Comparison of safety of acetaminophen and ibuprofen in minors: based on the FAERS database
CONCLUSIONS: The use of acetaminophen and ibuprofen in children of different age groups has different characteristics. Pediatric clinical pharmacists can provide medication monitoring to minimize ADEs based on these characteristics.PMID:38686870 | DOI:10.1080/14740338.2024.2348614 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 30, 2024 Category: Drugs & Pharmacology Authors: Jing Wang Guowen Feng Dan Li Xiaodan Zhou Jia Chen Fengdie Wang Li Chen Source Type: research
A case of paralytic shellfish poisoning caused by consumption of visceral balls from geoduck Panopea japonica in Japan
Toxicon. 2024 Apr 27:107738. doi: 10.1016/j.toxicon.2024.107738. Online ahead of print.ABSTRACTIn the end of March 2018, an unprecedented food poisoning incident due to ingestion of the visceral balls of geoduck Panopea japonica occurred in Japan. The patient, presented with symptoms of numbness on the lips and general weakness, was diagnosed as paralytic shellfish poisoning (PSP). The patient immediately treated with the mechanical ventilation recovered and left the hospital after 3 days treatment. Saxitoxins (STXs) in the plasma and urinary samples collected from the patient on the first and second day after hospitalizat...
Source: Toxicon - April 30, 2024 Category: Toxicology Authors: Ryuichi Watanabe Hiroshi Oikawa Takefumi Tsunemitsu Kazutaka Miyahara Mayu Ozawa Satoshi Numano Hajime Uchida Ryoji Matsushima Toshiyuki Suzuki Source Type: research
Preventable Premature Deaths from the Five Leading Causes of Death in Nonmetropolitan and Metropolitan Counties, United States, 2010-2022
This report provides estimates of preventable premature deaths for additional years (2010-2022).PERIOD COVERED: 2010-2022.DESCRIPTION OF SYSTEM: Mortality data for U.S. residents from the National Vital Statistics System were used to calculate preventable premature deaths from the five leading causes of death among persons aged <80 years. CDC's National Center for Health Statistics urban-rural classification scheme for counties was used to categorize the deaths according to the urban-rural county classification level of the decedent's county of residence (1: large central metropolitan [most urban], 2: large fringe metro...
Source: MMWR Surveill Summ - April 30, 2024 Category: Epidemiology Authors: Macarena C Garc ía Lauren M Rossen Kevin Matthews Gery Guy Katrina F Trivers Cheryll C Thomas Linda Schieb Michael F Iademarco Source Type: research
Preventable Premature Deaths from the Five Leading Causes of Death in Nonmetropolitan and Metropolitan Counties, United States, 2010-2022
This report provides estimates of preventable premature deaths for additional years (2010-2022).PERIOD COVERED: 2010-2022.DESCRIPTION OF SYSTEM: Mortality data for U.S. residents from the National Vital Statistics System were used to calculate preventable premature deaths from the five leading causes of death among persons aged <80 years. CDC's National Center for Health Statistics urban-rural classification scheme for counties was used to categorize the deaths according to the urban-rural county classification level of the decedent's county of residence (1: large central metropolitan [most urban], 2: large fringe metro...
Source: MMWR Surveill Summ - April 30, 2024 Category: Epidemiology Authors: Macarena C Garc ía Lauren M Rossen Kevin Matthews Gery Guy Katrina F Trivers Cheryll C Thomas Linda Schieb Michael F Iademarco Source Type: research
Preventable Premature Deaths from the Five Leading Causes of Death in Nonmetropolitan and Metropolitan Counties, United States, 2010-2022
This report provides estimates of preventable premature deaths for additional years (2010-2022).PERIOD COVERED: 2010-2022.DESCRIPTION OF SYSTEM: Mortality data for U.S. residents from the National Vital Statistics System were used to calculate preventable premature deaths from the five leading causes of death among persons aged <80 years. CDC's National Center for Health Statistics urban-rural classification scheme for counties was used to categorize the deaths according to the urban-rural county classification level of the decedent's county of residence (1: large central metropolitan [most urban], 2: large fringe metro...
Source: MMWR Surveill Summ - April 30, 2024 Category: Epidemiology Authors: Macarena C Garc ía Lauren M Rossen Kevin Matthews Gery Guy Katrina F Trivers Cheryll C Thomas Linda Schieb Michael F Iademarco Source Type: research
Delta-8 tetrahydrocannabinol, delta-10 tetrahydrocannabinol, and tetrahydrocannabinol-O acetate exposures reported to America ’s Poison Centers
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - April 30, 2024 Category: Toxicology Authors: Alice BurgessHannah L. HaysJaahnavi BadetiHenry A. SpillerNatalie I. RineChristopher E. GawKele DingGary A. Smitha Center for Injury Research and Policy, The Abigail Wexner Research Institute at Nationwide Children ’s Hospital, Columbus, OH, USAb Univer Source Type: research
Poisoning by alcohols and glycols
Ethanol intoxication is commonly encountered and can cause hypotension, hypoglycaemia, lactic acidosis, seizures and coma. Isopropyl alcohol and its metabolite acetone cause profound depression of the central nervous system with rapid onset. Toxic alcohols include methanol, ethylene glycol and diethylene glycol; these can cause severe metabolic acidosis, acute rena l failure and, for methanol, severe visual disturbance. Toxicity is attributable to metabolites and there is a characteristic delay between ingestion and the occurrence of severe toxicity. (Source: Medicine)
Source: Medicine - April 30, 2024 Category: Internal Medicine Authors: William Stephen Waring Tags: Poisonous substances Source Type: research
Ethnopharmacological uses of fauna among the people of central Punjab, Pakistan
This study focuses on investigating the utilization of animal-based traditional medicine by the people of Pakistan, specifically in the Gujranwala area.METHODS: Data collection took place from January to September 2019 through interviews with local communities. Ethnomedicinal applications of animal products were analyzed using several indices, including Relative Frequency of Citation (RFC), Relative Popularity Level (RPL), Folk Use Value (FL), and Relative Occurrence Percentage (ROP).RESULTS: The study identified the use of different body parts of 54 species of animals in treating various diseases and health issues. These ...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Abdul Majid Khan Muhammad Altaf Tanveer Hussain M Haroon Hamed Umaira Safdar Amina Ayub Zaibun-Nisa Memon Adnan Hafiz Sana Ashraf Muhammad Shoaib Amjad Muhammad Majeed Musheerul Hassan Rainer W Bussmann Arshad Mahmood Abbasi Mohamed Al-Yafrsi Hosam O Elan Source Type: research
Ethnopharmacological uses of fauna among the people of central Punjab, Pakistan
This study focuses on investigating the utilization of animal-based traditional medicine by the people of Pakistan, specifically in the Gujranwala area.METHODS: Data collection took place from January to September 2019 through interviews with local communities. Ethnomedicinal applications of animal products were analyzed using several indices, including Relative Frequency of Citation (RFC), Relative Popularity Level (RPL), Folk Use Value (FL), and Relative Occurrence Percentage (ROP).RESULTS: The study identified the use of different body parts of 54 species of animals in treating various diseases and health issues. These ...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Abdul Majid Khan Muhammad Altaf Tanveer Hussain M Haroon Hamed Umaira Safdar Amina Ayub Zaibun-Nisa Memon Adnan Hafiz Sana Ashraf Muhammad Shoaib Amjad Muhammad Majeed Musheerul Hassan Rainer W Bussmann Arshad Mahmood Abbasi Mohamed Al-Yafrsi Hosam O Elan Source Type: research
A case of Gloriosa superba poisoning
Volume 56, Issue sup1, May 2024 . (Source: Australian Journal of Forensic Sciences)
Source: Australian Journal of Forensic Sciences - April 29, 2024 Category: Forensic Medicine Authors: Kasun Bandara EkanayakeBandarage SanjayaAmal Nishantha VadysingheGayan KumarasingheSarathchandra KodikaraDinesh FernandoChathula WickramasingheTharanga NayakarathneDepartment of Forensic Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Source Type: research
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection
by Alexandra Maure, Emeline Lawar ée, Francesco Fiorentino, Alexandre Pawlik, Saideep Gona, Alexandre Giraud-Gatineau, Matthew J. G. Eldridge, Anne Danckaert, David Hardy, Wafa Frigui, Camille Keck, Claude Gutierrez, Olivier Neyrolles, Nathalie Aulner, Antonello Mai, Mélanie Hamon, Luis B. Barreiro, Priscille Brodin, Roland Brosch , Dante Rotili, Ludovic Tailleux
Antituberculosis drugs, mostly developed over 60 years ago, combined with a poorly effective vaccine, have failed to eradicate tuberculosis. More worryingly, multiresistant strains ofMycobacterium tuberculosis (MTB) are constantly emerging. Innovative strategie...
Source: PLoS Biology: Archived Table of Contents - April 29, 2024 Category: Biology Authors: Alexandra Maure Source Type: research
Poisoning by venomous animals
Poisoning by venomous creatures is common. Most is benign, causing only minor irritation or pain, but rarely significant morbidity and mortality can occur. Medically important venomous creatures include snakes, spiders, scorpions and marine creatures. For suspected cases of severe envenoming, seek early expert advice from a clinical toxicologist or poisons information centre. First aid measures include pressure bandaging of the affected limb with immobilization in suspected snakebite and funnel web spider bite, and hot water immersion therapy for many marin e stings. (Source: Medicine)
Source: Medicine - April 29, 2024 Category: Internal Medicine Authors: Katherine Z. Isoardi, Geoffrey K. Isbister Tags: Poisonous substances Source Type: research
Poisoning by antidepressants and antipsychotics
Tricyclic antidepressants, citalopram, venlafaxine and monoamine oxidase inhibitors are the most toxic antidepressants in overdose. Features include hypotension and arrhythmias that are best managed by the aggressive correction of metabolic acidosis with sodium bicarbonate. Antipsychotic drugs differ in their chemical structure and specificity at dopamine receptors. Overdose produces a range of adverse effects including sedation and acute extrapyramidal reactions. Cardiovascular effects including hypotension, prolongation of the QT interval and, potentially, arrhythmias including torsade de pointes are also seen. (Source: Medicine)
Source: Medicine - April 29, 2024 Category: Internal Medicine Authors: Aidan King, Ruben Thanacoody Tags: Poisonous substances Source Type: research
Principles of assessment and diagnosis of the poisoned patient
Assessment of patients with acute poisoning includes history-taking, assessment of airway, breathing, circulation and consciousness level, physical examination to elicit relevant clinical signs and appropriate investigations. Diagnosis is usually based on the history, recognition of toxidromes (when present) and results of investigations. (Source: Medicine)
Source: Medicine - April 29, 2024 Category: Internal Medicine Authors: Aidan King, Ruben Thanacoody Tags: General aspects of poisoning Source Type: research
Poisoning by opioids
Opioids are among the most commonly prescribed analgesic medications, and opioid toxicity is becoming an increasing problem across the world. Patients typically present with a triad of signs: reduced consciousness, miosis and a reduced respiratory rate with shallow breaths. Patients with significant opioid toxicity are at risk of airway compromise, and basic supportive measures should be performed. Naloxone is a non-selective μ-opioid receptor antagonist that competitively binds to the μ-opioid receptor and should be administered, ideally intravenously, to patients with significant opioid toxicity. (Source: Medicine)
Source: Medicine - April 29, 2024 Category: Internal Medicine Authors: Kerry A Layne, David M Wood Tags: Poisonous substances Source Type: research
