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T-2 toxin induces cytotoxicity and disrupts tight junction barrier in SerW3 cells
This study focused on revealing the cytotoxic effects of T-2 on Sertoli cells associated with cell junctional barriers. In the present study, SerW3 cells were exposed to T-2 toxin at 12, 120 and 1200ng/ml doses for 24 and 48hours. Cytotoxicity tests including cell viability (MTT), lactate dehydrogenase (LDH) cytotoxicity test and trypan blue exclusion assay were performed. Occludin, ZO-1, N-cadherin and β-catenin were immunolabelled, expressions of occludin and N-cadherin were determined by western blotting. SerW3 cell barrier integrity was measured by transepithelial electrical resistance (TEER). Cytotoxicity caused ...
Source: Environmental Toxicology and Pharmacology - October 13, 2017 Category: Environmental Health Source Type: research

Effects of glyphosate-based herbicide on pintado da Amaz ônia: Hematology, histological aspects, metabolic parameters and genotoxic potential
This study investigated the effects on the hybrid fish jundiara (Leiarius marmoratus×Pseudoplatystoma reticulatum) of an environmentally relevant exposure to this herbicide. Glucose levels in liver, muscle and plasma decreased after exposure to 1.357mgL−1 of Roundup Original® (glyphosate nominal concentration), while glycogen levels reduced in liver and muscle for different times. Elevated cholesterol and triglycerides revealed an adaptive response. Protein and lactate levels also increased during the experiment, however no changes were observed for muscle lactate. Increment of the transaminases suggests da...
Source: Environmental Toxicology and Pharmacology - October 12, 2017 Category: Environmental Health Source Type: research

Effect of repeated administration of 4-methylpyrazole on renal function and lipid peroxidation products in rat kidney after ethylene glycol poisoning
Publication date: Available online 10 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Karina Sommerfeld-Klatta, Jędrzej Przystanowicz, Joanna Kowalówka-Zawieja, Barbara Zielińska-Psuja Toxic effects of ethylene glycol (EG) and its metabolites are mainly related to metabolic acidosis and kidney damage. EG biotransformation involving CYP2E1 affects the oxidant-antioxidant balance. The study assessed the effect of repeated administration of 4-methylpyrazole (4MP, 15mg/kg b.w. after 2hours, followed by 10mg/kg b.w. every 12hours) on renal function (creatinine, urea and urinary protein levels)...
Source: Environmental Toxicology and Pharmacology - October 11, 2017 Category: Environmental Health Source Type: research

CYP2C9 and VKORC1 in therapeutic dosing and safety of acenocoumarol treatment: implication for clinical practice in Hungary
Publication date: Available online 8 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Reka Varnai, Csilla Sipeky, Lajos Nagy, Sandor Balogh, Bela Melegh The purpose of this work was to investigate the contribution of CYP2C9 and VKORC1 to acenocoumarol (AC) dose variability, bleeding events in Hungary. The study recruited 117 patients on long-term AC therapy (INR 2-3), and 510 healthy individuals to model the findings. Patients were genotyped for alleles proved to affect lower AC overdose CYP2C9*2, CYP2C9*3, VKORC1*2. Additionally, we tested VKORC1*3, VKORC1*4 to examine their effect in patients wit...
Source: Environmental Toxicology and Pharmacology - October 9, 2017 Category: Environmental Health Source Type: research

Effects of particulate matter from straw burning on lung fibrosis in mice
Conclusion Exposure of mice with BLM-induced IPF to PM2.5 from straw burning exacerbated lung inflammation and fibrosis and increased mortality; NAC increased the mouse survival, indicating protective effects. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - October 8, 2017 Category: Environmental Health Source Type: research

Toxicity of ZnO nanoparticles (NPs) to A549 cells and A549 epithelium in vitro: interactions with dipalmitoyl phosphatidylcholine (DPPC)
In this study, we investigated the effects of dipalmitoyl phosphatidylcholine (DPPC), the major component in lung surfactant, on stability and toxicity of ZnO NPs. The presence of DPPC increased the UV–vis spectra, hydrodynamic size, Zeta potential and dissolution rate of ZnO NPs, which indicates that DPPC might interact with NPs and affect the colloidal stability of NPs. Exposure to ZnO NPs induced cytotoxicity associated with increased intracellular Zn ions but not superoxide in A549 cells. In A549 epithelium model, exposure to ZnO NPs induced cytotoxicity and decreased the release of interleukin 6 (IL-6) without a...
Source: Environmental Toxicology and Pharmacology - October 8, 2017 Category: Environmental Health Source Type: research

The α-lipoic acid improves high-fat diet-induced cerebral damage through inhibition of oxidative stress and inflammatory reaction
This study is to clarify the protective role of α-lipoic acid in high-fat diet-induced cerebral damage mice. The mice were divided into 5 groups: normal control group, high-fat diet (HFD) group, low-dose α-lipoic acid group for prevention, high-dose α-lipoic acid group for prevention, and high-dose α-lipoic acid group for treatment. The groups’ weights and blood glucose changes were monitored. We used HE staining to observe morphological changes in the cerebral cortex. The expression levels of the oxidative stress proteins SOD2, catalase, and the inflammatory pathway proteins p-JNK, p-ERK were...
Source: Environmental Toxicology and Pharmacology - October 4, 2017 Category: Environmental Health Source Type: research

The potential effects of efavirenz on Oreochromis mossambicus after acute exposure
Publication date: Available online 2 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): L Robson, IEJ Barnhoorn, GM Wagenaar Antiretroviral drugs (ARVs) are hazardous therapeutic pharmaceuticals present in South African surface water. Efavirenz is an ARV commonly used in human immunodeficiency virus (HIV) treatment in South Africa. Although little is known about the toxic effects of efavirenz on fish health, threats of toxicity to the aquatic environment have been reported. Oreochromis mossambicus were exposed under controlled conditions to environmentally-relevant efavirenz concentrations (10.3ng/L)...
Source: Environmental Toxicology and Pharmacology - October 3, 2017 Category: Environmental Health Source Type: research

Low cytotoxicity of anisotropic gold nanoparticles coated with lysine on peripheral blood mononuclear cells “in vitro”
Publication date: December 2017 Source:Environmental Toxicology and Pharmacology, Volume 56 Author(s): Jorge O. Avila-Alejo, Ana K. González-Palomo, Germán Plascencia-Villa, Miguel José-Yacamán, Hugo R. Navarro-Contreras, Iván N. Pérez-Maldonado The aim of this study was to evaluate the cytotoxic effects of anisotropic (non spherical morphologies) gold nanoparticles coated with the amino acid Lysine (Lys) on peripheral blood mononuclear cells (PBMC) “in vitro”. Gold (Au) nanoparticles tested in this study were synthesized by a seed-mediated growth using Lys as a struct...
Source: Environmental Toxicology and Pharmacology - October 1, 2017 Category: Environmental Health Source Type: research

The ameliorating effects of selenium and vitamin C against fenitrothion-induced blood toxicity in Wistar rats
Publication date: December 2017 Source:Environmental Toxicology and Pharmacology, Volume 56 Author(s): Marija D. Milošević, Milica G. Paunović, Miloš M. Matić, Branka I. Ognjanović, Zorica S. Saičić Fenitrothion is widely used organophosphate pesticide in agriculture and health programs, but besides, it causes several toxic effects. The present study was designed to evaluate the possible protective effects of selenium (0.5mg/kg b.w.) and vitamin C (100mg/kg b.w) on altered haematological, biochemical and oxidative stress parameters in the blood of rats orally treated with fenitrothion (20mg/kg b.w) for...
Source: Environmental Toxicology and Pharmacology - September 28, 2017 Category: Environmental Health Source Type: research

Cellular pathways involved in silica nanoparticles induced apoptosis: A systematic review of in vitro studies
Publication date: December 2017 Source:Environmental Toxicology and Pharmacology, Volume 56 Author(s): Collins Otieno Asweto, Jing Wu, Mohamed Ali Alzain, Hejing Hu, Sebastian Andrea, Lin Feng, Xiaozhe Yang, Junchao Duan, Zhiwei Sun Silica nanoparticles (SiNPs) have been found to pass through biological barriers and get distributed in the human body. They induce cell apoptosis via various mechanisms in body organs. To understand these mechanisms, we carried out systematic review of in vitro studies on SiNPs-induced cell apoptosis. Office of Health Assessment and Translation approach for Systematic Review and Evidence Inte...
Source: Environmental Toxicology and Pharmacology - September 28, 2017 Category: Environmental Health Source Type: research

Selection of reference genes for quantitative real-time PCR analysis in chicken ovary following silver nanoparticle treatment
In conclusion, the results obtained depend on the algorithm used and it arises from the diverse calculation strategies used in these programs. The outcome from the NormFinder is considered to be the most trustworthy and used in further qPCR analysis. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 23, 2017 Category: Environmental Health Source Type: research

Elucidation of protective efficacy of Pentahydroxy flavone isolated from Madhuca indica against arsenite-induced cardiomyopathy: Role of Nrf-2, PPAR- γ, c-fos and c-jun
Conclusion Administration of 3,5,7,3′,4′- Pentahydroxy flavone (i.e. Quercetin (QTN)) isolated from MI-ALC showed significant protection against arsenic-induced oxido-nitrosative stress and myocardial injury via modulation of Nrf2, PPAR-γ, and apoptosis. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 22, 2017 Category: Environmental Health Source Type: research

Sulforaphane mitigates cadmium-induced toxicity pattern in human peripheral blood lymphocytes and monocytes
In this study, we investigated the protective role of sulforaphane on Cd-induced toxicity in human peripheral blood lymphocytes and monocytes. Sulforaphane did not show any major reduction in the viability of lymphocytes and monocytes. However, Cd treatment at a concentration of 50μM induced around 69% cell death. Treatment of IC10-Cd and 100μM sulforaphane combination for 24 and 48h increased viability by 2 and 9% in cells subjected to Cd toxicity, respectively. In addition, IC25 of Cd and 100μM sulforaphane combination recovered 17–20% of cell viability. Cd induced apoptotic and necrotic cell death. Sulfor...
Source: Environmental Toxicology and Pharmacology - September 21, 2017 Category: Environmental Health Source Type: research

Intestinal epithelial cell injury induced by copper containing nanoparticles in piglets
Publication date: Available online 17 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Hui Zhang, Xiaoxing Wu, Khalid Mehmood, Zhenyu Chang, Kun Li, Xiong Jiang, Fazul Nabi, Muhammad Ijaz, Mujeeb Ur Rehman, Muhammad Tariq Javed, Donghai Zhou The nano copper has been widely used in modern clinical medicine practice. However, it has been noticed that nano copper particles induce cell injury and toxicity. The present study was designed to determine the effect of nano copper particles on cell injury of intestinal epithelial cells (IECs) in piglets. The IECs were treated with different doses of nano c...
Source: Environmental Toxicology and Pharmacology - September 19, 2017 Category: Environmental Health Source Type: research

Butyl Benzyl Phthalate (BBP) Induces Caudal Defects During Embryonic Development
Publication date: Available online 17 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Nicole M. Roy, Ewelina Zambrzycka, Jenna Santangelo Butyl benzyl phthalate (BBP) is commonly added during the manufacturing of plastics to increase flexibility and elasticity. However, BBP leaches off of plastic and environment presence has been detected in soil, groundwater and sediment potentially effecting organisms in the environment. Given the widespread uses of BBP in household, consumer goods and the presence of BBP in the environment, studies on developmental toxicity are needed. Here, we use a zebrafis...
Source: Environmental Toxicology and Pharmacology - September 19, 2017 Category: Environmental Health Source Type: research

Distribution of chromosome breakpoints in benzene-exposed and unexposed AML patients
Publication date: October 2017 Source:Environmental Toxicology and Pharmacology, Volume 55 Author(s): Patrick J. Kerzic, Richard D. Irons Results of laboratory studies and investigations of occupationally exposed healthy individuals have been used to develop a mode of action for benzene-induced leukemia that mirrors disease following treatment with chemotherapeutic agents. Recently we have described series of AML and MDS cases with benzene exposure history, and have provided cytogenetic, molecular, and pathologic evidence that these cases differ significantly in many features from therapy-related disease. Here we have ext...
Source: Environmental Toxicology and Pharmacology - September 19, 2017 Category: Environmental Health Source Type: research

The genetic influence in fluorosis
Publication date: Available online 15 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Sreemanta Pramanik, Depanwita Saha Fluorosis, caused by ingestion of excess fluoride, is endemic in at least 25 countries across the globe, China and India being the worst affected among them. Dental, skeletal and non-skeletal are the major types of fluorosis affecting millions of people in these countries. A number of genetic epidemiological studies carried out by investigators have shown the evidence for association between genetic polymorphisms in candidate genes and differences in the susceptibility pattern...
Source: Environmental Toxicology and Pharmacology - September 16, 2017 Category: Environmental Health Source Type: research

The Role of PPAR alpha in Perfluorooctanoic Acid Induced Developmental Cardiotoxicity and L-carnitine Mediated Protection –Results of in ovo Gene Silencing
In conclusion, PFOA-induced heart rate elevation is likely PPAR alpha independent, while the right ventricular wall thinning seems to be PPAR alpha dependent. The protective effects of L-carnitine do not require PPAR alpha. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 15, 2017 Category: Environmental Health Source Type: research

Identification of key genes and pathways and therapeutic agents in Cadmium-treated liver cells: a bioinformatics study
Publication date: Available online 14 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Liang Zhang, Yi Huang, Zhen Yu, Mengmeng Shao, Yunbo Luo, Yi Zhu Evidence indicates that Cadmium (Cd) can accumulate in liver, which results in acute or chronic cell damage with unclear complex mechanisms. Thus, we aimed to explore the possible molecules and pathways by using bioinformatics methods Consequently, two datasets (GSE8865 and GSE31286) were retrieved and the differentially expressed genes (DEGs) were screened out. The intersection of the DEGs included seven up-regulated and forty-three down-regulate...
Source: Environmental Toxicology and Pharmacology - September 15, 2017 Category: Environmental Health Source Type: research

Hesperidin, a citrus bioflavonoid, alleviates trichloroethylene-induced oxidative stress in Drosophila melanogaster
Publication date: October 2017 Source:Environmental Toxicology and Pharmacology, Volume 55 Author(s): Amos Olalekan Abolaji, Oluwatoyin Victoria Babalola, Abimbola Kehinde Adegoke, Ebenezer Olatunde Farombi Trichloroethylene (TCE) is a chlorinated organic pollutant of groundwater with diverse toxic effects in animals and humans. Here, we investigated the ameliorative role of hesperidin, a citrus bioflavonoid on TCE-induced toxicity in Drosophila melanogaster. Four groups of D. melanogaster (50 flies/vial, with 5 vials/group) were exposed to ethanol (2.5%, control), HSP (400mg/10g diet), TCE (10μM/10g diet) and TCE (10&...
Source: Environmental Toxicology and Pharmacology - September 12, 2017 Category: Environmental Health Source Type: research

Wildfire smoke exposure and human health: Significant gaps in research for a growing public health issue
Publication date: October 2017 Source:Environmental Toxicology and Pharmacology, Volume 55 Author(s): Carolyn Black, Yohannes Tesfaigzi, Jed A. Bassein, Lisa A. Miller Understanding the effect of wildfire smoke exposure on human health represents a unique interdisciplinary challenge to the scientific community. Population health studies indicate that wildfire smoke is a risk to human health and increases the healthcare burden of smoke-impacted areas. However, wildfire smoke composition is complex and dynamic, making characterization and modeling difficult. Furthermore, current efforts to study the effect of wildfire smoke...
Source: Environmental Toxicology and Pharmacology - September 10, 2017 Category: Environmental Health Source Type: research

The risk of coronary artery disease estimated non-invasively in patients with essential hypertension environmentally exposed to cigarette smoke
Conclusions In patients with essential hypertension environmental exposure to cigarette smoke may result in elevated risk of coronary artery disease estimated non-invasively through measurement of coronary artery calcium score by computed tomography. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 9, 2017 Category: Environmental Health Source Type: research

Genetic susceptibility to breast cancer risk associated with inorganic arsenic exposure
Conclusion MTR c.2756A>G polymorphism may confer protection for BC associated with iAs exposure. Further research is warranted to elucidate the potential involvement of other polymorphisms in iAs-related BC. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 9, 2017 Category: Environmental Health Source Type: research

In vitro assessment of neurotoxicity and neuroinflammation of homemade MWCNTs
Publication date: Available online 7 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Giuseppa Visalli, Monica Currò, Daniela Iannazzo, Alessandro Pistone, Marianna Pruiti Ciarello, Giuseppe Acri, Barbara Testagrossa, Maria Paola Bertuccio, Raffaele Squeri, Angela Di Pietro Multi walled carbon nanotubes (MWCNTs) activate pathways involved in cytotoxicity, genotoxicity and inflammation. Inhaled MWCNTs are translocated to extra pulmonary organs and their hydrophobicity allows them to cross the blood–brain barrier (BBB). Further exposure of central nervous system (CNS) occurs via olfact...
Source: Environmental Toxicology and Pharmacology - September 8, 2017 Category: Environmental Health Source Type: research

Protective Effect of Thymoquinone against Diazinon-Induced Hematotoxicity, Genotoxicity and Immunotoxicity in Rats
This study showed that Thy (without the significant effect on genotoxicity) decreased the hematological toxicity, immunotoxicity and butyrl and acetyl cholinesterase activity induced by DZN. The success of Thy supplementation against DZN toxicity can be attributed to the antioxidant effects of its constituents. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 8, 2017 Category: Environmental Health Source Type: research

Environmental exposure to organophosphorus nerve agents
Publication date: Available online 7 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Slavica Vucinic, Biljana Antonijevic, Aristidis M. Tsatsakis, Loukia Vassilopoulou, Anca Oana Docea, Alexander E. Nosyrev, Boris N. Izotov, Horst Thiermann, Nikolaos Drakoulis, Dragica Brkic Exposure to organophosphorus nerve agents, the most deadly chemical warfare agents, is possible in a variety of situations, such as destruction of chemical warfare agents, terrorist attacks, armed conflicts or accidents in research laboratories and storage facilities. Hundreds of thousands of tons of chemical munitions were ...
Source: Environmental Toxicology and Pharmacology - September 8, 2017 Category: Environmental Health Source Type: research

Lead induces apoptosis in mouse TM3 Leydig cells through the Fas/FasL death receptor pathway
Publication date: December 2017 Source:Environmental Toxicology and Pharmacology, Volume 56 Author(s): Xiuyuan He, Jing Wu, Liyun Yuan, Feng Lin, Jine Yi, Jing Li, Hui Yuan, Jinling Shi, Tingting Yuan, Shufang Zhang, Yongheng Fan, Zhihang Zhao The study was aimed to investigate the effect of Pb toxicity on mouse Leydig cells and its molecular mechanism. The TM3 cells were cultured in vitro and exposed to Pb at different concentrations for 24h. The effects of Pb on cell proliferation and apoptosis were analyzed with MTT and Annexin V-FITC/PI via flow cytometry, respectively. Expression levels of Fas, Fas-L and caspase-8 in...
Source: Environmental Toxicology and Pharmacology - September 8, 2017 Category: Environmental Health Source Type: research

Trends in and factors affecting the observed levels of urinary inorganic and total blood mercury among US children, adolescents, adults, and senior citizens over 2005-2012
Publication date: Available online 6 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Ram B. Jain Data from National Health and Nutrition Examination Survey (NHANES) for 2005-2012 were used to (i) study adjusted and unadjusted trends in the levels of urinary inorganic mercury (UIHG) and total blood mercury (TBHG) and (ii) factors that affect the observed levels of UIHG and TBHG among children aged 1-5 (CHLD15) and 6-11 (CHLD611) years, adolescents aged 12-19 years (ADOL), adults aged 20-64 years (ADLT), and senior citizens aged >=65 years (SNR). Decrease in adjusted levels of UIHG for each...
Source: Environmental Toxicology and Pharmacology - September 7, 2017 Category: Environmental Health Source Type: research

Pre-treatment with melatonin decreases abamectin induced toxicity in a nocturnal insect Spodoptera litura (Lepidoptera: Noctuidae)
In conclusion, the results of the study revealed that abamectin toxicity generates oxidative stress in the insect, while pre-melatonin treatment reduces this damage due to its antioxidant properties, especially POX levels in midgut, fatbody, and hemolymph. Therefore, indoleamine can play a vital role curtailing the abamectin toxicity in time dependent manner in S.litura. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 7, 2017 Category: Environmental Health Source Type: research

Tolerance to dichloroacetonitrile-induced neurotoxicity in streptozotocin-induced diabetic rats
In conclusion, the present study indicated that STZ diabetic rats are resistant to DCAN-induced neurotoxicity at the dosage and with the dosage schedule in 28-day subacute toxicity test. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 7, 2017 Category: Environmental Health Source Type: research

Synthesis, characterization and evaluation cytotoxic activity of silver nanoparticles synthesized by Chinese herbal Cornus officinalis via environment friendly approach
In this study, a new eco-friendly approach for green synthesis of silver nanoparticles (AgNPs) by using the fruits of Cornus officinalis aqueous extract as a reducing and stabilizing agent. The so-synthesized AgNPs showed quasi-spherical in shape with uniform dispersal and an average mean size of 11.7nm. Water soluble biomolecules such as flavonoids and/or anthocyanins from the extract played important roles in the nanoparticles formation. The AgNPs displayed distinctive cytotoxicity activities against human prostate cancer (PC-3) and human liver cancer (HepG2) cell lines. The results provided a low cost, nontoxic and eco-...
Source: Environmental Toxicology and Pharmacology - September 7, 2017 Category: Environmental Health Source Type: research

The impact of demographic factors, behaviors and environmental exposure to mercury content in the hair of the population living in the region of Lodz (central Poland)
Publication date: Available online 5 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): M. Marcinek-Jacel, J. Albińska, A. Pawlaczyk, M.I. Szynkowska The aim of this work was to access the influence of different factors such as sex, age, fish consumption, hair dyeing or smoking habit on the content of mercury in human hair samples. The research was carried on 444 samples (102 males and 342 females) collected from the population of people living in the region of Lodz (central Poland). The content of mercury in human hair samples was determined using the Mercury Analyzer MA 3000 (Nippon Instruments,...
Source: Environmental Toxicology and Pharmacology - September 6, 2017 Category: Environmental Health Source Type: research

Tris (2-chloroethyl) phosphate induces senescence-like phenotype of hepatocytes via the p21Waf1/Cip1-Rb pathway in a p53-independent manner
Publication date: December 2017 Source:Environmental Toxicology and Pharmacology, Volume 56 Author(s): Wenjuan Zhang, Youjian Zhang, Jian Hou, Tian Xu, Wenjun Yin, Wei Xiong, Wenhong Lu, Hongyan Zheng, Jun Chen, Jing Yuan Tris (2-chloroethyl) phosphate (TCEP) has been widely used as a plasticizer and flame retardant. TCEP as a potential carcinogen is often detected in the occupational and nature environments. To investigate effects of TCEP on human hepatocytes, we assessed cell growth rate, cellular membrane integrity, senescence-associated β-galactosidase (SA-β-Gal) activity and analyzed expression of regulator...
Source: Environmental Toxicology and Pharmacology - September 6, 2017 Category: Environmental Health Source Type: research

Nonsteroidal mycotoxin alternariol is a full androgen agonist in the yeast reporter androgen bioassay
Publication date: Available online 4 September 2017 Source:Environmental Toxicology and Pharmacology Author(s): Sylwia Stypuła-Trębas, Maria Minta, Lidia Radko, Piotr Jedziniak, Andrzej Posyniak Alternariol (AOH) is a toxic metabolite of phytopathogenic fungi of the Alternaria spp. and important contaminant of agricultural commodities. According to the recent studies, AOH has a potential to modulate the endocrine system of humans and animals. In the view of these reports, our study addressed the effects of AOH on human estrogen receptor (hERα) and androgen receptor (hAR) signaling with the use of the yeast estroge...
Source: Environmental Toxicology and Pharmacology - September 5, 2017 Category: Environmental Health Source Type: research

A comparison of the effects of copper nanoparticles and copper sulfate on Phaeodactylum tricornutum physiology and transcription
This study delineates the cellular mechanism behind the toxicity of CuNPs and CuSO4 on marine diatoms. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 5, 2017 Category: Environmental Health Source Type: research

BDE-47 and BDE-85 stimulate insulin secretion in INS-1 832/13 pancreatic β-cells through the thyroid receptor and Akt
This study shows that BDE-47 and BDE-85 directly act on pancreatic β-cells to stimulate GSIS, and that this effect is mediated by the thyroid receptor (TR) and Akt activation. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 4, 2017 Category: Environmental Health Source Type: research

Detection rates, trends in and factors affecting observed levels of selected volatile organic compounds in blood among US adolescents and adults
Publication date: December 2017 Source:Environmental Toxicology and Pharmacology, Volume 56 Author(s): Ram B. Jain Data from National Health and Nutrition Examination Survey were analyzed to evaluate detection rates, trend in and factors affecting the observed levels of 1,4-dichlorobenzene, benzene, ethylbenzene, o-xylene, styrene, toluene, and m/p-xylene among US adolescents and adults over 2005–2012. Over 2005–20102, among adolescents, detection rates declined by more than 50% for benzene, ethylbenzene, and o-xylene, and among adults, detection rates declined by more than 50% for ethylbenzene and o-xylene an...
Source: Environmental Toxicology and Pharmacology - September 2, 2017 Category: Environmental Health Source Type: research

Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner
This study aimed to investigate the effects of formaldehyde on triglyceride metabolism in human hepatocellular carcinoma cells (HepG2). Cell viability was detected using a MTT (3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide) assay. Following treatment with different concentrations of formaldehyde for 24 and 48h, the intra and extra-hepatocellular triglyceride (TG) content was determined using a chemical-enzymatic method; Western blotting was used to detect the levels of fatty acid synthesis and VLDL-related proteins. Our results showed that cell viability significantly decreased after formaldehyde treatment (...
Source: Environmental Toxicology and Pharmacology - September 2, 2017 Category: Environmental Health Source Type: research

Cumulative effects of ibuprofen and air emersion in zebra mussels Dreissena polymorpha
In conclusion, exposure to Ibu has some anti-inflammatory effects to mussels based on COX activity but resulted in increased oxidative damage and lipid catabolism. Exposure to air stress could enhance some of these responses and contribute to decreased resistance to air exposures. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 30, 2017 Category: Environmental Health Source Type: research

Differential tissue regulation of peroxisome proliferator-activated receptor α (PPARα) and cannabinoid receptor 1 (CB1) gene transcription pathways by diethylene glycol dibenzoate (DEGB): preliminary observations in a seabream (Sparus aurata) in vivo model
Publication date: October 2017 Source:Environmental Toxicology and Pharmacology, Volume 55 Author(s): Paolo Cocci, Matteo Mozzicafreddo, Mauro Angeletti, Gilberto Mosconi, Francesco Alessandro Palermo Today a variety of endocrine disrupting chemicals (EDCs) are recognized in the group of metabolic disruptors, a wide range of environmental contaminants that alter energy balance regulation by affecting the peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) pathway. Herein, we investigated the effect of diethylene glycol dibenzoate (DEGB), a dibenzoate-based plasticizer used as alternative to phthala...
Source: Environmental Toxicology and Pharmacology - August 30, 2017 Category: Environmental Health Source Type: research

Therapeutic effect of carnosine in rat model of experimental liver carcinogenesis
Publication date: Available online 26 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Amr A. Fouad, Hatem O. Qutub, Abdullatif S. Al Rashed, Walid N. Al-Melhim The possible anticancer effect of carnosine versus doxorubicin was investigated against hepatocellular carcinoma (HCC) induced by trichloroacetic acid (TCA) (500mg/kg/day, p.o., for 5 days) in rats. Following induction of HCC, rats treated with either carnosine (10mg/kg/day, i.p.), or doxorubicin (2.5mg/kg, i.p., once weekly), for 2 weeks. Carnosine significantly decreased serum alanine aminotransferase, and hepatic lipid peroxidation, nitri...
Source: Environmental Toxicology and Pharmacology - August 27, 2017 Category: Environmental Health Source Type: research

Changes of respiratory system in mice exposed to PM4.0 or TSP from exhaust gases of combustion of cashew nut shell
Publication date: Available online 25 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jeanne Batista Josino, Daniel Silveira Serra, Maria Diana Moreira Gomes, Rinaldo Santos Araújo, Mona Lisa Moura de Oliveira, Francisco Sales Ávila Cavalcante Air pollution is a topic discussed all over the world and the search for alternatives to reduce it is of great interest to many researchers. The use of alternative energy sources and biofuels seems to be the environmentally safer solution. In this work, the deleterious effects on the respiratory system of mice exposed to PM4.0 or TSP, present in...
Source: Environmental Toxicology and Pharmacology - August 26, 2017 Category: Environmental Health Source Type: research

The oxidative stress response of oxytetracycline in the ciliate Pseudocohnilembus persalinus
Publication date: Available online 24 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Chongnv Wang, Xuming Pan, Yawen Fan, Ying Chen, Weijie Mu Oxytetracycline (OTC) is commonly employed in fish farms to prevent bacterial infections in China, and because of their widely and intensive use, the potential harmful effects on organisms in aquatic environment are of great concern. Ciliates play an important role in aquatic food webs as secondary producers, and Pseudocohnilembus persalinus, is one kind of them which are easily found in fish farms, surviving in polluted water. Therefore, using P. persalinu...
Source: Environmental Toxicology and Pharmacology - August 25, 2017 Category: Environmental Health Source Type: research

Imidacloprid Insecticide Exposure Induces Stress and Disrupts Glucose Homeostasis in Male Rats
Publication date: Available online 24 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Samah R. Khalil, Ashraf Awad, Hesham H. Mohammed, Mohamed Abdo Nassan In the present study, we evaluated the stress response in adult rats who were administered imidacloprid (IMI) orally in two doses (0.5 and 1.0mg/kg bw for 60 days). It led to an alteration in the levels of cortisone and catecholamines and induced behavioral deficits, particularly in the animals exposed to the dose of 1.0mg/kg. IMI was further analyzed for the effect on glucose homeostasis in developing and adult rats at a dose of 1.0mg/kg bw whe...
Source: Environmental Toxicology and Pharmacology - August 25, 2017 Category: Environmental Health Source Type: research

Enhanced thymocyte apoptosis induced by maternal undernutrition in late gestation results in declined mature T cells in rat fetal thymus
This study was designed to observe the effects of maternal food restriction (MFR) on the development of fetal thymus in different gestation periods. Timed pregnant rats were randomized into 3 groups: CN (free access to standard chow throughout gestation), MFR0-21 (50% MFR throughout gestation), MFR0-14 (50% MFR from gestational day (GD) 0 to GD14, early-mid gestation). Results showed that MFR during early-mid period had few impact on the fetal thymus and T cell subpopulations. However, MFR throughout gestation resulted in thymic atrophy, deceased frequency of both CD4+ and CD8+ single positive (SP) T cells and enhanced thy...
Source: Environmental Toxicology and Pharmacology - August 25, 2017 Category: Environmental Health Source Type: research

Cumulative effects of ibuprofen and air emersion in zebra mussels Dreissena polymorpha.
In conclusion, exposure to Ibu has some anti-inflammatory effects to mussels based on COX activity but resulted in increased oxidative damage and lipid catabolism. Exposure to air stress could enhance some of these responses and contribute to decreased resistance to air exposures. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 20, 2017 Category: Environmental Health Source Type: research

Long non-coding RNAs: the novel diagnostic biomarkers for leukemia
Publication date: Available online 18 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Shaoyun Chen, Hairong Liang, Hui Yang, Kairu Zhou, Longmei Xu, Jiaxian Liu, Bei Lai, Li Song, Hao Luo, Jianming Peng, Zhidong Liu, Yongmei Xiao, Wen Chen, Huanwen Tang Long non-coding RNAs (LncRNAs) are a category of non-coding RNAs (ncRNAs) with a length of 200nt∼100kb lacking a significant open reading frame. The study of lncRNAs is a newly established field, due in part to their capability to act as the novel biomarkers in disease. A growing body of research shows that lncRNAs may not only useful as biomark...
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced p53-mediated apoptosis through activation of cytochrome P450/aryl hydrocarbon receptor
This study highlights the critical role of CYP1B1 and AhR in TCDD activity and proposes that inhibition of these key molecules might serve as a potential therapeutic approach for treatment of allergy and cancer. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

Prevalence and characteristics of inhalational and dermal palytoxin exposures reported to the National Poison Data System in the U.S.
Conclusion The incidence of palytoxin exposure is low but significant symptoms can occur. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research