Epidemiology and treatment outcome of ANCA-associated vasculitis in South Korea: a nationwide, population-based cohort study
CONCLUSIONS: In South Korea, the incidence of MPA has increased over time. Although both GPA and MPA had high rates of mortality and morbidity, MPA has a poorer prognosis than GPA.PMID:38525995 | DOI:10.55563/clinexprheumatol/tqndi5 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 25, 2024 Category: Rheumatology Authors: Jun Won Park Jihun Song Seulggie Choi Sun Jae Park Sang Min Park Eun Young Lee Source Type: research

Association between treatment type and therapeutic response according to clinical form of SAPHO syndrome in adults from a multicentre retrospective cohort study
Clin Exp Rheumatol. 2024 Mar 19. doi: 10.55563/clinexprheumatol/n837l6. Online ahead of print.NO ABSTRACTPMID:38525997 | DOI:10.55563/clinexprheumatol/n837l6 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 25, 2024 Category: Rheumatology Authors: Pauline Brevet Paul Michelin Christian Marcelli Didier Alcaix Thierry Lequerre Olivier Vittecoq Source Type: research

Polyacrylamide gel versus hyaluronic acid for the treatment of knee osteoarthritis: a randomised controlled study
CONCLUSIONS: iPAAG was found to be as effective and safe as HA for treatment of knee OA symptoms for at least 1 year after a single injection.PMID:38525999 | DOI:10.55563/clinexprheumatol/i3fqee (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 25, 2024 Category: Rheumatology Authors: Henning Bliddal Jannie Beier Andreas Hartkopp Philip G Conaghan Marius Henriksen Source Type: research

Rilonacept use in lupus pericarditis
CONCLUSIONS: Rilonacept successfully treated lupus pericarditis in this case series. Rilonacept should be considered for the treatment of lupus pericarditis.PMID:38526001 | DOI:10.55563/clinexprheumatol/pb3hzb (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 25, 2024 Category: Rheumatology Authors: Andrea Fava Michael Cammarata Luigi Adamo Source Type: research

Synthesis and In Vitro and Silico Anti-inflammatory Activity of New Thiazolidinedione-quinoline Derivatives
CONCLUSION: These results demonstrate that the synthesis of quinoline-thiazolidinedione hybrids may be a useful strategy for obtaining promising candidates for new anti-inflammatory agents.PMID:38523516 | DOI:10.2174/0115680266295582240318060802 (Source: Molecular Medicine)
Source: Molecular Medicine - March 25, 2024 Category: Molecular Biology Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Jeann Fabiann Branco J únior Paulo Andr é Teixeira de Moraes Gomes Sim ão Kalebe Silva de Paula Douglas Carvalho Francisco Viana Eduardo Augusto Vasconcelos de Freitas Ramalho Jo ão Victor Source Type: research

A large cohort comparison of very late-onset systemic lupus erythematosus with younger-onset patients
CONCLUSIONS: Compared with younger patients, in vlSLE, female predominance is less pronounced. Arthritis, anti-dsDNA antibodies and low C3 levels are less frequent. SS and RA are more common. Despite lower disease activity, vlSLE patients have the lowest survival rate. While uncommon, SLE should not be excluded as a possible diagnosis in the elderly.PMID:38526004 | DOI:10.55563/clinexprheumatol/jgsyos (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 25, 2024 Category: Rheumatology Authors: Luisa Viveiros Ana Neves Teresa Gouveia David A Isenberg Source Type: research

Elevated DAS28-ESR in patients with rheumatoid arthritis who have comorbid fibromyalgia is associated more with tender joint counts than with patient global assessment or swollen joint counts: implications for assessment of inflammatory activity
CONCLUSIONS: DAS28-ESR is elevated significantly in FM+ vs. FM- RA patients; pooled effect sizes were highest for TJC, followed by PATGL, SJC and ESR. The findings appear relevant to response and remission criteria, treat-to-target, and general management of RA.PMID:38525998 | DOI:10.55563/clinexprheumatol/vfvso2 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 25, 2024 Category: Rheumatology Authors: Sandhya Kannayiram Juan Schmukler Tengfei Li Nicola Goodson Aarthi Sridhar Theodore Pincus Source Type: research

Demographic and Clinical Profile of Pediatric Uveitis in Delta Region, Egypt
CONCLUSION: Anterior uveitis was the most frequent presentation in our pediatric cohort. Despite the challenges, the majority of children with uveitis exhibited no significant visual impairment, with most causes of visual loss being reversible.PMID:38527189 | DOI:10.1080/09273948.2024.2328789 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - March 25, 2024 Category: Allergy & Immunology Authors: Nagwa Hussein Abdelmageed Anas Adi Samy Abo El-Khair Maha Shahin Doaa Mosad Mosa Dalia Sabry Amgad El Nokrashy Source Type: research

Synthesis and In Vitro and Silico Anti-inflammatory Activity of New Thiazolidinedione-quinoline Derivatives
CONCLUSION: These results demonstrate that the synthesis of quinoline-thiazolidinedione hybrids may be a useful strategy for obtaining promising candidates for new anti-inflammatory agents.PMID:38523516 | DOI:10.2174/0115680266295582240318060802 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 25, 2024 Category: Chemistry Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Jeann Fabiann Branco J únior Paulo Andr é Teixeira de Moraes Gomes Sim ão Kalebe Silva de Paula Douglas Carvalho Francisco Viana Eduardo Augusto Vasconcelos de Freitas Ramalho Jo ão Victor Source Type: research

Immune Checkpoint Inhibitor-Associated Systemic Sclerosis in the Treatment of a Small Cell Lung Cancer Patient with Durvalumab: A Case Report
Clin Cosmet Investig Dermatol. 2024 Mar 18;17:663-669. doi: 10.2147/CCID.S451386. eCollection 2024.ABSTRACTAs one of the key cancer treatment measures, immune-checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of various cancers, including malignancies previously thought to be untreatable. Immune checkpoint inhibitors work by targeting the dysfunctional immune system, to enhance cancer-cell killing by CD8-positive T cells. Despite the beneficial effects of ICIs, these treatments are also linked to a novel class of side effects, termed immune-related adverse events (irAEs). Immune-related adverse event...
Source: Clinical, Cosmetic and Investigational Dermatology - March 25, 2024 Category: Dermatology Authors: De-Hu Li Xian-Zhi Xiong Source Type: research

Impaired health-related quality of life in idiopathic inflammatory myopathies: a cross-sectional analysis from the COVAD-2 e-survey
CONCLUSION: Both physical and mental health are significantly impaired in IIM patients, particularly in those with comorbidities and increased fatigue, emphasizing the importance of patient-reported experiences and optimized multidisciplinary care to enhance well-being in people with IIMs.PMID:38524696 | PMC:PMC10960935 | DOI:10.1093/rap/rkae028 (Source: Adv Data)
Source: Adv Data - March 25, 2024 Category: Epidemiology Authors: Akira Yoshida Yuan Li Vahed Maroufy Masataka Kuwana Syahrul Sazliyana Shaharir Ashima Makol Parikshit Sen James B Lilleker Vishwesh Agarwal Esha Kadam Phonpen Akawatcharangura Goo Jessica Day Marcin Milchert Yi-Ming Chen Dzifa Dey Tsvetelina Velikova Sreo Source Type: research

Skin and lung fibrosis induced by bleomycin in mice: a systematic review
CONCLUSIONS: In animal studies, it is important to simultaneously evaluate lung tissues in addition to skin fibrosis induced in mice by subcutaneous BLM application, following the 3R (replacement, reduction, and refinement) principle to avoid cruelty to animals.PMID:38523580 | DOI:10.4081/reumatismo.2024.1642 (Source: Reumatismo)
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: S G ülle A Çelik M Birlik O Y ılmaz Source Type: research

Adult ocular adnexal xanthogranulomatous disease associated with immunoglobulin G4-related disease: an unusual association
Reumatismo. 2024 Mar 22;76(1). doi: 10.4081/reumatismo.2024.1641.ABSTRACTAdult-onset xanthogranuloma (AOX) and immunoglobulin G4-related disease (IgG4-RD) are uncommon fibrosing conditions that may exhibit localized ocular manifestations and occasionally systemic symptoms. These conditions exhibit overlapping clinical and histological features, suggesting a potential correlation between them, although their exact relationship remains unclear. This paper presents the case of a black male patient exhibiting typical histological indications of both AOX and IgG4-RD. The patient responded positively to corticosteroid treatment....
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: A R De Santana M D L Castro de Oliveira Figueir ôa A L Souza Pedreira G L Behrens Pinto M B Santiago Source Type: research

Post-diagnosis serum 25-hydroxyvitamin D concentrations in women treated for breast cancer participating in a lifestyle trial in Italy
CONCLUSIONS: Hypovitaminosis D in women recently diagnosed with BC and participating in a lifestyle trial in Italy was widespread and highest with obesity, hypertriglyceridemia, and chemotherapy use. Considering that hypovitaminosis D is a risk factor for lower efficacy of bone density treatments and possibly BC mortality, our results suggest the need to promptly address and treat vitamin D deficiency.PMID:38523582 | DOI:10.4081/reumatismo.2024.1632 (Source: Reumatismo)
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: A Fassio G Porciello G Carioli E Palumbo S Vitale A Luongo C Montagnese M Prete M Grimaldi R Pica E Rotondo L Falzone I Calabrese A Minopoli B Grilli M Cuomo P C Fiorillo C Evangelista E Cavalcanti M De Laurentiis D Cianniello C Pacilio M Pinto G Thomas M Source Type: research

Wunderlich syndrome as a rare complication of polyarteritis nodosa: a case report
We report a case of a 48-year-old male with a history of recurrent episodes of leg muscle tenderness and dysesthesia, bilateral flank pain, painful nodular skin lesions in the lower limbs, weight loss, and difficult-to-control arterial hypertension. The abdominopelvic computed tomography angiography showed a large left perirenal hematoma, leading to the patient's admission to the intensive care unit. After the exclusion of infectious or neoplastic foci, the patient was diagnosed with PAN and started intravenous methylprednisolone pulses with a good response. Since WS is a rare initial clinical manifestation of PAN, an earl...
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: D Oliveira A Martins F Martins M Rato F Pinheiro D Fonseca C Vaz E Mariz L Costa Source Type: research