More Quizzing About Kevin's Wacky Testing Scheme | Book Club | TAPP 100
After getting somequestions after theprevious episode, host Kevin Patton continues his discussion of his wacky scheme ofopen online testing. Not unrelated is a new entry of an old book intoThe A&P Professor Book Club—it ' s Ken Bain ' s classic bookWhat The Best College Teachers Do. And we celebrate theone hundredth episode of this podcast!0:00:00 | Introduction0:00:42 | 100th Episode!0:09:40 | Book Club0:14:23 | Sponsored by AAA0:16:07 | But, But, But...0:29:00| Sponsored by HAPI0:30:32 | An Open Test for All Seasons0:58:58 | Sponsored by HAPS1:00:27 | Test Feedback1:19:16 | Staying Connected★ If you cannot s...
Source: The A and P Professor - September 7, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, September 6th 2021
In conclusion, patients over 90 years of age had an overall low prevalence of fractures and relative preservation of bone health, suggesting a preserved bone molecular profile in these individuals. Epigenetic factors and activity levels might also have favorably affected bone health. The low percentage of osteoporosis and fractures likely reduced the morbidity and mortality in this population, potentially contributing to their overall longevity.
Building a Therapy for Aging Based on SIRT6 Upregulation
https://www.fightaging.org/archives/2021/08/building-a-therapy-for-aging-based-on-sirt6-upregulation/
G...
Source: Fight Aging! - September 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Immunoporosis: the Role of Immune Cells in Osteoporosis
Osteoporosis, the age-related loss of bone mass and strength, is a serious condition. Bone is constantly remodeled, created by osteoblasts and removed by osteoclasts. With age, the balance of these activities tips towards favoring the osteoclasts, and bone mineral density declines over time as a consequence. It is becoming clear that inflammatory signaling is an important contributing factor in this dysregulation of the normal balance. The chronic inflammation that accompanies aging, the consequence of rising numbers of senescent cells, as well as of the presence of molecular damage that provokes the immune system, can be ...
Source: Fight Aging! - September 3, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pregnancy in Hypertrophic cardiomyopathy : LSCS or vaginal delivery ?
Hypertrophic cardiomyopathy is a specific genetic disorder of myocyte (myosin and others) within the sarcomere. Though uncommon in pregnancy it raises considerable anxiety to the patient, family, and the obstetrician.
Hemodynamics
Though we tend to worry more about dynamic LVOT obstruction, it is actually the restrictive physiology of LV myocardium that might cause more concern. Three key variables operate in this entity namely preload, afterload, and contractility that determine the cardiac hemodynamics and possibly the symptoms. We know the classical consequence of pregnancy is a fall in systemic vascular resistance(...
Source: Dr.S.Venkatesan MD - August 27, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Pregnancy and heart pregnancy and heart disease Uncategorized esc ropac zahara pregnancy heart disease complicating pregnancy indication for lscs in hcm hocm lscs or normal delivery in hocm hcm pregnancy in hocm pregnancy in hypertrophic c Source Type: blogs
Fight Aging! Newsletter, August 23rd 2021
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns.
First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 22, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MOSAIC Program Announcements Reissued; Join Our Webinar September 7th
We’re pleased to share that the Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) funding opportunity announcements (FOAs) have been reissued. MOSAIC, a trans-NIH initiative that NIGMS oversees, has two components: a postdoctoral career transition award (K99/R00), and a cohort-based mentoring and career development program that supports the scholars (UE5 research education cooperative agreement).
MOSAIC Postdoctoral Career Transition Awards to Promote Diversity (K99/R00)
The MOSAIC K99/R00 program facilitates the timely transition of individuals from diverse backgrounds from th...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - August 18, 2021 Category: Biomedical Science Authors: Matt Mills Tags: Funding Opportunities Meetings/Events Training/Fellowships/Career Development Biomedical Graduate Education Biomedical Research Enterprise MOSAIC Postdoctoral Webinars Source Type: blogs
MOSAIC Program Announcements Reissued; Join Our Webinar September 7
We’re pleased to share that the Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) funding opportunity announcements (FOAs) have been reissued. MOSAIC, a trans-NIH initiative that NIGMS oversees, has two components: a postdoctoral career transition award (K99/R00), and a cohort-based mentoring and career development program that supports the scholars (UE5 research education cooperative agreement).
MOSAIC Postdoctoral Career Transition Awards to Promote Diversity (K99/R00)
The MOSAIC K99/R00 program facilitates the timely transition of individuals from diverse backgrounds...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - August 18, 2021 Category: Biomedical Science Authors: Matt Mills Tags: Funding Opportunities Meetings/Events Training/Fellowships/Career Development Biomedical Graduate Education Biomedical Research Enterprise MOSAIC Postdoctoral Webinars Source Type: blogs
A Focus on the Neuromuscular Junction in Muscle Aging
Neuromuscular junctions link the nervous system with muscle tissue, allowing control of muscle activity. Muscle mass and strength decreases with age, condition known as sarcopenia. This is a process that can be turned back to some degree by strength training, even in late life, but ultimately leads to frailty. Muscle isn't just a mechanical tissue, it also has important metabolic roles relevant to the regulation of immune system activity, inflammation, and more.
There are many viewpoints on which of the mechanisms of sarcopenia are likely the most important, the best targets for intervention. For example, leucine pr...
Source: Fight Aging! - August 17, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Quizzed About Tests | FAQs About Patton Test Strategies | TAPP 99
In this episode, I answer a bunch of questions fromJerry Anzalone about thewhacky strategies I have for testing in the A&P course. I discuss openonline tests withmultiple attempts,cumulative testing, pre-tests, test integrity, and much more. A virtual roundup ofoddities!0:00:00 | Introduction0:00:54 | Quizzed About Tests0:05:45 | Retaking Tests0:29:37 | More on Retaking Tests0:36:33 | Sponsored by AAA0:38:27 | High Stakes and Low Stakes0:46:06 | Sponsored by HAPI0:47:30 | Open Book Tests0:56:24 | Sponsored by HAPS0:57:25 | Academic Integrity1:06:17 | Final Thoughts1:11:27 | Staying Connected ★ If you cannot...
Source: The A and P Professor - August 17, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, August 9th 2021
In conclusion, the present study supports that some age-related diseases as well as education are causally related to longevity and highlights several new targets for achieving longevity, including management of venous thromboembolism, appropriate intake of sugar, and control of body fat. Our results warrant further studies to elucidate the underlying mechanisms of these reported causal associations.
Pol III Inhibition Extends Longevity in Short-Lived Species
https://www.fightaging.org/archives/2021/08/pol-iii-inhibition-extends-longevity-in-short-lived-species/
As this paper notes, Pol III is downstrea...
Source: Fight Aging! - August 8, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reverse Potts Shunt for Pulmonary Arterial Hypertension in Children
Potts shunt was a surgical anastomosis between left pulmonary artery and descending aorta to improve pulmonary blood flow in cyanotic congenital heart disease with decreased pulmonary blood flow. It is a systemic to pulmonary shunt. The report was published one year after the Blalock-Taussig shunt which was also used for a similar purpose [1]. Later Potts shunt like other central aortopulmonary shunts, were discontinued because of higher risk of excessive pulmonary blood flow. A modified Blalock-Taussig shunt is still in use.
Reverse Potts shunt is a pulmonary to systemic shunt for relieving pulmonary arterial hypertensio...
Source: Cardiophile MD - August 4, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
The Ability of Calorie Restriction to Aid in Kidney Regeneration Falters with Age
The practice of calorie restriction (also known as dietary restriction) improves health and slows aging. This occurs to a greater degree in short-lived species than in our own comparatively long-lived species, but nonetheless, the benefits are evident. Researchers here discuss the evidence for calorie restriction to be protective of kidney function, but for that protection to decline with age. This is an interesting perspective on calorie restriction, one that I haven't see much mentioned in the past. Very little of our biochemistry and function escapes aging, and we might expect near any measurable aspect of physiology an...
Source: Fight Aging! - August 2, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Star Power Helps Students Identify Learning Goals | TAPP 98
Students often ignore publishedlearning objectives, but we often use subtleclues to help them understand what they need to know. In this episode, Kevin Patton discusseshow to be less subtle about that, while also teaching our students how to spot important clues. Thatelephant in the room? It's thetextbook.Cilia are amazing andvital. InCOVID-19, we see howcilia damage can kill us. Did you know thatcells make soap? Listen and learn why.00:00 | Introduction00:54 | The Appearing Elephant Trick06:05 | Sponsored by AAA07:26 | COVID-19 and Cilia Damage10:54 | Soapy Cell Defense15:04 | Sponsored by HAPI16:35 | The Star S...
Source: The A and P Professor - August 2, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs
