Ethics Forum: What Are Conflicts of Interest?
Results from an ethics survey presented to attendees at the 2018 ACR/ARHP Annual Meeting highlight the complexities and challenges of assessing potential conflicts of interest. (Source: The Rheumatologist)
Source: The Rheumatologist - October 17, 2019 Category: Rheumatology Authors: Thomas R. Collins Tags: Ethics 2018 ACR/ARHP Annual Meeting Committee on Ethics and Conflict of Interest Jane Kang Source Type: research

Association among anti-citrullinated protein antibody status, erosive disease and healthcare resource utilization in patients with rheumatoid arthritis.
Conclusions: ACPA seropositivity with erosive disease was associated with higher rates of HCRU compared with seropositivity without erosions. These findings suggest that providers may want to manage anti-CCP + patients aggressively to achieve better disease control to prevent the development of erosions and the associated increase in HCRU. PMID: 31612736 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 17, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Differential diagnosis of multiple sclerosis and other inflammatory CNS diseases
Publication date: Available online 15 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Paula Wildner, Mariusz Stasiołek, Mariola MatysiakAbstractMultiple sclerosis (MS) is the most common acquired demyelinating disorder of the central nervous system (CNS). Diagnosing MS can be very challenging owing to its variable clinical features and lack of specific tests. Magnetic resonance imaging (MRI) is a key measure in this process. Although white matter lesions on brain MRI are regarded as a hallmark of MS, they are a common radiological finding and their pattern may overlap in particular CNS inflammatory ...
Source: Multiple Sclerosis and Related Disorders - October 17, 2019 Category: Neurology Source Type: research

Boswellic Acids as Natural Anticancer Medicine: Precious Gift to Humankind
Publication date: Available online 15 October 2019Source: Journal of Herbal MedicineAuthor(s): Tarun Sharma, Snehasis JanaAbstractBoswellic acids (BAs) are the important active constituents of the plant Boswellia serrata which has been widely used for the treatment of several acute and chronic inflammatory diseases. These acids have shown their very potent anti-inflammatory activities in both in vitro and in vivo animal models. Also, their anti-arthritic, anti-rheumatic, anti-diarrhoeal, anti-hyperlipidemic, anti-asthmatic, anticancer, anti-microbial, analgesic activity, hepatoprotective, and immunomodulatory activities ha...
Source: Journal of Herbal Medicine - October 17, 2019 Category: Complementary Medicine Source Type: research

A Jack of All Trades: Impact of Glucocorticoids on Cellular Cross-Talk in Osteoimmunology
Glucocorticoids (GCs) are known to have a strong impact on the immune system, metabolism, and bone homeostasis. While these functions have been long investigated separately in immunology, metabolism, or bone biology, the understanding of how GCs regulate the cellular cross-talk between innate immune cells, mesenchymal cells, and other stromal cells has been garnering attention rather recently. Here we review the recent findings of GC action in osteoporosis, inflammatory bone diseases (rheumatoid and osteoarthritis), and bone regeneration during fracture healing. We focus on studies of pre-clinical animal models that enable...
Source: Frontiers in Immunology - October 17, 2019 Category: Allergy & Immunology Source Type: research

Predictive genetic biomarkers for the efficacy of methotrexate in rheumatoid arthritis: a systematic review
The Pharmacogenomics Journal, Published online: 17 October 2019; doi:10.1038/s41397-019-0098-9Predictive genetic biomarkers for the efficacy of methotrexate in rheumatoid arthritis: a systematic review (Source: The Pharmacogenomics Journal)
Source: The Pharmacogenomics Journal - October 17, 2019 Category: Drugs & Pharmacology Authors: Frank Eektimmerman Jesse J. Swen Moenira B. Madhar Cornelia F. Allaart Henk-Jan Guchelaar Source Type: research

A Human Parvovirus-Associated Arthritis: Arthrocentesis may Resolve Coxalgia
(Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - October 17, 2019 Category: Pediatrics Source Type: research

Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis
AbstractObjectivesOur study objective was to explore whether abnormalities in the subtypes of T cells and B cells were present in peripheral blood of patients with osteoarthritis (OA) and healthy controls (HCs).MethodDemographic and clinical variables and blood were collected. OA severity was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire. Flow cytometry was used to establish the frequencies of lineage subsets. Monoclonal antibodies against 21 surface markers were used to distinguish and evaluate T cells ’ and B cells’ subpopulation. The proportion of eac...
Source: Clinical Rheumatology - October 17, 2019 Category: Rheumatology Source Type: research

How to investigate: Pre-clinical rheumatoid arthritis
Publication date: Available online 15 October 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Patrícia Martins, João Eurico FonsecaAbstractMultiple studies have shown that there is a pre-clinical period preceding the development of rheumatoid arthritis (RA). During this period, complex interactions between the environmental and genetic causes occur, and the expression “preclinical RA” has been proposed to define it. Early treatment intervention is associated with less joint damage and has an increased possibility of achieving remission. In this review, we provide an overvi...
Source: Best Practice and Research Clinical Rheumatology - October 16, 2019 Category: Rheumatology Source Type: research

Origin and function of synovial macrophage subsets during inflammatory joint disease.
l;nke G Abstract Mononuclear phagocytes, including monocytes and macrophages, are a central component of the host's innate immune system designated to protect against invading pathogens. However, these cells do not only interact with various parts of the innate and adaptive immune system, but also fulfill indispensable duties during the control of tissue homeostasis and organ function. Moreover, macrophages are crucially involved in tissue remodeling and repair in response to damage. Simultaneously, mononuclear phagocytes might also contribute to the pathogenesis of various inflammatory and autoimmune diseases. In...
Source: Advances in Immunology - October 16, 2019 Category: Allergy & Immunology Authors: Culemann S, Grüneboom A, Krönke G Tags: Adv Immunol Source Type: research

Rheumatoid arthritis induces enteric neurodegeneration and jejunal inflammation, and quercetin promotes neuroprotective and anti-inflammatory actions
Publication date: Available online 14 October 2019Source: Life SciencesAuthor(s): Gleison Daion Piovezana Bossolani, Bruna Thais Silva, Juliana Vanessa Colombo Martins Perles, Mariana Machado Lima, Flávia Cristina Vieira Frez, Sara Raquel Garcia de Souza, Camila Caviquioli Sehaber-Sierakowski, Ciomar Aparecida Bersani-Amado, Jacqueline Nelisis ZanoniAbstractAimsThe aim of our study was to study the pathological mechanisms induced by the rheumatoid arthritis (RA) on the Enteric Nervous System (ENS).Main methodsWe evaluated the effect of the chronic arthritis and its treatment with 50 mg/kg quercetin alone (AQ) and ...
Source: Life Sciences - October 16, 2019 Category: Biology Source Type: research

Infrared thermography in children: a reliable tool for differential diagnosis of peripheral microvascular dysfunction and Raynaud ’s phenomenon?
Infrared Thermography (IRT) has been used for over 30  years in the assessment of Raynaud Phenomenon (RP) and other peripheral microvascular dysfunctions in adults but, to date, very little experience is availa... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - October 16, 2019 Category: Rheumatology Authors: Giorgia Martini, Michela Cappella, Roberta Culpo, Fabio Vittadello, Monica Sprocati and Francesco Zulian Tags: Research article Source Type: research

Incorporating adjustments for variability in control group response rates in network meta-analysis: a case study of biologics for rheumatoid arthritis
The importance of adjusting for cross-study heterogeneity in control group response rates when conducting network meta-analyses (NMA) was demonstrated using a case study involving a comparison of biologics for... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 16, 2019 Category: Research Authors: Chris Cameron, Abhishek Varu, Arthur Lau, Mahdi Gharaibeh, Marcelo Paulino and Raina Rogoza Tags: Research article Source Type: research

Trump Administration Proposes Changes to Healthcare Anti-Kickback Rules
(Reuters)—The Trump administration has proposed changes to federal anti-kickback provisions that restrict the kinds of patient referrals doctors can make, saying it will improve healthcare coordination and foster payments based on the quality of care. The plan will change how the U.S. Department of Health and Human Services (HHS) enforces the Physician Self Referral Law,... [Read More] (Source: The Rheumatologist)
Source: The Rheumatologist - October 16, 2019 Category: Rheumatology Authors: Carl O'Donnell Tags: Professional Topics Anti-kickback Statue Stark Law Trump administration Source Type: research

One Quarter of Every U.S. Healthcare Dollars Wasted
(Reuters Health)—About a quarter of the dollars spent on healthcare in the U.S. may be wasted, a new analysis suggests. Six types of waste in healthcare could be costing as much as $935 billion annually, according to the study published in JAMA.1,2 The biggest source of waste is “administrative complexity,” says the study’s lead author... [Read More] (Source: The Rheumatologist)
Source: The Rheumatologist - October 16, 2019 Category: Rheumatology Authors: Linda Carroll Tags: Professional Topics cost cost of health care Healthcare money Source Type: research

Molecules, Vol. 24, Pages 3735: Water Extracts of Hull-less Waxy Barley (Hordeum vulgare L.) Cultivar ‘Boseokchal’ Inhibit RANKL-induced Osteoclastogenesis
In this study, we found that the water extracts of Boseokchal (BSC-W) inhibited osteoclast differentiation in vitro and investigated its inhibitory mechanism. BSC-W was obtained by extracting flour of Boseokchal using hexane and water. To osteoclast differentiation, bone marrow-derived macrophage cells (BMMs) were cultured with the vehicle (0.1% DMSO) or BSC-W in the presence of M-CSF and RANKL for 4 days. Cytotoxicity was measured by CCK-8. Gene expression of cells was confirmed by real-time PCR. Protein expression of cells was observed by western blot assay. Bone resorption activity of osteoclast evaluated by bone pit fo...
Source: Molecules - October 16, 2019 Category: Chemistry Authors: Kim Lee Son Lee Son Lee Lee Tags: Article Source Type: research

Apremilast in refractory alopecia areata
We report four cases of extensive AA successfully treated with apremilast. (Source: International Journal of Trichology)
Source: International Journal of Trichology - October 16, 2019 Category: Dermatology Authors: Andrea Est & #233;banez Nuria Est & #233;banez Jose M Mart & #237;n Encarna Montesinos Source Type: research

The Selective Oral Immunomodulator Vidofludimus in Patients with Active Rheumatoid Arthritis: Safety Results from the COMPONENT Study
ConclusionsVidofludimus demonstrated a positive safety profile, making it a promising candidate for the treatment of a variety of immune-related diseases.Trial RegistrationsClinicalTrials.gov identifier: NCT01010581. (Source: Drugs in R&D)
Source: Drugs in R&D - October 16, 2019 Category: Drugs & Pharmacology Source Type: research

Outcomes of semiconstrained total elbow arthroplasty performed for arthritis in patients under 55 years old
Total elbow arthroplasty (TEA) is a treatment option for end-stage arthritis. Even though results are satisfactory for the elderly population, TEA surgery is subject to controversy in younger patients. The purpose of this study was to evaluate clinical and radiographic outcomes of semiconstrained TEA performed for arthritis in patients younger than 55 years. (Source: Journal of Shoulder and Elbow Surgery)
Source: Journal of Shoulder and Elbow Surgery - October 16, 2019 Category: Orthopaedics Authors: Mahdi Siala, Pierre Laumonerie, Abdellah Hedjoudje, Stephanie Delclaux, Nicolas Bonnevialle, Pierre Mansat Source Type: research

The association of plasma fatty acids with hand and knee osteoarthritis: the NEO study
To investigate the association of postprandial and fasting plasma saturated fatty acid (SFAs), monounsaturated fatty acid (MUFAs) and polyunsaturated fatty acid (PUFAs) concentrations with hand and knee osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 16, 2019 Category: Rheumatology Authors: Marieke Loef, Andreea Ioan-Facsinay, Dennis O. Mook-Kanamori, Ko Willems van Dijk, Ren ée de Mutsert, Margreet Kloppenburg, Frits R. Rosendaal Source Type: research

Incidence rate and risk factors for radiographic hip osteoarthritis in Japanese men and women: A 10-year follow-up of the ROAD study
To investigate the incidence and progression rate of radiographic hip osteoarthritis (OA) and its risk factors in Japanese men and women using a large-scale population of a nationwide cohort study, Research on Osteoarthritis/osteoporosis Against Disability (ROAD). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 16, 2019 Category: Rheumatology Authors: Toshiko Iidaka, Shigeyuki Muraki, Hiroyuki Oka, Chiaki Horii, Hiroshi Kawaguchi, Kozo Nakamura, Toru Akune, Sakae Tanaka, Noriko Yoshimura Source Type: research

Association of Tramadol with Risk of Myocardial Infarction Among Patients with Osteoarthritis
Tramadol has been widely used among patients with osteoarthritis (OA); however, there is paucity of information on its cardiovascular risk. We aimed to examine the association of tramadol with risk of myocardial infarction (MI) among patients with OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 16, 2019 Category: Rheumatology Authors: Jie Wei, Malissa J. Wood, Maureen Dubreuil, Gunnar Tomasson, Marc R. LaRochelle, Chao Zeng, Na Lu, Jianhao Lin, Hyon K. Choi, Guanghua Lei, Yuqing Zhang Source Type: research

Prevalence and incidence of systemic sclerosis: A systematic review and meta ‐analysis
ConclusionThis review provides an assessment of the current estimates of disease prevalence and incidence of SSc. The epidemiological burdens of SSc vary among different regions of the world. The epidemiological data need to be interpreted with caution considering the methodological differences in deriving these estimates. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 16, 2019 Category: Rheumatology Authors: Lixian Zhong, Melinda Pope, Ye Shen, Jose J. Hernandez, Lin Wu Tags: ORIGINAL ARTICLE Source Type: research

Prevalence of undifferentiated inflammatory arthropathy in patients with Hashimoto's thyroiditis in an endocrinology clinic
ConclusionsAlmost 1 in 4 patients with HT had no definite rheumatic disease present with UIA. An early identification of concurrent arthritis in HT patients is necessary for thorough differential diagnosis and prompt treatment initiation to halt potential joint damage and disability. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 16, 2019 Category: Rheumatology Authors: Luis M. Valderrama ‐Hinds, Eliangel García‐Carrión, Evelyn Hernández, María I. Agostini, Omar R. Reyes‐Morales, Liliana Fung, Soham Al Snih, Martin A. Rodríguez Tags: ORIGINAL ARTICLE Source Type: research

Serum Immunoglobulin Free Light Chain levels in Systemic Autoimmune Rheumatic Diseases.
Abstract Several reports have highlighted the abnormal increments of serum immunoglobulin free light chains (FLC) in the course of systemic autoimmune rheumatic diseases (SARD) but a comparative analysis among different conditions is still lacking. A strong association between elevated FLC and HCV-related mixed cryoglobulinaemia (HCVMC) has been well established. Here, we aimed to analyze serum FLC levels in patients with four different SARDs in comparison with HCVMC. Using a turbidimetric assay, free k and λ chains were quantified in sera from 198 SARD patients (37 Rheumatoid Arthritis, RA; 47 Systemic Lup...
Source: Clinical and Developmental Immunology - October 16, 2019 Category: Allergy & Immunology Authors: Gulli F, Napodano C, Marino M, Ciasca G, Pocino K, Basile V, Visentini M, Stefanile A, Todi L, De Spirito M, Rapaccini GL, Basile U Tags: Clin Exp Immunol Source Type: research

Dendrobium officinale polysaccharide ameliorates diabetic hepatic glucose metabolism via glucagon-mediated signaling pathways and modifying liver-glycogen structure
ConclusionsThe hypoglycemic mechanism of DOP might be associated with the regulation of glucagon-mediated hepatic glycogen metabolism and gluconeogenesis, and of liver glycogen structure, contributing to improved hepatic glucose metabolism in diabetic mice.Graphical abstractDOP could regulate glucagon-mediated signaling pathways and reverse the instability of liver glycogen structure, contributing to improved hepatic glucose metabolism. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 15, 2019 Category: Drugs & Pharmacology Source Type: research

Invariant natural killer T cells are functionally impaired in patients with systemic sclerosis
Systemic sclerosis (SSc) is a potentially fatal autoimmune disease that leads to extensive fibrosis of the skin and internal organs. Invariant natural killer T (iNKT) cells are potent immunoregulatory T lympho... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 15, 2019 Category: Rheumatology Authors: Ann-Christin Pecher, Felix Kettemann, Elisa Asteriti, Hannes Schmid, Silke Duerr-Stoerzer, Hildegard Keppeler, Joerg Christoph Henes, Reinhild Klein, Clemens Hinterleitner, Kathy-Ann Secker, Corina Schneidawind, Lothar Kanz and Dominik Schneidawind Tags: Research article Source Type: research

Mid-term outcomes of arthroscopic-assisted Core decompression of Precollapse osteonecrosis of femoral head —minimum of 5 year follow-up
Osteonecrosis of the femoral head (ONFH) is a progressive disease that leads to collapse and the development of secondary arthritis. The preferred management of ONFH remains controversial. Arthroscopic-assiste... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - October 15, 2019 Category: Orthopaedics Authors: Mark R. Nazal, Ali Parsa and Scott D. Martin Tags: Research article Source Type: research

Annals Consult Guys - Preventing Coronary Disease in Rheumatoid Arthritis: Do Guidelines Apply?
PMID: 31610577 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - October 15, 2019 Category: Internal Medicine Authors: Merli GJ, Weitz HH Tags: Ann Intern Med Source Type: research

Rheumatic mitral valve repair: a physiologic and dynamic approach
AbstractRheumatic valve repair although complex but with better understanding of mitral complex and dynamics, successful rate of mitral repair is enhanced and promising. (Source: Indian Journal of Thoracic and Cardiovascular Surgery)
Source: Indian Journal of Thoracic and Cardiovascular Surgery - October 15, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Therapeutic potential of aryl hydrocarbon receptor in autoimmunity
AbstractAryl hydrocarbon receptor (AhR), a type of transcriptional factor, is widely expressed in immune cells. The activation of AhR signaling pathway depends on its ligands, which exist in environment and can also be produced by metabolism. Normal expressions of AhR and AhR-mediated signaling may be essential for immune responses, and effects of AhR signaling on the development and function of innate and adaptive immune cells have also been revealed in previous studies. Recent studies also indicate that aberrant AhR signaling may be related to autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus eryth...
Source: Inflammopharmacology - October 15, 2019 Category: Drugs & Pharmacology Source Type: research

Checkpoint inhibitor-induced arthritis is persistent
Nature Reviews Rheumatology, Published online: 15 October 2019; doi:10.1038/s41584-019-0329-0Checkpoint inhibitor-induced arthritis is persistent (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 15, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Increased risk of rheumatic disease in IPAF
Nature Reviews Rheumatology, Published online: 15 October 2019; doi:10.1038/s41584-019-0327-2Increased risk of rheumatic disease in IPAF (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 15, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Combined immunosuppression for ILD in myositis
Nature Reviews Rheumatology, Published online: 15 October 2019; doi:10.1038/s41584-019-0328-1Combined immunosuppression for ILD in myositis (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 15, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Ixekizumab superior to adalimumab for PsA
Nature Reviews Rheumatology, Published online: 15 October 2019; doi:10.1038/s41584-019-0326-3Ixekizumab superior to adalimumab for PsA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 15, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Effects of 17 β-estradiol deficiency and mechanical overload on osseous changes in the rat temporomandibular joint
To deduce the contributing factors of idiopathic condylar resorption (ICR) in young female patients, we hypothesized that 17 β-estradiol (E2) deficiency would cause arthritic changes of the mandibular condyle under mechanical overloading in rat animal model. Our second hypothesis was that osseous changes of microstructure by the combination of E2 deficiency and mechanical overloading would be different depending on the r egion of the condyle. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - October 15, 2019 Category: ENT & OMF Authors: Hoon Joo Yang, Soon Jung Hwang Source Type: research

Rheumatoid arthritis morning stiffness is associated with synovial fibrin and neutrophils
AbstractBackgroundMorning stiffness is a hallmark symptom of rheumatoid arthritis (RA), but its etiology is poorly understood. We sought to determine whether any histologic features of synovium associate with this symptom.MethodsPatient reports of morning stiffness duration, stiffness severity and disease activity scores (DAS28) were collected from 176 patients with RA undergoing arthroplasty. Histopathology of synovium was scored for 10 features: synovial lining hyperplasia, lymphocytes, plasma cells, Russell bodies, binucleate plasma cells, fibrin, synovial giant cells detritus, neutrophils and mucin. Fibrinolysis of clo...
Source: Arthritis and Rheumatology - October 15, 2019 Category: Rheumatology Authors: Dana E. Orange, Nathalie E. Blachere, Edward F. DiCarlo, Serene Mirza, Tania Pannellini, Caroline S. Jiang, Mayu O. Frank, Salina Parveen, Mark P. Figgie, Ellen M. Gravallese, Vivian P. Bykerk, Ana ‐Maria Orbai, Sarah L. Mackie, Susan M. Go Tags: FULL LENGTH Source Type: research

Disease severity is linked to an increase in autoantibody diversity in IgG4 ‐related disease
ConclusionAntibodies against prohibitin, annexin A11, and laminin 511 ‐E8 were found in only a small portion of patients with IgG4‐RD. A subset of IgG4‐RD patients, however, had IgG4 antibodies against ≥2 autoantigens. Patients with antibodies against ≥2 autoantigens present with robust IgG subclass elevations, complement consumption, and visceral organ invo lvement. This broader break in immunological tolerance in IgG4‐RD was associated with more severe disease. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - October 15, 2019 Category: Rheumatology Authors: Hang Liu, Cory A. Perugino, Musie Ghebremichael, Zachary S. Wallace, Sydney B. Montesi, John H. Stone, Shiv Pillai Tags: Full Length Source Type: research

Lymphopenia and neutropenia are associated with subsequent incident proteinuria in Danish patients with systemic lupus erythematosus.
Conclusion: Lymphopenia and neutropenia predicted the risk of first-time proteinuria independently of immunosuppressants. PMID: 31612777 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - October 15, 2019 Category: Rheumatology Authors: Tanha N, Hansen RB, Yang J, Lange T, Nielsen CT, Helleberg M, Kamper AL, Faurschou M, Jacobsen S Tags: Scand J Rheumatol Source Type: research

Delayed neutrophil apoptosis in granulomatosis with polyangiitis: dysregulation of neutrophil gene signature and circulating apoptosis-related proteins.
Conclusions: Circulating neutrophils in GPA have anti-apoptotic phenotype involving both intrinsic and extrinsic pathways of apoptosis. This is accompanied by increased levels of circulating pro-survival factors (GM-CSF, TNF-α, sFas), independent of disease activity. Anti-apoptotic phenotype of neutrophils in GPA is reproduced by exposure to low concentrations of TNF-α. PMID: 31610684 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - October 15, 2019 Category: Rheumatology Authors: Surmiak M, Hubalewska-Mazgaj M, Wawrzycka-Adamczyk K, Musiał J, Sanak M Tags: Scand J Rheumatol Source Type: research

Clinical Insights into Gout Management: Rheumatology Drugs at a Glance Pt. 4
Three clinical experts on gout offer their insights into common management errors, clinical pearls, new safety data from the FDA and the role of biologic therapies in the management of gout. (Source: The Rheumatologist)
Source: The Rheumatologist - October 14, 2019 Category: Rheumatology Authors: Mary Choy, PharmD, BCGP, FASHP Tags: Biologics & Biosimilars Conditions Crystal Arthritis DMARDs & Immunosuppressives Drug Updates Gout Source Type: research

Neutrophil extracellular traps-associated markers are elevated in patients with systemic lupus erythematosus
AbstractNeutrophil extracellular traps (NETs) are the main source of autoantigens in systemic lupus erythematosus (SLE). The aim of this study was to evaluate the clinical importance of NETs-associated markers in SLE. We compared NETs-associated markers in SLE patients (n = 111) with healthy controls (n = 50). Moreover, in 35 patients with drug-naïve SLE (n = 35), we investigated correlation between NETs-associated markers [DNase I concentration, myeloperoxidase (MPO) activity, anti-MPO antibodies, cell-free DNA (cfDNA), NETolytic activity] with serological parameters [anti-ds...
Source: Rheumatology International - October 14, 2019 Category: Rheumatology Source Type: research

Could hypereosinophilia at diagnosis estimate the current activity or predict relapse in systemic immunosuppressive drug-na ïve patients with eosinophilic granulomatosis with polyangiitis?
In this study, we investigated whether hypereosinophilia (peripheral eosinophil  ≥ 1500/mm3) at diagnosis could estimate the increased current activity and predict the poor prognosis during follow-up in patients with eosinophilic granulomatosis with polyangiitis (EGPA). We retrospectively reviewed the medical records of 42 patients with EGPA and finally included 30 systemic immunosuppressive drug-na ïve patients. We obtained clinical and laboratory data including clinical manifestations, Birmingham vasculitis activity score (BVAS), five-factor score (FFS) (2009), and routine laboratory results. Hypere...
Source: Rheumatology International - October 14, 2019 Category: Rheumatology Source Type: research

Anti-Smith antibody is associated with disease activity in patients with new-onset systemic lupus erythematosus
This study aimed to evaluate the association between anti-Sm antibodies and disease activity in patients with new-onset SLE. We included patients who were tested for anti-Sm antibodies at SLE diagnosis and within 12 months after diagnosis. SLE disease activity index (SLEDAI) was obtained at the time of the anti-Sm antibody test. The baseline disease activity was compared between patients with and without anti-Sm antibodies. The longitudinal association between disease activity and anti-Sm antibodies was also evaluated in total patients and in those with anti-Sm antibodies. Among 92 patients who were tested for anti-Sm anti...
Source: Rheumatology International - October 14, 2019 Category: Rheumatology Source Type: research

Reduced diffusing capacity for carbon monoxide predicts borderline pulmonary arterial pressure in patients with systemic sclerosis
This study included SSc patients who underwent right heart catheterization (RHC) in our hospital during 2010–2018. Following variables were assessed for performance to predict mPAP ≥ 25 mmHg or >  20 mmHg; anti-centromere or U1-RNP antibody, plasma BNP level, serum urate level, right axis deviation, forced vital capacity (FVC)/diffusing capacity for carbon monoxide (DLCO) ratio, and tricuspid regurgitation velocity. Of 58 patients enrolled in this study, 24 had mPAP of ≥ 25 mmHg an d 9 had mPAP of 21–24 mmHg. Among variables tested, only FVC...
Source: Rheumatology International - October 14, 2019 Category: Rheumatology Source Type: research

LAUDES Study: impact of digital ulcers on hand functional limitation, work productivity and daily activities, in systemic sclerosis patients
The objective of this study was to evaluate the impact of digital ulcers (DUs) in daily life of systemic sclerosis (SSc) Spanish patients. We developed a multicenter observational study to compare functional disability in SSc patients with active DUs vs. those without DUs. An additional correlation between perception of patients and physicians on disability due to DUs was performed. A total of 199 patients were enrolled, 70 (35%) with DUs. Patients with DUs were younger (48 vs. 58  years;p 
Source: Rheumatology International - October 14, 2019 Category: Rheumatology Source Type: research

Serum levels of selected cytokines [interleukin (IL)-17A, IL-18, IL-23] and chemokines (RANTES, IP10) in the acute phase of immunoglobulin A vasculitis in children
AbstractThe pathogenesis of the immunoglobulin A vasculitis (IgAV) is still unknown. The available data shows that interleukin (IL)-17, IL-18, IL-23, regulated on activation, normal T cell expressed and secreted (CCL 5, RANTES), and interferon (IFN)- γ-inducible protein 10 (IP10) participate in the pathogenesis of IgAV by influencing the recruitment of leukocytes to the site of inflammation. The aim of this study was to analyze the serum concentration of IL-17A, IL-18, IL-23, RANTES, and IP10 in patients with acute IgAV compared to healthy chil dren. Moreover, we wanted to assess the suitability of the levels of test...
Source: Rheumatology International - October 14, 2019 Category: Rheumatology Source Type: research

Delta-neutrophil index: a potential predictor of coronary artery involvement in Kawasaki disease by retrospective analysis
AbstractDNI is the immature granulocyte fraction provided by a blood cell analyzer, which is determined by subtracting the fraction of mature polymorphonuclear leukocytes from the sum of myeloperoxidase-reactive cells. We aimed to evaluate the role of Delta-neutrophil index (DNI) in cardiac prognosis prediction in children with Kawasaki disease (KD). Medical records of 193 patients were retrospectively reviewed. The values of DNI, white blood cells, erythrocyte sedimentation rate, the percent of polymorphonuclear leucocytes, C-reactive protein, aspartate transaminase, alanine aminotransferase, total bilirubin data of child...
Source: Rheumatology International - October 14, 2019 Category: Rheumatology Source Type: research

Fatigue in primary Sj ögren’s syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation study
This study aims to validate this observation. Blood levels of seven cytokines were measured in 120 patients with pSS from the United Kingdom Primary Sjögren’s Syndrome Registry and 30 age-matched healthy non-fatigued controls. Patient-reported scores for fatigue were classified acco rding to severity and compared to cytokine levels using analysis of variance. The differences between cytokines in cases and controls were evaluated using Wilcoxon test. A logistic regression model was used to determine the most important identifiers of fatigue. Five cytokines, interferon-γ-induced protein-10 (IP-10), tumour ne...
Source: Rheumatology International - October 14, 2019 Category: Rheumatology Source Type: research

Cocaine-induced ANCA-associated renal disease: a case-based review
We report two cases of AAV with different renal manifestations associated with cocaine consumption. Furthermore, we performed a review of the literature to identify, characterize and describe h istologically documented cases of renal involvement in AAV, related to cocaine abuse. Cocaine/levamisole-induced vasculitis may, therefore, mimic idiopathic AAV. Although the detection of ANCA and anti-PR3 (proteinase 3, PR3) as well as anti-MPO antibodies (myeloperoxidase, MPO) are the serological hallmark of idiopathic AAV, certain clinical- and antibody constellations should lead to consideration of illicit drugs as inductors of ...
Source: Rheumatology International - October 14, 2019 Category: Rheumatology Source Type: research