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The success of publicly funded rotavirus vaccine programs for preventing community- and hospital-acquired rotavirus infections in Canadian pediatric hospitals: an observational study
CMAJ Open. 2023 Dec 19;11(6):E1156-E1163. doi: 10.9778/cmajo.20220245. Print 2023 Nov-Dec.ABSTRACTBACKGROUND: Canadian immunization programs for rotavirus started in 2011. We sought to determine their effect on the burden of community-acquired admissions and hospital-acquired rotavirus at pediatric hospitals.METHODS: The Canadian Immunization Monitoring Program Active (IMPACT) network conducted active surveillance for rotavirus-positive hospital admissions between 2005 and 2020 at 12 pediatric hospitals. We used yearly rates of community-acquired rotavirus per 10 000 admissions and hospital-acquired rotavirus infections pe...
Source: cmaj - December 19, 2023 Category: General Medicine Authors: Nicole Le Saux Julie Bettinger Hennady P Shulha Manish Sadarangani Doug Coyle Timothy F Booth Taj Jadavji Scott A Halperin For members of Immunization Monitoring Program Active Source Type: research

Viruses, Vol. 15, Pages 2453: Emergence of Intergenogroup Reassortant G9P[4] Strains Following Rotavirus Vaccine Introduction in Ghana
Armah Kazuhiko Katayama Rotavirus (RVA) is a leading cause of childhood gastroenteritis. RVA vaccines have reduced the global disease burden; however, the emergence of intergenogroup reassortant strains is a growing concern. During surveillance in Ghana, we observed the emergence of G9P[4] RVA strains in the fourth year after RVA vaccine introduction. To investigate whether Ghanaian G9P[4] strains also exhibited the DS-1-like backbone, as seen in reassortant G1/G3/G8/G9 strains found in other countries in recent years, this study determined the whole genome sequences of fifteen G9P[4] and two G2P[4] RVA strains detec...
Source: Viruses - December 18, 2023 Category: Virology Authors: Yen Hai Doan Francis Ekow Dennis Nobuhiro Takemae Kei Haga Hiroyuki Shimizu Michael Gyasi Appiah Belinda Larteley Lartey Susan Afua Damanka Takaya Hayashi Toshihiko Suzuki Tsutomu Kageyama George Enyimah Armah Kazuhiko Katayama Tags: Article Source Type: research

Development of recombinant rotavirus carrying herpes simplex virus 2 glycoprotein D gene based on reverse genetics technology
In this study, we sought to develop simian RV (SA11) as a vector to express HSV-2 glycoprotein D (gD2) and evaluated its immunogenicity in mice. We generated the recombinant SA11-gD2 virus (rSA11-gD2) and confirmed its ability to express gD2 in vitro. The virus was orally inoculated into suckling BALB/c mice and into 8-week-old mice. Serum IgG and IgA titers against RV and gD2 were measured by ELISA. In the 8-week-old mice inoculated with rSA11-gD2, significant increases in not only antibodies against RV but also IgG against gD2 were demonstrated. In the suckling mice, antibodies against RV were induced, but gD2 antibody w...
Source: Herpes - December 15, 2023 Category: Infectious Diseases Authors: Yoshiki Kawamura Satoshi Komoto Saori Fukuda Masanori Kugita Shuang Tang Amita Patel Julianna R Pieknik Shizuko Nagao Koki Taniguchi Philip R Krause Tetsushi Yoshikawa Source Type: research

Effect of Nk-lysin peptides on bacterial growth, MIC, antimicrobial resistance, and viral activities
This study provided a novel treatment using NK-lysin peptides to inhibit expression of β-lactamase genes in β-lactam antibiotic-resistant bacterial infections.PMID:38100547 | DOI:10.1080/10495398.2023.2290520 (Source: Animal Biotechnology)
Source: Animal Biotechnology - December 15, 2023 Category: Biotechnology Authors: Haitham A Yacoub Maged Mostafa Mahmoud Ahmed M Al-Hejin Turki S Abujamel Shams Tabrez Sherif Abd-Elmaksoud Source Type: research