Exploring the immunomodulatory potential of Brahmi (Bacopa monnieri) in the treatment of invasive ductal carcinoma
AbstractBacopa monnieri (L) Wettst, commonly known as Brahmi, stands as a medicinal plant integral to India ’s traditional medical system, Ayurveda, where it is recognized as a “medhya rasayana”—a botanical entity believed to enhance intellect and mental clarity. Its significant role in numerous Ayurvedic formulations designed to address conditions such as anxiety, memory loss, impaired cognition, and diminished concentration underscores its prominence. Beyond its application in cognitive health, Brahmi has historically been employed in Ayurvedic practices for the treatment of inflammatory diseases, including arthr...
Source: Medical Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research
Osteochondral fluid transport in an ex vivo system
The objectives of this study were to (1) test for diffusion of 3kDa molecular tracers from bone-to-cartilage and (2) assess potential differences in bone-to-cartilage fluid transport between different loading conditions. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 15, 2024 Category: Rheumatology Authors: Brady David Hislop, Ara K. Mercer, Alexandria G. Whitley, Erik P. Myers, Marie Mackin, Chelsea M. Heveran, Ronald K. June Tags: Brief Report Source Type: research
Influenza vaccine uptake in juvenile idiopathic arthritis: a multi-centre cross-sectional study
Conclusion: Despite variations among countries, the uptake of influenza vaccines remains low in children with JIA. Improving awareness among families about the importance of influenza vaccination may increase vaccination rates in children with rheumatic diseases.What is Known:• Rheumatic children are at increased risk for influenza infection due to immunosuppressive therapy and immune dysregulation.• Influenza vaccine is formally recommended to children with rheumatic diseases.What is New:• This multicentre study showed that influenza vaccine uptake rates remain suboptimal among children with Juvenile Idiopathic Ar...
Source: European Journal of Pediatrics - April 15, 2024 Category: Pediatrics Source Type: research
Sensors, Vol. 24, Pages 2526: Design of a Self-Measuring Device Based on Bioelectrical Impedance Analysis for Regular Monitoring of Rheumatoid Arthritis
This study underscores the significance of considering patients’ disease activity during intervals between hospital visits and introduces a novel approach to self-RA care. (Source: Sensors)
Source: Sensors - April 15, 2024 Category: Biotechnology Authors: JuYoung Jeong Yun Soo Park Eunchae Lee SeoYoun Choi Dokshin Lim Jiho Kim Tags: Article Source Type: research
Crystal Structure of Bimekizumab Fab Fragment in Complex with IL-17F Provides Molecular Basis for Dual IL-17A and IL-17F Inhibition
Psoriasis (PSO) and psoriatic arthritis (PsA) are Th17-driven inflammatory diseases where interleukin (IL)-17 cytokines like IL-17A and IL-17F promote disease pathogenesis. There are six IL-17 isoforms (IL-17A –F) and five IL-17 receptors (IL-17RA–E; Liu et al., 2020). IL-17 cytokines primarily function as homodimers, although IL-17A and IL-17F can heterodimerize (Brembilla et al., 2018). IL-17A and IL-17F genes share the same chromosomal location (6p12), their proteins share ∼55% sequence homology, and both cytokines signal through the IL-17RA/RC heterodimeric complex (Brembilla et al., 2018, Liu et al., 2020). (Sou...
Source: Journal of Investigative Dermatology - April 15, 2024 Category: Dermatology Authors: Ralph Adams, Christopher G. Bunick, Alastair D.G. Lawson, Braulio Gomez, Stevan Shaw Tags: Letters to the Editor Source Type: research
Kawasaki disease in Kenya and review of the African literature
Kawasaki disease has been described across the globe, although publications from Africa are limited. To our knowledge, there are no publications on Kawasaki disease from Kenya, which triggered this report. (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - April 14, 2024 Category: Rheumatology Authors: A. Migowa, CM. Njeru, E. Were, T. Ngwiri, I. Colmegna, C. Hitchon and R. Scuccimarri Tags: Research article Source Type: research
Adiposity and cartilage lesions following ACL reconstruction
To determine if global, central, or peripheral adiposity is associated with prevalent and worsening cartilage lesions following anterior cruciate ligament reconstruction (ACLR). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 14, 2024 Category: Rheumatology Authors: Harvi F. Hart, Kay M. Crossley, Brooke E. Patterson, Ali Guermazi, Trevor B. Birmingham, Chris Koskoletos, Am élie Michaud, Alysha De Livera, Adam G. Culvenor Source Type: research
Targeting Epigenetic and Post-translational Modifications Regulating Pyroptosis for the Treatment of Inflammatory Diseases
Pharmacol Res. 2024 Apr 11:107182. doi: 10.1016/j.phrs.2024.107182. Online ahead of print.ABSTRACTInflammatory diseases, including infectious diseases, diabetes-related diseases, arthritis-related diseases, neurological diseases, digestive diseases, and tumor, continue to threaten human health and impose a significant financial burden despite advancements in clinical treatment. Pyroptosis, a pro-inflammatory programmed cell death pathway, plays an important role in the regulation of inflammation. Moderate pyroptosis contributes to the activation of native immunity, whereas excessive pyroptosis is associated with the occurr...
Source: Cell Research - April 13, 2024 Category: Cytology Authors: None Ri-Wen Yu-Hang Yang Tie-Ning Zhang Chun-Feng Liu Ni Yang Source Type: research
Incidence of Uveitis in Patients With Axial Spondylarthritis Treated With Biologics or Targeted Synthetics: A Systematic Review and Network Meta ‐Analysis
ConclusionAnti-TNF mAbs, JAKi, and anti –IL-17 appear protective against AU events in individuals with AxSpA, with no significant differences in risk of AU between treatments. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 13, 2024 Category: Rheumatology Authors: Katie Bechman,
Zijing Yang,
Maryam Adas,
Deepak Nagra,
Ali S U ğuzlar,
Mark D. Russell,
Nicky Wilson,
Sophia Steer,
Sam Norton,
James Galloway Tags: Full Length Source Type: research
Construct validity, reliability, and threshold value for treatment goals of the Thai version of the 12 ‐item Psoriatic Arthritis Impact of Disease Questionnaire for patients with psoriatic arthritis
ConclusionsThe Thai-PsAID is a valid, reliable, and feasible tool for measuring PsA prognosis. A cutoff of 2.7 accurately discriminates MDA and PASS and indicates no need for medication escalation. The Thai-PsAID may be used as a standalone measure. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 13, 2024 Category: Rheumatology Authors: Praveena Chiowchanwisawakit,
Annop Orawongpaisarn,
Wanruchada Katchamart Tags: ORIGINAL ARTICLE Source Type: research
Incidence of Uveitis in Patients With Axial Spondylarthritis Treated With Biologics or Targeted Synthetics: A Systematic Review and Network Meta ‐Analysis
ConclusionAnti-TNF mAbs, JAKi, and anti –IL-17 appear protective against AU events in individuals with AxSpA, with no significant differences in risk of AU between treatments. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 13, 2024 Category: Rheumatology Authors: Katie Bechman,
Zijing Yang,
Maryam Adas,
Deepak Nagra,
Ali S U ğuzlar,
Mark D. Russell,
Nicky Wilson,
Sophia Steer,
Sam Norton,
James Galloway Tags: Full Length Source Type: research
GSE228306 Wnt signaling regulates chemokine production and cell migration of circulating human monocytes
Contributors : Natalie Zelikson ; Shaina Ben ; Michal Caspi ; Raneen Tarabe ; Yonatan Shaleve ; Yael Peri-Paz Basson ; Oshrat Tayer-Shifman ; Elad Goldberg ; Shaye Kivity ; Rina Rosin-ArbesfeldSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe β-catenin dependent canonical Wnt signaling pathway plays a crucial role in maintaining normal homeostasis. However, when dysregulated, Wnt signaling is closely associated with various pathological conditions, including inflammation and different types of cancer.Here, we show a new connection between the leukocyte inflammatory respon...
Source: GEO: Gene Expression Omnibus - April 13, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with risk of rheumatoid arthritis in the U.S. adult population
Per- and polyfluoroalkyl substances (PFAS) are known environmental contaminants with immunosuppressive properties. Their connection to rheumatoid arthritis (RA), a condition influenced by the immune system, is... (Source: Environmental Health)
Source: Environmental Health - April 13, 2024 Category: Environmental Health Authors: Jian-Chao Qiao, Zhen-Hua Li, Yu-Bo Ma, Hui-Ya Ma, Meng-Yue Zhang, Xiu-Jun Zhang and Cheng-Yang Hu Tags: Research Source Type: research
Tofacitinib and Peficitinib inhibitors of Janus kinase for autoimmune diseases treatments: A Quantum Biochemistry Description
Phys. Chem. Chem. Phys., 2024, Accepted Manuscript DOI: 10.1039/D3CP06332A, PaperJackson Lima Amaral, Naiara Lucredi, Victor L. B. Fran ça, Samuel J. M. Santos, Francisco F. Maia, Pablo A. Morais, Pedro F. N. Souza, Jurandir F. Comar, Valder N. Freire Autoimmune inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis are associated with uncontrolled production of cytokines leading to the pronounced inflammatory response of these disorders. The therapy is... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 12, 2024 Category: Chemistry Authors: Jackson Lima Amaral Source Type: research
Standing on Shoulders: Interferon Research From Viral Interference to Lupus Pathogenesis and Treatment
The discovery of interferon in the 1950s represents much more than the identification of the first cytokine and the key mediator of antiviral host defense. Defining the molecular nature and complexity of the type I interferon family, as well as its inducers and molecular mechanisms of action, was the work of investigators working at the highest level and producing insights of great consequence. Current knowledge of receptor –ligand interactions, cell signaling, and transcriptional regulation derives from studies of type I interferon. It is on the shoulders of the giants who produced that knowledge that others stand and h...
Source: Arthritis and Rheumatology - April 12, 2024 Category: Rheumatology Authors: Mary K. Crow,
Mikhail Olferiev,
Kyriakos A. Kirou Tags: Review Source Type: research
