Principles of management of the poisoned patient
One of the fundamental complications within toxicology is that patients may not know or disclose what they have been poisoned with. Consequently, a sound and considered general approach to identify potential harms and plan clinical management is necessary. This chapter aims to guide the reader through the initial approach and general principles to consider when managi ng a poisoned patient. (Source: Medicine)
Source: Medicine - April 27, 2024 Category: Internal Medicine Authors: Emma E. Morrison, Euan A. Sandilands Tags: General aspects of poisoning Source Type: research
Poisoning by paracetamol
Paracetamol overdose is common. If left untreated, liver and/or renal failure can develop. Administration of the antidote, acetylcysteine, within 8 –10 hours of overdose minimizes or prevents liver damage. After overdose, the tests used to identify that patients are at risk of liver injury are well established but have limitations. Once liver injury has occurred, important prognostic factors are the presence of hepatic encephalopathy, the int ernational normalized ratio, acid–base status and renal function. (Source: Medicine)
Source: Medicine - April 27, 2024 Category: Internal Medicine Authors: James W Dear Tags: Poisonous substances Source Type: research
Metabolic complications of poisoning
Poisoning caused by a large range of drugs and chemicals can induce metabolic complications via many different mechanisms. Some metabolic complications are life-threatening but all require careful assessment, appropriate monitoring and consideration of treatment. Prompt diagnosis and management reduce morbidity and mortality. Treatment may be targeted to the specific poisoning, and can be time-critical, or can follow approaches similar to those of general and acute medicine. This review introduces metabolic complications associated with sodium, potassium, metabolic acidosis, rhabdomyolysis and methaemoglobinaemia. (Source: Medicine)
Source: Medicine - April 27, 2024 Category: Internal Medicine Authors: Darren M Roberts, Jessie Beaulieu Tags: General aspects of poisoning Source Type: research
Lepiota castanea mushroom growing in Turkiye does not contain phallotoxins and amatoxins
This study aimed to demonstrate the toxin levels of L. castanea collected from forests in different regions of Turkiye (Istanbul and Kocaeli) using sensitive methods. The collected mushrooms were analyzed for alpha amanitin, beta amanitin, gamma amanitin, amanin, phallacidin, and phalloidin levels using RP-HPLC-UV and LC-ESI-MS/MS methods. L. castanea mushroom was found to be free of amatoxin and phallotoxin. Our study revealed for the first time that L. castanea mushrooms from different geographical regions of Turkiye do not contain amatoxin and phallotoxin. Supporting these findings with new studies from different parts ...
Source: Toxicon - April 26, 2024 Category: Toxicology Authors: Ismail Yilmaz Ilgaz Akata Ersan Horoz Ertugrul Kaya Source Type: research
Lepiota castanea mushroom growing in Turkiye does not contain phallotoxins and amatoxins
This study aimed to demonstrate the toxin levels of L. castanea collected from forests in different regions of Turkiye (Istanbul and Kocaeli) using sensitive methods. The collected mushrooms were analyzed for alpha amanitin, beta amanitin, gamma amanitin, amanin, phallacidin, and phalloidin levels using RP-HPLC-UV and LC-ESI-MS/MS methods. L. castanea mushroom was found to be free of amatoxin and phallotoxin. Our study revealed for the first time that L. castanea mushrooms from different geographical regions of Turkiye do not contain amatoxin and phallotoxin. Supporting these findings with new studies from different parts ...
Source: Toxicon - April 26, 2024 Category: Toxicology Authors: Ismail Yilmaz Ilgaz Akata Ersan Horoz Ertugrul Kaya Source Type: research
Guanfacine poisoning resulting in transient ST-segment elevation: a case report
ConclusionsThis case highlights the need for careful monitoring of guanfacine poisoning patients due to the potential for various cardiovascular events. (Source: International Journal of Emergency Medicine)
Source: International Journal of Emergency Medicine - April 26, 2024 Category: Emergency Medicine Source Type: research
High-dose norepinephrine infusion (100 µg/kg/min) in a near-fatal amlodipine and perindopril poisoning: are there any limits?
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - April 26, 2024 Category: Toxicology Authors: Nozha BrahmiHassen Ben GhezalaAymen MradAmira Ben Jaziaa Department of Medical and Toxicological Intensive Care Unit, Mahmoud Yaacoub Emergency Medical Center, Montfleury, University Tunis El Manar, Tunis, Tunisiab Department of Medical and Toxicological Source Type: research
A special type of homicide-suicide: A retrospective study of the characteristics of extended suicide
Int J Law Psychiatry. 2024 Apr 24;94:101987. doi: 10.1016/j.ijlp.2024.101987. Online ahead of print.ABSTRACTExtended suicide, a specific type of homicide-suicide event, has severe social consequences yet remains lacking systematic research. This retrospective study investigated 51 cases of extended suicide involving mental disorders in central China with aim of better understanding risk factors for such events and guiding prevention strategies. Over an 8-year period from 2015 to 2022, cases were collected from forensic institutions, and demographic characteristics, case details, and psychiatric data were recorded. The 51 i...
Source: International Journal of Law and Psychiatry - April 25, 2024 Category: Medical Law Authors: Luyao Xu Cong Liu Quan Liu Xuemei Wang Ziqian Yang Man Liang Zilong Liu Source Type: research
A special type of homicide-suicide: A retrospective study of the characteristics of extended suicide
Int J Law Psychiatry. 2024 Apr 24;94:101987. doi: 10.1016/j.ijlp.2024.101987. Online ahead of print.ABSTRACTExtended suicide, a specific type of homicide-suicide event, has severe social consequences yet remains lacking systematic research. This retrospective study investigated 51 cases of extended suicide involving mental disorders in central China with aim of better understanding risk factors for such events and guiding prevention strategies. Over an 8-year period from 2015 to 2022, cases were collected from forensic institutions, and demographic characteristics, case details, and psychiatric data were recorded. The 51 i...
Source: International Journal of Law and Psychiatry - April 25, 2024 Category: Medical Law Authors: Luyao Xu Cong Liu Quan Liu Xuemei Wang Ziqian Yang Man Liang Zilong Liu Source Type: research
A special type of homicide-suicide: A retrospective study of the characteristics of extended suicide
Int J Law Psychiatry. 2024 Apr 24;94:101987. doi: 10.1016/j.ijlp.2024.101987. Online ahead of print.ABSTRACTExtended suicide, a specific type of homicide-suicide event, has severe social consequences yet remains lacking systematic research. This retrospective study investigated 51 cases of extended suicide involving mental disorders in central China with aim of better understanding risk factors for such events and guiding prevention strategies. Over an 8-year period from 2015 to 2022, cases were collected from forensic institutions, and demographic characteristics, case details, and psychiatric data were recorded. The 51 i...
Source: International Journal of Law and Psychiatry - April 25, 2024 Category: Medical Law Authors: Luyao Xu Cong Liu Quan Liu Xuemei Wang Ziqian Yang Man Liang Zilong Liu Source Type: research
A special type of homicide-suicide: A retrospective study of the characteristics of extended suicide
Int J Law Psychiatry. 2024 Apr 24;94:101987. doi: 10.1016/j.ijlp.2024.101987. Online ahead of print.ABSTRACTExtended suicide, a specific type of homicide-suicide event, has severe social consequences yet remains lacking systematic research. This retrospective study investigated 51 cases of extended suicide involving mental disorders in central China with aim of better understanding risk factors for such events and guiding prevention strategies. Over an 8-year period from 2015 to 2022, cases were collected from forensic institutions, and demographic characteristics, case details, and psychiatric data were recorded. The 51 i...
Source: International Journal of Law and Psychiatry - April 25, 2024 Category: Medical Law Authors: Luyao Xu Cong Liu Quan Liu Xuemei Wang Ziqian Yang Man Liang Zilong Liu Source Type: research
A special type of homicide-suicide: A retrospective study of the characteristics of extended suicide
Int J Law Psychiatry. 2024 Apr 24;94:101987. doi: 10.1016/j.ijlp.2024.101987. Online ahead of print.ABSTRACTExtended suicide, a specific type of homicide-suicide event, has severe social consequences yet remains lacking systematic research. This retrospective study investigated 51 cases of extended suicide involving mental disorders in central China with aim of better understanding risk factors for such events and guiding prevention strategies. Over an 8-year period from 2015 to 2022, cases were collected from forensic institutions, and demographic characteristics, case details, and psychiatric data were recorded. The 51 i...
Source: International Journal of Law and Psychiatry - April 25, 2024 Category: Medical Law Authors: Luyao Xu Cong Liu Quan Liu Xuemei Wang Ziqian Yang Man Liang Zilong Liu Source Type: research
A special type of homicide-suicide: A retrospective study of the characteristics of extended suicide
Int J Law Psychiatry. 2024 Apr 24;94:101987. doi: 10.1016/j.ijlp.2024.101987. Online ahead of print.ABSTRACTExtended suicide, a specific type of homicide-suicide event, has severe social consequences yet remains lacking systematic research. This retrospective study investigated 51 cases of extended suicide involving mental disorders in central China with aim of better understanding risk factors for such events and guiding prevention strategies. Over an 8-year period from 2015 to 2022, cases were collected from forensic institutions, and demographic characteristics, case details, and psychiatric data were recorded. The 51 i...
Source: International Journal of Law and Psychiatry - April 25, 2024 Category: Medical Law Authors: Luyao Xu Cong Liu Quan Liu Xuemei Wang Ziqian Yang Man Liang Zilong Liu Source Type: research
A special type of homicide-suicide: A retrospective study of the characteristics of extended suicide
Int J Law Psychiatry. 2024 Apr 24;94:101987. doi: 10.1016/j.ijlp.2024.101987. Online ahead of print.ABSTRACTExtended suicide, a specific type of homicide-suicide event, has severe social consequences yet remains lacking systematic research. This retrospective study investigated 51 cases of extended suicide involving mental disorders in central China with aim of better understanding risk factors for such events and guiding prevention strategies. Over an 8-year period from 2015 to 2022, cases were collected from forensic institutions, and demographic characteristics, case details, and psychiatric data were recorded. The 51 i...
Source: International Journal of Law and Psychiatry - April 25, 2024 Category: Medical Law Authors: Luyao Xu Cong Liu Quan Liu Xuemei Wang Ziqian Yang Man Liang Zilong Liu Source Type: research
A special type of homicide-suicide: A retrospective study of the characteristics of extended suicide
Int J Law Psychiatry. 2024 Apr 24;94:101987. doi: 10.1016/j.ijlp.2024.101987. Online ahead of print.ABSTRACTExtended suicide, a specific type of homicide-suicide event, has severe social consequences yet remains lacking systematic research. This retrospective study investigated 51 cases of extended suicide involving mental disorders in central China with aim of better understanding risk factors for such events and guiding prevention strategies. Over an 8-year period from 2015 to 2022, cases were collected from forensic institutions, and demographic characteristics, case details, and psychiatric data were recorded. The 51 i...
Source: International Journal of Law and Psychiatry - April 25, 2024 Category: Medical Law Authors: Luyao Xu Cong Liu Quan Liu Xuemei Wang Ziqian Yang Man Liang Zilong Liu Source Type: research
