Pharmacists are essential to poison centers
Am J Health Syst Pharm. 2024 Apr 4:zxae075. doi: 10.1093/ajhp/zxae075. Online ahead of print.NO ABSTRACTPMID:38572763 | DOI:10.1093/ajhp/zxae075 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - April 4, 2024 Category: Drugs & Pharmacology Authors: Kate Traynor Source Type: research
What Does the Military Health System Need to Support Future Combat Operations? Lessons from Aeromedical Evacuations from 2008 to 2020
CONCLUSIONS: The results of this study reveal what the MHS can expect in future conflicts. Most evacuations are for psychiatric-/injury-/musculoskeletal-related diagnoses, typically requiring care by psychiatrists, orthopedic surgeons, or general surgeons. Outpatient care is important, though it is critical to bolster inpatient care requirements as future conflicts may bring extensive numbers of inpatient casualties. The MHS should program and plan resources accordingly, planning for the care of surgical/injured and psychiatric patients.PMID:38573802 | DOI:10.1093/milmed/usae128 (Source: Military Medicine)
Source: Military Medicine - April 4, 2024 Category: International Medicine & Public Health Authors: Matthew M McDonough Isaiah R Gray Robert G Pickering Kyle N Remick Source Type: research
Noninvasive Airway Management of Comatose Patients With Acute Poisoning
To the Editor A recent study suggested clinical benefits of noninvasive airway management in comatose patients with acute poisoning. An accompanying editorial lauded the study as a practice-changing trial providing rigorous evidence. Although we have recommended against indiscriminate intubation of patients based on a low Glasgow Coma Scale (GCS) score, we are concerned about the ability of this study to provide conclusive evidence allowing a paradigm shift in clinical practice. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 4, 2024 Category: General Medicine Source Type: research
Noninvasive Airway Management of Comatose Patients With Acute Poisoning
To the Editor We read with interest the recent article that reported among comatose patients with suspected acute poisoning, a conservative strategy of withholding intubation was associated with a greater clinical benefit for the composite end point of in-hospital death, length of ICU stay, and length of hospital stay. We think that some methodological issues about this study deserve consideration. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 4, 2024 Category: General Medicine Source Type: research
Noninvasive Airway Management of Comatose Patients With Acute Poisoning
To the Editor A recent study reported that withholding intubation among patients with acute poisoning and coma, defined by a GCS score of up to 8, was safe and led to lower rates of ICU admission and adverse events. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 4, 2024 Category: General Medicine Source Type: research
Noninvasive Airway Management of Comatose Patients With Acute Poisoning
To the Editor We read with great interest the recent study about the effect of noninvasive airway management of comatose patients with acute poisoning, but are concerned about potential issues related to selection bias, confounding factors, and the unblinded study design that might have biased the results toward the intervention group (conservative strategy). (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 4, 2024 Category: General Medicine Source Type: research
Noninvasive Airway Management of Comatose Patients With Acute Poisoning —Reply
In Reply In response to our recent article, Dr Schober and colleagues suggest that reduction of length of stay in the ICU and hospital may not be considered a clinically relevant outcome. However, in the context of stretched resources and ICU bed shortages, we believe this is an important end point, and that improvement in the secondary end points in our trial also advocates for a clinical benefit of the intervention. As acknowledged, the reduced risk of pneumonia in the intervention group was not statistically significant, and we therefore did not make definitive claims about this. However, considering the absolute risk r...
Source: JAMA - Journal of the American Medical Association - April 4, 2024 Category: General Medicine Source Type: research
Acute Thyroid Hormone Exposure in Children: A National Retrospective Study Using Health Data Routinely Collected by the French Poison Control Centers
(Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - April 4, 2024 Category: Pediatrics Source Type: research
Acute death as a result of poisoning tropical (Bos taurus indicus) but not temperate (Bos taurus taurus) cattle after oral dosing with Lupinus leucophyllus (velvet lupine)
Toxicon. 2024 Apr 1:107706. doi: 10.1016/j.toxicon.2024.107706. Online ahead of print.ABSTRACTDue to climate change and increasing summer temperatures, tropical cattle may graze where temperate cattle have grazed, exposing tropical cattle to toxic plants they may be unfamiliar with. This work compared the toxicity of Lupinus leucophyllus (velvet lupine) in temperate and tropical cattle. Orally dosed velvet lupine in tropical cattle caused death. If producers opt to graze tropical cattle, additional care must be taken on rangelands where toxic lupines like velvet lupine grow.PMID:38570167 | DOI:10.1016/j.toxicon.2024.107706 (Source: Toxicon)
Source: Toxicon - April 3, 2024 Category: Toxicology Authors: Benedict T Green Kevin D Welch Stephen T Lee T Zane Davis Clinton A Stonecipher Bryan L Stegelmeier Daniel Cook Source Type: research
Blood Lead Levels and Their Association with Iron Deficiency and Anemia in Children
In conclusion, blood lead levels ≥ 5 µg/dL were significantly associated with ID and anemia in children aged 1-6 years.PMID:38568334 | DOI:10.1007/s12011-024-04163-y (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 3, 2024 Category: Biology Authors: Liliana Disalvo Ana Varea Natalia Matamoros Marisa Sala Mar ía V Fasano Horacio F Gonz ález Source Type: research
Effects of arsenic exposure on blood trace element levels in rats and sex differences
In this study, a rat model of As poisoning was established to investigate the levels of trace elements in the blood of rats and sex differences in the effect of As on every trace elements in rat blood. Twenty 6-week-old SD (Sprague Dawley) rats were randomly divided into the control group and the As-exposed group. After 3 months, the contents of 19 elements including As in the blood were detected in these two groups by inductively coupled plasma mass spectrometry (ICP-MS). As levels in the blood of As-exposed rats were significantly higher than those in the control group, with increased levels of Rb, Sr, Cs and Ce, and dec...
Source: Biometals - April 3, 2024 Category: Biochemistry Authors: Xiaoqian Ran Xi Yan Hongbin Zhuang Zhiyuan Liang Guanwei Ma Xiaolu Chen Yuhan Huang Xukun Liu Peng Luo Ting Hu Jun Zhang Liming Shen Source Type: research
Facile construction of sandwich ELISA based on double-nanobody for specific detection of α-hemolysin in food samples
Talanta. 2024 Apr 1;274:126021. doi: 10.1016/j.talanta.2024.126021. Online ahead of print.ABSTRACTα-hemolysin (Hla), a toxin secreted by Staphylococcus aureus (S. aureus), has been proved to be involved in the occurrence and aggravation of food poisoning. Hence, it is quite essential to establish its rapid detection methods to guarantee food safety. Sandwich ELISA based on nanobody is well known to be viable for toxins, but there is absence of nanobody against Hla, let alone a pair for it. Therefore, in this paper, we screened specific nanobodies by bio-panning and obtained the optimal nanobody pair for sandwich ELISA fir...
Source: Talanta - April 3, 2024 Category: Chemistry Authors: Yao Zhang Ting Wang Pengfei Zhang Yangli Wan Guanhong Chang Xu Xu Fuqian Ruan Ting Zhou Qin Zhao Min Zhang Xin Wang Source Type: research
Molybdenum oxide-based catalyst towards better hydrogen production: effects of isothermal carburization
This study underscores that the optimized duration of catalyst exposure is a key factor influencing the successful carburization of MoO3 catalysts. This emphasizes how important carbide species are to increasing H2 efficiency. Additionally, it is noted that carbon formation on the MoO3 active sites can act as a potential poison to the catalysts, leading to rapid deactivation after prolonged exposure to the CO precursor.PMID:38568305 | DOI:10.1007/s11356-024-33060-z (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - April 3, 2024 Category: Environmental Health Authors: Mohd Nor Latif Nur Syakirah Abdul Rahim Salma Samidin Siti Hasnawati Jamal Muhammad Rahimi Yusop Wan Nor Roslam Wan Isahak Alinda Samsuri Source Type: research
Investigating bleeding adverse events associated with BTK inhibitors in the Food and Drug Administration adverse event reporting system (FAERS)
CONCLUSION: Our findings indicate that bleeding AEs linked to BTK inhibitors in various conditions underscore the need for cautious clinical decision-making, particularly in nervous system disorders, injuries, poisoning, surgical complications, vascular disorders, and others.PMID:38568245 | DOI:10.1080/14740338.2024.2339448 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 3, 2024 Category: Drugs & Pharmacology Authors: Xianlin Li Nan Shang Qianci Yan Xiunan Yue Yang Liu Xiaojun Zheng Source Type: research
