Commentary on: ‘Do we understand sex-related differences governing dimorphic disease mechanisms in preclinical animal models of osteoarthritis?’ by Dvir-Ginzberg et al.
The commentary by Dvir-Ginzberg et al. challenges the field to improve rigor by evaluating OA mechanisms and therapeutic interventions in both male and female mice. The authors use the lens of senescence to evaluate how the preferential use of male mice has possibly skewed the current understanding of OA. Much like sex, age is a biological variable with a striking mismatch between clinical reality and preclinical models. There is a sharp increase in OA incidence after the age of 501, and yet most studies use joint injury in young mice to initiate consistent OA, with a defined window for intervention. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 27, 2024 Category: Rheumatology Authors: Dr. Brian Diekman Source Type: research

Low-frequency and rare genetic variants associated with rheumatoid arthritis risk
Nature Reviews Rheumatology, Published online: 27 March 2024; doi:10.1038/s41584-024-01096-7Rheumatoid arthritis has a substantial genetic component, some of which is associated with the presence of low-frequency or rare variants. Next-generation sequencing in large and well-defined cohorts can continue to identify these variants and thereby contribute to the future prediction, diagnosis and treatment of rheumatoid arthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 27, 2024 Category: Rheumatology Authors: Vanessa L. Kronzer Jeffrey A. Sparks Soumya Raychaudhuri James R. Cerhan Source Type: research

Cancers, Vol. 16, Pages 1298: Copy Number Analysis of 9p24.1 in Classic Hodgkin Lymphoma Arising in Immune Deficiency/Dysregulation
In this study, we examined PD-L1 expression levels and 9p24.1 copy number alterations in 27 patients with classic Hodgkin lymphoma arising from immune deficiency/dysregulation. All patients demonstrated PD-L1 protein expression and harbored 9p24.1 copy number alterations on the tumor cells. When comparing clinicopathological data and associations with 9p24.1 copy number features, the copy gain group showed a significantly higher incidence of extranodal lesions and clinical stages than the amplification group. Notably, all cases in the amplification group had latency type II, while 6/8 (75%) in the copy gain group had laten...
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: Kumiko Ohsawa Shuji Momose Asami Nishikori Midori Filiz Nishimura Yuka Gion Keisuke Sawada Morihiro Higashi Michihide Tokuhira Jun-ichi Tamaru Yasuharu Sato Tags: Article Source Type: research

Case report: Paralytic ileus resulted from nirmatrelvir/ritonavir-tacrolimus drug-drug interaction in a systemic lupus erythematosus patient with COVID-19
We present a case of paralytic ileus resulting from tacrolimus toxicity mediated by the use of nirmatrelvir/ritonavir in a patient with systemic lupus erythematosus (SLE). A 37-year-old female SLE patient was prescribed nirmatrelvir/ritonavir without discontinuing tacrolimus. She presented to the emergency room with symptoms of paralytic ileus including persistent abdominal pain, nausea, and vomiting, which were verified to be associated with tacrolimus toxicity. The blood concentration of tacrolimus was measured >30 ng/mL. Urgent medical intervention was initiated, while tacrolimus was withheld. The residual concentra...
Source: Frontiers in Pharmacology - March 27, 2024 Category: Drugs & Pharmacology Source Type: research

Cannabidiol exerts multitarget immunomodulatory effects on PBMCs from individuals with psoriasis vulgaris
ConclusionsThese data uncover new potential immunomodulatory properties of this cannabinoid suggesting a possible therapeutic action in the treatment of multiple inflammatory skin diseases. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 27, 2024 Category: Allergy & Immunology Source Type: research

Asymmetric darkened knuckles with subclinical myopathy revealed anti-Mi2b positive dermatomyositis
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research

Identification and verification of inflammatory biomarkers for primary Sj ögren’s syndrome
ConclusionFour inflammation-associated biomarkers (LY6E, EIF2AK2, IL15, and CXCL10) were explored, and the underlying regulatory mechanisms and targeted drugs associated with these biomarkers were preliminarily investigated according to a series of bioinformatics methods based on the online datasets of pSS, which provided a reference for understanding the pathogenesis of pSS.Key Points•Inflammation-associated biomarkers (LY6E, EIF2AK2, IL15, and CXCL10) were firstly identified in Sj ögren’s syndrome based on LASSO and SVM-RFE analyses.•CXCL10, EIF2AK2 and LY6E were prominently positively correlated with immature B c...
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research

Evaluation of Type 2 SLE symptoms in patients with a range of lupus nephritis activity
ConclusionsWhile Type 2 SLE symptoms are common in SLE, our findings suggest that patients with active nephritis experience significant Type 2 SLE symptoms that may be ameliorated as nephritis improves. We also observed that non-nephritis patients had a similar burden of Type 2 SLE symptoms as patients with active nephritis, despite having on average lower Type 1 SLE activity. Therefore, the etiology of Type 2 SLE symptoms is likely multifactorial and may be driven by inflammatory and non-inflammatory biopsychosocial factors.Key Points• Patients with active nephritis experienced significant Type 2 symptoms that may be am...
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research

Recurrent miscarriage and low-titer antiphospholipid antibodies
ConclusionNoteworthy distinctions in laboratory parameters were identified between the low-titer and medium-high titer groups. However, when appropriately treated, the fetal-maternal outcomes were comparable in both groups. Timely intervention by clinicians is imperative to enhance pregnancy outcomes in patients experiencing recurrent miscarriage with low levels of aPL.Key Points•This study challenges the conventional belief that only the higher antiphospholipid antibodies (aPL) titers directly correlated with worse pregnancy outcomes, which emphasized the importance of patients with low titer positive aPL-positive RM.â€...
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research

Commentary on the respiratory infection risk in primary Sj ögren’s syndrome complicated with interstitial lung disease
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research

Regarding the association between innate immune function with disease activity in systemic lupus erythematosus patients
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research

Real respiratory infection risk in  primary Sjögren’s syndrome complicated with interstitial lung disease
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research

Commentary on “Digital gangrene in systemic sclerosis patients: not only due to the microvascular disease’’
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research

Increased inferior vena cava wall thickness as a sign of extensive venous inflammation in Beh çet’s Disease
ConclusionThis study shows that venous wall inflammation is not limited to lower extremity veins and is also present in IVC walls of BD patients regardless of IVC involvement. Vascular wall inflammation is probably a widespread vascular event of all venous walls in BD.Key Points• Venous wall inflammation is not limited to lower extremity veins and is present also in IVC wall in Behçet’s disease.• Extensive venous wall inflammation in Behçet’s disease includes large venous structures despite not being clinically involved. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research

ANCA-associated vasculitis presenting with isolated neurological manifestations in a patient with cocaine abuse: a case report and literature review
We present a unique case of AAV with isolated neurological manifestations presenting with multiple cranial neuropathies, leptomeningeal enhancement on imaging and histopathologic evidence of small-vessel vasculitis in the leptomeninges and brain and extensive dural fibrosis in a patient with cocaine abuse. The patient ’s progressive neurological deficits were controlled after starting immunosuppression with rituximab and prednisone. We also reviewed the literature to provide the diagnostic overview of AAV and evaluate intervention options. To our knowledge, this is the first case of AAV with isolated neurologic al manife...
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research