Detection and Characterization of Bacterial and Viral Acute Gastroenteritis among Outpatient Children under 5 Years Old in Guangzhou, China
This study underscores the burden posed by coinfections and highlights the clinical characteristics associated with AGE when accompanied by coinfections among children under 5 years old.PMID:38412529 | DOI:10.4269/ajtmh.23-0725 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - February 27, 2024 Category: Tropical Medicine Authors: Xin Luo Jiankai Deng Mingyong Luo Nan Yu Xiaoyan Che Source Type: research
GSE256410 Delayed memory T cell expansion in HIV-exposed uninfected infants is preceded by premature skewing of T cell receptor clonality
Contributors : Aaron J Wilk ; Sonwabile Dzanibe ; Catherine A Blish ; Clive M GraySeries Type : OtherOrganism : Homo sapiensWhile preventing vertical HIV transmission has been very successful, the increasing number of HIV-exposed uninfected infants (iHEU) experience an elevated risk to infections compared to HIV-unexposed and uninfected infants (iHUU). Immune developmental differences between iHEU and iHUU remains poorly understood and here we present a longitudinal multimodal analysis of infant immune ontogeny that highlights the impact of HIV/ARV exposure. Using mass cytometry, we show alterations and differences in the...
Source: GEO: Gene Expression Omnibus - February 23, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Impact of the pandemic on various infectious diseases with different epidemiological patterns of seasonality, transmission and age
CONCLUSIONS: The impact of the pandemic is very different in these diseases. Pediatric and respiratory-transmitted seasonal viral infections are the ones that are most affected, but with different patterns of recovery to normality. Gastrointestinal bacterial infections suffer fewer variations, except for rotavirus. Gonorrhea do not interrupt its increasing trend seen in the pre-pandemic. Shingles show a slight post-pandemic increase. Several diseases with different epidemiological patterns have been studied for a sufficient period to observe how the acute phase of the pandemic emerges.PMID:38385502 (Source: Herpes)
Source: Herpes - February 22, 2024 Category: Infectious Diseases Authors: Juan Carlos Gasc ó-Laborda M Dolores Tirado-Balaguer Mar ía Gil-Fortuño Gabriela Dorina Deaconescu Oihana Sabalza-Bazt án Óscar Pérez-Olaso Iris G ómez-Alfaro Noelia Hern ández-Pérez Juan B Bellido-Blasco Source Type: research
Impact of the pandemic on various infectious diseases with different epidemiological patterns of seasonality, transmission and age
CONCLUSIONS: The impact of the pandemic is very different in these diseases. Pediatric and respiratory-transmitted seasonal viral infections are the ones that are most affected, but with different patterns of recovery to normality. Gastrointestinal bacterial infections suffer fewer variations, except for rotavirus. Gonorrhea do not interrupt its increasing trend seen in the pre-pandemic. Shingles show a slight post-pandemic increase. Several diseases with different epidemiological patterns have been studied for a sufficient period to observe how the acute phase of the pandemic emerges.PMID:38385502 (Source: Herpes)
Source: Herpes - February 22, 2024 Category: Infectious Diseases Authors: Juan Carlos Gasc ó-Laborda M Dolores Tirado-Balaguer Mar ía Gil-Fortuño Gabriela Dorina Deaconescu Oihana Sabalza-Bazt án Óscar Pérez-Olaso Iris G ómez-Alfaro Noelia Hern ández-Pérez Juan B Bellido-Blasco Source Type: research
Impact of Rotaviral Diarrhea on Child Growth in Sub-Saharan Africa and South Asia in the Global Enteric Multicenter Study
Am J Trop Med Hyg. 2024 Feb 20:tpmd230406. doi: 10.4269/ajtmh.23-0406. Online ahead of print.ABSTRACTRotavirus is the leading cause of dehydrating diarrhea among children in developing countries. The impact of rotaviral diarrhea on nutritional status is not well understood. We aimed to determine the association between rotavirus-positive moderate-to-severe diarrhea and nutrition in children under 5 years of age. We analyzed data from the Global Enteric Multicenter Study on children 0-59 months old from South Asia and sub-Saharan Africa. The relationships between explanatory variables and outcome variables were assessed usi...
Source: The American Journal of Tropical Medicine and Hygiene - February 20, 2024 Category: Tropical Medicine Authors: Rukaeya Amin Sobi Al-Afroza Sultana Soroar Hossain Khan Md Ahshanul Haque Sharika Nuzhat Md Nasif Hossain Pradip K Bardhan Mohammod Jobayer Chisti Subhra Chakraborty Tahmeed Ahmed Rina Das Abu S G Faruque Source Type: research
Impact of Rotaviral Diarrhea on Child Growth in Sub-Saharan Africa and South Asia in the Global Enteric Multicenter Study
Am J Trop Med Hyg. 2024 Feb 20:tpmd230406. doi: 10.4269/ajtmh.23-0406. Online ahead of print.ABSTRACTRotavirus is the leading cause of dehydrating diarrhea among children in developing countries. The impact of rotaviral diarrhea on nutritional status is not well understood. We aimed to determine the association between rotavirus-positive moderate-to-severe diarrhea and nutrition in children under 5 years of age. We analyzed data from the Global Enteric Multicenter Study on children 0-59 months old from South Asia and sub-Saharan Africa. The relationships between explanatory variables and outcome variables were assessed usi...
Source: Am J Trop Med Hyg - February 20, 2024 Category: Infectious Diseases Authors: Rukaeya Amin Sobi Al-Afroza Sultana Soroar Hossain Khan Md Ahshanul Haque Sharika Nuzhat Md Nasif Hossain Pradip K Bardhan Mohammod Jobayer Chisti Subhra Chakraborty Tahmeed Ahmed Rina Das Abu S G Faruque Source Type: research
Impact of Rotaviral Diarrhea on Child Growth in Sub-Saharan Africa and South Asia in the Global Enteric Multicenter Study
Am J Trop Med Hyg. 2024 Feb 20:tpmd230406. doi: 10.4269/ajtmh.23-0406. Online ahead of print.ABSTRACTRotavirus is the leading cause of dehydrating diarrhea among children in developing countries. The impact of rotaviral diarrhea on nutritional status is not well understood. We aimed to determine the association between rotavirus-positive moderate-to-severe diarrhea and nutrition in children under 5 years of age. We analyzed data from the Global Enteric Multicenter Study on children 0-59 months old from South Asia and sub-Saharan Africa. The relationships between explanatory variables and outcome variables were assessed usi...
Source: The American Journal of Tropical Medicine and Hygiene - February 20, 2024 Category: Tropical Medicine Authors: Rukaeya Amin Sobi Al-Afroza Sultana Soroar Hossain Khan Md Ahshanul Haque Sharika Nuzhat Md Nasif Hossain Pradip K Bardhan Mohammod Jobayer Chisti Subhra Chakraborty Tahmeed Ahmed Rina Das Abu S G Faruque Source Type: research
Impact of Rotaviral Diarrhea on Child Growth in Sub-Saharan Africa and South Asia in the Global Enteric Multicenter Study
Am J Trop Med Hyg. 2024 Feb 20:tpmd230406. doi: 10.4269/ajtmh.23-0406. Online ahead of print.ABSTRACTRotavirus is the leading cause of dehydrating diarrhea among children in developing countries. The impact of rotaviral diarrhea on nutritional status is not well understood. We aimed to determine the association between rotavirus-positive moderate-to-severe diarrhea and nutrition in children under 5 years of age. We analyzed data from the Global Enteric Multicenter Study on children 0-59 months old from South Asia and sub-Saharan Africa. The relationships between explanatory variables and outcome variables were assessed usi...
Source: Am J Trop Med Hyg - February 20, 2024 Category: Infectious Diseases Authors: Rukaeya Amin Sobi Al-Afroza Sultana Soroar Hossain Khan Md Ahshanul Haque Sharika Nuzhat Md Nasif Hossain Pradip K Bardhan Mohammod Jobayer Chisti Subhra Chakraborty Tahmeed Ahmed Rina Das Abu S G Faruque Source Type: research
Viruses, Vol. 16, Pages 317: Assessment of Gastroenteric Viruses in Marketed Bivalve Mollusks in the Tourist Cities of Rio de Janeiro, Brazil, 2022
This study investigated the prevalence and genetic diversity of gastroenteric viruses in mussels and oysters in Rio de Janeiro, Brazil. One hundred and thirty-four marketed bivalve samples were obtained between January and December 2022. The viral analysis was performed according to ISO/TS 15216, and the screening revealed the detection of norovirus GII/GI (40.3%), sapovirus (SaV; 12.7%), human mastadenovirus (7.5%), and rotavirus A (RVA; 5.9%). In total, 44.8% (60) of shellfish samples tested positive for one or more viruses, 46.7% (28/60) of the positive samples tested positive for a single viral agent, 26.7% (16) tested...
Source: Viruses - February 20, 2024 Category: Virology Authors: Carina Pacheco Cantelli Guilherme Caetano Lanzieri Tavares Sylvia Kahwage Sarmento Fernanda Marcicano Burlandy Tulio Machado Fumian Adriana Gon çalves Maranhão Emanuelle de Souza Ramalho Ferreira da Silva Marco Aur élio Pereira Horta Marize Pereira Mia Tags: Article Source Type: research
Molnupiravir inhibits human norovirus and rotavirus replication in 3D human intestinal enteroids
Antiviral Res. 2024 Feb 17:105839. doi: 10.1016/j.antiviral.2024.105839. Online ahead of print.ABSTRACTHuman norovirus (HuNoV) and human rotavirus (HRV) are the leading causes of gastrointestinal diarrhea. There are no approved antivirals and rotavirus vaccines are insufficient to cease HRV associated mortality. Furthermore, treatment of chronically infected immunocompromised patients is limited to off-label compassionate use of repurposed antivirals with limited efficacy, highlighting the urgent need of potent and specific antivirals for HuNoV and HRV. Recently, a major breakthrough in the in vitro cultivation of HuNoV an...
Source: Antiviral Research - February 19, 2024 Category: Virology Authors: Nanci Santos-Ferreira Jana Van Dycke Winston Chiu Johan Neyts Jelle Matthijnssens Joana Rocha-Pereira Source Type: research
Molnupiravir inhibits human norovirus and rotavirus replication in 3D human intestinal enteroids
Antiviral Res. 2024 Feb 17:105839. doi: 10.1016/j.antiviral.2024.105839. Online ahead of print.ABSTRACTHuman norovirus (HuNoV) and human rotavirus (HRV) are the leading causes of gastrointestinal diarrhea. There are no approved antivirals and rotavirus vaccines are insufficient to cease HRV associated mortality. Furthermore, treatment of chronically infected immunocompromised patients is limited to off-label compassionate use of repurposed antivirals with limited efficacy, highlighting the urgent need of potent and specific antivirals for HuNoV and HRV. Recently, a major breakthrough in the in vitro cultivation of HuNoV an...
Source: Antiviral Research - February 19, 2024 Category: Virology Authors: Nanci Santos-Ferreira Jana Van Dycke Winston Chiu Johan Neyts Jelle Matthijnssens Joana Rocha-Pereira Source Type: research
Molnupiravir inhibits human norovirus and rotavirus replication in 3D human intestinal enteroids
Antiviral Res. 2024 Feb 17;223:105839. doi: 10.1016/j.antiviral.2024.105839. Online ahead of print.ABSTRACTHuman norovirus (HuNoV) and human rotavirus (HRV) are the leading causes of gastrointestinal diarrhea. There are no approved antivirals and rotavirus vaccines are insufficient to cease HRV associated mortality. Furthermore, treatment of chronically infected immunocompromised patients is limited to off-label compassionate use of repurposed antivirals with limited efficacy, highlighting the urgent need of potent and specific antivirals for HuNoV and HRV. Recently, a major breakthrough in the in vitro cultivation of HuNo...
Source: Antiviral Research - February 19, 2024 Category: Virology Authors: Nanci Santos-Ferreira Jana Van Dycke Winston Chiu Johan Neyts Jelle Matthijnssens Joana Rocha-Pereira Source Type: research
Literature review to identify evidence of secondary transmission of pentavalent human-bovine reassortant rotavirus vaccine (RV5) strains to unvaccinated subjects
CONCLUSIONS: We found no evidence of horizontal transmission of RV5 strains to unvaccinated infants in a context of a limited amount and the descriptive nature of the identified studies.PMID:38355319 | DOI:10.1016/j.vaccine.2024.01.083 (Source: Vaccine)
Source: Vaccine - February 14, 2024 Category: Allergy & Immunology Authors: Yuanqiu Li Xiaojin Sun Yaqun Fu Xuedan You Susanne Hartwig Source Type: research
Development of real-time RT-PCR systems for detection and quantitation of bovine enteric viral pathogens
In conclusion, real time PCR developed for these viruses are highly specific and sensitive technique for the detection of diarrheic viral pathogens of cattle and buffalo.PMID:38347693 | DOI:10.1080/10495398.2023.2182314 (Source: Animal Biotechnology)
Source: Animal Biotechnology - February 13, 2024 Category: Biotechnology Authors: Monika Punia Sushila Maan Kanisht Batra Deepika Chaudhary Bhanita Devi Aman Kumar Suresh Kumar Gahlawat Narender Singh Maan Source Type: research
Development of real-time RT-PCR systems for detection and quantitation of bovine enteric viral pathogens
In conclusion, real time PCR developed for these viruses are highly specific and sensitive technique for the detection of diarrheic viral pathogens of cattle and buffalo.PMID:38347693 | DOI:10.1080/10495398.2023.2182314 (Source: Animal Biotechnology)
Source: Animal Biotechnology - February 13, 2024 Category: Biotechnology Authors: Monika Punia Sushila Maan Kanisht Batra Deepika Chaudhary Bhanita Devi Aman Kumar Suresh Kumar Gahlawat Narender Singh Maan Source Type: research
