Fight Aging! Newsletter, August 15th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 14, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Lasting Engineering of the Gut Microbiome
The gut microbiome is important in long-term health. At a guess, its influence on health may be on a par with, say, the state of physical fitness exhibited by an individual. The relative sizes of microbial populations change over a lifetime, and in detrimental ways. Inflammatory microbes and those producing harmful metabolites increase in number, while useful metabolite production declines. This occurs for a range of reasons, easy enough to list, but hard to put in an order of relative importance. For example, the intestinal mucosal barrier declines in effectiveness; the immune system becomes less capable of suppressing pr...
Source: Fight Aging! - August 12, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is.
Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes?
https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/
Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Anatomy & Physiology Syllabus: It's an Art | TAPP 120
Host Kevin Patton discusses the importance of thecourse syllabus in setting the tone for a course and helping to create apositive course culture. He includes a list ofpractical steps we can take as wereview and update our anatomy and physiology course syllabus.00:00 | Introduction02:02 | What, If Anything, Is a Course Syllabus?13:03 | Sponsored by AAA14:16 | Sparking a Course Culture23:58 | Sponsored by HAPI25:07 | Odds& Ends: Part 136:13 | Sponsored by HAPS37:28| Odds& Ends: Part 247:15 | Staying Connected★ If you cannot see or activate the audio player, go to:theAPprofessor.org/podcast-episode-120.htm...
Source: The A and P Professor - August 5, 2022 Category: Physiology Authors: Kevin Patton Source Type: blogs
Interviews on Aspects of Aging with Judith Campisi and Dena Dubal
Today I'll point out a pair of interviews with researchers Judith Campisi and Dena Dubal, in which they discuss quite different aspects of aging. Campisi's research has a heavy focus on cellular senescence in aging. Cells become senescent constantly in the body, most because they hit the Hayflick limit on replication imposed upon the somatic cells that are the overwhelming majority of cells in our tissues. Cells can also become senescent because of damage, or encouraged into senescence by the signaling of other, nearby senescent cells. Once senescent, cells are normally quickly removed by the immune system or programmed ce...
Source: Fight Aging! - August 4, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Lumen: World ’s First Device and App for Real-time Metabolic Feedback
Lumen is the first device and app available to anyone that provides real-time feedback on whether you’re burning carbohydrates or fats. These measurements are usually only made for athletes or patients through special testing centers, hospitals, or clinics, but with Lumen they are now available to everyone, anywhere.
Nutrition is a very individualized topic, while metabolism is just as nuanced – one size does not fit all when it comes to diet and nutrition plans – and that’s why dieticians and nutrition coaches can play an important role in health and well-being. However, a personalized diet comes with a need fo...
Source: Medgadget - August 3, 2022 Category: Medical Devices Authors: Alice Ferng Tags: Exclusive Medicine Source Type: blogs
Bonus Features – July 24, 2022 – OCR resolves 11 HIPAA enforcement actions, ONC releases USCDI v3, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
The HHS Office for Civil Rights resolved 11 investigations as part of its HIPAA Right of Access Initiative, issuing fines ranging from $3,500 for a Massachusetts psychiatric consultant to $240,000 for the 17-hospital Memori...
Source: EMR and HIPAA - July 24, 2022 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Healthcare IT Today Bonus Features Source Type: blogs
Fight Aging! Newsletter, July 25th 2022
This study further demonstrates that AMD is not a single condition or an isolated disease, but is often a signal of systemic malfunction which could benefit from targeted medical evaluation in addition to localized eye care."
Microglia in the Aging Brain, Both Protective and Harmful
https://www.fightaging.org/archives/2022/07/microglia-in-the-aging-brain-both-protective-and-harmful/
A growing body of evidence implicates the changing behavior of microglia in the aging of the brain and onset of neurodegeneration. Microglia are analogous to macrophages, innate immune cells unique to the central nervous sys...
Source: Fight Aging! - July 24, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
DNA Damage is a Part of Neural Plasticity, Complicating the Study of Its Relevance to Aging in the Brain
As noted by the authors of today's open access paper, there is ample evidence to show that double strand breaks in DNA occur during the normal activity of neurons, such as during the synaptic remodeling necessary to learning and memory. Evolution loves reuse, and few possibilities are ignored! This process of utilitarian double strand breaks appears to be used to ensure that nuclear DNA is spatially reconfigured in such a way as to ensure that certain genes are expressed for a time; recall that the pattern of gene expression at any given moment is very much a function of how the mass of nuclear DNA is packaged, which parts...
Source: Fight Aging! - July 21, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Minding the Mind's Eye in Slides | Feedback on Abortion Misconceptions | TAPP 119
Phantasia, forming mental images in ourmind ' s eye, can be enhanced by making effectivevisually oriented slides. Facts about biologymisconceptions can stir things up when they relate topregnancy and abortion.00:00 | Introduction00:41 | Offensive, strongly disagree or disapprove08:45 | Sponsored by AAA09:55 | Pregnant People16:27 | Sponsored by HAPI17:18 | MInd ' s Eye: Phantasia25:42 | Sponsored by HAPS27:13| Mental Imagery in Slides40:50| Digital Micro-Credentials42:33| Single Field of View49:27 | Staying Connected ★ If you cannot see or activate the audio player, go to:theAPprofessor.org/podcast-episode...
Source: The A and P Professor - July 20, 2022 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, July 18th 2022
In conclusion, we show that PVS morphology in mice is variable and that the structure and function of pia suggests a previously unrecognized role in regulating CSF transport and amyloid clearance in aging and disease.
Reversing Ovarian Fibrosis in Mice
https://www.fightaging.org/archives/2022/07/reversing-ovarian-fibrosis-in-mice/
Researchers here provide evidence for ovarian fibrosis to be an important mechanism in limiting the age at which female mammals can remain fertile. Interestingly, existing antifibrotic drugs can produce some reversal of this fibrosis, enough to restore ovulation in mice. Fibro...
Source: Fight Aging! - July 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
On the Development and Use of Aging Clocks and Mortality Timers
There are many ways in which biological data can be processed via machine learning techniques to produce clocks that assess the burden of aging. Today's open access paper draws a distinction between aging clocks, which provide information on biological age, and mortality timers, which provide information on risk of death. Aging affects everything in the body, and all aspects of physiology and cellular biochemistry undergo at least some change. So epigenetic marks on the genome, levels of transcription of various genes, circulating proteins in the bloodstream, the pattern of microbial populations in the gut microbiome, spec...
Source: Fight Aging! - July 13, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 11th 2022
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reporting on the Systems Aging Gordon Research Conference
Alex Zhavoronkov, who these days is as much interested in accelerating progress in cryonics as in translational research for the treatment of aging, here reports on his time at the recent Systems Aging Gordon Research Conference, one of a growing number of new conference series serving academic efforts make headway in the matter of treating aging as a medical condition. As a general rule, more successful conference series tend to indicate a larger and more successful field: more researchers, more funding, more attention from the world at large. The proliferation of conferences focused on aging is a good sign.
With...
Source: Fight Aging! - July 7, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pregnancy & Abortion Misconceptions We can Fix in A & P | TAPP 118
Host Kevin Patton uses arecent article fromScience News as a basis for discussing thebiological processes involved inpregnancy, birth, and abortion care toclarify misconceptions and support productivepublic conversation.00:00 | Introduction00:56 | Why Address These Concepts14:53 | Sponsored by AAA16:15 | Strategies21:44 | Sponsored by HAPI22:44 | Concepts& Misconceptions32:15 | Sponsored by HAPS34:44| More Concepts& Misconceptions43:31 | Staying Connected★ If you cannot see or activate the audio player, go to:theAPprofessor.org/podcast-episode-118.html🏅 Apply for your credential (badge/certificate) f...
Source: The A and P Professor - July 5, 2022 Category: Physiology Authors: Kevin Patton Source Type: blogs
