Fight Aging! Newsletter, April 24th 2023
In this study, researchers show that mice lacking a functional ATF4 gene show little to no loss of grip strength and treadmill performance into late life; it is quite an impressive effect size. Assessments of muscle biochemistry do show age-related declines, but to a lesser degree than the controls. How ATF4 knockout functions to produce this outcome is an interesting question. The researchers point out a range of possible downstream and upstream targets that have been implicated in the regulation of muscle growth, but it will clearly require further work to identify the important mechanisms involved.
Aging slowly...
Source: Fight Aging! - April 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Investigating Mechanisms By Which Some Gut Microbes May Shorten Fly Life Span
The lifespan of flies is especially sensitive to intestinal function, making them perhaps an interesting model in which to study mechanisms by which changes in the gut microbiome can affect health and longevity. It is clear that the gut microbiome changes with age, and different microbial populations can affect health in different ways. At the high level, it is thought that much of the harm done in later life is mediated by increased chronic inflammation, a reaction to harmful species or the metabolites that they produce. At the detail level, a lot of work remains to be accomplished when it comes to mapping the biochemistr...
Source: Fight Aging! - April 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Uncertainty Effect with Michelle Lazarus | TAPP 135
Dr. Michelle Lazarus, author of the new book,The Uncertainty Effect: How to Survive and Thrive through the Unexpected, joins host Kevin Patton for a lively discussion of ofuncertainty in science, medicine, and academia.00:00 | Introduction00:50 | Dr. Michelle Lazarus04:57 | Sponsored by AAA05:31 | Why Is Uncertainty Important?17:05 | Sponsored by HAPI17:49 | The Uncertainty of Teaching A&P27:07 | Sponsored by HAPS28:05 | Uncertainty and Inclusion36:38 | Uncertainty and Risk38:48 | Book: The Uncertainty Effect39:51 | Staying Connected ★ If you cannot see or activate the audio player, go to:the...
Source: The A and P Professor - April 12, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, March 27th 2023
This study has potentially significant implications in the field of OA as it provides a novel strategy for OA treatment.
A Vicious Cycle of Heart Failure and Dementia
https://www.fightaging.org/archives/2023/03/a-vicious-cycle-of-heart-failure-and-dementia/
The end of life is not pretty. The body is a failing machine of many complex essential parts, and the failures cascade and feed into one another as it breaks down. There is pain, loss of capacity, loss of the self as the brain runs down. There is a tendency to paper over the ugly reality in public discussion, to not talk about the facts of the matter...
Source: Fight Aging! - March 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing Blood-Brain Barrier Dysfunction in the Context of Alzheimer's Disease
The biochemistry of the central nervous system is separated from the biochemistry of the rest of the body by the blood-brain barrier, a specialized lining of cells that wrap blood vessels that pass through the brain. Only some molecules and cells are permitted to pass into and out of the brain. Like all bodily systems, the blood-brain barrier breaks down with age, leading to leakage of unwanted molecules and cells into the brain, where they can provoke inflammation and dysfunction. This is thought to provide a significant contribution to the onset and further progression of age-related neurodegenerative conditions, given t...
Source: Fight Aging! - March 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
NT-3 Gene Therapy Improves Muscle Function in Old Mice
In this study, we used a triple muscle-specific creatine kinase (tMCK) promoter to restrict NT-3 expression to the skeletal muscle and self-complimentary adeno-associated virus serotype 1 (scAAV1) as vector. The treatment efficacy was assessed at 6 months post-injection using run to exhaustion and rotarod tests, in vivo muscle contractility assay, and histopathological studies of the peripheral nervous system, including NMJ connectivity and muscle.
NT-3 gene therapy in WT-aged C57BL/6 mice resulted in functional and in vivo muscle physiology improvements, supported by quantitative histology from muscle, peripheral n...
Source: Fight Aging! - March 23, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Letting AI Physicians Into the Guild
BY KIM BELLARD
Let’s be honest: we’re going to have AI physicians.
Now, that prediction comes with a few caveats. It’s not going to be this year, and maybe not even in this decade. We may not call them “physicians,” but, rather, may think of them as a new category entirely. AI will almost certainly first follow its current path of become assistive technology, for human clinicians and even patients. We’re going to continue to struggle to fit them into existing regulatory boxes, like clinical decision support software or medical devices, until those boxes prove to be the wrong shape and size for ho...
Source: The Health Care Blog - March 14, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech AI physicians Kim Bellard Medical Education Prediction Source Type: blogs
Anatomical Sciences Education with Jason Organ | TAPP 134
In Episode 134,Jason Organ, the new Editor-in-Chief ofAnatomical Sciences Education (ASE). joins us for a chat about hisvision for this popular journal for anatomy and physiology faculty. Ranging from specific goals to general —and insightful—observations about teaching A&P,you ' ll want to listen in to this thought-provoking discussion.00:00 | Introduction00:54 | Introducing Jason Organ& ASE03:31 | Sponsored by AAA03:56 | A New Vision for ASE16:46 | Sponsored by HAPI17:24 | Humanity in Teaching Human A&P28:28 | Sponsored by HAPS28:58 | Who Reads ASE?35:42 | Staying Connected ★ If you ...
Source: The A and P Professor - March 9, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
The 7 Habits of Highly Stress-Resilient Minds
Are you suffering from chronic stress? Many of us are—whether we’re stressed out by our jobs, complicated relationships, caregiving responsibilities, or the general state of the world.
That’s where Elissa Epel’s new book, The Stress Prescription, comes in. A health psychologist and director of the Aging, Metabolism, and Emotions Center at the University of California, San Francisco, Epel explains how stress affects our bodies and minds—including our health, happiness, and longevity—and how to manage it in the best way possible.
Too many of us are in a constant state of alertness, she argues, which makes us ill-...
Source: SharpBrains - March 7, 2023 Category: Neuroscience Authors: Greater Good Science Center Tags: Brain/ Mental Health Education & Lifelong Learning aging chronic-stress deep breathing Gratitude high-intensity interval training meditation mindfulness mindfulness-meditation physiological stress Stress Prescription Stress Respons Source Type: blogs
Whoops! AI might have invented 40000 new toxic nerve agents … but probably not
TL:DR – Software used to predict which chemicals in a database have potential as new medicines has been flipped as a warning demonstrating that the same system could be used to predict whether they are highly toxic.
Artificial intelligence, AI, machine learning, language models, neural networks, generative models, algorithms trained on big data. A lovely collection of buzzwords that have been littering grant proposals for years and are now emerging into the real world as apps and websites and citizen science projects. For chemists and pharmaceutical scientists, AI has been a tool to experiment with for a long time. ...
Source: David Bradley Sciencebase - Songs, Snaps, Science - March 4, 2023 Category: Science Authors: David Bradley Tags: Artificial Intelligence Chemistry Source Type: blogs
Patient-Specific Soft Robotic Heart Replicas for Treatment Planning
Researchers at MIT have developed soft robotic heart replicas that closely match the anatomy of real people. The researchers used medical images of patient hearts to construct computer models that are suitable for 3D printing. Once printed with a soft material, the patient-specific heart models can be actuated using external inflatable sleeves, in the style of blood pressure cuffs, allowing the team to match the blood flow and pressure parameters parameters of the original heart. These models allow clinicians to accurately model cardiac anatomy, physiology, and mechanics for an individual patient, and test the effects of v...
Source: Medgadget - March 1, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology aortic stenosis mit Source Type: blogs
Mindi Fried on Teaching & Learning with Aphantasia | TAPP 133
In Episode 133,Dr. Mindi Fried joins us to discuss her experience ofaphantasia, the inability to picture thoughts and memories in themind ' s eye, and how that affects how sheteaches and learns anatomy and physiology. This is a chat that willincrease our awareness of the huge and sometimesinvisible diversity that exists among our students.00:00 | Introduction01:01 | What is Aphantasia?05:45 | Sponsored by AAA07:07 | Introducing Mindi Fried09:03 | Sponsored by HAPI09:48 | Mindi Friend on Aphantasia29:25 | Sponsored by HAPS30:20 | More with Mindi Fried46:19 | Staying Connected ★ If you cannot see or act...
Source: The A and P Professor - February 24, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
Why In Winter It Feels Like You ’ re Running On Empty (M)
Sleep adapts to the seasons and human physiology is 'down-regulated' in the winter. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 23, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Neuroscience Sleep subscribers-only Source Type: blogs
Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Automated Mass Spec Technique to Detect Antidepressants
Scientists at Brown University have designed an automated liquid chromatography tandem mass spectrometry (LC-MS/MS) system that allows clinicians to rapidly and easily process patient samples to determine levels of antidepressant drugs in the body. Getting the correct dose of antidepressant drugs into the bloodstream is important to ensure efficacy and avoid side-effects. However, current assays to measure the levels of such drugs in the blood are cumbersome, require large blood samples, and involve multiple time-consuming steps, limiting their use by clinicians. This new system requires very small sample volumes, and empl...
Source: Medgadget - February 16, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Psychiatry antidepressants brown university BrownUniversity Source Type: blogs
