Third Generation Solid Dispersion-Based Formulation of Novel Anti-Tubercular Agent Exhibited Improvement in Solubility, Dissolution and Biological Activity
AbstractThe long treatment period and development of drug resistance in tuberculosis (TB) necessitates the discovery of new anti-tubercular agents. The drug discovery program of the institute leads to the development of an anti-tubercular lead (IIIM-019), which is an analogue of nitrodihydroimidazooxazole and exhibited promising anti-tubercular action. However, IIIM-019 displays poor aqueous solubility (1.2 µg/mL), which demands suitable dosage form for its efficient oral administration. In the present study, third generation solid dispersion-based formulation was developed to increase the solubility and dissolution of ...
Source: The AAPS Journal - April 22, 2024 Category: Drugs & Pharmacology Source Type: research
Off-label Use of Balloon-Expandable Transcatheter Valves to Treat Pure Aortic Regurgitation
Transcatheter aortic valve implantation (TAVI) in native pure aortic regurgitation (AR) with off-label use of balloon expandable valves (BEV) has been reported. However, there are scant data regarding optimal oversizing and its safety and our study assessed BEV oversizing and outcomes of TAVI. Thirteen consecutive tricuspid aortic valve patients undergoing transfemoral TAVIs for pure AR with Sapien BEV at our centre between 2019 and 2023 (69.2% males, mean age 80.8 years, STS 4.0%) were divided into small annulus group ( ≤618mm2, SA) where ≥20% oversizing is achievable based on published data on BEV overexpansion, and ...
Source: The American Journal of Cardiology - April 22, 2024 Category: Cardiology Authors: Mateusz Orzalkiewicz, Marco Foroni, Francesco Chietera, Francesco Bendandi, Alessandro Mazzapicchi, Antonio Giulio Bruno, Gabriele Ghetti, Nevio Taglieri, Cinzia Marrozzini, Nazzareno Gali è, Tullio Palmerini, Francesco Saia Tags: Brief report Source Type: research
Off- to in-season body composition adaptations in elite male and female endurance and power event athletics competitors: an observational study
ConclusionsThe present study found that male athletes gained more BM, LM and trunk LM than females. Within-group increases in regional and whole-body LM and BMC were predominantly found among power event competitors. Incorporating individual meaningful changes alongside traditional statistics provided additional insights into sex and event-group differences. Future research on elite athletic event groups should include DXA measurements closer to major outdoor-season competitions, coupled with site-specific measures (ultrasound, MRI) for better detection of subtle changes in LM and FM. (Source: BMC Sports Science, Medicine and Rehabilitation)
Source: BMC Sports Science, Medicine and Rehabilitation - April 22, 2024 Category: Sports Medicine Source Type: research
Factors associated with development of retinopathy in patients with type 2 diabetes mellitus at onset and within three years after diagnosis
. (Source: Scandinavian Journal of Primary Health Care)
Source: Scandinavian Journal of Primary Health Care - April 22, 2024 Category: Primary Care Authors: Kajsa AnderssonAnders HallingBj örn Agvalla Capio Husläkarna Vallda, Kungsbacka, Region Halland, Halmstad, Swedenb Center for Primary Health Care Research, Department of Clinical Sciences Malmö, Lund University, Malmö, Swedenc Department of Research a Source Type: research
The role of computed tomography with external rotation and dorsiflexion in decision making for acute isolated non-displaced posterior malleolar fractures Barton íček and Rammelt type II: a prospective study
ConclusionThe conventional computed tomography with external rotation and dorsiflexion represents a reproducible and accurate diagnostic option for detecting syndesmosis instability and fracture instability in acute isolated non-displaced posterior malleolar fractures Barton íček and Rammelt type II.Level of Evidence: Prospective study among consecutive patients (Diagnosis); Level of evidence, 2. (Source: European Journal of Orthopaedic Surgery and Traumatology)
Source: European Journal of Orthopaedic Surgery and Traumatology - April 22, 2024 Category: Orthopaedics Source Type: research
Using an artificial intelligence software improves emergency medicine physician intracranial haemorrhage detection to radiologist levels
Conclusion
The Caire ICH software significantly improved the accuracy and sensitivity of detecting an ICH by the EP to a level comparable to general radiologists. Further prospective research with larger numbers will be needed to understand the impact of Caire ICH on ED logistics and patient outcomes. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - April 22, 2024 Category: Emergency Medicine Authors: Warman, P., Warman, A., Warman, R., Degnan, A., Blickman, J., Smith, D., McHale, P., Coburn, Z., McCormick, S., Chowdhary, V., Dash, D., Sangal, R., Vadhan, J., Bueso, T., Windisch, T., Neves, G. Tags: Original research Source Type: research
Effect of substrate material and abutment geometry on the accuracy of intraoral scanning: An in vitro study
Digital scanning is gradually replacing conventional impression making, but consensus on how tooth preparation influences the accuracy of intraoral scanning is lacking. (Source: Journal of Prosthetic Dentistry)
Source: Journal of Prosthetic Dentistry - April 22, 2024 Category: Dentistry Authors: Ziwei Zhang, Xianqing Ming, Yichen Luo, Wei Zhang Tags: Research and education Source Type: research
Influence of the ambient color lighting on the accuracy of complete arch implant scans recorded by using two intraoral scanners
The influence of different ambient factors including lighting has been previously studied. However, the influence of ambient color lighting settings on intraoral scanning accuracy remains uncertain. (Source: Journal of Prosthetic Dentistry)
Source: Journal of Prosthetic Dentistry - April 22, 2024 Category: Dentistry Authors: Gast ón Ochoa-López, Marta Revilla-León, Miguel Gómez-Polo Tags: Research and education Source Type: research
A comparison study of dynamic [18F]Alfatide II imaging and [11C]MET in orthotopic rat models of glioblastoma
Conclusion[18F]Alfatide II demonstrates potential in imaging tumor-associated neovascularization in the context of glioblastoma multiforme (GBM), suggesting its utility as a tool for further exploration in neovascular characterization. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Synthesis and preclinical evaluation of novel 18F-vancomycin-based tracers for the detection of bacterial infections using positron emission tomography
ConclusionHere we present the synthesis and first evaluation of the vancomycin-based PET tracers [18F]BODIPY-FL-vancomycin and [18F]PQ-VE1-vancomycin for image-guided detection of Gram-positive bacteria. Our study paves the way towards real-time bacteria-targeted diagnosis of soft tissue and implant-associated infections that are oftentimes caused by Gram-positive bacteria, even after prophylactic treatment with vancomycin. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 22, 2024 Category: Nuclear Medicine Source Type: research
Echogenic intracardiac foci detection and location in the second-trimester ultrasound and association with fetal outcomes: A systematic literature review
ConclusionEIF alone was not associated with adverse outcomes for the infant. Only persistent EIF on the right side showed evidence of carrying a higher risk of cardiac abnormality and would warrant further follow-up. (Source: PLoS One)
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Hope Eleri Jones Source Type: research
Impact of a board certification system and adherence to the clinical practice guidelines for gastric cancer on risk-adjusted surgical mortality after distal and total gastrectomy in Japan: a questionnaire survey of departments registered in the National Clinical Database
ConclusionsMultiple structural and process QIs are associated with surgical mortality after gastrectomy in Japan. Measuring and visualizing QIs may enhance healthcare improvements. (Source: Surgery Today)
Source: Surgery Today - April 21, 2024 Category: Surgery Source Type: research
Exploring the Effectiveness of Carboxymethylated and Crosslinked Albizia Procera Gum in Diltiazem Hydrochloride Matrix Tablets: A Comparative Analysis
This study investigates the efficacy of modified Albizia procera gum as a release-retardant polymer in Diltiazem hydrochloride (DIL) matrix tablets. Carboxymethylated Albizia procera gum (CAP) and ionically crosslinked carboxymethylated Albizia procera gum (Ca-CAP) were utilized, with Ca-CAP synthesized via crosslinking CAP with calcium ions (Ca2+) using calcium chloride (CaCl2). FTIR analysis affirmed polymer compatibility, while Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) assessed thermal behavior and crystallinity, respectively. Zeta potential analysis explored surface charge and electrostatic in...
Source: Chemical and Pharmaceutical Bulletin - April 21, 2024 Category: Drugs & Pharmacology Authors: Sudipta Mukherjee Jasmina Khanam Source Type: research
Radio-anatomical evaluation of clinical and radiomic profile of multi-parametric magnetic resonance imaging of de novo glioblastoma multiforme
CONCLUSION: The current study takes a third-party database and reduces physician bias from interfering with study findings. Further prospective and retrospective studies are needed to provide conclusive data.PMID:38644430 | DOI:10.1186/s43046-024-00217-3 (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - April 21, 2024 Category: Cancer & Oncology Authors: H Shafeeq Ahmed Trupti Devaraj Maanini Singhvi T Arul Dasan Priya Ranganath Source Type: research
Functional imaging in neuroendocrine tumors: assessment of molecular heterogeneity using [68Ga]Ga-DOTA-TOC and [18 F]FDG PET/CT
CONCLUSIONS: The performance of both PET/CT, particularly in G2 and G3, demonstrates the molecular heterogeneity of metastatic NETs and contributes to the selection of a more appropriate treatment, particularly in those high-grade patients who may benefit from radionuclide therapy (PRRT).PMID:38643835 | DOI:10.1016/j.remnie.2024.500011 (Source: Molecular Medicine)
Source: Molecular Medicine - April 21, 2024 Category: Molecular Biology Authors: Z Nogareda Seoane M C Mall ón Araújo A Calatayud Cubes C Barber án Corral Y Dom ínguez Novoa A Cousillas Casti ñeira N Mart ínez Lago J M de Mat ías Leralta V Pubul Nu ñez Source Type: research
