Learning enhances representations of taste-guided decisions in the mouse gustatory insular cortex
Curr Biol. 2024 Apr 12:S0960-9822(24)00374-9. doi: 10.1016/j.cub.2024.03.034. Online ahead of print.ABSTRACTLearning to discriminate overlapping gustatory stimuli that predict distinct outcomes-a feat known as discrimination learning-can mean the difference between ingesting a poison or a nutritive meal. Despite the obvious importance of this process, very little is known about the neural basis of taste discrimination learning. In other sensory modalities, this form of learning can be mediated by either the sharpening of sensory representations or the enhanced ability of "decision-making" circuits to interpret sensory info...
Source: Current Biology - April 17, 2024 Category: Biology Authors: Joshua F Kogan Alfredo Fontanini Source Type: research
MALDI-mass spectrometry imaging as a new technique for detecting non-heme iron in peripheral tissues via caudal vein injection of deferoxamine
Anal Bioanal Chem. 2024 Apr 17. doi: 10.1007/s00216-024-05289-7. Online ahead of print.ABSTRACTAs one of the most common iron-chelating agents, deferoxamine (DFO) rapidly chelates iron in the body. Moreover, it does not compete for the iron characteristic of hemoglobin in the blood cells, which is common in the clinical treatment of iron poisoning. Iron is a trace element necessary to maintain organism normal life activities. Iron deficiency can lead to anemia, whereas iron overload can cause elevated levels of cellular oxidative stress and cell damage. As a consequence, detection of the iron content in tissues and blood i...
Source: Analytical and Bioanalytical Chemistry - April 17, 2024 Category: Chemistry Authors: Xiaofang Jin Xintong Shi Tong Zhang Xingyao Li Yajing Xie Siyu Tian Kang Han Source Type: research
On the performance of Sargassum-derived calcium alginate ion exchange resins for Pb < sup > 2+ < /sup > adsorption: batch and packed bed applications
Environ Sci Pollut Res Int. 2024 Apr 17. doi: 10.1007/s11356-024-33314-w. Online ahead of print.ABSTRACTDriven by climate change and human activity, Sargassum blooming rates have intensified, producing copious amount of the invasive, pelagic seaweed across the Caribbean and Latin America. Battery recycling and lead-smelter wastes have heavily polluted the environment and resulted in acute lead poisoning in children through widespread heavy metal contamination particular in East Trinidad. Our study details a comprehensive investigation into the use of Sargassum (S. natans), as a potential resource-circular feedstock for the...
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Akeem Mohammed Chantal Mohammed Andreas Mautner Matika Kistow Pooran Chaitram Alexander Bismarck Keeran Ward Source Type: research
Learning enhances representations of taste-guided decisions in the mouse gustatory insular cortex
Curr Biol. 2024 Apr 12:S0960-9822(24)00374-9. doi: 10.1016/j.cub.2024.03.034. Online ahead of print.ABSTRACTLearning to discriminate overlapping gustatory stimuli that predict distinct outcomes-a feat known as discrimination learning-can mean the difference between ingesting a poison or a nutritive meal. Despite the obvious importance of this process, very little is known about the neural basis of taste discrimination learning. In other sensory modalities, this form of learning can be mediated by either the sharpening of sensory representations or the enhanced ability of "decision-making" circuits to interpret sensory info...
Source: Current Biology - April 17, 2024 Category: Biology Authors: Joshua F Kogan Alfredo Fontanini Source Type: research
Impact of COVID-19 restrictions on self-poisoning behaviour with mild analgesics in Danish youth
CONCLUSION: These findings indicate that the restrictions enforced during the second lockdown greatly impacted youth mental health, especially girls, leading to an 85% increase in self-poisonings. We hope for increased awareness of mental health in children and adolescents during possible future lockdowns.PMID:38625374 | DOI:10.1080/08039488.2024.2339433 (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - April 16, 2024 Category: Psychiatry Authors: Gurbhej Singh Jonathan Pommer Hansen Ditte Hulgaard Mads Damkj ær Erik Christiansen Source Type: research
Eight-year epidemiological study for drug poisoning in Qassim, Saudi Arabia, 2008 –2015
. (Source: Drug and Chemical Toxicology)
Source: Drug and Chemical Toxicology - April 16, 2024 Category: Toxicology Authors: Sulaiman AlnasserAbubakr AlfadlMohammed Saif AnaamMeshal Alotaibia Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim, Saudi Arabiab Department of Pharmacy, Faculty of Medicine and Health Sciences, University of Scie Source Type: research
Patterns and trends of medicinal poisoning substances: a population-based cohort study of injuries in 0 –11 year old children from 1998–2018
ConclusionsPoisonings from DWRDs decreased by 33%, while paracetamol poisonings increased by 43% during the study period. There was a gradient by area-level socioeconomic deprivation in prescribed medication poisonings, including drugs with withdrawal/dependence risk, but not OTC medication poisonings. Households in more socioeconomically deprived areas have the potential to benefit most from measures to improve safe storage of medicines and are likely to require targeted interventions providing education and safety equipment. In addition, universal promotion of the safe storage of OTC and prescribed medicines must be prov...
Source: Archives of Public Health - April 16, 2024 Category: International Medicine & Public Health Source Type: research
Clinical presentation and management of methanol poisoning outbreaks in Riyadh, Saudi Arabia: a retrospective analysis
Acute methanol intoxication, whether unintentional or deliberate, necessitates prompt intervention to prevent severe morbidity and mortality. Homemade alcoholic beverages are a frequent source of such poisonin... (Source: BMC Emergency Medicine)
Source: BMC Emergency Medicine - April 16, 2024 Category: Emergency Medicine Authors: Faisal Alhusain, Mohammed Alshalhoub, Moath Bin Homaid, Laila Carolina Abu Esba, Mohammad Alghafees and Mohammad Al Deeb Tags: Research Source Type: research
Guide for the treatment of acute altered mental status. Iberoamerican Academy of Pediatric Neurology
Rev Neurol. 2024 Apr 16;78(8):229-235. doi: 10.33588/rn.7808.2023302.ABSTRACTIn pediatric patients, an acute altered mental status refers to a sudden and significant change in a child's brain function and level of consciousness. It may manifest as confusion, disorientation, agitation, lethargy or even a loss of consciousness. This condition is a medical emergency, and requires immediate evaluation and attention. There are several causes of acute altered mental status in children, including infections of the central nervous system such as meningitis or encephalitis, traumatic brain injury, metabolic disorders, seizures and ...
Source: Revista de Neurologia - April 15, 2024 Category: Neurology Authors: D L ópez F Espinel E Andrade A S Aguirre Source Type: research
Guide for the treatment of acute altered mental status. Iberoamerican Academy of Pediatric Neurology
Rev Neurol. 2024 Apr 16;78(8):229-235. doi: 10.33588/rn.7808.2023302.ABSTRACTIn pediatric patients, an acute altered mental status refers to a sudden and significant change in a child's brain function and level of consciousness. It may manifest as confusion, disorientation, agitation, lethargy or even a loss of consciousness. This condition is a medical emergency, and requires immediate evaluation and attention. There are several causes of acute altered mental status in children, including infections of the central nervous system such as meningitis or encephalitis, traumatic brain injury, metabolic disorders, seizures and ...
Source: Revista de Neurologia - April 15, 2024 Category: Neurology Authors: D L ópez F Espinel E Andrade A S Aguirre Source Type: research
Burton line and basophilic stippling in lead poisoning
CMAJ. 2024 Apr 14;196(14):E487. doi: 10.1503/cmaj.231405.NO ABSTRACTPMID:38621780 | DOI:10.1503/cmaj.231405 (Source: cmaj)
Source: cmaj - April 15, 2024 Category: General Medicine Authors: Takahide Morita Toshinori Nishizawa Toru Morikawa Source Type: research
