Fight Aging! Newsletter, March 7th 2022
This study estimates that prescreening with a 500 blood test could reduce by half both the cost and the time it takes to enroll patients in clinical trials that use PET scans. Screening with blood tests alone could be completed in less than six months and cut costs by tenfold or more, the study finds. Known as Precivity AD, the commercial version of the test is marketed by C2N Diagnostics. The current study shows that the blood test remains highly accurate, even when performed in different labs following different protocols, and in different cohorts across three continents.
xCT Knockout Modestly Extends Life in M...
Source: Fight Aging! - March 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Arguing for a Rate of Living View of Aging
The rate of living view of aging is one of the discarded historical hypotheses that occurred along the way to the modern competing ideas about why aging occurs, and why there are differences in longevity between species. Roughly, the rate of living hypothesis says that a faster metabolism means a shorter life, that underlying processes (such as accumulation of molecular damage) depend strongly on metabolic rate. This doesn't appear to be the case, however; setting aside more detailed considerations, there are enough exceptions to the rule, species with high metabolism and exceptional longevity, to sink the argument. It isn...
Source: Fight Aging! - March 4, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Biomedical Researchers RISE From the University of Texas, San Antonio
“One thing that we try to develop in students is a sense of belonging and scientific identity,” says Edwin Barea-Rodriguez, Ph.D., the director of the Research Training Initiative for Student Enhancement (RISE) program at the University of Texas, San Antonio (UTSA). The program provides undergraduate and graduate students from underrepresented backgrounds with research experiences, professional development opportunities, and faculty mentorships. The UTSA RISE program has helped hundreds of students build strong foundations for scientific careers over its more than 20-year history. Here, we share the stories of three st...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 2, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs
Sins Against Science - A Chat with Judi Nath | TAPP 110
AuthorJudi Nath stops by for a chat about her new bookSins Against Science: How Misinformation Affects Our Lives and Laws. We discuss theorigins of the book, its central message, and how we can use the book's content to becomebetter teachers of human anatomy& physiology.00:00 | Introduction00:42 | Introducing Judi Nath03:56 | Sponsored by AAA04:47 | Sins Against Science14:13 | Sponsored by HAPI15:01 | Stories About Science25:17 | Sponsored by HAPS26:24 | Hard Topics35:40 | Staying Connected★ If you cannot see or activate the audio player, go to:theAPprofessor.org/podcast-episode-110.html🏅 Apply for ...
Source: The A and P Professor - March 1, 2022 Category: Physiology Authors: Kevin Patton Source Type: blogs
Smart Orthopedic Implant to Enhance Bone Growth: Interview with Ben Hertzog, CEO at Intelligent Implants
Intelligent Implants, a medtech company based in Cork, Ireland, has developed the SmartFuse TLIF cage, a spinal implant intended to enhance bone healing and reduce rates of non-union following spinal fusion surgery. The implant is equipped with electrodes that are designed to enhance bone growth, as well as provide a means of monitoring bone healing.
A significant proportion of spinal fusion surgeries fail, leading to complications including pain and the requirement for corrective procedures. In many cases, spinal fusion fails because of non-union, where the vertebrae do not fuse. The SmartFuse TLIF cage implant is inte...
Source: Medgadget - February 28, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Orthopedic Surgery Source Type: blogs
Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty.
Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying r...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
GSK3 β Overexpression and Cellular Senescence in the Aging Kidney
Senescent cells accumulate with age, a growing imbalance between pace of creation and pace of clearance. The majority of senescent cells come into being as cells reach the Hayflick limit on replication, and survive for only a short time before succumbing to programmed cell death or immune system activity. But senescent cells can be created by injury, inflammation, and other forms of damage as well. Senescent cells secrete pro-growth, inflammatory signals. This is useful in the short term as a way to help the body clear up damage or potentially cancerous cells, but when sustained over the long term it is highly disruptive t...
Source: Fight Aging! - February 25, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Next-Generation Simulation Learning: Interview with James Archetto, VP of Gaumard Scientific
Gaumard Scientific, a Florida-based patient simulator company, has developed an advanced multidisciplinary patient simulator – the HAL S5301. Given the strain placed on healthcare systems by the pandemic, training with a robot may let more clinicians focus on patients rather than medical students, and help to reduce the risk of viral transmission posed to healthcare staff and patients.
However, there are a host of other benefits. This next-generation adult male simulator introduces robotics, AI-powered speech, and leading-edge simulated physiology and anatomy to medical education. The robot can understand what med...
Source: Medgadget - February 23, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Education Exclusive Source Type: blogs
Fight Aging! Newsletter, February 21st 2022
In conclusion, clinical trials targeting aging in humans have shown promising but limited results on biomarkers so far.
Mycobacterium Vaccae Immunization as an Anti-Inflammatory Strategy
https://www.fightaging.org/archives/2022/02/mycobacterium-vaccae-immunization-as-an-anti-inflammatory-strategy/
In today's open access paper, researchers discuss immunization with Mycobacterium vaccae as an approach to reduce the inflammatory overactivity of the aged immune system. Researchers have made some initial inroads into studying the way in which this bacteria can alter the function of the immune system, and her...
Source: Fight Aging! - February 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Protein Import Systems Influence Longevity
Mitochondria, the power plants of the cell, are the evolved descendants of ancient symbiotic bacteria. They have a small remnant mitochondrial genome, but over time most of the proteins necessary to mitochondrial function migrated to the nuclear genome. Such proteins are produced in the normal way in and around the cell nucleus, and are then imported into mitochondria for use. Researchers here investigate how this import system relates to longevity, finding that it can be adjusted in ways that influence quality control mechanisms and other aspects of mitochondrial metabolism.
Sustained mitochondrial fitness relies...
Source: Fight Aging! - February 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Inclusive Anatomy & Physiology Course | Part 2 | TAPP 109
This episode continues a discussion of the manysimple strategies available for making our anatomy and physiology coursemore inclusive. Here, we learneight more easy ways to make our courseswork better for all learners.0:00:00 | Introduction0:00:46 | More on the Inclusive Course0:07:51 | Sponsored by AAA0:08:38 | 8. Student Interest Survey0:14:35 | 9. Inclusive Office Hours0:24:22 | Sponsored by HAPI0:25:27 | 10. Valuing Diverse Viewpoints0:29:08 | 11. Inclusive Classroom Demeanor0:55:44 | Sponsored by HAPS0:56:38 | 12. Learning from Mistakes0:58:56 | 13. Suggest a Different Instructor1:08:33 | 14. Many Challenges Are Invis...
Source: The A and P Professor - February 15, 2022 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, February 14th 2022
In conclusion, this first examination of the effects of age and the ageing process on the small intestinal microbiome demonstrates that the duodenal microbiome changes with increasing age, with significant decreases in duodenal microbial diversity due to increased prevalence of phylum Proteobacteria, particularly coliforms and anaerobic taxa. Given the key roles of small intestinal microbes in nutrient absorption and host metabolism, these changes may be clinically relevant for human health during the ageing process.
Naked Mole Rats Exhibit Minimal Cardiac Aging
https://www.fightaging.org/archives/2022/02/nake...
Source: Fight Aging! - February 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Career Conversations: Q & A with Neuroimmunology Researcher Jingru Sun
Dr. Jingru Sun. Credit: Cori Kogan.
“If you want to pursue a career in science, it’s very important to foster a hardworking attitude, a creative mind, and critical thinking,” says Jingru Sun, Ph.D., an associate professor of translational medicine and physiology at Washington State University’s Elson S. Floyd College of Medicine in Spokane. Our interview with Dr. Sun highlights how her career path led her to research the way the nervous system regulates immune responses.
Q: How did you become interested in science?
A: In high school, I had an amazing teacher who introduced me to the scientific world, guide...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 9, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Injury and Illness Profiles Source Type: blogs
Continued Exploration of Age-Related Differences in the Human Gut Microbiome
In conclusion, this first examination of the effects of age and the ageing process on the small intestinal microbiome demonstrates that the duodenal microbiome changes with increasing age, with significant decreases in duodenal microbial diversity due to increased prevalence of phylum Proteobacteria, particularly coliforms and anaerobic taxa. Given the key roles of small intestinal microbes in nutrient absorption and host metabolism, these changes may be clinically relevant for human health during the ageing process. (Source: Fight Aging!)
Source: Fight Aging! - February 8, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 7th 2022
In this study, we used accelerometer measurements (1) to examine the association of physical activity and mortality in a population-based sample of US adults and (2) to estimate the number of deaths prevented annually with modest increases in moderate-to-vigorous physical activity (MVPA) intensity.
This analysis included 4,840 participants. Increasing MVPA by 10, 20, or 30 minutes per day was associated with a 6.9%, 13.0%, and 16.9% decrease in the number of deaths per year, respectively. We estimated that approximately 110,000 deaths per year could be prevented if US adults aged 40 to 85 years or older increased th...
Source: Fight Aging! - February 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
