Viruses, Vol. 16, Pages 211: Safety, Immunogenicity, and Mechanism of a Rotavirus mRNA-LNP Vaccine in Mice
sheng Sun
Yan Zhou
Hongjun Li
Rotaviruses (RVs) are a major cause of diarrhea in young children worldwide. The currently available and licensed vaccines contain live attenuated RVs. Optimization of live attenuated RV vaccines or developing non-replicating RV (e.g., mRNA) vaccines is crucial for reducing the morbidity and mortality from RV infections. Herein, a nucleoside-modified mRNA vaccine encapsulated in lipid nanoparticles (LNP) and encoding the VP7 protein from the G1 type of RV was developed. The 5′ untranslated region of an isolated human RV was utilized for the mRNA vaccine. After undergoing ...
Source: Viruses - January 31, 2024 Category: Virology Authors: Chenxing Lu Yan Li Rong Chen Xiaoqing Hu Qingmei Leng Xiaopeng Song Xiaochen Lin Jun Ye Jinlan Wang Jinmei Li Lida Yao Xianqiong Tang Xiangjun Kuang Guangming Zhang Maosheng Sun Yan Zhou Hongjun Li Tags: Article Source Type: research
Identification of a novel intra-genotype reassortant G1P[8] rotavirus in Italy, 2021
Rotavirus group A (RVA) is a major aetiological agent of acute gastroenteritis (AGE) in children and animals worldwide [1]. RVA are classified in G and P- types on the bases of the two outer capsid proteins, VP7 and VP4, both eliciting neutralizing antibodies, and, currently, at least 42 G and 58 P types have been identified (https://rega.kuleuven.be/cev/viralmetagenomics/virus-classification/rcwg). Historically, G1P[8] represents the prevalent genotype, targeted by vaccines (Rotarix and Rotateq). (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - January 31, 2024 Category: Infectious Diseases Authors: Simona De Grazia, Chiara Filizzolo, Floriana Bonura, Mariangela Pizzo, Francesca Di Bernardo, Antonina Collura, Francesco Pellegrini, Vito Martella, Giovanni M. Giammanco Tags: Short Communication Source Type: research
Prevalence, Clinical Features, and Genotypes of Norovirus-Associated Diarrhea in Wuxi, China, 2013-2020
This study aimed to determine the prevalence, clinical features, and genotypes of NoV-associated diarrhea in Wuxi, China. A total of 4,416 stool samples were collected from patients with diarrhea at enteric disease clinics of sentinel hospitals in Wuxi from February 1, 2013 to December 31, 2020. Univariate and Akaike information criterion stepwise logistic regression were used to identify differences as integrated within a clinical setting (NoV positive [+] versus NoV negative [-], NoV+ versus rotavirus [RV]+, NoV+ versus bacteria+, genogroup [G] I and GII genotypes). Norovirus was detected in 9.85% of stool samples, which...
Source: Am J Trop Med Hyg - January 24, 2024 Category: Infectious Diseases Authors: Yan Wang Yumeng Gao Chao Shi Yuan Shen Mingyan Lu Dan Sha Yujun Chen Ding Zhu Ping Shi Source Type: research
Prevalence, Clinical Features, and Genotypes of Norovirus-Associated Diarrhea in Wuxi, China, 2013-2020
This study aimed to determine the prevalence, clinical features, and genotypes of NoV-associated diarrhea in Wuxi, China. A total of 4,416 stool samples were collected from patients with diarrhea at enteric disease clinics of sentinel hospitals in Wuxi from February 1, 2013 to December 31, 2020. Univariate and Akaike information criterion stepwise logistic regression were used to identify differences as integrated within a clinical setting (NoV positive [+] versus NoV negative [-], NoV+ versus rotavirus [RV]+, NoV+ versus bacteria+, genogroup [G] I and GII genotypes). Norovirus was detected in 9.85% of stool samples, which...
Source: The American Journal of Tropical Medicine and Hygiene - January 24, 2024 Category: Tropical Medicine Authors: Yan Wang Yumeng Gao Chao Shi Yuan Shen Mingyan Lu Dan Sha Yujun Chen Ding Zhu Ping Shi Source Type: research
Epidemiology of group A rotavirus in children under five years of age with gastroenteritis in N ’Djamena, Chad
Group A Rotaviruses (RVA) is one of the most common causes of severe diarrhoea in infants and children under 5 years of age. Unlike many countries in the world where RVA surveillance/control is active, in Chad... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - January 22, 2024 Category: Infectious Diseases Authors: Bertrand Djikoloum, Mahamat Fayiz Abakar, Valentine Ngum Ndze, Rahinatou Ghapoutsa Nkandi, Carine Ngah Enjeh, Pidou Kimala, Jean Paul Assam Assam and Maurice BODA Tags: Research Source Type: research
Viruses, Vol. 16, Pages 130: Equine Rotavirus A under the One Health Lens: Potential Impacts on Public Health
Parreño
Group A rotaviruses are a well-known cause of viral gastroenteritis in infants and children, as well as in many mammalian species and birds, affecting them at a young age. This group of viruses has a double-stranded, segmented RNA genome with high genetic diversity linked to point mutations, recombination, and, importantly, reassortment. While initial molecular investigations undertaken in the 1900s suggested host range restriction among group A rotaviruses based on the fact that different gene segments were distributed among different animal species, recent molecular surveillance and genome constellation geno...
Source: Viruses - January 16, 2024 Category: Virology Authors: Mariano Carossino Maria Aldana Vissani Maria E. Barrandeguy Udeni B. R. Balasuriya Viviana Parre ño Tags: Review Source Type: research
Effect of Covid pandemic on immunization status of children in tertiary care Hospital of North India: reason for partial and non-immunization a cross-sectional study
CONCLUSIONS: Although COVID-19 pandemic resulted in disruptions in routine immunization services, sociodemographic factors such as awareness for immunization, parental education and various beliefs for immunization were responsible for the children remaining unimmunized or partially immunized after the pandemic.PMID:38221618 | PMC:PMC10789037 | DOI:10.1186/s41043-023-00494-z (Source: Journal of Health, Population, and Nutrition)
Source: Journal of Health, Population, and Nutrition - January 14, 2024 Category: International Medicine & Public Health Authors: Narender Kumar Pinki Allyhan Anju Aggarwal Source Type: research
Foodborne Viruses and Somatic Coliphages Occurrence in Fresh Produce at Retail from Northern Mexico
This study aimed to establish the occurrence and correlation of foodborne viruses and somatic coliphages in leafy greens in northern Mexico. A total of 320 vegetable samples were collected, resulting in 80 composite rinses, 40 of lettuce and 40 of parsley. Somatic coliphages were determined using the EPA 1602 method, while foodborne viruses (HAV, RoV, NoV GI, and GII) were determined by qPCR. The occurrence of RoV was 22.5% (9/40, mean 2.11 log gc/g) in lettuce and 20% (8/40, mean 1.91 log gc/g) in parsley. NoV and HAV were not detected in any samples. Somatic coliphages were present in all lettuce and parsley samples, wit...
Source: Food and Environmental Virology - January 10, 2024 Category: Virology Source Type: research
Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus
Volume 16, Issue 1, January-December 2024 . (Source: Gut Microbes)
Source: Gut Microbes - January 8, 2024 Category: Microbiology Authors: Valentin GreigertIti SaraavJuhee SonYinxing ZhuDenise DayaoAvan AntiaSaul TziporiWilliam H. WitolaThaddeus S. StappenbeckSiyuan DingL. David Sibleya Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USAb Depart Source Type: research
Temporal changes in the positivity rate of common enteric viruses among paediatric admissions in coastal Kenya, during the COVID-19 pandemic, 2019 –2022
ConclusionOur study finds that in 2020 the transmission of common enteric viruses, especially RVA and astrovirus, in Kilifi Kenya may have been disrupted due to the COVID-19 NPIs. After 2020, local enteric virus transmission patterns appeared to return to pre-pandemic levels coinciding with the removal of most of the government COVID-19 NPIs. (Source: Gut Pathogens)
Source: Gut Pathogens - January 4, 2024 Category: Microbiology Source Type: research
Etiologies of Mild and Moderate Diarrheal Illness among Children in Consuelo, Dominican Republic
This study aimed to determine the contribution of rotavirus as an etiology of acute gastroenteritis over a 12-month period in children under 5 years of age in both an inpatient and an outpatient setting in Consuelo, Dominican Republic. All children who were seen at Niños Primeros en Salud clinic or admitted to Hospital Municipal Dr. Angel Ponce Pinedo for acute gastroenteritis during January 2021-April 2022 were enrolled in the study. Stools were evaluated for rotavirus, enteric parasites, and pathogenic bacteria. Pathogen detection was compared between outpatients and inpatients and on the basis of child's vaccination st...
Source: The American Journal of Tropical Medicine and Hygiene - January 3, 2024 Category: Tropical Medicine Authors: Ingrid Japa Derartu Ahmed Anabel Fernandez Angie Alvarez Shirley Sabino Japa Ramona Cordero Francia Acosta Andrew P Steenhoff Elizabeth D Lowenthal Source Type: research
Etiologies of Mild and Moderate Diarrheal Illness among Children in Consuelo, Dominican Republic
This study aimed to determine the contribution of rotavirus as an etiology of acute gastroenteritis over a 12-month period in children under 5 years of age in both an inpatient and an outpatient setting in Consuelo, Dominican Republic. All children who were seen at Niños Primeros en Salud clinic or admitted to Hospital Municipal Dr. Angel Ponce Pinedo for acute gastroenteritis during January 2021-April 2022 were enrolled in the study. Stools were evaluated for rotavirus, enteric parasites, and pathogenic bacteria. Pathogen detection was compared between outpatients and inpatients and on the basis of child's vaccination st...
Source: Am J Trop Med Hyg - January 3, 2024 Category: Infectious Diseases Authors: Ingrid Japa Derartu Ahmed Anabel Fernandez Angie Alvarez Shirley Sabino Japa Ramona Cordero Francia Acosta Andrew P Steenhoff Elizabeth D Lowenthal Source Type: research
Etiologies of Mild and Moderate Diarrheal Illness among Children in Consuelo, Dominican Republic
This study aimed to determine the contribution of rotavirus as an etiology of acute gastroenteritis over a 12-month period in children under 5 years of age in both an inpatient and an outpatient setting in Consuelo, Dominican Republic. All children who were seen at Niños Primeros en Salud clinic or admitted to Hospital Municipal Dr. Angel Ponce Pinedo for acute gastroenteritis during January 2021-April 2022 were enrolled in the study. Stools were evaluated for rotavirus, enteric parasites, and pathogenic bacteria. Pathogen detection was compared between outpatients and inpatients and on the basis of child's vaccination st...
Source: The American Journal of Tropical Medicine and Hygiene - January 3, 2024 Category: Tropical Medicine Authors: Ingrid Japa Derartu Ahmed Anabel Fernandez Angie Alvarez Shirley Sabino Japa Ramona Cordero Francia Acosta Andrew P Steenhoff Elizabeth D Lowenthal Source Type: research
