Six More Textbook Tricks | Teaching With Your Textbook Effectively | TAPP 97
We faculty rarely talk abouthow to use textbooks effectively. Not with each other, not with students, not with anybody. And we've probablynot ever had any training in how to use what is akey tool in teaching and learning the typical A&P course. This episodesolves that problem!00:00 | Introduction00:46 | More Textbook Tricks03:20 | Transparency06:46 | Sponsored by AAA08:04 | Read and Raid12:46 | Sponsored by HAPI14:17 | Honor The Textbook32:44 | Sponsored by HAPS34:28 | (You) Read The Textbook39:44 | Teach Your Students How to Read Textbooks49:26 | Loving& Learning About Textbooks51:16 | Staying ConnectedI...
Source: The A and P Professor - July 19, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs

Even More Slide Tricks | Ultimate Effective Teaching Presentations | TAPP 96
We continue our two-part series that exploressimple ways that we canmake our teaching slides more engaging—and thereforemore effective for learning. Let's leave behind those boring slide templates andmake our presentations work better for our lectures, case studies, labs, and other learning activities.00:00 | Introduction00:46 | Previous Slide Tricks06:23 | Sponsored by AAA07:36 | Proper Use of Terminology14:34 | Distorting Images15:50 | Sponsored by HAPI17:06 | Terrific Title Slides29:12 | Sponsored by HAPS30:07 | Avoid Presenting in Edit Mode32:12 | Don't Read Slides& Don't Always Follow Rules34:...
Source: The A and P Professor - July 5, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs

Fight Aging! Newsletter, July 5th 2021
In conclusion, the findings suggest that DNAm GrimAge is a strong predictor of mortality independent of genetic influences. Heart Failure Correlates with Increased Cancer Risk Age-related disease results from the underlying cell and tissue damage that causes aging. Different people accumulate that damage at modestly different rates, the result of lifestyle choices and exposure to infectious disease. Thus the presence of a sufficient burden of damage to produce one age-related disease will be accompanied by a ...
Source: Fight Aging! - July 4, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

CD22 Inhibition Improves Microglia Function in Old Mice
Microglia are innate immune cells of the central nervous system, responsible for clearing harmful molecular waste, tracking down pathogens, and a range of other supporting roles in the function and tissue maintenance of the brain. Unfortunately microglia are known to become dysfunctional with age: notable more inflammatory, and less capable when it comes to clearing protein aggregates such as the amyloid-β associated with Alzheimer's disease. This is thought to be an important contribution to the age-related nature of neurodegenerative conditions. Targeted clearance of senescent microglia has been shown to produce mea...
Source: Fight Aging! - June 29, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Congenitally corrected transposition of great arteries
Congenitally corrected transposition of the great arteries (CCTGA or cTGA) is a condition in which there is atrioventricular and ventricular arterial discordance so that the circulation is physiological. Congenitally corrected transposition of great arteries is also known as l-transposition of great arteries (l-TGA) because of the levo transposition of aorta. Levo posed aorta forms a hump along the left upper heart border on chest X-ray. The right atrium connects to the morphological left ventricle, which in turn connects to the pulmonary artery so that systemic venous blood reaches the pulmonary circulation. The left atr...
Source: Cardiophile MD - June 24, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

More Slide Tricks | Effective Teaching Presentations | TAPP 95
Everybody loves to hate teaching with slides. But maybe that's because we've not fully developed our skills! Host Kevin Patton build on previous advice to improve our mastery of theslide-of-hand we need for effective learning.Let's turn that hate into love! This is the first of a two-episode series.00:00 | Introduction00:58 | Buy One, Get One02:06 | I Need Help!10:20 | Sponsored by AAA11:47 | Less Text, More Story24:25 | Sponsored by HAPI25:49 | Chunky Style Slides39:44 | Sponsored by HAPS41:08 | Where Art Thou?48:16 | Slide Tricks50:12 | Staying Connected If you cannot see or activate the audio player,...
Source: The A and P Professor - June 21, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs

Twins For Everyone!
By KIM BELLARD I have lived my entire life as a twin, and, while it isn’t an unalloyed blessing, on balance I’d recommend it.  Most of you, though, probably aren’t twins and have missed the experience.  Don’t worry: you may still get a chance – with a digital twin.  It could have profound implications for your health and for healthcare generally. A digital twin, in case you are not familiar with the concept, is a virtual representation of a physical object.  It is created from data about that physical object, and is fed ongoing data (e.g., via IoT) about it to keep...
Source: The Health Care Blog - June 16, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech digital twins Kim Bellard Source Type: blogs

The Digital Reconstruction of Healthcare is Upon Us
The transition from brick and mortar to digital medicine will profoundly impact the way clinicians and patients interact —and will likely improve clinical outcomes.John Halamka, M.D., president, Mayo Clinic Platform, and Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, wrote this article.Paul Cerrato and I are excited to finally announce the publication of our 5th book together:The Digital Reconstruction of Healthcare: Transitioning from Brick and Mortar to Virtual Care.In March, we posted thetable of contents of the new book. Now that it ’s reached the “news...
Source: Life as a Healthcare CIO - June 11, 2021 Category: Information Technology Source Type: blogs

Do A & P Textbooks Have Too Much Content? | TAPP 94
Oh, thathuge A&P textbook I teach from! Do I really need tocover all of it? Host Kevin Patton discusses his take on this age-old problem. Does thecolor of my marking pen send a signal that I don't want to send to my students? A breakthrough in understandinghow teeth sense cold. And what in the world is atunneling nanotube—and can I get one at my local hardware store?Greek names for SARS-CoV-2 variants simplifies conversation and avoids stigma.00:00 | Introduction00:43 | How Do Teeth Sense Cold?07:04 | Sponsored by AAA08:32 | Red& Green for Student Feedback18:03 | What's a TNT?23:52 | Sponsored by HA...
Source: The A and P Professor - June 7, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs

Don ’t worry, be happy: How excessive worrying may influence the rate of neurodegeneration
Worrying and the Aging Brain (Dana Foundation): Over the past decade, scientists and clinicians have noted a significant association between common mental health conditions and accelerated brain aging—the changes to brain structure, physiology, and function that are thought to lead to later cognitive decline. Both depression and anxiety disorders, for example, are strongly correlated with the development of dementias including Alzheimer’s disease later in life, yet it has been unclear why. Neuroscientists and gerontologists around the globe have diligently worked to investigate which particular symptoms might c...
Source: SharpBrains - June 3, 2021 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health anxiety anxiety-disorders brain-age brain-aging brain-structure cognitive decline dementia depression neurodegeneration worry Source Type: blogs

Webinar for Postdoctoral Research Associate Training (PRAT) Program Applicants
We’re hosting a webinar for students and fellows interested in the Postdoctoral Research Associate Training (PRAT) program for the October 4, 2021, receipt date: Tuesday, June 22, 2:00-3:00 p.m. ET PRAT is a competitive 3-year fellowship program that prepares trainees for leadership positions in biomedical careers. Training includes a mentored laboratory research experience and intensive career and leadership development activities. PRAT fellows conduct research in laboratories in the NIH Intramural Research Program (IRP) in basic biomedical research areas within the NIGMS mission....
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - June 1, 2021 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Funding Opportunities Meetings/Events Training/Fellowships/Career Development PRAT Preparing an Application Webinars Source Type: blogs

Fight Aging! Newsletter, May 31st 2021
In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD. Cell Signaling via Exosomes in the Development of Vascular Calcification Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells caus...
Source: Fight Aging! - May 30, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Short In Vivo Reprogramming Treatment Modestly Slows Accelerated Aging in Progeroid Mice
In this study, we investigate a single short period of in vivo OSKM induction as pre-clinical proof of principle for a potential usage in clinic to prevent aging defects. We focused on heterozygous animals, which have moderate lifespan and levels of progerin, as these heterozygotes might be extremely sensitive to anti-aging therapies. As a short OSKM induction, was described to ameliorate immediate tissue regeneration after experimentally induced tissues injuries, we wondered whether a short period of OSKM genes induction might improve lifespan and tissues aging of heterozygotes mice. Surprisingly, we found that man...
Source: Fight Aging! - May 27, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, May 24th 2021
In conclusion, we showed that addition of resistance exercise training, but not dietary EAAs, to the myostatin inhibition further increased muscle mass through the attenuation of muscle protein breakdown with proportionate improvements in muscle strength. Interestingly, addition of dietary EAAs to the myostatin inhibition with or without resistance exercise training improved muscle quality. Thus, dissection of the underlying mechanisms behind the combined positive effect of dietary EAAs and resistance exercise training on muscle mass and quality can shed light on the discovery of effective therapeutics against muscle wasti...
Source: Fight Aging! - May 23, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

What to consider when recommending yoga to patients [PODCAST]
“Yoga therapy differs from contemporary yoga in that the profession has a defined scope of practice based on educational standards and accreditation requirements for training schools and yoga therapists. In dealing with pain conditions, certified yoga therapists possess understanding and knowledge of pain theories and pain physiology and may collaborate with a patient ’s health careRead more …Find jobs at  Careers by  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 22, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Primary Care Source Type: blogs

Correlations Between Mechanisms of Aging and Diseases of Aging
Researchers here mine a very large data set to establish whether age-related diseases linked to a specific underlying single causative mechanism of aging will show up together in patients more often than not. One would expect that they will. To pick one example, multiple age-related diseases appear likely to be primarily caused by the increased presence of senescent cells in old tissues. A patient's senescent cell burden will thus largely determine the risk of suffering from all of those conditions. Patients exhibiting one condition, most likely because they have more senescent cells than their healthier peers, should be m...
Source: Fight Aging! - May 21, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Coronary physiology update : Why did the “ French FLOWER ” failed to blossom ?
The concept of Fractional flow reserve ( FFR) has dominated the coronary interventional field for over a decade. It gave us a (false) sense of security and pride that we have been advocating physiology-based appropriate stenting. The much-expected FlOWER-MI trial was presented in ACC & NEJM a week ago. (May 16th  Issue 2021) FFR, though physiologically an attractive concept, has many well-known confounders right from the technical factors, lesion-related errors in physics, mirage of true hyperemia induction with Adenosine, finally & most importantly microvascular dynamism. The value of FFR in the ACS setti...
Source: Dr.S.Venkatesan MD - May 20, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized FFR FLOWER trial FFR IFR QFR CT FFR FLOWER MI Source Type: blogs

Weight Stigma! The Difficult Cadaver | Journal Club Episode | TAPP 93
Weight stigma among health professionals is a form ofdiscrimination that can haveserious consequences in the lives of people who are overweight or obese. These folks are therefore often pre-judged as being difficult patients, for example.Krista Rompolski joins us for aJournal Club episode, where we discuss a paper on how attitudes aboutlarge body donors may contribute to weight stigma amonghealth professionals. What's going on? Is there anything we educators do to influence student attitudes? An important topic for our times, for sure!00:00 | Introduction01:10 | Journal Club with Krista Rompolski03:05 | Sponsored by A...
Source: The A and P Professor - May 17, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs

Fight Aging! Newsletter, May 17th 2021
This study is consistent with previous evidence showing that inflammaging, or age-related inflammation, is naturally heightened in the nervous system. Moreover, the authors disproved their hypothesis that anti-inflammatory microglia-specific genes are responsible for the elevated inflammatory response in aged brains since the expression of anti-inflammatory mediators was elevated in middle-aged brains following infection. Thus, the cause for the increase in pro-inflammatory genes remains to be elucidated. Mixed Results in Animal Studies of Gene Therapy Targeting Axonal Regrowth
Source: Fight Aging! - May 16, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Freshwater Fish Species of Bigmouth Buffalo Exhibits Negligible Senescence
In this study we examined the potential relationship between age and multiple physiological systems including: stress levels, immune function, and telomere length in individuals ranging in age from 2 to 99 years old in bigmouth buffalo (Ictiobus cyprinellus), the oldest known freshwater teleost fish. Contrary to expectation, we did not find any evidence for age-related declines in these physiological systems. Instead, older fish appeared to be less stressed and had greater immunity than younger fish, suggesting age-related improvements rather than declines in these systems. There was no significant effect of age on ...
Source: Fight Aging! - May 11, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Are We Answering Student Questions? | Science Updates | TAPP 92
Episode 92 is all about how we canuse customer-service concepts in education. Tune in and hear Kevin Patton discuss the importance of being agood listener andempathetic responder. You ’ll also hear about new research that showsnot all plaques are bad actors when it comes to Alzheimer disease. And finally, find out how to get freealmost-daily updates on life science, teaching, and learning!00:00 | Introduction00:53 | New Discovery about Plaque08:33 | Sponsored by AAA09:51 | New TAPP Science& Education Updates15:23 | Sponsored by HAPI16:45 | Are We Answering Student Questions?30:52| Sponsored by HAPS31:40...
Source: The A and P Professor - May 3, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs

Wanted: NIGMS Program Director, Biochemistry and Bio-related Chemistry Branch
We’re recruiting an accomplished scientist for a position in the Biochemistry and Bio-related Chemistry Branch of our Division of Pharmacology, Physiology, and Biological Chemistry. The Branch supports research studies in enzymology, bioenergetics, glycoscience, synthetic method development, biosynthesis, oxidative stress, and synthetic biology.  Applicants should have broad expertise in biochemistry, familiarity with modern experimental methods, and experience in applying this knowledge to biological systems. Familiarity with NIH extramural funding as an applicant, reviewer, or NIH scientific administra...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - April 29, 2021 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs

What is an Intermediate coronary lesion & What shall we do with it ?
This question might squeeze the collective coronary knowledge of any cardiologist. (At least, it does for me !) What is an intermediate coronary lesion? (ICL)  Traditionally it is an “angio-ocular reflex” measurement of coronary arterial diameter stenosis that lies between 40 to 70% (Mind you, 70 diameter stenosis is 90% area. So,we must be clear what we really mean in any  revascularisation debate). Above one is the simplest expression of ICL. (* While 70% cutoff is fairly constant, the lower limit 40% is still not a settled issue. It can even be 30 %. I think we haven’t yet ...
Source: Dr.S.Venkatesan MD - April 25, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized diameter vs area stenosis fame s fame study ffr ifr qfr intermediate coronary lesion minimal cad coronary erosion what is intermediate coronary lesion ? Source Type: blogs

Major aortopulmonary collateral arteries
Major aortopulmonary collateral arteries (MAPCA) occur in cyanotic congenital heart diseases with decreased pulmonary blood flow (tetralogy of Fallot like physiology). They are a natural protective mechanism to improve pulmonary blood flow. MAPCAs are more likely to occur in pulmonary atresia than in simple tetralogy of Fallot. MAPCAs can also occur in conditions other than the typical pulmonary atresia with ventricular septal defect. In a retrospective review of such cases, 33 had single ventricle anatomy while the rest had two ventricle anatomy. Among those with single ventricle, 15 had unbalanced complete atrioventricu...
Source: Cardiophile MD - April 23, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

Burnout! A Chat with Rebecca Pope-Ruark | TAPP 91
Burnout is a serious issue that can affect your health, relationships, and job performance. It ’s important toknow the signs of burnout so you can take steps to prevent it from happening in the first place. But if you do experience burnout,don ’t panic! There are ways for you to get back on track and feel good again. Listen to this episode ofThe A&P Professor withDr. Rebecca Pope-Ruark about how we canavoid, deal with, or be there for others experiencing burnout! You'll be glad you did!00:00 | Introduction00:48 | Rebecca Pope-Ruark02:42 | Sponsored by AAA04:08 | Burnout& How to Fix It18:41&nbs...
Source: The A and P Professor - April 19, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs

Fight Aging! Newsletter, April 19th 2021
In conclusion, airway pressure treatment and adherence are independently associated with lower odds of incident AD diagnoses in older adults. Results suggest that treatment of OSA may reduce risk of subsequent dementia. (Source: Fight Aging!)
Source: Fight Aging! - April 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Targeting Cell Maintenance Processes to Improve Mitochondrial Function and Slow Aging
We present genetic and pharmacological interventions that effectively extend health- and life-span by acting on specific mitochondrial and pro-autophagic molecular targets. In the end, we delve into the crosstalk between autophagy and mitochondria, in what we refer to as the mitochondria-proteostasis axis, and explore the prospect of targeting this crosstalk to harness maximal therapeutic potential of anti-aging interventions. Link: (Source: Fight Aging!)
Source: Fight Aging! - April 13, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, April 12th 2021
In conclusion, the MR exhibited the protective effects against age-related behavioral disorders, which could be partly explained by activating circulating FGF21 and promoting mitochondrial biogenesis, and consequently suppressing the neuroinflammation and oxidative damages. These results demonstrate that FGF21 can be used as a potential nutritional factor in dietary restriction-based strategies for improving cognition associated with neurodegeneration disorders. Senescent T Cells Cause Changes in Fat Tissue that are Harmful to Long-Term Health
Source: Fight Aging! - April 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Recent Thought on Alzheimer's Disease as a Lifestyle Condition
The overwhelming majority of type 2 diabetes patients suffer their condition because they became significantly overweight. Being significantly overweight clearly produces the metabolic syndrome that leads to type 2 diabetes, and the more visceral fat tissue, the worse off you are. In this sense type 2 diabetes is a lifestyle condition, a choice. Attempting to explain Alzheimer's disease in the same way runs into an immediate challenge, in that there is no such very clear cause and effect. Too large a fraction of significantly overweight people do not develop Alzheimer's, and being overweight doesn't appear to correlate wit...
Source: Fight Aging! - April 8, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Third heart sound in health and disease
Third heart sound (S3) occurs in early diastole due to rapid deceleration of transmitral blood flow as the ventricles fill [1]. It corresponds in timing to shortly after the peak of the early diastolic E wave of transmitral flow. S3 occurs just after the opening of the atrioventricular valve as blood filling the atria during ventricular systole flows quickly into the ventricles [2]. Third heart sound can occur under physiological conditions as well as in disease, though not heard in all individuals. A prospective study of 580 patients had isolated valvular mitral regurgitation in 299, aortic regurgitation in 121 and prim...
Source: Cardiophile MD - April 8, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

From digital therapeutics to personalized mental health solutions: Pear Therapeutics expands platform via partnerships with Empatica, etectRx, KeyWise, and Winterlight
Pear Therapeutics Expands Platform with Digital Biomarkers, Machine Learning Algorithms and Sensor-Based Technologies (press release): Pear Therapeutics, Inc. announced today that it has entered into agreements with multiple technology companies, including Empatica Inc., etectRx, Inc., and KeyWise, Inc. The new technologies complement the voice-based biomarkers previously licensed from Winterlight Labs. These new agreements bolster Pear’s Prescription Digital Therapeutics (PDT) platform, by adding to its library of digital biomarkers, machine learning algorithms, sensor-based technologies, and digital therapeutics. T...
Source: SharpBrains - April 7, 2021 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Technology & Innovation digital biomarkers digital therapeutics Empatica etectRx KeyWise Pear Therapeutics WinterLight Labs Source Type: blogs

Taking Bold Steps in Teaching | Notetaking | Science Updates | TAPP 90
Episode 90 of The A&P Professor podcast is athematic sm örgåsbord, full of tasty tidbits to share with students and colleagues. Host Kevin Patton talks about dealing withresistance when we try to take bold steps in teaching. Isnote taking better with a paper or an electronic device? The effects ofdiluting blood plasma onaging (don't try this at home).And the phenomenon ofpandemic weight change.00:00 | Introduction01:06 | Notetaking: Paper or Digital?13:14 | Sponsored by AAA14:53 | Pandemic Twenty?19:27 | Sponsored by HAPI20:39 | Diluted Blood: Fountain of Youth?28:25 | Sponsored by HAPS29:37 |...
Source: The A and P Professor - April 5, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs

Fight Aging! Newsletter, April 5th 2021
In this study, the research team designed a way to identify small molecules that improve the function of ABCA1 in the body while avoiding unwanted effects to the liver. The researchers honed in on a specific small molecule, CL2-57, due to its ability to stimulate ABCA1 activity with positive effects on liver and plasma triglycerides. The use of this compound showed improved glucose tolerance and insulin sensitivity, as well as reduced weight gain, among other beneficial effects. Age-Related Upregulation of Autophagy as a Possible Contribution to Bat Longevity
Source: Fight Aging! - April 4, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Tau Knockout in Normal Mice Improves Mitochondrial Function and Slows Cognitive Decline
Tau is involved in Alzheimer's disease and other tauopathies; it is one of the few proteins in the body capable of becoming naturally altered in ways that encourage aggregation of the protein into solid deposits that are toxic to cells. Tau is highly expressed in nerve cells, and helps in the function of the microtubule network of the cell. It also has roles in other processes peculiar to nerve cells, such as synaptic transmission. Mice lacking tau exhibit issues with regulation of insulin metabolism and behavior. That isn't preventing the exploration of lowered tau levels as a basis for therapies to treat Alzheimer's dise...
Source: Fight Aging! - April 2, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Is there a “g-neuron”? Establishing a systematic link between general intelligence (g) and the von Economo neuron - ScienceDirect
 Is there a " g-neuron " ? Establishing a systematic link between general intelligence (g) and the von Economo neuron - ScienceDirect construct of general intelligence (g) is one of psychology's most replicated and predictively useful constructs. Although research indicates that g is a highly heritable trait, deeply rooted in brain physiology, to date neither a strong biological correlate nor a comprehensive explanatory model involving neuronal mechanisms have been established. In this article I aim ...
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - March 30, 2021 Category: Neuroscience Source Type: blogs

Growing research supports Heart Rate Variability (HRV) biofeedback training to lower stress and anxiety, increase sports performance
Conclusions: HRV biofeedback training is associated with a large reduction in self-reported stress and anxiety. Although more well-controlled studies are needed, this intervention offers a promising approach for treating stress and anxiety with wearable devices. Effect of Heart Rate Variability Biofeedback on Sport Performance, a Systematic Review (Applied Psychophysiology and Biofeedback ) Abstract: Aim is to determine if the training with heart rate variability biofeedback allows to improve performance in athletes of different disciplines. Methods such as database search … All studies had a small sample size (ra...
Source: SharpBrains - March 29, 2021 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Peak Performance Technology & Innovation ambulatory monitoring anxiety athletic performance athletic training biofeedback biofeedback training exercise heart-rate-variability HRV lower anxiety lower stress Source Type: blogs

Fight Aging! Newsletter, March 29th 2021
Discussion of Systemic Inflammation and its Contribution to Dementia Fisetin Reduces D-Galactose Induced Cognitive Loss in Mice Reprogramming Cancer Cells into Normal Somatic Cells Considering Longevity Medicine and the Education of Physicians Researchers Generate Thyroid Organoids Capable of Restoring Function in Mice In Search of Transcriptional Signatures of Aging A Pace of Aging Biomarker Correlates with Manifestations of Aging Targeting Tissues with Extracellular Vesicles Calorie Restriction Slows Aging of the Gut Microbiome in Mice Mitochondrial DNA Heteroplasmy in the Aging Heart Evidence for Hea...
Source: Fight Aging! - March 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Micro-Aneurysm-On-A-Chip to Model Vascular Disease
An international research collaboration, including teams from Nanyang Technological University, Singapore (NTU Singapore), Brown University, and MIT, has developed an AI platform that can assess blood flow characteristics through microvasculature. The system relies on a microfluidic chip that mimics vascular disease, in this case a micro-aneurysm in the eye. The AI platform uses 2D images of fluid flow through the chip to calculate how blood would flow in three dimensions. The resulting data could help clinicians to learn more about vascular diseases, improve their diagnosis, and track their progression. “Curre...
Source: Medgadget - March 25, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology Ophthalmology Vascular Surgery Source Type: blogs

Mitochondrial DNA Heteroplasmy in the Aging Heart
Every cell contains hundreds of mitochondria, bacteria-like structures that carry their own small genome, the mitochondrial DNA. Mitochondria replicate like bacteria to maintain their population size, and are destroyed when worn and damaged by the quality control mechanism of mitophagy. The primary task undertaken by mitochondria is the generation of chemical energy store molecules (adenosine triphosphate, ATP) to power the cell, but they also play many other roles in fundamental cell processes. Mitochondrial DNA is poorly protected and repaired in comparison to nuclear DNA, and accumulates mutational damage over time. It ...
Source: Fight Aging! - March 25, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Smooth Teaching with Slides: Animations to Dramatize the Story of Anatomy & Physiology | Science Updates | TAPP 89
Host Kevin Patton outlines several new discoveries, including the function ofbackground noise in the brain, howexercise triggers immunity, a possibleblood marker for longevity, and howmitochondria are organized during cell division. And he discusses how easyanimation effects can help students focus on important elements of the story of anatomy and physiology.00:00 | Quotation& Intro00:47 | Brain's Background Noise08:06 | Sponsored by AAA09:12 | How Exercise Triggers Immunity13:30 | Sponsored by HAPI14:41 | Mitochondria During Cell Division22:10 | Sponsored by HAPS23:03 | How Old Will We Get26:22&nbs...
Source: The A and P Professor - March 18, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs

The Art of Asking: What Else is Going on?
By HANS DUVEFELT Walter Brown’s blood sugars were out of control. Ellen Meek had put on 15 lbs. Diane Meserve’s blood pressure was suddenly 30 points higher than ever before. In Walter’s case, he turned out to have an acute thyroiditis that caused many other symptoms that came to light during our standard Review of Systems. Ellen, it turned out, was pretty sure her husband was having an affair with one of his coworkers. And, since this wasn’t the first time, she was secretly working on a plan to move out and file for divorce. She admitted she’d always had a tendency to stress eat. ...
Source: The Health Care Blog - March 15, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Primary Care Hans Duvefelt health communication Source Type: blogs

80-something year old with acute chest pain. 3 visits. Fascinating Ultrasound progression
An 80-something year old man with history of metastatic cancer had acute onset of chest pain and called 911.Here is his prehospital ECG:What do you think?The computer read ***Anterior STEMI*** along with RBBB.Smith interpretation: There is Right Bundle Branch Block (RBBB).  There is 1 mm of STE in inferior leads and also in lateral precordial leads.  As a general rule, RBBB should not have ST Elevation (there are some infrequent patients with RBBB who have non-ischemic STE, usually discordant to the negative S-wave, as in this case).  Moreover, the T-waves appear hyperacute.I would activate the cath lab base...
Source: Dr. Smith's ECG Blog - March 15, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs

The Proper Order of Topics in A & P | Leaderboards | Student Frustration | TAPP 88
Ever wonder why topics in A&P seem to have auniform order of topics in all the courses& textbooks? Host Kevin Patton discusses theproper order of those concepts. We continue the discussion ofgamification, including a focus onleaderboards. And we tackle whypandemic learning causes students to lament that theyhave to teach themselves.00:00 | Quotation& Intro00:44 | More on Gamification06:20 | Sponsored by AAA07:38 | Leaderboard Competition16:02 | Sponsored by HAPI17:16 | Pandemic Feelings of Learning25:12 | Sponsored by HAPS26:16 | Order of A&P Topics35:27 | TAPP Community36:03 | The Prope...
Source: The A and P Professor - February 24, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs

PhD Student Positions in Speech Neuroscience - Univ. of South Carolina
  Department of Communication Sciences and Disorders  PhD Student Positions in Speech Neuroscience  The Speech Neuroscience Lab at the University of South Carolina is inviting highly-motivated students with interest in research on neuroscience of speech to apply for our PhD program. The PhD degree prepares professionals for academic careers with emphasis on research and the scholarly study of the science of human speech production system and its disorders. Doctoral students will complete their research training under direct mentorship, regularly participate in laboratory activities and pu...
Source: Talking Brains - February 18, 2021 Category: Neuroscience Authors: Greg Hickok Source Type: blogs

Fight Aging! Newsletter, February 15th 2021
This study assessed cancer risk associations for 3 recently developed methylation-based biomarkers of aging: PhenoAge, GrimAge, and predicted telomere length. We observed relatively strong associations of age-adjusted PhenoAge with risk of colorectal, kidney, lung, mature B-cell, and urothelial cancers. Similar findings were obtained for age-adjusted GrimAge, but the association with lung cancer risk was much larger, after adjustment for smoking status, pack-years, starting age, time since quitting, and other cancer risk factors. Most associations appeared linear, larger than for the first-generation measures, and w...
Source: Fight Aging! - February 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Loss of Capillary Density as a Hallmark of Aging
In this study, we implement a large-scale 3D spatial comparison of vascular cells and molecules in young and aging mouse tissues from several organs to define the major changes across both axes. This in-depth analysis of aging tissues revealed vascular attrition as a primary hallmark of aging and provides unprecedented insights into the microenvironmental tissue-level changes during aging. Our imaging datasets reveal that the loss of vascular abundance accompanied by the decline in pericytes is a key feature of aging tissues. This is the first comprehensive study highlighting age-dependent vascular changes across se...
Source: Fight Aging! - February 10, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Micro-Credentials & Gamification in the A & P Course | Brown & Black Skin | Refresher Tests | TAPP 87
Allowing students toearn badges in the A&P course provides motivation to master all the concepts and also provides granular documentation of learning beyond the transcripted course grade. Host Kevin Patton shares his experience, along with a discussion ofskin color in teaching future health professionals and the use ofrefresher tests to get students ready for their A&P course.00:00 | Quotation00:46 | Refresher Tests08:49 | Sponsored by AAA10:13 | Black& Brown Skin19:48 | Sponsored by HAPI20:54 | Badges 1: Digital Micro-Credentials29:06 | Sponsored by HAPS30:07 | Badges 2: Gamification38:11&n...
Source: The A and P Professor - February 9, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs

History of cardiology : Robert F Rushmer, a cardiac scientist par excellence .
Few individual’s works mattered more than others in the field of cardiology. Here was a man born in Utah, studied at Rush university trained in Mayo, settled in Seattle as a pediatrician. But his passion drove him to become a specialist cardiac physiologist with an urge to find the answers to all those lingering queries that arise as a practicing clinical cardiologist.  He built an exclusive animal lab to study the mechanics and physics of circulation and cardiac pumps.   He can be called new age, Harvey. He seemed to always bother, how is it that the 6 liters of blood traverse fro...
Source: Dr.S.Venkatesan MD - February 1, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Basic sciecne Basic science -Physiology Best books in cardiology bio ethics great cardiologists best books in cardiac physiology best cardiology books cardiovascular physiology famous Seattle doctors Great Men in cardiology history of Source Type: blogs

What a Year! | Pandemic Teaching & More | A Reflection | TAPP 86
Discussions that matter. In our private space, we can have the vulnerability needed for authentic, deep discussions. Discussions not limited to a sentence or two at a time.No ads. No spam. No fake news. No thoughtless re-shares. Just plain old connection with others who do what you do!Privacy. The A&P Professor community has the connectivity of Facebook and Twitter, but the security of a private membership site. None of your information can be shared outside the community, so you can share what you like without it being re-shared to the world. Like your dean, for instance. In our community, you can share your frustrati...
Source: The A and P Professor - January 27, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs

Will We All Have To Become Biologically Enhanced Superhumans?
Okay, hands up who can tell who’s the most famous biologically enhanced superhuman in the world? True, it’s a quite close call between Captain America and The Incredible Hulk (sorry Spidey, you’re not even close). But is a human-invented superhuman just a thing of a Stan Lee comic, or is it an actual scientific idea from a real laboratory? As a matter of fact, enhancing human capabilities has been on the mind of people for ages, but it came a long way from ancient training methods to exoskeletons. Enhancing our abilities, be it permanently or temporarily is a tempting but risky matter. For will it...
Source: The Medical Futurist - January 21, 2021 Category: Information Technology Authors: Judit Kuszkó Tags: Forecast Artificial Intelligence in Medicine Augmented Reality Bioethics Biotechnology Cyborgization Digital Health Research E-Patients Genomics Health Sensors & Trackers Healthcare Policy Medical Education Robotics Science Ficti Source Type: blogs