Spectroscopic Analysis of the Bacterially Expressed Head Domain of Rotavirus VP6
Biosci Rep. 2024 Apr 9:BSR20232178. doi: 10.1042/BSR20232178. Online ahead of print.ABSTRACTThe rotavirus capsid protein VP6 forms the middle of three protein layers and is responsible for many critical steps in the viral life cycle. VP6 as a structural protein can be used in various applications including as a subunit vaccine component. The head domain of VP6 (VP6H) contains key sequences that allow the protein to trimerize and that represent epitopes that are recognized by human antibodies in the viral particle. The domain is rich in beta-sheet secondary structures. Here VP6H was solubilised from bacterial inclusion bodi...
Source: Bioscience Reports - April 9, 2024 Category: Biomedical Science Authors: Milaan Simone Strachan Tshepo Mashapa Samantha Gildenhuys Source Type: research
Spectroscopic Analysis of the Bacterially Expressed Head Domain of Rotavirus VP6
Biosci Rep. 2024 Apr 9:BSR20232178. doi: 10.1042/BSR20232178. Online ahead of print.ABSTRACTThe rotavirus capsid protein VP6 forms the middle of three protein layers and is responsible for many critical steps in the viral life cycle. VP6 as a structural protein can be used in various applications including as a subunit vaccine component. The head domain of VP6 (VP6H) contains key sequences that allow the protein to trimerize and that represent epitopes that are recognized by human antibodies in the viral particle. The domain is rich in beta-sheet secondary structures. Here VP6H was solubilised from bacterial inclusion bodi...
Source: Bioscience Reports - April 9, 2024 Category: Biomedical Science Authors: Milaan Simone Strachan Tshepo Mashapa Samantha Gildenhuys Source Type: research
Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019
CONCLUSION: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.PMID:38582992 | DOI:10.3967/bes2024.031 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Jie Ying Jiang Dan Liang Li Wang Yun Xiao Yu Feng Liang Bi Xia Ke Juan Su Hong Xiao Tao Wang Min Zou Hong Jian Li Chang Wen Ke Source Type: research
Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019
CONCLUSION: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.PMID:38582992 | DOI:10.3967/bes2024.031 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Jie Ying Jiang Dan Liang Li Wang Yun Xiao Yu Feng Liang Bi Xia Ke Juan Su Hong Xiao Tao Wang Min Zou Hong Jian Li Chang Wen Ke Source Type: research
Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019
CONCLUSION: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.PMID:38582992 | DOI:10.3967/bes2024.031 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Jie Ying Jiang Dan Liang Li Wang Yun Xiao Yu Feng Liang Bi Xia Ke Juan Su Hong Xiao Tao Wang Min Zou Hong Jian Li Chang Wen Ke Source Type: research
Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019
CONCLUSION: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.PMID:38582992 | DOI:10.3967/bes2024.031 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Jie Ying Jiang Dan Liang Li Wang Yun Xiao Yu Feng Liang Bi Xia Ke Juan Su Hong Xiao Tao Wang Min Zou Hong Jian Li Chang Wen Ke Source Type: research
Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019
CONCLUSION: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.PMID:38582992 | DOI:10.3967/bes2024.031 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Jie Ying Jiang Dan Liang Li Wang Yun Xiao Yu Feng Liang Bi Xia Ke Juan Su Hong Xiao Tao Wang Min Zou Hong Jian Li Chang Wen Ke Source Type: research
Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019
CONCLUSION: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.PMID:38582992 | DOI:10.3967/bes2024.031 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Jie Ying Jiang Dan Liang Li Wang Yun Xiao Yu Feng Liang Bi Xia Ke Juan Su Hong Xiao Tao Wang Min Zou Hong Jian Li Chang Wen Ke Source Type: research
Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019
CONCLUSION: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.PMID:38582992 | DOI:10.3967/bes2024.031 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Jie Ying Jiang Dan Liang Li Wang Yun Xiao Yu Feng Liang Bi Xia Ke Juan Su Hong Xiao Tao Wang Min Zou Hong Jian Li Chang Wen Ke Source Type: research
Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019
CONCLUSION: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.PMID:38582992 | DOI:10.3967/bes2024.031 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Jie Ying Jiang Dan Liang Li Wang Yun Xiao Yu Feng Liang Bi Xia Ke Juan Su Hong Xiao Tao Wang Min Zou Hong Jian Li Chang Wen Ke Source Type: research
Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019
CONCLUSION: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.PMID:38582992 | DOI:10.3967/bes2024.031 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Jie Ying Jiang Dan Liang Li Wang Yun Xiao Yu Feng Liang Bi Xia Ke Juan Su Hong Xiao Tao Wang Min Zou Hong Jian Li Chang Wen Ke Source Type: research
Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019
CONCLUSION: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.PMID:38582992 | DOI:10.3967/bes2024.031 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Jie Ying Jiang Dan Liang Li Wang Yun Xiao Yu Feng Liang Bi Xia Ke Juan Su Hong Xiao Tao Wang Min Zou Hong Jian Li Chang Wen Ke Source Type: research
Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019
CONCLUSION: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.PMID:38582992 | DOI:10.3967/bes2024.031 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Jie Ying Jiang Dan Liang Li Wang Yun Xiao Yu Feng Liang Bi Xia Ke Juan Su Hong Xiao Tao Wang Min Zou Hong Jian Li Chang Wen Ke Source Type: research
Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019
CONCLUSION: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.PMID:38582992 | DOI:10.3967/bes2024.031 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Jie Ying Jiang Dan Liang Li Wang Yun Xiao Yu Feng Liang Bi Xia Ke Juan Su Hong Xiao Tao Wang Min Zou Hong Jian Li Chang Wen Ke Source Type: research
Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019
CONCLUSION: This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China, further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity. Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.PMID:38582992 | DOI:10.3967/bes2024.031 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Jie Ying Jiang Dan Liang Li Wang Yun Xiao Yu Feng Liang Bi Xia Ke Juan Su Hong Xiao Tao Wang Min Zou Hong Jian Li Chang Wen Ke Source Type: research
