Considering the Longevity of Eusocial Insect Queens
Eusocial species are characterized by reproductive and non-reproductive castes, such as the familiar division of queens and workers in common insect species. Eusociality is more common in insects and less so in other classes of life, although there are a few eusocial mammals, such as the naked mole-rat. For researchers who investigate the comparative biology of aging, one of the more interesting aspects of eusociality is that queens live longer than workers, many times longer in some species, while being genetically identical. Why is this?
Comparing very similar species with divergent life spans is a desirable start...
Source: Fight Aging! - February 4, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Photographing the Physics of Cells
Dr. Melike Lakadamyali with a microscope. Credit: Courtesy of Dr. Lakadamyali.
“It would be a dream come true if I could look at a cell within a tissue and have a Google Maps view to zoom in until I saw individual molecules,” says Melike Lakadamyali, Ph.D., an associate professor of physiology at the University of Pennsylvania’s Perelman School of Medicine in Philadelphia. Her lab is helping make part of that dream a reality by developing super-resolution microscopy tools that visualize cells at a near-molecular level.
Blending Physics and Biology
Science and math fascinated Dr. Lakadamyali since childhood, ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 2, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Cellular Imaging Cellular Processes Cool Tools/Techniques Profiles Source Type: blogs
The Inclusive Anatomy & Physiology Course | Part 1 | TAPP 108
As anatomy and physiology faculty, we put a lot of effort into developing strategies forlearning the core concepts of human biology. It'seasy to forget to build in someinclusive strategies that help all students grow and succeed. In this first of two episode, host Kevin Patton begins a list ofsimple and effective ways to make our A&P course more inclusive.00:00 | Introduction00:46 | The Inclusive Course04:45 | 1. Reflect Diversity12:21 | 2. Accessible Resources21:06 | Sponsored by AAA21:52 | 3. Inclusive Syllabus26:03 | 4. Use Inclusive Language30:25 | Sponsored by HAPI31:30 | 5. Gender Pronouns34:09 | 6. Use Preferred...
Source: The A and P Professor - February 1, 2022 Category: Physiology Authors: Kevin Patton Source Type: blogs
A few slow-paced breaths are enough to significantly reduce physiological stress
Welcome to a new edition of SharpBrains’ e‑newsletter, sharing important brain & mental health news plus a couple fun brain teasers to test your mental self-rotation skills.
#1. Study: Education and lifestyle helped over a million older Americans avoid serious cognitive problems in 2017
Let’s kickstart 2022 with some good news: “The prevalence of serious cognitive problems in the US population aged 65 and older declined from 12.2% to 10.0% between 2008 and 2017. Had the prevalence remained at the 2008 levels, there would have been an additional 1.13 million older Americans with serious cognitive problems in 201...
Source: SharpBrains - January 31, 2022 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health SharpBrains Monthly eNewsletter Technology & Innovation ADHD-medication Akili Interactive APA Big Health Breathing Cognitive Neuroscience cognitive problems consumer technology digital therapeutics Headspace He Source Type: blogs
Digital therapeutics pioneer Akili Interactive plans to go public in mid-2022 at a $1B valuation
Palihapitiya-Led SPAC to Merge With Akili in $1 Billion Deal (Bloomberg):
Akili Interactive, a startup that has developed a video game to help treat attention-deficit disorders in kids, has agreed to go public through a merger with one of Chamath Palihapitiya’s blank-check companies.
The deal, which confirms a Bloomberg News report, values the combined entity at about $1 billion, Akili and Social Capital Suvretta Holdings Corp. I said in a statement seen by Bloomberg. It will provide as much as $412 million in gross cash proceeds, the companies said.
Led by Chief Executive Officer Eddie Martucci, Akili has developed the ...
Source: SharpBrains - January 26, 2022 Category: Neuroscience Authors: SharpBrains Tags: Attention & ADD/ADHD Brain/ Mental Health Technology & Innovation Akili Interactive attention deficit hyperactivity disorder Chamath Palihapitiya cognitive-impairments digital therapeutics EndeavorRx FDA neuropsychiatric neuropsychia Source Type: blogs
Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Directions in A & P Teaching | Where We've Been & Where We Are Going | Future Trends | TAPP 107
Episode 107 of The A&P Professor podcast for anatomy& physiology faculty starts off its fifth season with adebriefing of the last year, just like we do with our teaching, plusa look ahead. We'll review host Kevin Patton'spredictions from last year and make somenew predictions for this year. And makes some plans, too.0:00:00 | Introduction0:01:19 | Look Back: Milestones& New Projects0:19:17 | 2021 Topics: Teaching& Learning0:35:29 | Remembering Linda Swisher0:37:00 | 2021 Topics: Science Updates0:43:22 | Our Sponsors0:47:23 | 2021 Predictions Revisited0:58:06 | Look Forward: New Habits1:02:04 | Look Forward:...
Source: The A and P Professor - January 19, 2022 Category: Physiology Authors: Kevin Patton Source Type: blogs
Directions in A & P Teaching | Where We've Been & Where We Are Going | Future Trends | TAPP 107
Episode 107 of The A&P Professor podcast for anatomy& physiology faculty starts off its fifth season with adebriefing of the last year, just like we do with our teaching, plusa look ahead. We ' ll review host Kevin Patton ' spredictions from last year and make somenew predictions for this year. And makes some plans, too.0:00:00 | Introduction0:01:19 | Look Back: Milestones& New Projects0:19:17 | 2021 Topics: Teaching& Learning0:35:29 | Remembering Linda Swisher0:37:00 | 2021 Topics: Science Updates0:43:22 | Our Sponsors0:47:23 | 2021 Predictions Revisited0:58:06 | Look Forward: New Habits1:02:04 | Look Forw...
Source: The A and P Professor - January 19, 2022 Category: Physiology Authors: Kevin Patton Source Type: blogs
Gameto Raises $20M at an Early Stage to Focus on Ovarian Aging
One of the signs of investor enthusiasm for an industry is the existence of projects that raise significant funding at a very early stage of their development. We're seeing that happen for cellular reprogramming, but companies started by well-connected individuals in other parts of the longevity industry are now raising a great deal of funding in early preclinical stages of development. This suggests that we will continue to see a growing influx of capital into the development of ways to treat aging as a medical condition, pulling more research projects out of the constraints of academia and into an environment of greater ...
Source: Fight Aging! - January 18, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Theorizing on the Contribution of the Gut Microbiome to Crocodile Longevity
Researchers studying the comparative biology of aging examine differences between species of varying life spans, in search of insights into mechanisms of aging and potential interventions that might slow or reverse aging in our own species. This is a slow process. Even given the discovery of specific mechanisms that likely contribute to greater longevity or resilience in a given species, it tends to be challenging to determine how large a contribution is made by those mechanisms, and quite speculative as to whether any given mechanism can be used as a basis for therapy in our species. Still, there are many areas of ongoing...
Source: Fight Aging! - January 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
In AF why the ventricular rate is irregular?
Here is a case report from Dr. Brugada’s group. What is your diagnosis?
Source & Courtesy Sergio Richter, Joseph Brugada et all , 100(1), 154–156. doi:10.1016/j.amjcard.2007.02.067
Whoever diagnosed AF in the above ECG need not feel bad. The rhythm is not AF, though it mimics very closely. In cardiology, especially in electrophysiology, we can get surprises on a daily basis. (Read below)
Why the ventricular rate is irregular in AF?
Atrial fibrillation (AF) may sound like a simple clinical arrhythmia until we ask this delicate question. The traditional and fairly accepted answer is that, AV node w...
Source: Dr.S.Venkatesan MD - January 14, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Atrial fibrillation Cardiology Patho physiology Infrequently asked questions in cardiology (iFAQs) AV node anatomy AVNRT and AF Dual AV nodal path way poly av nodal pathway Pseudo atrial fibrillation Source Type: blogs
Study: A few slow-paced breaths are enough to significantly reduce physiological stress
This study is the first to show that taking a few slow, deep breaths in an everyday setting can have a significant effect on a child’s stress physiology,” said the study’s lead author, Jelena Obradovic, an associate professor at Stanford Graduate School of Education (GSE) and director of the Stanford Project on Adaptation and Resilience in Kids (SPARK Lab). “But just telling children to take a deep breath may not be enough – children need scaffolding. So we’re excited that we can also offer an easy-to-use tool to help kids learn this technique.”
The study, which was coauthored by GSE research associate Michae...
Source: SharpBrains - January 12, 2022 Category: Neuroscience Authors: Stanford Graduate School of Education Tags: Education & Lifelong Learning deep breath deep breathing physiological physiological stress response young children Source Type: blogs
Knowledge check in Brugada syndrome : A rapid fire session
A 5-minute session: Answers are my own. Please cross-check.
1. Is Brugada syndrome clinical or ECG diagnosis?
Always clinical. Never get confused on this.
2. Spontaneous type 1 vs Induced Type 1 (from type 2) which carries more risk?
Both are risky since they are close cousins. But, spontaneous type 1 is the dreaded devil.
3. Is Brugada primarily a defect of myocardial depolarization or repolarisation?
Not clear. Often in both. In fact a mismatch between them. (Don’t ask how Na+ Channel defect affects repolarisation !)
4. Is Brugada VT is monomorphic, polymorphic?
Both. What determines m...
Source: Dr.S.Venkatesan MD - January 5, 2022 Category: Cardiology Authors: dr s venkatesan Tags: cardiac electrophysiology cardiology -Therapeutics Cardiology -unresolved questions Cardiology-Arrhythmias early repolarisation syndrome Electro physiology Electrocardiography-ECG ICD and Pacemakers amiodarone for brugada brugada syndrom Source Type: blogs
Senescent Astrocytes May Negatively Affect the Function of Neurons
A good deal of evidence points towards cellular senescence in the supporting cells of the brain, such as astrocytes and microglia, as an important contribution to neurodegeneration, cognitive decline, and dementia. Senescent cells behave abnormally and secrete a potent mix of pro-growth, pro-inflammatory signals that are known to degrade structure and function in many different organs. Chronic inflammation in brain tissue is strongly implicated in the onset and progression of neurodegenerative conditions, and clearance of senescent cells in the brain via senolytic therapies has been shown to reverse pathology in animal mod...
Source: Fight Aging! - January 3, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 13th 2021
In conclusion, there is a good amount of pre-clinical and clinical data showing a strong positive correlation between reduction of senescent cells frequencies and functional improvement of skin. Whether senescence of skin cells makes a significant causal contribution to skin ageing can still not be conclusively decided, however. Nonetheless, there is strong evidence existing today to assume that better understanding of cell senescence in skin may lead to a breakthrough in interventions into skin ageing.
Isomerization of Tau May be Involved in Alzheimer's Disease
https://www.fightaging.org/archives/2021/12/isom...
Source: Fight Aging! - December 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
