The role of early life origin B cells in adult immunity
The adult immune system is a mosaic of short-lived cells that are continuously replenished by ongoing hematopoiesis and self-sustaining cells that originated from times long gone. Using lineage tracing mediated by CD79aCreERT2 induced at various time points during ontogeny we have identified a neonatal wave of B cell output that is remarkably well preserved into adulthood. In addition to B-1 cells, early-life time-stamped B cells contributed substantially to IgA plasma cells. These were actively maintained by B cell memory within gut chronic germinal centers and contained commensal microbiota reactivity. Interestingly, neo...
Source: Videocast - All Events - November 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
