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Muhammad Imtiaz, Muhammad Adnan Mushtaq, Muhammad Amjad Nawaz, Muhammad Ashraf, Muhammad Shahid Rizwan, Sajid Mehmood, Omar Aziz, Muhammad Rizwan, Muhammad Safiullah Virk, Qaiser Shakeel, Raina Ijaz, Vasilis P. Androutsopoulos, Aristides M. Tsatsakis, Michael D. ColemanAbstractThe present study aimed to elucidate the photosynthetic performance, antioxidant enzyme activities, anthocyanin contents, anthocyanin biosynthetic gene expression, and vanadium uptake in mustard genotypes (purple and green) that differ in photosynth...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Unraveling CYP2E1 haplotypes in alcoholics from Central Brazil: A comparative study with 1000 genomes population
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Jheneffer Sonara Aguiar Ramos, Leandro Prado Felício, Alessandro Arruda Alves, Mariana Paiva Lopes, Thannya Nascimento Soares, Daniela de Melo e SilvaAbstractWe evaluated genetic variability of single nucleotide polymorphisms (SNPs) situated in the CYP2E1 gene promoter in alcoholics. We also compared 1000 Genomes Project of CYP2E1 polymorphisms with frequencies of genotypes and haplotypes. Eight variation points were exclusively found in Brazilians. The allelic distributions of the rs3813867, rs2031920 and rs203192...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Blood-brain barrier breakdown, memory impairment and neurotoxicity caused in mice submitted to orally treatment with thymol
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Matheus D. Baldissera, Carine F. Souza, Antônio Francisco Igor M. De Matos, Pedro Henrique Doleski, Bernardo Baldisserotto, Aleksandro S. Da Silva, Silvia G. MonteiroAbstractSeveral evidences have related the biochemical and pharmacological properties of thymol, but the possible neurotoxic effects of this compound remain unknown and not evaluated. Thus, the purpose of this study was to evaluate whether intake of thymol in different doses (10, 20 and 40 mg/kg) induce neurotoxicity and behavioral alterations using m...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Responses of antioxidant and biotransformation enzymes in Carassius carassius exposed to hexabromocyclododecane
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Huike Dong, Guanghua Lu, Zhenhua Yan, Jianchao Liu, Matthew Nkoom, Haohan YangAbstractThe ubiquitous existence of hexabromocyclododecane (HBCD) in environmental matrices has made it attractive to both field investigators as well as laboratory researchers. However, literature on the biological effects caused by HBCD on aquatic vertebrates seldom exist. This has inevitably increased the difficulty of toxicological assessment in the aquatic environment. Juvenile crucian carp (Carassius carassius) were exposed (flow-through) ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Joint toxicity on hepatic detoxication enzymes in goldfish (Carassius auratus) exposed to binary mixtures of lead and paraquat
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Xiaoming Xu, Zhaojie Cui, Shanshan WangAbstractCompared to single exposure, chemical mixtures might induce joint toxicity including additive, synergistic and antagonistic effects on both organisms and environment. Owing to the specific toxicity of oxidative stress and binding to proteins, lead (Pb) is generally recognized a non-essential and threatening heavy metal to animals and human. Paraquat (PQ) is a widely used herbicide in agriculture and can trigger oxidative stress as well as Pb. Little information was available ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Eric A. Rodriguez, Brigitte C. Vanle, Jonathan A. Doorn, Hans-Joachim Lehmler, Larry W. Robertson, Michael W. DuffelAbstractAlthough neurotoxicity and hepatotoxicity have long been associated with exposure to polychlorinated biphenyls (PCBs), less is known about the selective toxicity of those hydroxylated PCBs (OH-PCBs) and PCB sulfates that are metabolites derived from exposure to PCBs found in indoor air. We have examined the toxicity of OH-PCBs and PCB sulfates derived from PCBs 3, 8, 11, and 52 in two neural cell lin...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

The PKCδ-Nrf2-ARE signalling pathway may be involved in oxidative stress in arsenic-induced liver damage in rats
This study may provide a new pathway for studies of the mechanisms of arsenism. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Effect of salinity on the bioaccumulation and depuration of cadmium in the pacific cupped oyster, Crassostrea gigas
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Ming Sun, Guangbin Liu, Hong Lin, Tianwen Zhang, Wen GuoAbstractAs a euryhaline species, the oyster Crassostrea gigas can adapt rapid and dramatic salinity fluctuations, and show physiological mechanisms of adaption to tolerant salinity changes. They are continuously exposed to Cd because they are filter feeders and their mobility is poor. In order to understand the influence of salinity on the molecular responses of C. gigas exposed to Cd, oysters were acclimatized to different salinities (13, 20, 27, and 34) for 14 days...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Effects of the food additives sodium acid pyrophosphate, sodium acetate, and citric acid on hemato-immunological pathological biomarkers in rats: Relation to PPAR-α, PPAR-γ and tnfα signaling pathway
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Yasmina M. Abd-Elhakim, Mohamed M. Hashem, Abeer Anwar, Abeer E. El-Metwally, Khaled Abo-El-Sooud, Gihan G. Moustafa, Samar M. Mouneir, Haytham A. AliAbstractThe food additives sodium acid pyrophosphate (SAPP), sodium acetate (SA), and citric acid (CA) were evaluated for their hemato-immunotoxic effects. Forty adult Sprague-Dawley rats were distributed into four groups and were orally administered water, SAPP (12.6 mg/kg), CA (180 mg/kg), or SA (13.5 mg /kg) daily for 90 days. Erythrogram and leukogram profiles were...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Stress-responsive genes (hsp70 and mt) and genotoxicity elicited by roxarsone exposure in Carassius auratus
In this study, comet assay (single-cell gel electrophoresis), real-time quantitative PCR (qPCR) and proteomics approach were used to comprehensively assess toxicity elicited by roxarsone exposure in C. auratus at 50, 150 and 300 μg/L for 7, 14 and 21 days. Results of comet assay showed that DNA were seriously damaged under the pressure of roxarsone, especially the concentration of 50 μg/L that always maintained a sustained and increased damage effect to fish liver cell during the 21 days experiment. The expressions of biomarker genes showed that hsp70 gene expressions raised significantly and the group of 50 &m...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Effect of Diafenthiuron exposure under short and long term experimental conditions on hematology, serum biochemical profile and elemental composition of a non-target organism, Labeo rohita
In conclusion, we are reporting that Diafenthiuron can adversely affect the hematological, serum and elemental concentrations of a non-target organism like L. rohita and may therefore pose a threat to the food web.Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Blood-brain barrier breakdown, memory impairment and neurotoxicity caused in mice submitted to orally treatment with thymol
Publication date: Available online 8 July 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Matheus D. Baldissera, Carine F. Souza, Antônio Francisco Igor M. De Matos, Pedro Henrique Doleski, Bernardo Baldisserotto, Aleksandro S. Da Silva, Silvia G. MonteiroAbstractSeveral evidences have related the biochemical and pharmacological properties of thymol, but the possible neurotoxic effects of this compound remain unknown and not evaluated. Thus, the purpose of this study was to evaluate whether intake of thymol in different doses (10, 20 and 40 mg/kg) induce neurotoxicity and behavioral alterations usin...
Source: Environmental Toxicology and Pharmacology - July 8, 2018 Category: Environmental Health Source Type: research

Reversal of behavioral decline and neuropathology by a complex vitamin supplement involves modulation of key neurochemical stressors
Publication date: Available online 7 July 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Olayemi Joseph Olajide, John Oluwasegun Fatoye, Oluwakunmi Folashade Idowu, Damilola Ilekoya, Ismail Temitayo Gbadamosi, Monsurat Titi Gbadamosi, Nnaemeka Tobechukwu AsogwaAbstractMetal ions are crucial for normal neurochemical signaling and perturbations in their homeostasis have been associated with neurodegenerative processes. Hypothesizing that in vivo modulation of key neurochemical processes including metal ion regulation (by transferrin receptor-1: TfR-1) in cells can improve disease outcome, we investigated the...
Source: Environmental Toxicology and Pharmacology - July 8, 2018 Category: Environmental Health Source Type: research

Stress-responsive genes (hsp70 and mt) and genotoxicity elicited by roxarsone exposure in Carassius auratus
In this study, comet assay (single-cell gel electrophoresis), real-time quantitative PCR (qPCR) and proteomics approach were used to comprehensively assess toxicity elicited by roxarsone exposure in C. auratus at 50, 150 and 300 µg/L for 7, 14 and 21 days. Results of comet assay showed that DNA were seriously damaged under the pressure of roxarsone, especially the concentration of 50 μg/L that always maintained a sustained and increased damage effect to fish liver cell during the 21 days experiment. The expressions of biomarker genes showed that hsp70 gene expressions raised significantly and the group of 50...
Source: Environmental Toxicology and Pharmacology - July 7, 2018 Category: Environmental Health Source Type: research

Effect of salinity on the bioaccumulation and depuration of Cadmium in the pacific cupped oyster, Crassostrea gigas
Publication date: Available online 28 May 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ming Sun, Guangbin Liu, Hong Lin, Tianwen Zhang, Wen GuoAbstractAs a euryhaline species, the oyster Crassostrea gigas can adapt rapid and dramatic salinity fluctuations, and show physiological mechanisms of adaption to tolerant salinity changes. They are continuously exposed to Cd because they are filter feeders and their mobility is poor. In order to understand the influence of salinity on the molecular responses of C. gigas exposed to Cd, oysters were acclimatized to different salinities (13, 20, 27, and 34) for 14 d...
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Effects of diesel exhaust particles on the expression of tau and autophagy proteins in human neuroblastoma cells
The objective of the present study was to evaluate the neurotoxic effects caused by diesel exhaust particles (DEPs). We determined the ability of DEPs and carbon black (CB) to induce neurotoxicity, oxidative stress and inflammation, and to disrupt the expression of tau and autophagy proteins in human neuroblastoma IMR-32 cells. Spherical CB (dominated by C, N, and S) and DEPs (dominated by C, N, and O) in aggregates were observed using a field emission-scanning electron microscope (FE-SEM) equipped with energy-dispersive x-ray (EDX) microanalysis. Cell viability was significantly decreased by CB and DEPs in IMR-32 cells, b...
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Corrigendum to “Effect of probiotic supplement on aflatoxicosis and gene expression in the liver of broiler chicken” [Environ. Toxicol. Pharmacol. 60 (2018) 118–127]
Publication date: Available online 29 June 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ramadan Salem, Nagwan El-Habashi, Sabreen E. Fadl, Osama A. Sakr, Zizy I. Elbialy (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Anxiety- associated behavior and genotoxicity found in adult Danio rerio exposed to tebuconazole-based commercial product
Publication date: Available online 30 June 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Tássia Flávia Dias Castro, José Gilmar da Silva Souza, Aline Ferreira Souza de Carvalho, Isadora de Lima Assis, Marcel José Palmieri, Larissa Fonseca Andrade Vieira, Silvana Marcussi, Monica Rodrigues Ferreira Machado, Luis David Solis MurgasAbstractThe effects of different concentrations of commercial product based on tebuconazole, on adults of Danio rerio, were evaluated through novel tank diving test and micronucleus and comet assay tests. A total of 320 adult D. rerio were divided into ...
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

In vivo investigation on the chronic hepatotoxicity induced by sertraline
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Mansour I. Almansour, Yazun B. Jarrar, Bashir M. JarrarAbstractAlthough sertraline is widely prescribed as relatively safe antidepressant drug, hepatic toxicity was reported in some patients with sertraline treatment. The present study was conducted to investigate the morphometric, hepatotoxicity, and change in gene expression of drug metabolizing enzymes. Male healthy adult rabbits (Oryctolagus cuniculus) ranging from 1050 to 1100 g were exposed to oral daily doses of sertraline (0, 1, 2, 4, 8 mg/kg) for 9 weeks. The anim...
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

CLZ-8, a potent small-molecular compound, protects radiation-induced damages both in vitro and in vivo
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Tian Feng, Jiyuan Liu, Nan Zhou, Libin Wang, Xueying Liu, Shengyong Zhang, Siwang Wang, Hui ChenAbstractPUMA (p53 up-regulated mediator of apoptosis) is particularly important in initiating radiation-induced damage and apoptosis. It has been shown that inhibition of PUMA can provide a profound benefit for the long-term survival of the mice, without an increased risk of malignancies after irradiation. It becomes to be a potential target for developing an effective treatment aimed to protect cells from lethal radiation. CLZ-8, a...
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Corrigendum to “The research of genetic toxicity of β-phellandrene” [Environ. Toxicol. Pharmacol. 54 (2017) 28–33]
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Zhiyuan Cheng, Jianjun Jiang, Xiaohua Yang, Hongqian Chu, Ming Jin, Yuan Li, Tao Xi, Siqi Wang, Yao Huang, Lanqin Shang, Shuang Wu, Weidong Hao, Yueying Qian, Xuetao Wei (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Editorial Board
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research

Diabetes escalates knee osteoarthritis in rats: Evidence of adaptive mechanism
In conclusion, diabetic-osteoarthritic state is characterised by more altered biochemical profile, relative to what is probable in either disease condition. Nevertheless, this situation remains subject to the influence of endogenous homeostatic mechanisms. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 5, 2018 Category: Environmental Health Source Type: research