Blue Notes
Immune-mediated inflammatory disorders (IMIDs) including inflammatory bowel disease (IBD), rheumatoid arthritis (RA), psoriasis/psoriatic arthritis (PSO), and ankylosing spondylitis (AS), are associated with increased risk of major adverse cardiovascular events (MACE). There is uncertainty regarding the cardiovascular safety of newer medications for IMIDs such as biologics and small molecules (anti-IL-23, anti-IL-12/23, anti-TNFs, and JAKi). This network meta-analysis pooled 40 studies (36 RCTs) that reported MACE (myocardial infarction, cerebrovascular accident, unstable angina, cardiovascular death, or heart failure) in ...
Source: Clinical Gastroenterology and Hepatology - April 23, 2024 Category: Gastroenterology Authors: Charles J. Kahi Tags: Blue Notes Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
Induction treatment for lupus nephritis at a high-complexity hospital in Chile
CONCLUSION: This study did not find significant differences in the clinical response to IVC or MMF at 6 months. Future prospective studies are required to determine the optimal induction therapy for LN, especially in Latin populations.PMID:38652826 | DOI:10.1177/09612033241249574 (Source: Lupus)
Source: Lupus - April 23, 2024 Category: Rheumatology Authors: Paulina Ramirez Andres Giglio Jorge Verdugo Francisco Gutierrez Source Type: research
TNF- α signals through ITK-Akt-mTOR to drive CD4 < sup > + < /sup > T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis
Sci Signal. 2024 Apr 23;17(833):eadg5678. doi: 10.1126/scisignal.adg5678. Epub 2024 Apr 23.ABSTRACTUpon activation, T cells undergo metabolic reprogramming to meet the bioenergetic demands of clonal expansion and effector function. Because dysregulated T cell cytokine production and metabolic phenotypes coexist in chronic inflammatory disease, including rheumatoid arthritis (RA), we investigated whether inflammatory cytokines released by differentiating T cells amplified their metabolic changes. We found that tumor necrosis factor-α (TNF-α) released by human naïve CD4+ T cells upon activation stimulated the expression o...
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Emma L Bishop Nancy Gudgeon Taylor Fulton-Ward Victoria Stavrou Jennie Roberts Adam Boufersaoui Daniel A Tennant Martin Hewison Karim Raza Sarah Dimeloe Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
Arthritis and osteomyelitis in childhood and adolescence-Bacterial and nonbacterial
Z Rheumatol. 2024 Apr 23. doi: 10.1007/s00393-024-01504-z. Online ahead of print.ABSTRACTBacterial arthritis and osteomyelitis are usually acute diseases, which in this way differ from the often insidious course of nonbacterial osteomyelitis; however, there is often an overlap both in less acute courses of bacterial illnesses and also in nonbacterial osteitis. The overlapping clinical phenomena can be explained by similar pathophysiological processes. In bacteria-related illnesses the identification of the pathogen and empirical or targeted anti-infectious treatment are prioritized, whereas no triggering agent is known for...
Source: Zeitschrift fur Rheumatologie - April 23, 2024 Category: Rheumatology Authors: T Hospach T Kallinich L Martin T V Kalle F Reichert H J Girschick C M Hedrich Source Type: research
IL-22, a vital cytokine in autoimmune diseases
Clin Exp Immunol. 2024 Apr 23:uxae035. doi: 10.1093/cei/uxae035. Online ahead of print.ABSTRACTInterleukin-22 (IL-22) is a vital cytokine that is dysregulated in various autoimmune conditions including rheumatoid arthritis (RA), multiple sclerosis (MS), and Alzheimer's disease (AD). As the starting point for the activation of numerous signaling pathways, IL-22 plays an important role in the initiation and development of autoimmune diseases. Specifically, imbalances in IL-22 signaling can interfere with other signaling pathways, causing cross regulation of target genes which ultimately leads to the development of immune dis...
Source: Clinical and Developmental Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Jiajin Li Zhen Wu Yuxin Wu Xin Yu Hu Jun Yang Dacheng Zhu Mingyue Wu Xin Li Lutterodt Bentum-Ennin Wanglai Hu Source Type: research
Association of the multi-biomarker disease activity score with arterial 18-fluorodeoxyglucose uptake in rheumatoid arthritis
CONCLUSIONS: Among treated RA patients, achieved MBDA predicts of changes in arterial inflammation. Achieving low MBDA at 24 weeks was associated with clinically meaningful reductions in arterial inflammation, regardless of treatment.PMID:38652572 | DOI:10.1093/rheumatology/keae242 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Jon T Giles Daniel H Solomon Katherine P Liao Pamela M Rist Zahi A Fayad Ahmed Tawakol Joan M Bathon Source Type: research
The Effect of Crystal Arthropathy on the Diagnostic Criteria of Native Septic Arthritis
DISCUSSION: The presence of synovial crystals reduced the likelihood of septic arthritis and altered the laboratory diagnostic criteria. PMN% was nondiagnostic in the setting of synovial crystals.PMID:38652879 | DOI:10.5435/JAAOS-D-23-00857 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 23, 2024 Category: Orthopaedics Authors: Benjamin D Pesante Maryam Salimi Whitney L Miller Heather L Young Timothy C Jenkins Joshua A Parry Source Type: research
Effect of Spaceflight and Microgravity on the Musculoskeletal System: A Review
J Am Acad Orthop Surg. 2024 Apr 17. doi: 10.5435/JAAOS-D-23-00954. Online ahead of print.ABSTRACTWith National Aeronautics and Space Administration's plans for longer distance, longer duration spaceflights such as missions to Mars and the surge in popularity of space tourism, the need to better understand the effects of spaceflight on the musculoskeletal system has never been more present. However, there is a paucity of information on how spaceflight affects orthopaedic health. This review surveys existing literature and discusses the effect of spaceflight on each aspect of the musculoskeletal system. Spaceflight reduces b...
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 23, 2024 Category: Orthopaedics Authors: Robert Lee Satcher Benjamin Fiedler Abdullah Ghali Douglas R Dirschl Source Type: research
TNF- α signals through ITK-Akt-mTOR to drive CD4 < sup > + < /sup > T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis
Sci Signal. 2024 Apr 23;17(833):eadg5678. doi: 10.1126/scisignal.adg5678. Epub 2024 Apr 23.ABSTRACTUpon activation, T cells undergo metabolic reprogramming to meet the bioenergetic demands of clonal expansion and effector function. Because dysregulated T cell cytokine production and metabolic phenotypes coexist in chronic inflammatory disease, including rheumatoid arthritis (RA), we investigated whether inflammatory cytokines released by differentiating T cells amplified their metabolic changes. We found that tumor necrosis factor-α (TNF-α) released by human naïve CD4+ T cells upon activation stimulated the expression o...
Source: Science Signaling - April 23, 2024 Category: Biomedical Science Authors: Emma L Bishop Nancy Gudgeon Taylor Fulton-Ward Victoria Stavrou Jennie Roberts Adam Boufersaoui Daniel A Tennant Martin Hewison Karim Raza Sarah Dimeloe Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
Induction treatment for lupus nephritis at a high-complexity hospital in Chile
CONCLUSION: This study did not find significant differences in the clinical response to IVC or MMF at 6 months. Future prospective studies are required to determine the optimal induction therapy for LN, especially in Latin populations.PMID:38652826 | DOI:10.1177/09612033241249574 (Source: Lupus)
Source: Lupus - April 23, 2024 Category: Rheumatology Authors: Paulina Ramirez Andres Giglio Jorge Verdugo Francisco Gutierrez Source Type: research
Arthritis and osteomyelitis in childhood and adolescence-Bacterial and nonbacterial
Z Rheumatol. 2024 Apr 23. doi: 10.1007/s00393-024-01504-z. Online ahead of print.ABSTRACTBacterial arthritis and osteomyelitis are usually acute diseases, which in this way differ from the often insidious course of nonbacterial osteomyelitis; however, there is often an overlap both in less acute courses of bacterial illnesses and also in nonbacterial osteitis. The overlapping clinical phenomena can be explained by similar pathophysiological processes. In bacteria-related illnesses the identification of the pathogen and empirical or targeted anti-infectious treatment are prioritized, whereas no triggering agent is known for...
Source: Zeitschrift fur Rheumatologie - April 23, 2024 Category: Rheumatology Authors: T Hospach T Kallinich L Martin T V Kalle F Reichert H J Girschick C M Hedrich Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
