Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls.
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Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/
The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Synaptic Dysfunction Precedes the Death of Neurons in Parkinson's Disease
Parkinson's disease is characterized by the loss of dopamine-generating neurons, with the inflammatory pathology leading up to that issue thought to be driven by the spread of misfolded α-synuclein. Dysfunctional mitochondrial quality control can make these dopamine-generating neurons more vulnerable to the underlying pathology, however, and thus a fraction of Parkinson's disease arises in people with mutations that cause this sort of dysfunction. That has directed researchers towards mitochondrial function as an important factor in the progression of the condition, but it will probably turn out to be more useful to focus...
Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Muscle: A Gripping Story by Roy Meals | TAPP 142
Get pumped up for Episode 142, where we have the honor of hostingDr. Roy Meals, the musculoskeletal maestro! 💪 We ' re gonnaflex our curiosity muscles and explore every nook and cranny of his latest masterpiece,Muscle: The Gripping Story of Strength and Movement. This episode ' s so dynamic, you might need a protein shake afterward!0:00:00 | Introduction0:01:13 | Re-Introducing Dr. Roy Meals0:04:08 | Muscle Strain& Why We Train0:13:53 | What Sword Swallowing Teaches Us About Muscle0:24:49 | Muscle Stories: Learning Should Be Fun0:38:48 | Staying Connected★ If you cannot see or activate the...
Source: The A and P Professor - September 19, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Damage Done by Non-Standard Scientific Controls
To say that there is a lack of standardization in aging research is understating the matter. Pity the authors of reviews and meta-reviews, as they struggle to compare outcomes of animal studies between completely different, incompatible methodologies. Inconsistency in results is something of a feature even when different research groups attempt replication. The authors of this paper-length complaint focus down on one specific issue, the lack of standarization in the scientific control arm of a life span study, which is enough in and of itself to make comparison and replication challenging.
The search for intervent...
Source: Fight Aging! - September 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Wanted: Division of Pharmacology, Physiology, and Biological Chemistry Branch Chief
We’re seeking a highly qualified scientist to serve as a branch chief in our Division of Pharmacology, Physiology, and Biological Chemistry (PPBC). This is a newly created position for the Division as it reorganizes into three branches. Applicants should have significant interest and experience in the scientific areas managed by the Division, which will continue to encompass all the existing research portfolios and will generally be arranged into branches covering physiology and clinical sciences, biochemistry and molecular pharmacology, and chemistry and chemical biology. For a listing of the current scientifi...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - September 11, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.
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Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/
Neurogenesis is the process by which new neurons are created by neural stem c...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Wanted: Division of Pharmacology, Physiology, and Biological Chemistry Branch Chief
We’re seeking a highly qualified scientist to serve as a branch chief in our Division of Pharmacology, Physiology, and Biological Chemistry (PPBC). This is a newly created position for the Division as it reorganizes into three branches. Applicants should have significant interest and experience in the scientific areas managed by the Division, which will continue to encompass all the existing research portfolios and will generally be arranged into branches covering physiology and clinical sciences, biochemistry and molecular pharmacology, and chemistry and chemical biology. For a listing of the current scientifi...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - August 30, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
PGC-1 α4 Gene Therapy Reduces Sarcopenia and Metabolic Disease in Aged Mice
Researchers here demonstrate that aged muscle metabolism can be improved via gene therapy to deliver a short isoform of PGC-1α. Upregulating PGC-1α in muscle tissue is suggested to be a good approach to therapy based on its declining expression with age. It is interesting that the researchers focus on an isoform of the protein shown to be upregulated in exercise, in effect aiming to produce an exercise mimetic gene therapy that switches on one of the reactions to exercise and leaves it switched on indefinitely.
Sarcopenia is characterized of muscle mass loss and functional decline in elder individuals which seve...
Source: Fight Aging! - August 30, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Webinar for NIH MOSAIC Program Applicants
Are you preparing a grant application for the NIH Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) K99/R00 or UE5 programs? If so, please join our webinar to learn more about the programs and application components and to ask questions:
Tuesday, September 12, 1:00-3:00 p.m. ET
Zoom meeting link
Join by phone
Meeting ID: 160 151 7840
Passcode: 249272
MOSAIC is an NIH-wide initiative to enhance faculty diversity in the biomedical research workforce. It has two components: a postdoctoral career transition award (K99/R00) and a cohort-based mentoring and career...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - August 28, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Funding Opportunities Meetings/Events Training/Fellowships/Career Development Biomedical Graduate Education Biomedical Research Enterprise MOSAIC Postdoctoral Webinars Source Type: blogs
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Study Courses Supercharge Anatomy & Physiology Success | TAPP 141
Get ready for a mind-bending 😲 rendezvous with Kevin Patton inEpisode 141, where he continues to spill the beans on histop-secret recipe for student triumph. 🏆 Brace yourself for this next adventure on his whirlwind tour of revolutionizing A&P 1 education, as we dissect the art of identifyingstudent pain points, personalizing preparation, and serving up the kind ofmentorship they ' ve been yearning for!0:00:00 | Introduction0:00:45 | One of Two Success Courses0:09:48 | Setting Up the Supplement Course0:18:44 | Structure of Class Sessions0:40:17 | Grading0:42:45 | Does an A&P Sup...
Source: The A and P Professor - August 17, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
Predicting Mildly Age-Slowing Drugs will be a Focus of Future Research
It is clear that new ways of analyzing large amounts of data via machine learning will be used extensively in the near future in the field of aging research, employed to speed up the process of finding new drug targets and small molecules that might alter metabolism to slightly slow aging. This will no doubt be a sizable component of the longevity industry, if we judge the near future by the present distribution of companies and efforts. I can't say that I think that is likely to produce sizable benefits in aging humans, however, when compared to the rational design of therapies to specifically repair underlying causes of ...
Source: Fight Aging! - August 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Semi-Automated Manufacture of E-Skin Sensors
Engineers at the Technical University of Munich in Germany have developed a system that allows them to semi automate the production of tactile sensors. Such sensors can provide robotic systems, such as robotic prostheses, with a sense of compression and tension with regard to the objects and surfaces they come in contact with. Most robotic systems have integrated sensors, but this design allows researchers to create sensors for a variety of arbitrary surfaces, and then just wrap them around the object they wish to imbue with a sense of touch. The system includes software that assists with designing the sensors, and the des...
Source: Medgadget - August 8, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Rehab e-skin electronic skin TU_Muenchen Source Type: blogs
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
