A rationally designed nuclei-targeting FAPI 04-based molecular probe with enhanced tumor uptake for PET/CT and fluorescence imaging
ConclusionsThe NOTA-FAPI-MB was successfully synthesized, in which FAPI and MB simultaneously contributed to the targeting effect. Notably, the nuclear delivery mechanism of the probes improved intracellular retention time and targeting efficacy, broadening the imaging time window for fluorescence imaging. In vivo PET/CT demonstrated favorable performance of NOTA-FAPI-MB compared to [18F]F-FDG. This study highlights the significance of fluorescence imaging as an adjunct technique to PET/CT. Furthermore, the encouraging results obtained from the imaging of human HCC tissues hold promise for the potential application of NOTA...
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
The accuracy and intra- and interobserver variability of PSMA PET/CT for the local staging of primary prostate cancer
ConclusionIn a large, multicentre study evaluating 600 patients with newly diagnosed intermediate and high-risk PCa, we showed that PSMA PET/CT may have a value in local tumour staging when pathological tumour stage in the radical prostatectomy specimen was used as the reference standard. The intra-observer and interobserver variability of assessment of tumour extent on PSMA PET/CT was moderate to substantial. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
Development of small-molecular-based radiotracers for PET imaging of PD-L1 expression and guiding the PD-L1 therapeutics
ConclusionPET imaging with [68Ga]Ga-D-pep-PMED, a small-molecule radiotracer, is a promising tool for evaluating PD-L1 expression and quantifying the target blockade of PD-L1 to assist in the development of effective therapeutic regimens.Graphical abstract (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
Thrombus or tumor? A case report of a rare sarcoma entity: intimal sarcoma of the pulmonary arteries
CONCLUSION: In case of atypical presentation of a pulmonary embolism, a tumor originating from the great vessels should be considered. Molecular pathology techniques support in establishing a reliable diagnosis.PMID:38656400 | DOI:10.1007/s11033-024-09467-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: A D örr A Fl örcken L Bullinger D Capper A Von Deimling D Kaul S M ärdian C Starck D Horst M P Dragomir F M Sch äfer A Jarosch Source Type: research
Multiparametric prenatal imaging characterization of fetal brain edema in Chiari II malformation might help to select candidates for fetal surgery
ConclusionsBrain edema in fetuses with Chiari II is common and radiologically detectable on T2-weighted fetal MRI sequences, and DTI-based FA values and radiomics features provide further evidence of microstructure differences between subgroups with and without edema.Clinical relevance statementA more severe phenotype of fetuses with Chiari II malformation is characterized by prenatal brain edema and more postnatal clinical morbidity and disability. Fetal brain edema is a promising prenatal MR imaging biomarker candidate for optimizing the risk-benefit evaluation of selection for fetal surgery.Key PointsBrain edema of fetu...
Source: European Radiology - April 24, 2024 Category: Radiology Source Type: research
Biparametric MRI in prostate cancer during active surveillance: is it safe?
AbstractActive surveillance (AS) is the preferred option for patients presenting with low-intermediate-risk prostate cancer. MRI now plays a crucial role for baseline assessment and ongoing monitoring of AS. The Prostate Cancer Radiological Estimation of Change in Sequential Evaluation (PRECISE) recommendations aid radiological assessment of progression; however, current guidelines do not advise on MRI protocols nor on frequency. Biparametric (bp) imaging without contrast administration offers advantages such as reduced costs and increased throughput, with similar outcomes to multiparametric (mp) MRI shown in the biopsy na...
Source: European Radiology - April 24, 2024 Category: Radiology Source Type: research
[18F]fluorodeoxyglucose positron emission tomography/computed tomography in combination with clinical data in predicting overall survival in non-small-cell lung cancer patients: A retrospective study
Positron emission tomography/computed tomography (PET/CT) has an established role in evaluating patients with lung cancer. The aim of this work was to assess the predictive capability of [18F]Fluorodeoxyglucose ([18F]FDG) PET/CT parameters on overall survival (OS) in lung cancer patients using an artificial neural network (ANN) in parallel with conventional statistical analysis. (Source: Radiography)
Source: Radiography - April 24, 2024 Category: Radiology Authors: P. Cegla, G.M. Currie, W. Cholewinski, M. Bryl, M. Trojanowski, K. Matuszewski, T. Piotrowski, R. Czepczy ński Source Type: research
Molecules, Vol. 29, Pages 1944: A Rapid Self-Assembling Peptide Hydrogel for Delivery of TFF3 to Promote Gastric Mucosal Injury Repair
Zhao
Luo
Self-assembled peptide-based nanobiomaterials exhibit promising prospects for drug delivery applications owing to their commendable biocompatibility and biodegradability, facile tissue uptake and utilization, and minimal or negligible unexpected toxicity. TFF3 is an active peptide autonomously secreted by gastric mucosal cells, possessing multiple biological functions. It acts on the surface of the gastric mucosa, facilitating the repair process of gastric mucosal damage. However, when used as a drug, TFF3 faces significant challenges, including short retention time in the gastric mucosal cavity and deacti...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Chen Luo Su Lu Zhao Luo Tags: Article Source Type: research
Sensors, Vol. 24, Pages 2716: Hardware and Software Setup for Quantitative 23Na Magnetic Resonance Imaging at 3T: A Phantom Study
ncesca Frijia
Magnetic resonance (MR) with sodium (23Na) is a noninvasive tool providing quantitative biochemical information regarding physiology, cellular metabolism, and viability, with the potential to extend MR beyond anatomical proton imaging. However, when using clinical scanners, the low detectable 23Na signal and the low 23Na gyromagnetic ratio require the design of dedicated radiofrequency (RF) coils tuned to the 23Na Larmor frequency and sequences, as well as the development of dedicated phantoms for testing the image quality, and an MR scanner with multinuclear spectroscopy (MNS) capabilities. In this work,...
Source: Sensors - April 24, 2024 Category: Biotechnology Authors: Giulio Giovannetti Alessandra Flori Nicola Martini Filippo Cademartiri Giovanni Donato Aquaro Alessandro Pingitore Francesca Frijia Tags: Article Source Type: research
Sensors, Vol. 24, Pages 2704: Image Reconstruction Requirements for Short-Range Inductive Sensors Used in Single-Coil MIT
p
MIT (magnetic induction tomography) image reconstruction from data acquired with a single, small inductive sensor has unique requirements not found in other imaging modalities. During the course of scanning over a target, measured inductive loss decreases rapidly with distance from the target boundary. Since inductive loss exists even at infinite separation due to losses internal to the sensor, all other measurements made in the vicinity of the target require subtraction of the infinite-separation loss. This is accomplished naturally by treating infinite-separation loss as an unknown. Furthermore, since contributions...
Source: Sensors - April 24, 2024 Category: Biotechnology Authors: Joe R. Feldkamp Tags: Article Source Type: research
Venous congestion in septic shock quantified with point-of-care ultrasound: a pilot prospective multicentre cohort study
ConclusionsIt is feasible to conduct a definitive observational study exploring the association between venous congestion quantified with POCUS and clinical outcomes in patients with septic shock. We hypothesize that venous congestion may be associated with an increased hazard of receiving RRT. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - April 23, 2024 Category: Anesthesiology Source Type: research
Characterization of structural, genotoxic, and immunological effects of methyl methanesulfonate (MMS) induced DNA modifications: Implications for inflammation-driven carcinogenesis
This study focuses on an in-depth understanding of the structural instability, induced antigenicity on the DNA molecule, cross-reactive anti-DNA antibodies, and cytotoxic potential of MMS in peripheral lymphocytes and cancer cell lines. The findings are decisive in identifying the hazardous nature of MMS to alter the intricacies of DNA and morphology of the cell. Structural alterations were assessed through UV-Vis, fluorescence, liquid chromatography, and mass spectroscopy (LCMS). The thermal instability of DNA was analyzed using duplex melting temperature profiles. Scanning and transmission electron microscopy revealed gr...
Source: International Journal of Biological Macromolecules - April 23, 2024 Category: Biochemistry Authors: Mohd Mustafa Safia Habib Khalid Imtiyaz Neda Tufail Rizwan Ahmad Bazigha Hamim Kashif Abbas Waleem Ahmad Shifa Khan None Moinuddin M Moshahid A Rizvi Md Imtaiyaz Hassan Shahid Ali Siddiqui Source Type: research
Formation of Supernarrow Borophene Nanoribbons
Angew Chem Int Ed Engl. 2024 Apr 23:e202406535. doi: 10.1002/anie.202406535. Online ahead of print.ABSTRACTBorophenes have sparked considerable interest owing to their fascinating physical characteristics and diverse polymorphism. However, borophene nanoribbons (BNRs) with widths less than 2 nm have not been achieved. Herein, we report the experimental realization of supernarrow BNRs. Combining scanning tunneling microscopy imaging with density functional theory modeling and ab initio molecular dynamics simulations, we demonstrate that, under the applied growth conditions, boron atoms can penetrate the outermost layer of A...
Source: Angewandte Chemie - April 23, 2024 Category: Chemistry Authors: Haochen Wang Pengcheng Ding Guang-Jie Xia Xiangyun Zhao Wenlong E Miao Yu Zhibo Ma Yang-Gang Wang Lai-Sheng Wang Jun Li Xueming Yang Source Type: research
Rational design of CdS-enwrapped polypyrrole nanoparticles for wastewater treatment: removal of hazardous pollutants in aqueous solutions
Environ Sci Pollut Res Int. 2024 Apr 24. doi: 10.1007/s11356-024-33285-y. Online ahead of print.ABSTRACTThe modern world requires a chemical industry that can run at low production costs while producing high-quality products with minimal environmental impact. The development of environmentally friendly, cost-effective, and efficient wastewater treatment materials remains a major problem for the sustainable approach. We prepared nanoscale cadmium sulfide (CdS)-enwrapped polypyrrole (PPy) polymer composites for degradation of organic pollutants. The prepared CdS@PPy nanocomposites were characterized by powder X-ray diffracti...
Source: Environmental Science and Pollution Research International - April 23, 2024 Category: Environmental Health Authors: Vadivel Siva Anbazhagan Murugan Abdul Samad Shameem Sahadevan Jhelai Baskaran Palanivel Sankaiya Asaithambi Poongavanam GaneshKumar Ikhyun Kim Palanisamy Govindasamy Jintae Lee Sivaprakash Paramasivam Source Type: research
Retrospective correction of second-order concomitant fields in 3D axial stack-of-spirals imaging on a high-performance gradient system
CONCLUSIONS: The described retrospective correction method provides a means to correct erroneous phase accruals due to second-order concomitant fields in 3D axial stack-of-spirals imaging.PMID:38650101 | DOI:10.1002/mrm.30113 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - April 23, 2024 Category: Radiology Authors: Afis Ajala Nastaren Abad Thomas K F Foo Seung-Kyun Lee Source Type: research
