Psoriatic arthropathy in patients with previous neoplasia: a case series of four patients treated with secukinumab and literature review
CONCLUSIONS: In conclusion, our case series, consisting of four PsA patients with concurrent neoplasia treated with secukinumab, showed no evidence of cancer progression and represents the first case of PsA described in the literature treated during active oncological disease, lending support to the safety of secukinumab for the treatment of patients with PsA and concomitant neoplasia.PMID:38639525 | DOI:10.26355/eurrev_202404_35919 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: U G Massafra F Giovannangeli A Migliore Source Type: research
Orthopedic Articular and Periarticular Joint Infections
Emerg Med Clin North Am. 2024 May;42(2):249-265. doi: 10.1016/j.emc.2024.01.002. Epub 2024 Mar 2.ABSTRACTAcute nontraumatic joint pain has an extensive differential. Emergency physicians must be adept at identifying limb and potentially life-threatening infection. Chief among these is septic arthritis. In addition to knowing how these joint infections typically present, clinicians need to be aware of host and pathogen factors that can lead to more insidious presentations and how these factors impact the interpretation of diagnostic tests.PMID:38641390 | DOI:10.1016/j.emc.2024.01.002 (Source: The Medical Clinics of North America)
Source: The Medical Clinics of North America - April 19, 2024 Category: General Medicine Authors: Pim Jetanalin Yanint Raksadawan Pholaphat Charles Inboriboon Source Type: research
Psoriatic arthropathy in patients with previous neoplasia: a case series of four patients treated with secukinumab and literature review
CONCLUSIONS: In conclusion, our case series, consisting of four PsA patients with concurrent neoplasia treated with secukinumab, showed no evidence of cancer progression and represents the first case of PsA described in the literature treated during active oncological disease, lending support to the safety of secukinumab for the treatment of patients with PsA and concomitant neoplasia.PMID:38639525 | DOI:10.26355/eurrev_202404_35919 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 19, 2024 Category: Drugs & Pharmacology Authors: U G Massafra F Giovannangeli A Migliore Source Type: research
Severe fibromyalgia alleviated by the unique muscle relaxation method of applying low force: A case report
Medicine (Baltimore). 2024 Apr 19;103(16):e37929. doi: 10.1097/MD.0000000000037929.ABSTRACTRATIONALE: Fibromyalgia (FM) is characterized by idiopathic persistent chronic pain in the ligaments or musculoskeletal system, and more than half of the patients with FM might have migraine headaches. Direct musculoskeletal intervention could be a non-pharmacological management to relieve symptoms. However, patients with severe FM often have intense pain from only a soft touch, thereby rendering musculoskeletal intervention challenging.PATIENT CONCERNS: A 47-year-old man had progressing intense pain, and this affected his everyday l...
Source: Pain Physician - April 19, 2024 Category: Anesthesiology Authors: Haruka Amitani Ryusei Nishi Takamasa Fukumoto Kazumasa Hamada Ryuichi Kato Takako Yamamoto Yuuki Fuku Kenichiro Sagiyama Akihiro Asakawa Source Type: research
A single chain variable fragment antibody (Tn 64) cognate to fibronectin type III repeats promotes corneal wound healing by inhibiting fibrosis
We examined corneal epithelial as well as stromal wound healing through Tn64 binding to Tn fn 3-5, using a human corneal epithelial cell (HCEC) line, primary cultures of human corneal fibroblasts (HCFs), and an ex-vivo corneal organ culture model. Tn64 enhanced proliferation and adhesion of corneal epithelial cells, while inhibiting the migration of corneal fibroblasts and myofibroblasts. Tn64 appears to attenuate inflammation through downregulation of TNF-α, prevent corneal fibrosis by limiting fibronectin polymerization, and promote regeneration of corneal epithelia and stroma, suggesting that it could be developed as a...
Source: International Immunopharmacology - April 19, 2024 Category: Allergy & Immunology Authors: Ashu Shukla Vyshak Suresh Parul Chawla Gupta Maryada Sharma Uma Nahar Saikia Jagat Ram Manni Luthra-Guptasarma Source Type: research
Bone health and physical activity in adolescents with juvenile idiopathic arthritis: a cross-sectional case-control study
Adolescents with juvenile idiopathic arthritis (JIA) tend to engage in less physical activity than their typically developing peers. Physical activity is essential for bone development and reduced physical act... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - April 19, 2024 Category: Rheumatology Authors: Egi Vasil, Colleen M. Nesbitt, Clodagh Toomey, Gregor Kuntze, Shane Esau, Carolyn A. Emery and Leigh Gabel Tags: Research article Source Type: research
Retraction Note: Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4+CCR6+ Th/Treg cell subset imbalance in ankylosing spondylitis
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 19, 2024 Category: Rheumatology Authors: Yanfeng Wu, Mingliang Ren, Rui Yang, Xinjun Liang, Yuanchen Ma, Yong Tang, Lin Huang, Jichao Ye, Keng Chen, Peng Wang and Huiyong Shen Tags: Retraction Note Source Type: research
Measuring synovial thickness on knee MRI in pediatric patients with arthritis: is contrast necessary?
ConclusionUnenhanced knee MRI is equivalent to contrast-enhanced MRI in assessment of synovial thickness using conventional MRI sequences. Contrast material helped improve inter-reader reliability.Graphical abstract (Source: Pediatric Radiology)
Source: Pediatric Radiology - April 19, 2024 Category: Radiology Source Type: research
Genes, Vol. 15, Pages 513: Genome Sequencing in an Individual Presenting with 22q11.2 Deletion Syndrome and Juvenile Idiopathic Arthritis
In this report, the authors describe a patient presenting with a short stature, neurodevelopmental delay, and dysmorphisms, who had an episode of polyarticular arthritis at the age of three years and eight months, resulting in severe joint limitations, and was later diagnosed with 22q11.2 deletion syndrome. Investigation through Whole Genome Sequencing revealed that he had no pathogenic or likely-pathogenic variants in both alleles of the MIF gene or in genes associated with monogenic arthritis (LACC1, LPIN2, MAFB, NFIL3, NOD2, PRG4, PRF1, STX11, TNFAIP3, TRHR, UNC13DI). However, the patient presented 41 risk polymorphisms...
Source: Genes - April 19, 2024 Category: Genetics & Stem Cells Authors: Ruy Pires de Oliveira-Sobrinho Simone Appenzeller Ianne Pessoa Holanda J úlia Lôndero Heleno Josep Jorente on behalf of the Rare Genomes Project Consortium on behalf of the Rare Genomes Project Consortium T ársis Paiva Vieira Carlos Eduardo Steiner Tags: Case Report Source Type: research
FDA Approves New Biosimilars to Denosumab with an Interchangeable Designation
The FDA has approved the first interchangeable biosimilars for denosumab. (Source: The Rheumatologist)
Source: The Rheumatologist - April 18, 2024 Category: Rheumatology Authors: Michele B. Kaufman, PharmD, BCGP Tags: Biologics/DMARDs Conditions Drug Updates Osteoarthritis and Bone Disorders denosumab denosumab-bbdz Jubbonti Prolia Wyost Xgeva Source Type: research
Clinically Significant Pain Relief with a Non-Opioid Drug
In a phase 3 trial, treatment with VX-548 led to statistically and clinically significant improvements in pain compared with placebo. (Source: The Rheumatologist)
Source: The Rheumatologist - April 18, 2024 Category: Rheumatology Authors: Michele B. Kaufman, PharmD, BCGP Tags: Analgesics Drug Updates Pain Syndromes VX-548 Source Type: research
Analysis of risk factors associated with diffuse alveolar haemorrhage in patients with ANCA-associated vasculitis and construction of a risk prediction model using line graph
CONCLUSIONS: The new nomogram, which included age, Hb, ESR, PLT and haematuria as variables, had the potential to predict the risk of AAV patients complicated with DAH.PMID:38634373 | DOI:10.55563/clinexprheumatol/7m21vr (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 18, 2024 Category: Rheumatology Authors: Xuanwei Li Congyuan Ma Jiamei Xu Meng Zhang Qin Xiang Yue Li Wenlai Li Ping Zhu Source Type: research
Endothelial mesenchymal transition promotes pannus formation in ankylosing spondylitis by activation of TGF-β/SMAD signalling pathway
CONCLUSIONS: Our findings show that EndMT is involved in the promotion of pannus formation by TGF-β/SMAD signalling pathway activation in AS.PMID:38634365 | DOI:10.55563/clinexprheumatol/9u1vzp (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 18, 2024 Category: Rheumatology Authors: Shaojie Li Zhiduo Hou Yao Gong Jianhua Peng Hongjin Liang Danmin Wang Ling Lin Source Type: research
Lower total cholesterol and triglyceride levels in ankylosing spondylitis than non-inflammatory rheumatic disease controls in a 1978-98 study: a potential effect of increased physical energetics in manual occupations in the pre-2000 chronologic era
CONCLUSIONS: In the 1978-98 survey, AS had significantly lower mean serum cholesterol and triglyceride levels than NIRD control patients. Associated manual labour occupations may have significantly contributed to results, possibly related to increased energy expenditures from physical activity in the pre-2000 era.PMID:38634375 | DOI:10.55563/clinexprheumatol/u41mn1 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 18, 2024 Category: Rheumatology Authors: Alfonse T Masi Ponnaiah C Mohan Tsr Murugan Chadrick R Evans Michael J Ryan Megan L Brezka Vaughn Hanna Gerald R Cooper Jean C Aldag Source Type: research
Effectiveness and safety of filgotinib in rheumatoid arthritis patients: data from the GISEA registry
CONCLUSIONS: In an Italian real-life setting, filgotinib is confirmed to be safe and with a good effectiveness profile both in monotherapy and without glucocorticoids.PMID:38634362 | DOI:10.55563/clinexprheumatol/b40rv4 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 18, 2024 Category: Rheumatology Authors: Marco Fornaro Roberto Caporali Martina Biggioggero Serena Bugatti Ludovico De Stefano Alberto Cauli Mattia Congia Fabrizio Conti Maria Sole Chimenti Chiara Bazzani Simone Perniola Fabiola Atzeni Giovanni Lapadula Gianfranco Ferraccioli Florenzo Iannone fr Source Type: research
