Pediatric poisoning management: How clinical practice can benefit from forensic approach
J Forensic Sci. 2024 Apr 1. doi: 10.1111/1556-4029.15517. Online ahead of print.ABSTRACTPediatric population represents the most vulnerable and at risk for unintentional poisoning, with children younger than 6 years old accounting for nearly half of poison exposures. Poisoning is a time-dependent emergency. The need to reach a scientific agreement on diagnostic protocol and treatment seems to be crucial to reduce morbidity and mortality. Starting from a buprenorphine pediatric intoxication case, this article highlights the limits and pitfalls of the traditional diagnostic approach. Diagnosis of drug intoxication was achiev...
Source: Journal of Forensic Sciences - April 1, 2024 Category: Forensic Medicine Authors: Pascale Basilicata Mariagrazia Marisei Rossella Guadagni Michelina Sibilio Massimo Niola Maria Pieri Source Type: research
In patients with coma due to acute poisoning, withholding intubation improved clinical outcomes
Ann Intern Med. 2024 Apr 2. doi: 10.7326/J24-0011. Online ahead of print.ABSTRACTFreund Y, Viglino D, Cachanado M, et al. Effect of noninvasive airway management of comatose patients with acute poisoning: a randomized clinical trial. JAMA. 2023;330:2267-2274. 38019968.PMID:38560902 | DOI:10.7326/J24-0011 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 1, 2024 Category: Internal Medicine Authors: Evan S Schwarz Source Type: research
In patients with coma due to acute poisoning, withholding intubation improved clinical outcomes
Ann Intern Med. 2024 Apr 2. doi: 10.7326/J24-0011. Online ahead of print.ABSTRACTFreund Y, Viglino D, Cachanado M, et al. Effect of noninvasive airway management of comatose patients with acute poisoning: a randomized clinical trial. JAMA. 2023;330:2267-2274. 38019968.PMID:38560902 | DOI:10.7326/J24-0011 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 1, 2024 Category: Internal Medicine Authors: Evan S Schwarz Source Type: research
In patients with coma due to acute poisoning, withholding intubation improved clinical outcomes
Ann Intern Med. 2024 Apr 2. doi: 10.7326/J24-0011. Online ahead of print.ABSTRACTFreund Y, Viglino D, Cachanado M, et al. Effect of noninvasive airway management of comatose patients with acute poisoning: a randomized clinical trial. JAMA. 2023;330:2267-2274. 38019968.PMID:38560902 | DOI:10.7326/J24-0011 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 1, 2024 Category: Internal Medicine Authors: Evan S Schwarz Source Type: research
In patients with coma due to acute poisoning, withholding intubation improved clinical outcomes
Ann Intern Med. 2024 Apr 2. doi: 10.7326/J24-0011. Online ahead of print.ABSTRACTFreund Y, Viglino D, Cachanado M, et al. Effect of noninvasive airway management of comatose patients with acute poisoning: a randomized clinical trial. JAMA. 2023;330:2267-2274. 38019968.PMID:38560902 | DOI:10.7326/J24-0011 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 1, 2024 Category: Internal Medicine Authors: Evan S Schwarz Source Type: research
Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning
摘要草铵膦作为谷氨酸(Glu)的结构类似物,可以不可逆地抑制植物中谷氨酰胺合成酶(GS)和谷氨酸脱羧酶活性,从而阻止谷氨酰胺(Gln)生成,最终导致植物因氮代谢紊乱和细胞内氨积累而死亡。人误服草胺磷后也会出现相应的中毒症状,包括 胃肠道症状和神经毒性。草铵膦作为最常见的致癫痫类除草剂,且无特定解毒剂,因此支持性治疗至关重要。在临床诊治过程中,如何及时有效识别草铵膦除草剂引起的神经毒性并提供适当治疗尤为关键。本文介绍了我院三名草铵膦 中毒患者的主要...
Source: Journal of Zhejiang University. Science. B. - April 1, 2024 Category: Universities & Medical Training Source Type: research
Effects of the nerve agent VX on hiPSC-derived motor neurons
Arch Toxicol. 2024 Mar 30. doi: 10.1007/s00204-024-03708-3. Online ahead of print.ABSTRACTPoisoning with the organophosphorus nerve agent VX can be life-threatening due to limitations of the standard therapy with atropine and oximes. To date, the underlying pathomechanism of VX affecting the neuromuscular junction has not been fully elucidated structurally. Results of recent studies investigating the effects of VX were obtained from cells of animal origin or immortalized cell lines limiting their translation to humans. To overcome this limitation, motor neurons (MN) of this study were differentiated from in-house feeder- a...
Source: Archives of Toxicology - March 30, 2024 Category: Toxicology Authors: Catherine Schaefers Wolfgang Schmei ßer Harald John Franz Worek Theo Rein Simone Rothmiller Annette Schmidt Source Type: research
Transforming toxins into treatments: the revolutionary role of α-amanitin in cancer therapy
Arch Toxicol. 2024 Mar 30. doi: 10.1007/s00204-024-03727-0. Online ahead of print.ABSTRACTAmanita phalloides is the primary species responsible for fatal mushroom poisoning, as its main toxin, α-amanitin, irreversibly and potently inhibits eukaryotic RNA polymerase II (RNAP II), leading to cell death. There is no specific antidote for α-amanitin, which hinders its clinical application. However, with the advancement of precision medicine in oncology, including the development of antibody-drug conjugates (ADCs), the potential value of various toxic small molecules has been explored. These ADCs ingeniously combine the targe...
Source: Archives of Toxicology - March 30, 2024 Category: Toxicology Authors: Deyuan Ning Jinfang Xue Xiran Lou Ruifei Shao Yu Liu Guobing Chen Source Type: research
Effects of the nerve agent VX on hiPSC-derived motor neurons
Arch Toxicol. 2024 Mar 30. doi: 10.1007/s00204-024-03708-3. Online ahead of print.ABSTRACTPoisoning with the organophosphorus nerve agent VX can be life-threatening due to limitations of the standard therapy with atropine and oximes. To date, the underlying pathomechanism of VX affecting the neuromuscular junction has not been fully elucidated structurally. Results of recent studies investigating the effects of VX were obtained from cells of animal origin or immortalized cell lines limiting their translation to humans. To overcome this limitation, motor neurons (MN) of this study were differentiated from in-house feeder- a...
Source: Archives of Toxicology - March 30, 2024 Category: Toxicology Authors: Catherine Schaefers Wolfgang Schmei ßer Harald John Franz Worek Theo Rein Simone Rothmiller Annette Schmidt Source Type: research
Transforming toxins into treatments: the revolutionary role of α-amanitin in cancer therapy
Arch Toxicol. 2024 Mar 30. doi: 10.1007/s00204-024-03727-0. Online ahead of print.ABSTRACTAmanita phalloides is the primary species responsible for fatal mushroom poisoning, as its main toxin, α-amanitin, irreversibly and potently inhibits eukaryotic RNA polymerase II (RNAP II), leading to cell death. There is no specific antidote for α-amanitin, which hinders its clinical application. However, with the advancement of precision medicine in oncology, including the development of antibody-drug conjugates (ADCs), the potential value of various toxic small molecules has been explored. These ADCs ingeniously combine the targe...
Source: Archives of Toxicology - March 30, 2024 Category: Toxicology Authors: Deyuan Ning Jinfang Xue Xiran Lou Ruifei Shao Yu Liu Guobing Chen Source Type: research
Effects of the nerve agent VX on hiPSC-derived motor neurons
Arch Toxicol. 2024 Mar 30. doi: 10.1007/s00204-024-03708-3. Online ahead of print.ABSTRACTPoisoning with the organophosphorus nerve agent VX can be life-threatening due to limitations of the standard therapy with atropine and oximes. To date, the underlying pathomechanism of VX affecting the neuromuscular junction has not been fully elucidated structurally. Results of recent studies investigating the effects of VX were obtained from cells of animal origin or immortalized cell lines limiting their translation to humans. To overcome this limitation, motor neurons (MN) of this study were differentiated from in-house feeder- a...
Source: Archives of Toxicology - March 30, 2024 Category: Toxicology Authors: Catherine Schaefers Wolfgang Schmei ßer Harald John Franz Worek Theo Rein Simone Rothmiller Annette Schmidt Source Type: research
Transforming toxins into treatments: the revolutionary role of α-amanitin in cancer therapy
Arch Toxicol. 2024 Mar 30. doi: 10.1007/s00204-024-03727-0. Online ahead of print.ABSTRACTAmanita phalloides is the primary species responsible for fatal mushroom poisoning, as its main toxin, α-amanitin, irreversibly and potently inhibits eukaryotic RNA polymerase II (RNAP II), leading to cell death. There is no specific antidote for α-amanitin, which hinders its clinical application. However, with the advancement of precision medicine in oncology, including the development of antibody-drug conjugates (ADCs), the potential value of various toxic small molecules has been explored. These ADCs ingeniously combine the targe...
Source: Archives of Toxicology - March 30, 2024 Category: Toxicology Authors: Deyuan Ning Jinfang Xue Xiran Lou Ruifei Shao Yu Liu Guobing Chen Source Type: research
Trends in Adolescent Suicide by Method in the US, 1999-2020
CONCLUSIONS AND RELEVANCE: Suicide rates increased across all methods from 1999 to 2020. Differences were noted by sex, age, and race and ethnicity. Increasing suicide rates among racial and ethnic minoritized youth are especially concerning, and effective prevention strategies are urgently needed.PMID:38551558 | DOI:10.1001/jamanetworkopen.2024.4427 (Source: Cancer Control)
Source: Cancer Control - March 29, 2024 Category: Cancer & Oncology Authors: Cameron K Ormiston Wayne R Lawrence Saanie Sulley Meredith S Shiels Emily A Haozous Catherine M Pichardo Erica S Stephens Aleah L Thomas David Adzrago David R Williams Faustine Williams Source Type: research
Comparative analysis of organophosphorus versus carbamate pesticide poisoning: a case study
Arh Hig Rada Toksikol. 2024 Mar 29;75(1):81-84. doi: 10.2478/aiht-2024-75-3781. eCollection 2024 Mar 1.ABSTRACTOrganophosphorus poisoning is a critical condition that can cause central nervous system depression, respiratory failure, and death early on. As its clinical manifestations closely resemble those of carbamate pesticide poisoning, the aim of this case study is to present a case of misdiagnosis, initially identifying carbofuran poisoning as organophosphate in a patient suspect of a heatstroke. We also present a case of intentional self-poisoning with organophosphate dichlorvos to underline the likelihood of pesticid...
Source: Arhiv za Higijenu Rada i Toksikologiju - March 28, 2024 Category: Occupational Health Authors: Jia-Ding Xia Hui Wang Li-Wei Hua Min Xu Xin Zheng Kun Zhang Source Type: research
Blood lead levels in an endangered vulture decline following changes in hunting activity
Environ Res. 2024 Mar 26:118712. doi: 10.1016/j.envres.2024.118712. Online ahead of print.ABSTRACTLead ammunition stands out as one of the most pervasive pollutants affecting wildlife. Its impact on bird populations have spurred efforts for the phase-out of leaded gunshot in several countries, although with varying scopes and applications. Ongoing and future policy changes require data to assess the effectiveness of adopted measures, particularly in the current context of biodiversity loss. Here, we assessed the long-term changes in blood lead (Pb) levels of Egyptian vultures from the Canary Islands, Spain, which have been...
Source: Environmental Research - March 28, 2024 Category: Environmental Health Authors: L Gangoso R Mateo C Santamar ía-Cervantes M Garc ía-Alfonso C Gimeno-Castellano E Arrondo D Serrano T van Overveld M de la Riva M A Cabrera J A Don ázar Source Type: research
