The unique interplay between antinuclear antibodies and nuclear molecules in the pathogenesis of SLE
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that primarily affects young women and causes a wide range of inflammatory manifestations. The hallmark of SLE is the production of antibodies to components of the cell nucleus (antinuclear antibodies or ANAs). These antibodies can bind to DNA, RNA and protein complexes with nucleic acids. Among ANAs, antibodies to DNA (anti-DNA) are markers for classification and disease activity, waxing and waning in many patients. In the blood, anti-DNA antibodies can bind DNA to form immune complexes with two distinct roles in pathogenesis: renal deposition to provok...
Source: Arthritis and Rheumatology - April 16, 2024 Category: Rheumatology Authors: David S. Pisetsky Tags: Review Source Type: research
Cluster analysis of long COVID symptoms for deciphering a syndrome and its long-term consequence
AbstractThe long-term symptoms of COVID-19 are the subject of public and scientific discussions. Understanding how those long COVID symptoms co-occur in clusters of syndromes may indicate the pathogenic mechanisms of long COVID. Our study objective was to cluster the different long COVID symptoms. We included persons who had a COVID-19 and assessed long-term symptoms (at least 4 weeks after first symptoms). Hierarchical clustering was applied to the symptoms as well as to the participants based on the Euclidean distanceh of the log-values of the answers on symptom severity. The distribution of clusters within our cohort ...
Source: Immunologic Research - April 16, 2024 Category: Allergy & Immunology Source Type: research
Multimorbidity and the Etiology of Schizophrenia
AbstractPurpose of ReviewA global study of multimorbidity in schizophrenia, especially of the association with physical conditions, might offer much needed etiological insights.Recent FindingsOur review suggests that life-style factors and medication related to schizophrenia are only part of the explanation of the increase in risk for cardiovascular, metabolic, pulmonary disorders, and some cancers. Positive associations with autoimmune disorders (with the exception of rheumatoid arthritis) and epilepsy are promising avenues of research but to date have not been fully exploited. The same holds for the negative comorbidit...
Source: Current Psychiatry Reports - April 16, 2024 Category: Psychiatry Source Type: research
The Oral –Lung Microbiome Axis in Connective Tissue Disease-Related Interstitial Lung Disease
Semin Respir Crit Care Med DOI: 10.1055/s-0044-1785673Connective tissue disease-related interstitial lung disease (CTD-ILD) is a frequent and serious complication of CTD, leading to high morbidity and mortality. Unfortunately, its pathogenesis remains poorly understood; however, one intriguing contributing factor may be the microbiome of the mouth and lungs. The oral microbiome, which is a major source of the lung microbiome through recurrent microaspiration, is altered in ILD patients. Moreover, in recent years, several lines of evidence suggest that changes in the oral and lung microbiota modulate the pulmonary immune re...
Source: Seminars in Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Bongers, Kale S. Massett, Angeline O'Dwyer, David N. Tags: Review Article Source Type: research
Peripheral ulcerative keratitis associated with tralokinumab therapy: a case report and review of IL-13 inhibitor-associated ocular surface disease
ConclusionThis case report documents ulcerative keratitis occurring in association with tralokinumab therapy for AD, which has previously been described with dupilumab but not tralokinumab. This report demonstrates the need for vigilant ocular surface monitoring for patients on tralokinumab and illustrates successful management and long-term control of adverse ocular events associated with this medication. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - April 16, 2024 Category: Opthalmology Source Type: research
Efficacy and Safety of Secukinumab in US Patients with Psoriatic Arthritis: A Subgroup Analysis of the Phase 3 FUTURE Studies
ConclusionsIn this challenging sub-population of US patients with PsA, secukinumab provided rapid improvements in disease activity and QoL. Patients with PsA and active psoriasis might benefit more from secukinumab 300 mg than 150 mg. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - April 16, 2024 Category: Rheumatology Source Type: research
Efficacy and safety of tofacitinib for chronic plaque psoriasis and psoriatic arthritis: a systematic review and meta-analysis of randomized controlled trials
ConclusionsA comprehensive analysis revealed that tofacitinib has a positive effect on addressing skin and joint symptoms, as well as improving the quality of life for patients with chronic plaque psoriasis and psoriatic arthritis (PsA). However, the safety of the drug ’s long-term usage even requires further validation.Key Points• In 6 analyses involving a total of 1393 patients, tofacitinib exhibits positive effect on the treatment of both chronic plaque psoriasis and psoriatic arthritis (PsA).• Although dose-based subgroup analyses have demonstrated effectiveness. Some studies indicate that the 5-mg dose (twice da...
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
Identification of EPSTI1 as a new potential biomarker for SLE based on GEO database
ConclusionTogether,EPSTI1 was found to be a potential biomarker for SLE, closely related to T cell immune imbalance.Key Points• EPSTI1 expression was significantly increased in PBMCs of SLE patients.• EPSTI1 was positively correlated with disease activity and T cell activation- or differentiation-associated genes in SLE patients.• EPSTI1 might have a good diagnostic value for SLE. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
Raman spectroscopic analysis of joint capsule calcification of the fingers
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
A retrospective cohort study of Epstein-Barr virus infection status and systemic lupus erythematosus
ConclusionsPatients with SLE with lytic EBV infection have higher disease activity and take longer to achieve remission. Our study furthers our understanding of the relationship between SLE and EBV infection and may inform better treatment practices in the future. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
How can clinicians enhance self-efficacy beliefs in osteoarthritis? An overview of systematic reviews with meta-analysis
AbstractThis overview of reviews aimed to synthesize the effectiveness of non-pharmacological approaches to enhance self-efficacy in people with osteoarthritis. The CINAHL, Embase, PsycINFO, PubMed, SPORTDiscus, and the Cochrane Library databases were searched from inception to December 2023. We considered systematic reviews with meta-analysis of randomized clinical trials evaluating any non-pharmacological intervention. We used AMSTAR 2 to assess the methodological quality of reviews. The overlap between reviews was calculated. We included eight systematic reviews with meta-analysis evaluating 30 different clinical trials...
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
High Frequency of Diffuse Idiopathic Skeletal Hyperostosis in Patients With Obesity Hypoventilation Syndrome
J Rheumatol. 2024 Apr 15:jrheum.2024-0081. doi: 10.3899/jrheum.2024-0081. Online ahead of print.ABSTRACTDiffuse idiopathic skeletal hyperostosis (DISH) is known to be associated with metabolic syndrome and with obesity in particular. The prevalence of DISH increases with age, with an average of 10% in those aged 70 years and older.PMID:38621799 | DOI:10.3899/jrheum.2024-0081 (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2024 Category: Rheumatology Authors: Shay Brikman Reuven Mader Amir Bieber Source Type: research
Knowledge of and stated adherence to the 2020 ACR Guideline for Gout Management: Results of a survey of US rheumatologists
CONCLUSION: The self-reported practice of the surveyed US rheumatologists was generally concordant with the 2020 ACR Guideline for the Management of Gout. However, there were gaps in guideline knowledge and stated adherence among rheumatologists, mainly concerning the dosing of treatment regimens.PMID:38621796 | DOI:10.3899/jrheum.2023-0981 (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2024 Category: Rheumatology Authors: Naomi Schlesinger Michael H Pillinger Peter E Lipsky Source Type: research
Patient-Initiated Follow-Up
J Rheumatol. 2024 Apr 15:jrheum.2024-0302. doi: 10.3899/jrheum.2024-0302. Online ahead of print.ABSTRACTIn the contemporary healthcare climate, we are acutely aware that our resources are finite. This is particularly pertinent in government-funded healthcare settings, where clinical teams often face the challenge of meeting increasing patient demand with static or dwindling capacity.1-4.PMID:38621794 | DOI:10.3899/jrheum.2024-0302 (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2024 Category: Rheumatology Authors: Edward Alveyn James Galloway Laura C Coates Source Type: research
