Letter to the Editor on Cross-Protection of RotaTeq
Ma et al estimated the effectiveness of RotaTeq™ (pentavalent rotavirus vaccine, RV5), containing human bovine reassortants G1, G2, G3, G4, and P[8], against rotavirus gastroenteritis at 97% (95% CI, 83%-100%) in a cohort of children (14 weeks to 2 years of age) predominantly infected (79%) with G8P [8], in Shanghai, China.1 RV5 has been shown to be efficacious and effective across geographic settings, time-periods, and strains, but protection of RV5 against a G8 strain had been demonstrated previously only in Africa. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 7, 2024 Category: Pediatrics Authors: Cristina Carias, Susanne Hartwig, Nabi Kanibir, Jelle Matthijnssens, Yingmei Tu Tags: Letters to the Editor Source Type: research
Tumour necrosis factor inhibitors and serious infections in reproductive-age women and their offspring: a narrative review
Scand J Rheumatol. 2024 Feb 5:1-12. doi: 10.1080/03009742.2024.2303832. Online ahead of print.ABSTRACTTumour necrosis factor inhibitors (TNFi) are commonly used to treat patients with chronic inflammatory diseases, and function by inhibiting the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α). Although beneficial in reducing disease activity, they are associated with an increased risk of serious infections. Data on the risk of serious infections associated with TNFi use during the reproductive years, particularly in pregnancy, are limited. For pregnant women, there is an additional risk of immunosuppression in...
Source: Scandinavian Journal of Rheumatology - February 5, 2024 Category: Rheumatology Authors: L K Flatman I Malham é I Colmegna A B érard S Bernatsky É Vinet Source Type: research
Genetic diversity of G9, G3, G8 and G1 rotavirus group A strains circulating among children with acute gastroenteritis in Vietnam from 2016 to 2021
Infect Genet Evol. 2024 Feb 3;118:105566. doi: 10.1016/j.meegid.2024.105566. Online ahead of print.ABSTRACTRotavirus group A (RVA) is the most common cause of severe childhood diarrhea worldwide. The introduction of rotavirus vaccination programs has contributed to a reduction in hospitalizations and mortality caused by RVA. From 2016 to 2021, we conducted surveillance to monitor RVA prevalence and genotype distribution in Nam Dinh and Thua Thien Hue (TT Hue) provinces where a pilot Rotavin-M1 vaccine (Vietnam) implementation took place from 2017 to 2020. Out of 6626 stool samples, RVA was detected in 2164 (32.6%) by ELISA...
Source: Infection, Genetics and Evolution - February 5, 2024 Category: Genetics & Stem Cells Authors: Ly K T Le Mai N T Chu Jacqueline E Tate Baoming Jiang Michael D Bowen Mathew D Esona Rashi Gautam Jose Jaimes Thao P T Pham Nguyen T Huong Dang D Anh Nguyen V Trang Umesh Parashar Source Type: research
Use of live attenuated recombinant Newcastle disease virus carrying avian paramyxovirus 2 HN and F protein genes to enhance immune responses against species A rotavirus VP6 protein
AbstractNumerous infectious diseases in cattle lead to reductions in body weight, milk production, and reproductive performance. Cattle are primarily vaccinated using inactivated vaccines due to their increased safety. However, inactivated vaccines generally result in weaker immunity compared with live attenuated vaccines, which may be insufficient in certain cases. Over the last few decades, there has been extensive research on the use of the Newcastle disease virus (NDV) as a live vaccine vector for economically significant livestock diseases. A single vaccination dose of NDV can sufficiently induce immunity; therefore, ...
Source: Veterinary Research - February 5, 2024 Category: Veterinary Research Source Type: research
Viruses, Vol. 16, Pages 243: Genetic Profile of Rotavirus Type A in Children under 5 Years Old in Africa: A Systematic Review of Prevalence
uel Brito
Human type A rotavirus (RV-A) is world-recognized as the major pathogen causing viral gastroenteritis in children under 5 years of age. The literature indicates a substantial increase in the diversity of rotavirus strains across continents, especially in Africa, which can pose significant challenges including an increase of disease burden and a reduction of vaccines’ effectiveness. However, few studies have mapped the variety of circulating virus strains in different regions, which may hamper decisions on epidemiological surveillance and preventive public health measures. Thus, our aim was to co...
Source: Viruses - February 3, 2024 Category: Virology Authors: Sandra Miranda Fernanda S. Tonin Carlos Pinto-Sousa Elsa Fortes-Gabriel Miguel Brito Tags: Systematic Review Source Type: research
Molecular detection of waterborne pathogens in infants' drinking water and their relationship with water quality determinants in eastern Ethiopia: loop-mediated isothermal amplification (LAMP)-based study
This study aimed to investigate the presence of these pathogens in infants' drinking water samples and analyzing using water quality determinants in eastern Ethiopia. A molecular (LAMP)-based cross-sectional study design was employed. A total of 410 and 37 water samples were tested from infant point-of-use at household and corresponding water source, respectively, from June 2020 to May, 2021. Cryptosporidium, Shigella, toxin-producing E. coli, and rotavirus were detected in 28.5, 30.0, 26.3, and 32.2%, of water samples tested from infant point-of-use, respectively. About 13.2% of the water samples were positive for all (fo...
Source: Journal of Water and Health - January 31, 2024 Category: Environmental Health Authors: Samuel Mebrahtom Gebregziabher Alemayehu Worku Yalew Heven Sime Adugna Abera Source Type: research
