How rotavirus causes severe gastrointestinal disease
(Baylor College of Medicine) Using intercellular calcium waves, rotavirus amplifies its ability to cause disease beyond the cells it directly infects. This is the first virus identified to activate ADP-mediated intercellular calcium waves. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 19, 2020 Category: International Medicine & Public Health Source Type: news

The origin of diarrhea in rotavirus infection
(Source: ScienceNOW)
Source: ScienceNOW - November 19, 2020 Category: Science Authors: Stanifer, M., Boulant, S. Tags: perspective Source Type: news

Rotavirus induces intercellular calcium waves through ADP signaling
Rotavirus causes severe diarrheal disease in children by broadly dysregulating intestinal homeostasis. However, the underlying mechanism(s) of rotavirus-induced dysregulation remains unclear. We found that rotavirus-infected cells produce paracrine signals that manifested as intercellular calcium waves (ICWs), observed in cell lines and human intestinal enteroids. Rotavirus ICWs were caused by the release of extracellular adenosine 5'-diphosphate (ADP) that activated P2Y1 purinergic receptors on neighboring cells. ICWs were blocked by P2Y1 antagonists or CRISPR-Cas9 knockout of the P2Y1 receptor. Blocking the ADP signal re...
Source: ScienceNOW - November 19, 2020 Category: Science Authors: Chang-Graham, A. L., Perry, J. L., Engevik, M. A., Engevik, K. A., Scribano, F. J., Gebert, J. T., Danhof, H. A., Nelson, J. C., Kellen, J. S., Strtak, A. C., Sastri, N. P., Estes, M. K., Britton, R. A., Versalovic, J., Hyser, J. M. Tags: Microbiology, Molecular Biology, Online Only r-articles Source Type: news

Investigator at Children's Hospital Los Angeles awarded $3.4M to study rotavirus vaccine
(Children's Hospital Los Angeles) The rotavirus vaccine--which protects against diarrhea and resulting dehydration-- is less effective in children in middle- and low-income countries. Investigators will use genomics to optimize effectiveness of the vaccine in order to decrease hospitalizations and deaths in young children worldwide. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 9, 2020 Category: Infectious Diseases Source Type: news

Revenge against rotavirus
(Source: ScienceNOW)
Source: ScienceNOW - October 8, 2020 Category: Science Authors: Fogg, C. N. Tags: twis Source Type: news

Biomedical sciences researchers find new way to prevent and cure rotavirus, other viral infections
(Georgia State University) A combination of two substances secreted by the immune system can cure and prevent rotavirus infection, as well as potentially treat other viral infections that target epithelial cells, which cover body surfaces such as skin, blood vessels, organs and the urinary tract, according to researchers in the Institute for Biomedical Sciences at Georgia State University. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 2, 2020 Category: Infectious Diseases Source Type: news

Slow-growing rotavirus mutant reveals early steps of viral assembly
(Baylor College of Medicine) A serendipitous observation led researchers at Baylor College of Medicine to uncover new insights into the formation of rotavirus viroplasms. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 23, 2020 Category: Biology Source Type: news

Mystery solved, rotavirus VP3 is a unique capping machine
(Baylor College of Medicine) After eluding researchers for more than 30 years, the VP3 protein of rotavirus has finally revealed its unique structure and function to a team led by scientists at Baylor College of Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 16, 2020 Category: Infectious Diseases Source Type: news

Rotavirus Vaccination, Type 1 Diabetes Not Linked in Children
MONDAY, March 9, 2020 -- Rotavirus vaccination seems not to be associated with type 1 diabetes in children, according to a study published online March 9 in JAMA Pediatrics. Jason M. Glanz, Ph.D., from Kaiser Permanente Colorado in Aurora, and... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 9, 2020 Category: Pharmaceuticals Source Type: news

Rotavirus May Be Overdiagnosed Due to Vaccine Virus Shedding Rotavirus May Be Overdiagnosed Due to Vaccine Virus Shedding
Nearly half of infants with rotavirus in their stool test positive due to vaccine virus shedding, new findings show.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - January 2, 2020 Category: Pathology Tags: Infectious Diseases News Source Type: news

Immune mystery solved in mice points to better protection from rotavirus in humans
(University of Toronto) Researchers at the University of Toronto have discovered how a brief disruption to a molecular pathway in the guts of mice before they are born can compromise adult immunity to a common and often deadly intestinal virus. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 20, 2019 Category: International Medicine & Public Health Source Type: news

Rotavirus Vaccination: 5 Things to Know Rotavirus Vaccination: 5 Things to Know
With rotavirus vaccination rates lagging behind those of other childhood vaccines, many children still suffer from severe rotavirus disease. Here are five things to know.CDC Expert Commentary (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 2, 2019 Category: Consumer Health News Tags: Pediatrics Commentary Source Type: news

Rotavirus, Hib, PCV immunisation large economic benefits in India
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - October 31, 2019 Category: Drugs & Pharmacology Source Type: news

Medical News Today: Gut microbiota may 'prevent and cure' rotavirus
Scientists have found gut bacteria in mice that could cure rotavirus infections, which cause the death of hundreds of thousands of children each year. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 20, 2019 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Medical News Today: Does the rotavirus vaccine prevent type 1 diabetes?
Scientists present a link between rotavirus infection and type 1 diabetes and suggest vaccination as a method to prevent the condition. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 16, 2019 Category: Consumer Health News Tags: Diabetes Type 1 Source Type: news

Routine infant rotavirus vaccination tied to fewer hospitalizations
(Reuters Health) - More than a decade after the rotavirus vaccine was added to the roster of routine shots recommended for all infants in the U.S., vaccination is still reducing hospitalizations for severe infections, researchers say. (Source: Reuters: Health)
Source: Reuters: Health - October 1, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

Study predicts modest impact from additional dose of rotavirus vaccine
YSPH researchers have shed insight on the vaccine ’s effectiveness in low-income countries concerned about protecting against the highly contagious disease. (Source: Yale Science and Health News)
Source: Yale Science and Health News - August 15, 2019 Category: Universities & Medical Training Source Type: news

Rotavirus cell invasion triggers a cacophony of calcium signals
(Baylor College of Medicine) Time-lapsing imaging and other experimental approaches reveal that rotavirus induces hundreds of discrete and highly dynamic calcium spikes that increase during peak infection. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 25, 2019 Category: Infectious Diseases Source Type: news

Trends in the Laboratory Detection of Rotavirus Trends in the Laboratory Detection of Rotavirus
How effect has the rotavirus vaccination program been in reducing the prevalence of rotavirus disease in the United States?Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 8, 2019 Category: Consumer Health News Tags: Public Health & Prevention Journal Article Source Type: news

Rotavirus Vaccine Led to Reduced Disease Prevalence, Season Duration
MONDAY, June 24, 2019 -- Implementation of rotavirus vaccination has reduced disease prevalence and season duration in the United States, according to research published in the June 21 issue of the U.S. Centers for Disease Control and Prevention... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 24, 2019 Category: Pharmaceuticals Source Type: news

Nationwide Shortage of Tuberculin Skin Test Antigens: CDC Recommendations for Patient Care and Public Health Practice
CDC recommends general approaches to prevent a reduction in tuberculin skin testing capability resulting from the expected shortage of Aplisol. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - June 20, 2019 Category: American Health Tags: Chronic Obstructive Pulmonary Disease (COPD) Influenza (Flu) Influenza Vaccination MMWR Morbidity & Mortality Weekly Report Public Health Rotavirus Rotavirus Vaccination Skin Cancer Smoking Tobacco Use Cigarette Smoking Source Type: news

Update: Influenza Activity in the United States During the 2018-19 Season and Composition of the 2019-20 Influenza Vaccine
The 2018-19 influenza season was a moderate severity season with two waves of influenza A activity in the United States. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - June 20, 2019 Category: American Health Tags: Chronic Obstructive Pulmonary Disease (COPD) Influenza (Flu) Influenza Vaccination MMWR Morbidity & Mortality Weekly Report Public Health Rotavirus Rotavirus Vaccination Smoking Tobacco Use Cigarette Smoking Source Type: news

Trends in the Laboratory Detection of Rotavirus Before and After Implementation of Routine Rotavirus Vaccination --- United States, 2000--2018
During 2000-2018, implementation of the U.S. rotavirus vaccination program reduced the annual proportion of positive rotavirus tests. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - June 20, 2019 Category: American Health Tags: Chronic Obstructive Pulmonary Disease (COPD) MMWR Morbidity & Mortality Weekly Report Public Health Rotavirus Rotavirus Vaccination Smoking Tobacco Use Cigarette Smoking Source Type: news

U.S. Cases of Infant Gut Illness Plummet After Vaccine Introduced
THURSDAY, June 20, 2019 -- In the midst of the " anti-vaxxer " movement comes more scientific proof that vaccines help save children's lives. Researchers report that since the 2006 introduction of a vaccine against rotavirus -- a common and... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 20, 2019 Category: General Medicine Source Type: news

Rotavirus Vaccine May Help Protect Against Type 1 Diabetes
Children who completed a full course of rotavirus vaccine were at lower risk of developing Type 1 diabetes. (Source: NYT Health)
Source: NYT Health - June 19, 2019 Category: Consumer Health News Authors: Nicholas Bakalar Tags: Diabetes Vaccination and Immunization Rotaviruses Children and Childhood Source Type: news

Rotavirus Vaccination Tied to Lower Risk for T1DM in Children
FRIDAY, June 14, 2019 -- Completion of full rotavirus vaccination appears to be associated with a reduction in the risk of type 1 diabetes in children, according to a study published online June 13 in Scientific Reports. Mary A.M. Rogers, Ph.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 14, 2019 Category: Pharmaceuticals Source Type: news

Common Infant Rotavirus Vaccine May Also Shield Kids From Type 1 Diabetes
FRIDAY, June 14, 2019 -- Vaccinating against the common infant infection rotavirus not only cuts a child's odds of getting sick, it might also prevent them from developing type 1 diabetes later in life, new research suggests. Infants who got all of... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 14, 2019 Category: General Medicine Source Type: news

Common Infant Vaccine May Also Shield Kids From Type 1 Diabetes
FRIDAY, June 14, 2019 -- Vaccinating against the common infant infection rotavirus not only cuts a child's odds of getting sick, it might also prevent them from developing type 1 diabetes later in life, new research suggests. Infants who got all of... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 14, 2019 Category: General Medicine Source Type: news

Infants vaccinated against a stomach bug have a one-third lower risk of diabetes
The rotavirus vaccine - recommended for infants between two and four months of age - may reduce their risks of type 1 diabetes by a third, a new University of Michigan study suggests. (Source: the Mail online | Health)
Source: the Mail online | Health - June 13, 2019 Category: Consumer Health News Source Type: news

Lower risk of Type 1 diabetes seen in children vaccinated against 'stomach flu' virus
(Michigan Medicine - University of Michigan) Vaccinating babies against a virus that causes childhood 'stomach flu' greatly reduces their chance of getting so sick that they need hospital care, a new study shows. But the study also reveals a surprise: Getting fully vaccinated against rotavirus in the first months of life is associated with a lower risk of developing Type 1 diabetes later on. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 13, 2019 Category: Infectious Diseases Source Type: news

Podcast: Vaccines for preventing rotavirus diarrhoea: vaccines in use
Rotavirus infection is a common cause of diarrhoea and a variety of vaccines are used to try to prevent it. The evidence for these is examined in the fourth update of a Cochrane Review, published in March 2019 and we asked Hanna Bergman one of the authors based in the Cochrane Response team in London UK to tell us about the problem and the latest findings." Rotavirus infection is common across the world and although some babies and young children might not develop any symptoms, others might get so ill that they need to go into hospital and some may die. Most of the deaths associated with rotavirus occur in children in...
Source: Cochrane News and Events - June 6, 2019 Category: Information Technology Authors: Lydia Parsonson Source Type: news

How Long Does Fecal Shedding Occur for Oral Vaccines?
Discussion Vaccination has reduced infectious disease morbidity and mortality since its introduction. Vaccines can be given intramuscularly, subcutaneously or orally. Oral virus vaccines currently used in the US include rotavirus, cholera, typhoid and adenovirus. Adenovirus vaccine is used in military personnel. As these are attenuated viruses there is concern for household contacts who are immunocompromised who may inadvertently be exposed to the virus through fecal shedding. Additionally, there is a concern that the attenuated virus may mutate and revert back to its wild-form and potentially cause disease. Injectable po...
Source: PediatricEducation.org - March 25, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

VACCINE INSANITY: Multiple strains of deadly pig virus discovered in Rotavirus oral vaccines with no legitimate reason for their use
(Natural News) Isn’t it bad enough that today’s vaccinations contain neurotoxins, extreme allergens, genetically modified organisms, and DNA from abortions? Do we really need to find out that a popular childhood vaccine that’s highly recommended by the CDC contains two strains of a rare and deadly virus that’s killing pigs by the thousands in China?... (Source: NaturalNews.com)
Source: NaturalNews.com - February 11, 2019 Category: Consumer Health News Source Type: news

Rotavirus Vaccine May Protect Against Type 1 Diabetes
An Australian study found that in children up to 4 years old, the rate of Type 1 diabetes decreased by 14 percent in the years following the rotavirus vaccine ’ s introduction. (Source: NYT Health)
Source: NYT Health - January 30, 2019 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Diabetes Vaccination and Immunization Rotaviruses Source Type: news

Rotavirus Vaccine & T1D; Insulin Price Hikes; Genetic Thinness
(MedPage Today) -- News and commentary from the endocrinology world (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - January 25, 2019 Category: Cardiology Source Type: news

Rotavirus Vaccination Tied to Lower Rates of Type 1 Diabetes Rotavirus Vaccination Tied to Lower Rates of Type 1 Diabetes
Young kids who receive the rotavirus vaccine may be less likely to develop type 1 diabetes than children who don't get this routine childhood vaccination, an Australian study suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 24, 2019 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Drop in Infant Type 1 Diabetes Linked to Rotavirus Vaccination
Results from an observational study find that the introduction of a routine vaccine in Australia coincided with a fall in the incidence of the autoimmune condition. (Source: The Scientist)
Source: The Scientist - January 23, 2019 Category: Science Tags: News & Opinion Source Type: news

Rotavirus vaccination tied to lower rates of type 1 diabetes
(Reuters Health) - Young kids who receive the rotavirus vaccine may be less likely to develop type 1 diabetes than children who don't get this routine childhood vaccination, an Australian study suggests. (Source: Reuters: Health)
Source: Reuters: Health - January 22, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

Health Tip: Prevent Rotavirus
-- Rotavirus causes diarrhea, vomiting, fever and abdominal pain. It is highly contagious, especially among young children with weaker immune systems, the U.S. Centers for Disease Control and Prevention says. Children can become dehydrated and may... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 18, 2019 Category: General Medicine Source Type: news

Health Tip: Prevent Rotavirus
Title: Health Tip: Prevent RotavirusCategory: Health NewsCreated: 1/18/2019 12:00:00 AMLast Editorial Review: 1/18/2019 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - January 18, 2019 Category: Pediatrics Source Type: news

Rotavirus Causes Severe Diarrhea in Kids
Rotavirus is the leading cause of severe diarrhea in infants and young children worldwide, especially in children under 2 years of age. The highly contagious illness is most common in the winter and spring months. (Source: TMA News Room)
Source: TMA News Room - January 2, 2019 Category: Consumer Health News Source Type: news

Cost of rotavirus diarrhoea substantial in Thailand
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - January 1, 2019 Category: Drugs & Pharmacology Source Type: news

Rotavirus Is Still With Us--How to Prevent an Outbreak Rotavirus Is Still With Us--How to Prevent an Outbreak
Rotavirus outbreaks can affect almost anyone--healthy and unhealthy, young and old, vaccinated and unvaccinated.CDC Expert Commentary (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 3, 2018 Category: Consumer Health News Tags: Infectious Diseases Commentary Source Type: news

Rotavirus outsources cellular protein CK1 & #945; to assemble virus factories
(Baylor College of Medicine) Rotavirus outsources cellular protein CK1α to assemble virus factories. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 3, 2018 Category: Infectious Diseases Source Type: news

Rotarix preferred for rotavirus vax in Bangladesh, Ghana, Malawi
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - December 1, 2018 Category: Drugs & Pharmacology Source Type: news

Sugars and microbiome in mother's milk influence neonatal rotavirus infection
(Baylor College of Medicine) An international team of researchers reveals that complex interactions between sugars and the microbiome in human milk influence neonatal rotavirus infection and identifies maternal components that could improve the performance of live, attenuated rotavirus vaccines. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 27, 2018 Category: Infectious Diseases Source Type: news

Meningitis progress lags substantially behind that of other preventable diseases
(Meningitis Research Foundation) The global disease burden of meningitis remains unacceptably high, and progress lags substantially behind that of other vaccine-preventable diseases. The Institute for Health Metrics and Evaluation (IHME) Global Burden of Disease study showed that meningitis deaths reduced by just 21 percent globally between 1990-2016, whereas other preventable diseases such as measles, tetanus, and diarrhea due to rotavirus saw declines of 93 percent, 90.7 percent, and 57.9 percent, respectively, suggesting that progress in meningitis could have been substantially faster. (Source: EurekAlert! - Infectious ...
Source: EurekAlert! - Infectious and Emerging Diseases - November 13, 2018 Category: Infectious Diseases Source Type: news

Nine ways research could save the NHS money
This highlight provides nine treatments and initiatives that are cost effective for the NHS including weight loss surgery, misaligned shoulder fractures, rotavirus vaccine, public health interventions, oxygen levels for acute bronchiolitis in children, routine replacement of intravenous cannulae, behavioural activation, oral surgery in primary care, and uterine polyps. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 16, 2018 Category: Consumer Health News Source Type: news

The Number of Children Without Vaccinations Has Skyrocketed Since 2001, New Reports Find
The number of children who have not received vaccines for preventable diseases has quadrupled since 2001, to an estimated 100,000 individuals, according to a report released by the Centers for Disease Control and Prevention (CDC). Using data from the National Immunization Survey-Child, the CDC report published Thursday found that in 2017, “the percentage of children with no vaccinations by age 2 years increased from 0.9% for children born in 2011 to 1.3% for those born in 2015.” In 2001, that figure was only 0.3%. The survey found that children were least likely to have received vaccinations for hepatitis A and...
Source: TIME: Health - October 12, 2018 Category: Consumer Health News Authors: Wilder Davies Tags: Uncategorized onetime public health Source Type: news

New insight on rotavirus mechanics could lead to improved treatments
(eLife) Researchers have provided new insight on the mechanics of a virus that causes severe diarrhea and sickness in young children, according to a report published in eLife. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 11, 2018 Category: International Medicine & Public Health Source Type: news