A rare case of non ‐lupus full house nephropathy in a transplanted kidney, case report
Key Clinical MessageNon-lupus full house nephropathy is a rare entity that is still poorly understood. It can complicate post-transplant kidneys and result in a de novo process. Treatment is difficult but can be possibly achieved with optimization of immune suppression.AbstractNon-lupus full house nephropathy is a rare entity with an unclear incidence. It describes the kidney biopsy findings of positive deposits for IgG, IgA, IgM, C3, and C1q on immunofluorescence in the absence of the classical diagnostic features of systemic lupus nephritis. This disease entity is becoming more recognized but further studies are still ne...
Source: Clinical Case Reports - May 3, 2024 Category: General Medicine Authors: Ahmad Samir Matarneh,
Omar Salameh,
Sundus Sardar,
Amanda Karasinski,
Theja Channapragada,
Muhammad Abdulbasit,
Erik Washburn,
Nasrollah Ghahramani Tags: CASE REPORT Source Type: research
TNFSF13B rs9514828 C > T Polymorphism is Associated with Incidence of Atherosclerosis and Therapeutic Outcomes in Patients with Systemic Lupus Erythematosus
(Source: Biologics: Targets and Therapy)
Source: Biologics: Targets and Therapy - May 2, 2024 Category: Biochemistry Tags: Biologics: Targets and Therapy Source Type: research
Pancytopenia as a first presentation of late-onset systemic lupus erythematosus: a case report
CONCLUSION: It is important to assess any unusual presentation of SLEs when clinical suspicion remains high and conducting further laboratory and imaging investigation.PMID:38694390 | PMC:PMC11060222 | DOI:10.1097/MS9.0000000000001891 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Ghina Haidar Naram Khalayli Tasneem Drie Mhd Homam Safiah Maysoun Kudsi Source Type: research
ST2 levels and neurodegenerative diseases: is this a significant relation?
Ann Med Surg (Lond). 2024 Mar 12;86(5):2812-2817. doi: 10.1097/MS9.0000000000001939. eCollection 2024 May.ABSTRACTInterleukin-33 (IL-33), belonging to the interleukin-1 cytokine family, has a decoy receptor soluble ST2 (sST2). IL-33 is found in oligodendrocytes and astrocytes and is involved in central nervous system healing and repair, whereas ST2 is found in microglia and astrocytes. Some studies have found a link between changes in the IL-33/ST2 pathway and neurodegenerative disorders. This review article investigates the relationship between the interleukin-33 (IL-33)/ST2 pathway and neurodegenerative disorders. It was...
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Himanshu Arora Binish Javed L V Simhachalam Kutikuppala Mayuri Chaurasia Kaarvi Khullar Shreevikaa Kannan Varshitha Golla Source Type: research
Pancytopenia as a first presentation of late-onset systemic lupus erythematosus: a case report
CONCLUSION: It is important to assess any unusual presentation of SLEs when clinical suspicion remains high and conducting further laboratory and imaging investigation.PMID:38694390 | PMC:PMC11060222 | DOI:10.1097/MS9.0000000000001891 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Ghina Haidar Naram Khalayli Tasneem Drie Mhd Homam Safiah Maysoun Kudsi Source Type: research
ST2 levels and neurodegenerative diseases: is this a significant relation?
Ann Med Surg (Lond). 2024 Mar 12;86(5):2812-2817. doi: 10.1097/MS9.0000000000001939. eCollection 2024 May.ABSTRACTInterleukin-33 (IL-33), belonging to the interleukin-1 cytokine family, has a decoy receptor soluble ST2 (sST2). IL-33 is found in oligodendrocytes and astrocytes and is involved in central nervous system healing and repair, whereas ST2 is found in microglia and astrocytes. Some studies have found a link between changes in the IL-33/ST2 pathway and neurodegenerative disorders. This review article investigates the relationship between the interleukin-33 (IL-33)/ST2 pathway and neurodegenerative disorders. It was...
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Himanshu Arora Binish Javed L V Simhachalam Kutikuppala Mayuri Chaurasia Kaarvi Khullar Shreevikaa Kannan Varshitha Golla Source Type: research
Study of the metabolic syndrome severity index as a predictive factor of a major cardiovascular event in premenopausal women with systemic lupus erythematosus
CONCLUSIONS: The MetSx-IMC severity index, contrary to the binary approaches, is recommended to evaluate MS as a predictor of MACE in SLE patients. Offering improved and more accurate prognosis in patients at risk of developing MCE.PMID:38697892 | DOI:10.1016/j.medcli.2024.01.041 (Source: Medicina Clinica)
Source: Medicina Clinica - May 2, 2024 Category: General Medicine Authors: Elsy Aid é García-Villegas Cruz Vargas-de-Le ón Antonio Rafael Villa-Romero Itzelly Ibarra Valdovinos Horacio M árquez-González Source Type: research
Nurses ’ roles, interventions, and implications for management of rheumatic diseases
This article provides a comprehensive review of nurses ’ roles, interventions, and impacts in several rheumatic diseases, including rheumatoid arthritis, osteoarthritis, spondyloarthritis, gout, systemic lupus erythematosus, and polymyalgia rheumatica. It has been demonstrated that care under nursing supervision is effective and safe, with benefits in cluding disease management, quality of life, and treatment adherence. In addition, nurses play a crucial role in promoting health, educating patients, and administering biological disease-modifying anti-rheumatic drugs. The COVID-19 pandemic has highlighted the significance...
Source: Rheumatology International - May 2, 2024 Category: Rheumatology Source Type: research
Adalimumab for the Treatment of Non-Infectious Uveitis: A Real Life Experience
CONCLUSIONS: We consider adalimumab as a leading drug in the treatment of NIU with high safety and efficacy.PMID:38691840 | DOI:10.1080/09273948.2024.2344712 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - May 1, 2024 Category: Allergy & Immunology Authors: F átima Raad Paula Luque Sof ía García Ledo Alicia Alda Lozano V íctor Llorens Antonio Espejo Henar Heras Luc ía Santana Luis Trapiella Patricia Fanlo Alfredo Ad án Gerard Espinosa Nuria Navarrete Source Type: research
SIT1 identifies circulating hypoactive T cells with elevated cytotoxic molecule secretion in systemic lupus erythematosus patients
This study aims to elucidate the expression and functionality of SIT1 in circulating CD8/CD4 + T cells in humans and to delineate its significance in systemic lupus erythematosus (SLE) patients. We employed multiparametric flow cytometry to investigate the expression of SIT1 in circulating CD8/CD4 + T cells and their respective subsets, comparing healthy controls (HCs) with SLE patients. Furthermore, we assessed the levels of granzyme B, perforin, IL-17, and IFN-γ in SIT1-related CD8/CD4 + T cells from both HCs and SLE patients, both before and after PMA stimulation. Clinically, we conducted receiver operating characteris...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Ainizati Hasimu Ayibaota Bahabayi Ziqi Xiong Qi Li Zhonghui Zhang Xingyue Zeng Mohan Zheng Zihang Yuan Chen Liu Source Type: research
Abnormal energy metabolism in the pathogenesis of systemic lupus erythematosus
Int Immunopharmacol. 2024 Apr 30;134:112149. doi: 10.1016/j.intimp.2024.112149. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a severe autoimmune disease with significant socioeconomic impact worldwide. Orderly energy metabolism is essential for normal immune function, and disordered energy metabolism is increasingly recognized as an important contributor to the pathogenesis of SLE. Disorders of energy metabolism are characterized by increased reactive oxygen species, ATP deficiency, and abnormal metabolic pathways. Oxygen and mitochondria are critical for the production of ATP, and both mitochondrial...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Shumei Cao Jiao Jiang Haoyuan Yin Lai Wang Qianjin Lu Source Type: research
Elevated type I IFN signalling directly affects CD8 < sup > + < /sup > T-cell distribution and autoantigen recognition of the skeletal muscles in active JDM patients
This study aimed to understand the effect of elevated type I IFN signaling on CD8+ T cell-associated muscle damage in juvenile dermatomyositis (JDM). This study used flow cytometry (FC) and RT‒PCR were used to examine the circulating cell ratio and type I IFN response. And scRNA-seq was used to examine peripheral immunity in 6 active JDM patients, 3 stable JDM patients, 3 juvenile IMNM patients and 3 age-matched healthy children. In vivo validation experiments were conducted using a mouse model induced by STING agonists and an experimental autoimmune myositis model (EAM). In vitro experiments were conducted using isolate...
Source: Journal of Autoimmunity - May 1, 2024 Category: Allergy & Immunology Authors: Baozhen Huang Huiyu Li Qian Jiang Yucong Li Zhaowei Jiang Huijuan Cao Shaoxi Wang Xinluan Wang Jianguo Li Gang Li Source Type: research
Animal models of studying the pathogenesis of multi-organ tissue damage in lupus
Clin Immunol. 2024 Apr 29:110231. doi: 10.1016/j.clim.2024.110231. Online ahead of print.ABSTRACTModerate-to-severe systemic lupus erythematosus (SLE) is characterized by extensive autoantibody deposition and persistent autoinflammation. As the existing animal models are limited in accurately reproducing the pathological characteristics of human SLE, we introduced a novel animal model simulating multi-organ autoinflammation through intra-organ injections. The model closely mimicked key features of SLE, including IgG deposition, inflammation, and tissue damage. The model could be used to assess the roles of IgG, immune cell...
Source: Clinical Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Xuefei Wang Guo-Min Deng Source Type: research
Adalimumab for the Treatment of Non-Infectious Uveitis: A Real Life Experience
CONCLUSIONS: We consider adalimumab as a leading drug in the treatment of NIU with high safety and efficacy.PMID:38691840 | DOI:10.1080/09273948.2024.2344712 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - May 1, 2024 Category: Allergy & Immunology Authors: F átima Raad Paula Luque Sof ía García Ledo Alicia Alda Lozano V íctor Llorens Antonio Espejo Henar Heras Luc ía Santana Luis Trapiella Patricia Fanlo Alfredo Ad án Gerard Espinosa Nuria Navarrete Source Type: research
