Correlates of immune protection against human rotaviruses: natural infection and vaccination
AbstractSpecies A rotaviruses are the leading viral cause of acute gastroenteritis in children under 5 years of age worldwide. Despite progress in the characterization of the pathogenesis and immunology of rotavirus-induced gastroenteritis, correlates of protection (CoPs) in the course of either natural infection or vaccine-induced immunity are not fully understood. There are numerous factors such as serological responses (IgA and IgG), the presence of maternal antibodies (Abs) in breast milk, changes in the intestinal microbiome, and rotavirus structural and non-structural proteins that contribute to the outcome of the Co...
Source: Archives of Virology - March 8, 2024 Category: Virology Source Type: research
Viruses, Vol. 16, Pages 411: Production of OSU G5P[7] Porcine Rotavirus Expressing a Fluorescent Reporter via Reverse Genetics
atton
Rotaviruses are a significant cause of severe, potentially life-threatening gastroenteritis in infants and the young of many economically important animals. Although vaccines against porcine rotavirus exist, both live oral and inactivated, their effectiveness in preventing gastroenteritis is less than ideal. Thus, there is a need for the development of new generations of porcine rotavirus vaccines. The Ohio State University (OSU) rotavirus strain represents a Rotavirus A species with a G5P[7] genotype, the genotype most frequently associated with rotavirus disease in piglets. Using complete genome sequences that ...
Source: Viruses - March 7, 2024 Category: Virology Authors: Anthony J. Snyder Chantal A. Agbemabiese John T. Patton Tags: Article Source Type: research
Genomic diversity of group A rotaviruses from wild boars and domestic pigs in Japan: wide prevalence of NSP5 carrying the H2 genotype
AbstractGroup A rotavirus (RVA) sequences were detected in 10.8% (23/212) and 20.7% (87/421) of fecal samples collected in 2017-2022 from wild boars and domestic pigs, using next-generation sequencing. Complete genome sequence analysis of one wild boar and 13 domestic pig RVAs revealed that six of them carried the rare H2 NSP5 genotype. Out of the 39 samples for which the NSP5 genotype could be determined, 23 (59.0%) were of genotype H2. H2 porcine RVAs consist exclusively of Japanese porcine RVAs and exhibit sequence diversity in each segment, suggesting that H2 porcine RVAs may have evolved through reassortment within th...
Source: Archives of Virology - March 7, 2024 Category: Virology Source Type: research
Corrigendum to: < em > Valeriana jatamansi < /em > Jones Inhibits Rotavirus-Induced Diarrhea via Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway
J Microbiol Biotechnol. 2024 Feb 28;34(2):484-485. doi: 10.4014/jmb.2024.3402.484.NO ABSTRACTPMID:38419325 | DOI:10.4014/jmb.2024.3402.484 (Source: Journal of Microbiology and Biotechnology)
Source: Journal of Microbiology and Biotechnology - February 29, 2024 Category: Biotechnology Authors: Bin Zhang Yan Wang Chunmao Jiang Caihong Wu Guangfu Guo Xiaolan Chen Shulei Qiu Source Type: research
