Inhibition kinetics of acetylcholinesterase and butyrylcholinesterase from various species by 2-(2-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP)
Toxicol Lett. 2024 Apr 18;396:28-33. doi: 10.1016/j.toxlet.2024.04.003. Online ahead of print.ABSTRACTThe aerotoxic syndrome has been associated with exposure to tricresyl phosphate (TCP), which is used as additive in hydraulic fluids and engine lubricants. The toxic metabolite 2-(2-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP) is formed from the TCP isomer tri-ortho-cresyl phosphate (TOCP) in vivo and is known to react with the active site serine in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) resulting in the inhibition of the enzymes. Previous in vitro studies showed pronounced species differences...
Source: Toxicology Letters - April 20, 2024 Category: Toxicology Authors: Gabriele Horn Sebastian Rappengl ück Franz Worek Source Type: research
Evaluation of capillary miR-122 as a prognostic biomarker of paracetamol-induced liver toxicity
CONCLUSION: This work supports the potential use of capillary miR-122 as a prognostic biomarker of liver injury throughout clinical management of patients with paracetamol overdose. Capillary miR-122 can be measured in a blood drop collected by a finger prick, a minimally invasive diagnostic test for patient stratification.PMID:38642142 | DOI:10.1007/s11033-024-09327-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Marco Cirronis Sarah Schneemann Janice Pettie Guido Mannaioni James W Dear Source Type: research
Inhibition kinetics of acetylcholinesterase and butyrylcholinesterase from various species by 2-(2-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP)
Toxicol Lett. 2024 Apr 18;396:28-33. doi: 10.1016/j.toxlet.2024.04.003. Online ahead of print.ABSTRACTThe aerotoxic syndrome has been associated with exposure to tricresyl phosphate (TCP), which is used as additive in hydraulic fluids and engine lubricants. The toxic metabolite 2-(2-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP) is formed from the TCP isomer tri-ortho-cresyl phosphate (TOCP) in vivo and is known to react with the active site serine in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) resulting in the inhibition of the enzymes. Previous in vitro studies showed pronounced species differences...
Source: Toxicology Letters - April 20, 2024 Category: Toxicology Authors: Gabriele Horn Sebastian Rappengl ück Franz Worek Source Type: research
Inhibition kinetics of acetylcholinesterase and butyrylcholinesterase from various species by 2-(2-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP)
Toxicol Lett. 2024 Apr 18;396:28-33. doi: 10.1016/j.toxlet.2024.04.003. Online ahead of print.ABSTRACTThe aerotoxic syndrome has been associated with exposure to tricresyl phosphate (TCP), which is used as additive in hydraulic fluids and engine lubricants. The toxic metabolite 2-(2-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP) is formed from the TCP isomer tri-ortho-cresyl phosphate (TOCP) in vivo and is known to react with the active site serine in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) resulting in the inhibition of the enzymes. Previous in vitro studies showed pronounced species differences...
Source: Toxicology Letters - April 20, 2024 Category: Toxicology Authors: Gabriele Horn Sebastian Rappengl ück Franz Worek Source Type: research
Factors affecting safe pesticide-use behaviors among farm plant agriculturists in northeastern Thailand
Pesticide poisoning is a major public health problem in Thailand and is the result of intensive inappropriate and unsafe use of pesticides. This analytical cross-sectional study aimed to determine the factors ... (Source: BMC Public Health)
Source: BMC Public Health - April 20, 2024 Category: Consumer Health News Authors: Bunliang Suphim and Archin Songthap Tags: Research Source Type: research
Challenges and Limitations of Extracorporeal Membrane Oxygenation Therapy in Severe Paraquat Poisoning: An Analysis of Unsuccessful Cases
Arch Bronconeumol. 2024 Mar 13:S0300-2896(24)00063-2. doi: 10.1016/j.arbres.2024.03.004. Online ahead of print.NO ABSTRACTPMID:38641437 | DOI:10.1016/j.arbres.2024.03.004 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - April 19, 2024 Category: Respiratory Medicine Authors: Zhenhua Du Yu-Hua Zhang Liang Sun Source Type: research
Effective skin decontamination with RSDL ® (Reactive Skin Decontamination Lotion Kit) following dermal exposure to a Novichok class nerve agent
This study determines RSDL decontamination as an effective treatment strategy for dermal exposure to the Novichok agent A234 and underscores the importance of early, forward use of skin decontamination, as rapidly as possible.PMID:38641146 | DOI:10.1016/j.cbi.2024.111001 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - April 19, 2024 Category: Molecular Biology Authors: Alex S Cornelissen Roland M van den Berg Jan P Langenberg Marco van Grol Rowdy Bross John Pittman Laura Cochrane Vladimir Savransky Source Type: research
Amanitin-induced variable cytotoxicity in various cell lines is mediated by the different expression levels of OATP1B3
Food Chem Toxicol. 2024 Apr 17;188:114665. doi: 10.1016/j.fct.2024.114665. Online ahead of print.ABSTRACTAmanita phalloides is one of the deadliest mushrooms worldwide, causing most fatal cases of mushroom poisoning. Among the poisonous substances of Amanita phalloides, amanitins are the most lethal toxins to humans. Currently, there are no specific antidotes available for managing amanitin poisoning and treatments are lack of efficacy. Amanitin mainly causes severe injuries to specific organs, such as the liver, stomach, and kidney, whereas the lung, heart, and brain are hardly affected. However, the molecular mechanism o...
Source: Food and Chemical Toxicology - April 19, 2024 Category: Food Science Authors: Mengqiang Gong Zhi Li Hua Xu Bo Ma Pengxia Gao Lili Wang Junkai Li Qinglai Wu Jianfeng Wu Jianwei Xie Source Type: research
Risk and safety profile of electronic nicotine delivery systems (ENDS): an umbrella review to inform ENDS health communication strategies
Conclusions
As evidence is accumulating, ENDS communication can focus on high-level evidence on ENDS association with toxicity, nicotine addiction, respiratory disease, ENDS-specific harm (explosion, poisoning) and anti-ENDS industry sentiment. Direct comparison between the harm of CCs and ENDS should be avoided.
PROSPERO registration number
CRD42021241630. (Source: Tobacco Control)
Source: Tobacco Control - April 19, 2024 Category: Respiratory Medicine Authors: Asfar, T., Jebai, R., Li, W., Oluwole, O. J., Ferdous, T., Gautam, P., Schmidt, M., Noar, S. M., Lindblom, E. N., Eissenberg, T., Bursac, Z., Vallone, D., Maziak, W. Tags: Editor's choice Systematic review Source Type: research
Capacity, Rationality, and the Promotion of Autonomy: A Trauma-Informed Approach to Refusals of Care After Opioid Poisoning
Am J Bioeth. 2024 May;24(5):48-51. doi: 10.1080/15265161.2024.2327285. Epub 2024 Apr 18.NO ABSTRACTPMID:38635442 | DOI:10.1080/15265161.2024.2327285 (Source: The American Journal of Bioethics : AJOB)
Source: The American Journal of Bioethics : AJOB - April 18, 2024 Category: Medical Ethics Authors: Cameron Cattell Elaine Hyshka Brendan Leier Cheryl Mack Source Type: research
Capacity, Rationality, and the Promotion of Autonomy: A Trauma-Informed Approach to Refusals of Care After Opioid Poisoning
Am J Bioeth. 2024 May;24(5):48-51. doi: 10.1080/15265161.2024.2327285. Epub 2024 Apr 18.NO ABSTRACTPMID:38635442 | DOI:10.1080/15265161.2024.2327285 (Source: American Journal of Bioethics)
Source: American Journal of Bioethics - April 18, 2024 Category: Medical Ethics Authors: Cameron Cattell Elaine Hyshka Brendan Leier Cheryl Mack Source Type: research
Capacity, Rationality, and the Promotion of Autonomy: A Trauma-Informed Approach to Refusals of Care After Opioid Poisoning
Am J Bioeth. 2024 May;24(5):48-51. doi: 10.1080/15265161.2024.2327285. Epub 2024 Apr 18.NO ABSTRACTPMID:38635442 | DOI:10.1080/15265161.2024.2327285 (Source: The American Journal of Bioethics : AJOB)
Source: The American Journal of Bioethics : AJOB - April 18, 2024 Category: Medical Ethics Authors: Cameron Cattell Elaine Hyshka Brendan Leier Cheryl Mack Source Type: research
Capacity, Rationality, and the Promotion of Autonomy: A Trauma-Informed Approach to Refusals of Care After Opioid Poisoning
Am J Bioeth. 2024 May;24(5):48-51. doi: 10.1080/15265161.2024.2327285. Epub 2024 Apr 18.NO ABSTRACTPMID:38635442 | DOI:10.1080/15265161.2024.2327285 (Source: American Journal of Bioethics)
Source: American Journal of Bioethics - April 18, 2024 Category: Medical Ethics Authors: Cameron Cattell Elaine Hyshka Brendan Leier Cheryl Mack Source Type: research
Sudden death syndrome in domestic ruminants: a review
AbstractThis review provides a comprehensive exploration of factors contributing to sudden death (SD) in ruminants, focusing on cattle, sheep, and goats. The definition of unexpected death varies based on the farming system. In intensive systems, constant surveillance enables rapid detection of diseases, while in extensive systems, irregular checks may result in finding animals dead after a prolonged illness. SD syndrome definitions vary; some involve clear clinical signs, while others consider acute death in apparently healthy animals. Various infectious causes of SD are discussed, including enterotoxemia, hemorrhagic bow...
Source: Comparative Clinical Pathology - April 18, 2024 Category: Pathology Source Type: research
Increasing severity of medical outcomes and associated substances in cases reported to United States poison centers
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - April 18, 2024 Category: Toxicology Authors: Rita FarahRyan J. ColeChristopher P. HolstegeDivision of Medical Toxicology, Department of Emergency Medicine, University of VA, Charlottesville, VA, USA Source Type: research
