Your A+ in anatomy and physiology won ’ t improve the American health care system
March 30th marks National Doctors’ Day – a day meant to honor the immense work and impact physicians have in caring for our patients and their communities. As resident physicians, we are proud and honored to have joined this noble profession. However, on this particular Doctors’ Day, we are also acutely aware that medicine is–once
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Your A+ in anatomy and physiology won’t improve the American health care system originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 25, 2024 Category: General Medicine Authors: Faith Crittenden, MD, MPH, Pratiksha Yalakk Tags: Physician Medical school Source Type: blogs
Fractional flow reserve for guiding coronary intervention and functional SYNTAX score
Coronary angiography gives a visual impression about the severity of the stenosis. But it need not imply the actual functional significance of the stenosis in terms of flow physiology. It is often difficult to decide which are the flow limiting lesions when there are multiple stenoses in same or different territories. It is here that the fractional flow reserve estimation helps.
FFR is estimated using a guide wire with a pressure transducer. FFR wires have properties similar to the floppy guide wires so that they can passed across coronary lesions back and forth easily to assess the pressure drop across the lesions.
The f...
Source: Cardiophile MD - April 22, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Pulse of Progress: Looking Back, Moving Forward | TAPP 147
In Episode 147, host Kevin Patton reviews thehighlights and events of theprevious year in theworld of The A&P Professor. He then turns to last year ' s predictions for teaching human anatomy and physiology to see if he was on the right track. Finally,predictions for the coming year are revealed. And lots of other stuff —this episode istwo hours long, after all!0:00:00 | Introduction0:00:50 | Debrief: Topics, Stats, Reflections0:21:28 | A Long, Long, Long Episode0:23:05 | Debrief: More Reviewing& Reflecting0:38:59 | Did I Get My Predictions Right?0:50:22 | Textbook& Academic Authors Association0:57:47 | Lookin...
Source: The A and P Professor - April 12, 2024 Category: Physiology Authors: Kevin Patton Source Type: blogs
Arterial Switch Operation
Transcript of the video: Arterial switch operation is the ideal corrective surgery for D-Transposition or dextro transposition of great arteries, if it can be detected early in life. As the left ventricle is facing the pulmonary artery in dextro transposition of great arteries, if there is a delay beyond two to three weeks of life, there is possibility that the muscle mass of the left ventricle can regress, so that, later if arterial switch operation is done, it will not be able to face the systemic vascular resistance and it will fail. That is why, arterial switch operation has to be done very early in life. For the same ...
Source: Cardiophile MD - April 1, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Human Exosomes Harvested from Stem Cells in Urine Produce Rejuvenation in Mice
In this study, we further analyzed these data and found that a class of USC-EVs-enriched proteins have been previously shown to possess anti-aging function, such as tissue inhibitor of metalloproteinases 1 (TIMP1), plasminogen activator urokinase (PLAU), insulin-like growth factor binding protein 5, senescence marker protein-30, and connective tissue growth factor. Thus, we hypothesized that USC-EVs might be capable of rejuvenating old organs from aging via transferring of anti-aging proteins.
Here, we tested the effects of USC-EVs on cellular senescence in vitro and on the aging-related phenotypes in different orga...
Source: Fight Aging! - March 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Simple Prebiotic Supplementation Improves Cognition in Older Individuals
Researchers here report that a small trial in humans showed that modulation of the aged gut microbiome via dietary supplementation with a prebiotic produced modest benefits to cognitive function. It is interesting that a prebiotic strategy, generally a weak form of intervention characterized by short duration of effect and small effect size, managed this outcome. There was no improvement in physical performance in the study group, only cognitive function. One might contrast this with what is known of the effects of fecal microbiota transplant from a young individual or flagellin immunization on the gut microbiome, meaning ...
Source: Fight Aging! - March 12, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Bemoaning the Lack of Standardization in Animal Studies of Aging
It is fair to say that the diversity of academia brings downsides in addition to upsides. A monolithic culture tends to mean slow progress: too little is explored at the borders of what is known when one viewpoint prevails at the expense of all others. A diverse culture produces such a variety of standards that it becomes challenging to compare any two studies. The paper-length complaint here is outlines the problems facing any scientist who is engaged in an analysis of published animal study data on the topic of intervening to slow or reverse aging, with a particular focus on the harms produced by a diversity of strategie...
Source: Fight Aging! - March 11, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 11th 2024
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
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Considering the Mechanisms of Vascular Calcification
https://www.fightaging.org/archives/2024/03/considering-the-mechanisms-of-vascular-calcification/
Harmful calcification of structures in the cardiovascular system proceeds alongside the development of the fatty lesions of atherosclerosis. Both disease processes are accelerated by chronic inflammation, but d...
Source: Fight Aging! - March 10, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Searching for a Causal Link Between Gut Microbiome Populations and Pace of Aging
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
Link: https://doi.org/10.3390/microorganisms12020370 (Source: Fight Aging!)
Source: Fight Aging! - March 5, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Blackbird Health Raises $17 Million Series A to Expand Access to Integrated, Technology-Backed Youth Mental Health Model
Blackbird Health Leverages a Neuroscience-Driven, “Understanding-First” Care Model to Take the Trial and Error out of Pediatric, Adolescent, and Young-Adult Mental Health Diagnosis and Treatment
Blackbird Health, a neuroscience-led and technology-backed youth mental health provider, announced today it raised $17 million in series A funding. The round was led by Define Ventures and also included participation from Frist Cressey Ventures and GreyMatter. Blackbird has raised nearly $23 million to date.
Blackbird Health is a mental health company for kids and young adults struggling with social, emotional, devel...
Source: EMR and HIPAA - March 4, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Amy Edgar Blackbird Health Chirag Shah Define Ventures Dr. Matt Keener Frist Cressey Ventures GreyMatter Health IT Funding Health IT Fundings Health IT Investment Tom Peterson Source Type: blogs
Why ICDs are less effective in Non Ischemic DCM ?
We wish, our understanding about cardiac contractile physiology is deep and nearly complete. Heart is an irreversibly coupled electro-mechanical organ , right from the fetal days until the final heart beat. In myocardial pathology, the genesis and sustainability of ventricular arrhythmia are intricately related to the degree of LV dysfunction of any cause.
SCD is the leading cause of mortality in heart failure. Tackling SCD was in God’s domain, until the brilliance of Dr. Michel Mirowski shrunk the defibrillator and implanted it under the chest in 1980. (Dr. MM’s s a unique and inspiring story, from Poland a...
Source: Dr.S.Venkatesan MD - February 20, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized crt device crt-p vs crt-d danish trial ischemic dcm madit trial non ischemic dcm Source Type: blogs
A NOTIONal truth : Surgical AVR deteriorates faster than TAVI, for some mysterious reasons!
Conclusion
The study results finds the valve deployed percutaneously under semi- blind vision, was equipoise with SAVR done under direct vision. The surprise however is, TAVI was superior to cardiac surgeons in multiple aspects .The mysterious finding is TAVI had less Structural valve dysfunction, and possibly low bio valvular failure (BVF), if Kaplan -Myer curve trend is little extrapolated. No doubt ,the Aortic interventional world is applauding and everyone is joining the party.
Now, some academic queries ?
1.Did the trial compared best practices of TAVI & SAVR ?
No. Because it was done in 2010-2013. (W...
Source: Dr.S.Venkatesan MD - February 10, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized acc aha esc guidlines aortic stenosis Aortic valve replacement avr core valve edward sapien notion 10 year follow up notion trial partner savr st judes valve surtavi tavi tavr in low risk category uk tavi Source Type: blogs
Research Organism Superheroes: Fruit Flies
Credit: iStock.
Those pesky little bugs flying around the overripe bananas in your kitchen may hold the key to understanding something new about how our bodies work. That’s right, the fruit fly (Drosophila melanogaster) is a widely used research organism in genetics because of its superpower of reproducing quickly with similar genes to people.
Researchers have been studying fruit flies for over a century for many reasons. First, they’re easy to please—just keep them at room temperature and feed them corn meal, sugar, and yeast (or those bananas on your counter!). Second, they reproduce more quickly and have shor...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 17, 2024 Category: Research Authors: Chrissa Chverchko Tags: STEM Education Tools and Techniques Cool Creatures Research Organisms Source Type: blogs
Anatomy of Trust: Promoting Integrity in A & P Education | Winter Shorts | TAPP 146
Episode 146 of The A&P Professor podcast is one of ourwinter shorts, where I replay interesting segments from previous episodes. In this one, we discuss the importance ofacademic integrity in the Anatomy& Physiology course. We emphasize the need to incorporatediscussions about integrity in the syllabus and course materials and sharereal-life examples of violations in the healthcare field. We highlight how dishonesty can haveserious consequences and discuss strategies for prevention, such as using multiple test versions and unique topics for papers/projects. Providingexamples of acceptable practices and discouraging...
Source: The A and P Professor - January 16, 2024 Category: Physiology Authors: Kevin Patton Source Type: blogs
