Fight Aging! Newsletter, August 2nd 2021
This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Over 95% of participants had normal cognition at baseline. After multivariable adjustment, cognitive decline was associated with bone loss in women but not men. Approximately 13% of participants experienced sign...
Source: Fight Aging! - August 1, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Endothelin-1 Involved in Mechanisms by which Calorie Restriction Slows Renal Artery Aging
Calorie restriction is perhaps the most studied of all interventions known to slow aging, and yet undergoing calorie restriction changes so much of metabolism that it remains a challenge to understand which of the countless mechanisms involved are important. It is clearly the case that the cellular maintenance processes of autophagy are critical, as researchers have shown that when autophagy is sabotaged via genetic engineering, calorie restriction no longer produces its well-known benefits to health and longevity. Beyond that, different research groups peer intently at very localized portions of cell and tissue biochemist...
Source: Fight Aging! - July 30, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Considering the Contribution of the Gut Microbiome to Age-Related Frailty
Frailty is a condition with a strong inflammatory component. It isn't just physical weakness, but also the vulnerability of an incapable and constantly overactive immune system, generating inflammatory signaling that disrupts tissue and organ function throughout the body. In recent years, there has been a considerable growth of interest in the gut microbiome and its contribution to aging. It is clear that microbial populations shift with age in ways that promote inflammatory engagement with the immune system. Replacing an old gut microbiome with a young gut microbiome, such as via fecal microbiota transplantation, produces...
Source: Fight Aging! - July 29, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Six More Textbook Tricks | Teaching With Your Textbook Effectively | TAPP 97
We faculty rarely talk abouthow to use textbooks effectively. Not with each other, not with students, not with anybody. And we've probablynot ever had any training in how to use what is akey tool in teaching and learning the typical A&P course. This episodesolves that problem!00:00 | Introduction00:46 | More Textbook Tricks03:20 | Transparency06:46 | Sponsored by AAA08:04 | Read and Raid12:46 | Sponsored by HAPI14:17 | Honor The Textbook32:44 | Sponsored by HAPS34:28 | (You) Read The Textbook39:44 | Teach Your Students How to Read Textbooks49:26 | Loving& Learning About Textbooks51:16 | Staying ConnectedI...
Source: The A and P Professor - July 19, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs
Even More Slide Tricks | Ultimate Effective Teaching Presentations | TAPP 96
We continue our two-part series that exploressimple ways that we canmake our teaching slides more engaging—and thereforemore effective for learning. Let's leave behind those boring slide templates andmake our presentations work better for our lectures, case studies, labs, and other learning activities.00:00 | Introduction00:46 | Previous Slide Tricks06:23 | Sponsored by AAA07:36 | Proper Use of Terminology14:34 | Distorting Images15:50 | Sponsored by HAPI17:06 | Terrific Title Slides29:12 | Sponsored by HAPS30:07 | Avoid Presenting in Edit Mode32:12 | Don't Read Slides& Don't Always Follow Rules34:33&n...
Source: The A and P Professor - July 5, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, July 5th 2021
In conclusion, the findings suggest that DNAm GrimAge is a strong predictor of mortality independent of genetic influences.
Heart Failure Correlates with Increased Cancer Risk
https://www.fightaging.org/archives/2021/07/heart-failure-correlates-with-increased-cancer-risk/
Age-related disease results from the underlying cell and tissue damage that causes aging. Different people accumulate that damage at modestly different rates, the result of lifestyle choices and exposure to infectious disease. Thus the presence of a sufficient burden of damage to produce one age-related disease will be accompanied by a...
Source: Fight Aging! - July 4, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CD22 Inhibition Improves Microglia Function in Old Mice
Microglia are innate immune cells of the central nervous system, responsible for clearing harmful molecular waste, tracking down pathogens, and a range of other supporting roles in the function and tissue maintenance of the brain. Unfortunately microglia are known to become dysfunctional with age: notable more inflammatory, and less capable when it comes to clearing protein aggregates such as the amyloid-β associated with Alzheimer's disease. This is thought to be an important contribution to the age-related nature of neurodegenerative conditions. Targeted clearance of senescent microglia has been shown to produce meaning...
Source: Fight Aging! - June 29, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Congenitally corrected transposition of great arteries
Congenitally corrected transposition of the great arteries (CCTGA or cTGA) is a condition in which there is atrioventricular and ventricular arterial discordance so that the circulation is physiological. Congenitally corrected transposition of great arteries is also known as l-transposition of great arteries (l-TGA) because of the levo transposition of aorta. Levo posed aorta forms a hump along the left upper heart border on chest X-ray.
The right atrium connects to the morphological left ventricle, which in turn connects to the pulmonary artery so that systemic venous blood reaches the pulmonary circulation. The left atr...
Source: Cardiophile MD - June 24, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
More Slide Tricks | Effective Teaching Presentations | TAPP 95
Everybody loves to hate teaching with slides. But maybe that's because we've not fully developed our skills! Host Kevin Patton build on previous advice to improve our mastery of theslide-of-hand we need for effective learning.Let's turn that hate into love! This is the first of a two-episode series.00:00 | Introduction00:58 | Buy One, Get One02:06 | I Need Help!10:20 | Sponsored by AAA11:47 | Less Text, More Story24:25 | Sponsored by HAPI25:49 | Chunky Style Slides39:44 | Sponsored by HAPS41:08 | Where Art Thou?48:16 | Slide Tricks50:12 | Staying Connected If you cannot see or activate the audio player,...
Source: The A and P Professor - June 21, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs
Twins For Everyone!
By KIM BELLARD
I have lived my entire life as a twin, and, while it isn’t an unalloyed blessing, on balance I’d recommend it. Most of you, though, probably aren’t twins and have missed the experience. Don’t worry: you may still get a chance – with a digital twin.
It could have profound implications for your health and for healthcare generally.
A digital twin, in case you are not familiar with the concept, is a virtual representation of a physical object. It is created from data about that physical object, and is fed ongoing data (e.g., via IoT) about it to keep the model accurate....
Source: The Health Care Blog - June 16, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech digital twins Kim Bellard Source Type: blogs
The Digital Reconstruction of Healthcare is Upon Us
The transition from brick and mortar to digital medicine will profoundly impact the way clinicians and patients interact —and will likely improve clinical outcomes.John Halamka, M.D., president, Mayo Clinic Platform, and Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, wrote this article.Paul Cerrato and I are excited to finally announce the publication of our 5th book together:The Digital Reconstruction of Healthcare: Transitioning from Brick and Mortar to Virtual Care.In March, we posted thetable of contents of the new book. Now that it ’s reached the “newsstand,” we...
Source: Life as a Healthcare CIO - June 11, 2021 Category: Information Technology Source Type: blogs
Do A & P Textbooks Have Too Much Content? | TAPP 94
Oh, thathuge A&P textbook I teach from! Do I really need tocover all of it? Host Kevin Patton discusses his take on this age-old problem. Does thecolor of my marking pen send a signal that I don't want to send to my students? A breakthrough in understandinghow teeth sense cold. And what in the world is atunneling nanotube—and can I get one at my local hardware store?Greek names for SARS-CoV-2 variants simplifies conversation and avoids stigma.00:00 | Introduction00:43 | How Do Teeth Sense Cold?07:04 | Sponsored by AAA08:32 | Red& Green for Student Feedback18:03 | What's a TNT?23:52 | Sponsored by HAPI25...
Source: The A and P Professor - June 7, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs
