Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
DISCUSSION: AD-GRS and APOE4 may have different impacts on potential intervention effects on amyloid, that is, less accumulation in the higher-risk group (AD-GRS) versus lower-risk group (APOE).HIGHLIGHTS: First study of neuroimaging and AD genetics in a multidomain lifestyle intervention. Possible intervention effect on brain amyloid deposition may rely on genetic risk. AD-GRS and APOE4 allele may have different impacts on amyloid during intervention.PMID:38647197 | DOI:10.1002/alz.13843 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Gazi Saadmaan Maria Carolina Dalmasso Alfredo Ramirez Mikko Hiltunen Nina Kemppainen Jenni Lehtisalo Francesca Mangialasche Tiia Ngandu Juha Rinne Hilkka Soininen Ruth Stephen Miia Kivipelto Alina Solomon Source Type: research
Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in Alzheimer's disease
DISCUSSION: Our results suggest that WMH may be associated with AD-intrinsic processes of degeneration, in addition to vascular mechanisms.HIGHLIGHTS: We studied white matter hyperintensities (WMHs) and WMH-connected cortical changes. WMHs are associated with more severe regional cortical degeneration. Findings suggest WMHs may be associated with Alzheimer's disease-intrinsic processes of degeneration.PMID:38648354 | DOI:10.1002/alz.13845 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Junfang Zhang Haijuan Chen Jie Wang Qi Huang Xiaomeng Xu Wenjing Wang Wei Xu Yihui Guan Jun Liu Joanna M Wardlaw Yulei Deng Fang Xie Binyin Li Source Type: research
National trends of surgery for benign prostatic hyperplasia in Finland
CONCLUSION: The implementation of PVP did not challenge the dominating position of TURP in Finland, but it has probably influenced the overall use of other surgical therapies, excluding transurethral incision of the prostate. The results might suggest that the conservative treatment is accentuated, patient selection is more thorough, and surgical intervention might be placed at a later stage of BPO.PMID:38647246 | DOI:10.2340/sju.v59.32425 (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - April 22, 2024 Category: Urology & Nephrology Authors: Alisa Salmivalli Peter Bostr öm Pertti Nurminen Pekka Kinnala Ville Kyt ö Otto Ettala Source Type: research
Demonstration Study of Reflector-Based Volumetric Speed-of-Sound Imaging With Linear Ultrasound Arrays
In this study, we introduce a 3D SoS reconstruction system that utilizes hand-held linear arrays instead. This system employs a passive reflector positioned opposite the linear arrays, serving as an echogenic reference for time-of-flight (ToF) measurements, and a high-definition camera to track the location corresponding to each group of transmit-receive data. To merge these two streams of ToF measurements and location tracking, a voxel-based reconstruction algorithm is implemented. Experimental results with gelatin phantom and ex vivo tissue have demonstrated the stability of our proposed method. Moreover, the results und...
Source: Ultrasonic Imaging - April 22, 2024 Category: Radiology Authors: Xiaoyi Jiang Kexin Gan Yuxin Wang Chao Tao Xiaojun Liu Jie Yuan Zhibin Jin Source Type: research
Aloe vera Gel –Reinforced Biodegradable Starch–PVA Blends for Sustainable Packaging of Green Chillies
The objective of the current study was to evaluate the feasibility ofAloe vera gel as a plasticizer and crosslinker in improving the properties of starch –polyvinyl alcohol blends that could find applications in packaging. The concentration ofAloe vera gel was varied (1%, 3%, 5% and 7% wt/wt) to produce SPA-1, SPA-3, SPA-5 and SPA-7 films, respectively. The plasticizing and crosslinking characteristics associated withAloe vera gel had a positive influence on the mechanical properties of the films. Addition ofAloe vera gel increased the tensile strength of films from 27.45 MPa (control) to 32.98, 32.53 and 32.32, for S...
Source: Packaging Technology and Science - April 22, 2024 Category: Food Science Authors: Snehal S. Tambe,
Smita Zinjarde,
Anjali A. Athawale Tags: RESEARCH ARTICLE Source Type: research
Sub-pixel target fine spatial feature extraction method based on aperture coding and micro-scanning imaging mechanism
The small imaging size of targets over long distances results in the loss of geometry and spatial features. Current methods are subject to ... (Source: Optics Express)
Source: Optics Express - April 22, 2024 Category: Physics Authors: Chao Zhang Ying yuan Xiaorui Wang Yang Ning Yue Li Yangyang Li Source Type: research
Age-based diagnostic reference levels and achievable doses for paediatric CT: a survey in Shanghai, China
Computed tomography (CT) is extensively utilised in medical diagnostics due to its notable radiographic superiority. However, the cancer risk associated with CT examinations, particularly in children, is of significant concern. The assessment of cancer risk relies on the radiation dose to examinees. Diagnostic reference levels (DRLs) and achievable doses (ADs) were used to assess the level of radiation dose in CT examinations widely. Although the national DRLs of paediatric CT have been explored in China, few local DRLs at the city level have been assessed. To set up the local DRLs and ADs of paediatric CT, we investigated...
Source: Journal of Radiological Protection - April 22, 2024 Category: Physics Authors: Fanqiaochu Yang and Linfeng Gao Source Type: research
Toupet fundoplication to prevent progression of scleroderma-associated interstitial lung damage: a study protocol
ConclusionsThe expected reduction of reflux burden in SSc patients selected for Toupet fundoplication may improve GERD symptoms/complications, pulmonary function, and quality of life, and may be associated with a reduced risk for lung transplant. (Source: European Surgery)
Source: European Surgery - April 22, 2024 Category: Surgery Source Type: research
Third Generation Solid Dispersion-Based Formulation of Novel Anti-Tubercular Agent Exhibited Improvement in Solubility, Dissolution and Biological Activity
AbstractThe long treatment period and development of drug resistance in tuberculosis (TB) necessitates the discovery of new anti-tubercular agents. The drug discovery program of the institute leads to the development of an anti-tubercular lead (IIIM-019), which is an analogue of nitrodihydroimidazooxazole and exhibited promising anti-tubercular action. However, IIIM-019 displays poor aqueous solubility (1.2 µg/mL), which demands suitable dosage form for its efficient oral administration. In the present study, third generation solid dispersion-based formulation was developed to increase the solubility and dissolution of ...
Source: The AAPS Journal - April 22, 2024 Category: Drugs & Pharmacology Source Type: research
Off-label Use of Balloon-Expandable Transcatheter Valves to Treat Pure Aortic Regurgitation
Transcatheter aortic valve implantation (TAVI) in native pure aortic regurgitation (AR) with off-label use of balloon expandable valves (BEV) has been reported. However, there are scant data regarding optimal oversizing and its safety and our study assessed BEV oversizing and outcomes of TAVI. Thirteen consecutive tricuspid aortic valve patients undergoing transfemoral TAVIs for pure AR with Sapien BEV at our centre between 2019 and 2023 (69.2% males, mean age 80.8 years, STS 4.0%) were divided into small annulus group ( ≤618mm2, SA) where ≥20% oversizing is achievable based on published data on BEV overexpansion, and ...
Source: The American Journal of Cardiology - April 22, 2024 Category: Cardiology Authors: Mateusz Orzalkiewicz, Marco Foroni, Francesco Chietera, Francesco Bendandi, Alessandro Mazzapicchi, Antonio Giulio Bruno, Gabriele Ghetti, Nevio Taglieri, Cinzia Marrozzini, Nazzareno Gali è, Tullio Palmerini, Francesco Saia Tags: Brief report Source Type: research
Off- to in-season body composition adaptations in elite male and female endurance and power event athletics competitors: an observational study
ConclusionsThe present study found that male athletes gained more BM, LM and trunk LM than females. Within-group increases in regional and whole-body LM and BMC were predominantly found among power event competitors. Incorporating individual meaningful changes alongside traditional statistics provided additional insights into sex and event-group differences. Future research on elite athletic event groups should include DXA measurements closer to major outdoor-season competitions, coupled with site-specific measures (ultrasound, MRI) for better detection of subtle changes in LM and FM. (Source: BMC Sports Science, Medicine and Rehabilitation)
Source: BMC Sports Science, Medicine and Rehabilitation - April 22, 2024 Category: Sports Medicine Source Type: research
Factors associated with development of retinopathy in patients with type 2 diabetes mellitus at onset and within three years after diagnosis
. (Source: Scandinavian Journal of Primary Health Care)
Source: Scandinavian Journal of Primary Health Care - April 22, 2024 Category: Primary Care Authors: Kajsa AnderssonAnders HallingBj örn Agvalla Capio Husläkarna Vallda, Kungsbacka, Region Halland, Halmstad, Swedenb Center for Primary Health Care Research, Department of Clinical Sciences Malmö, Lund University, Malmö, Swedenc Department of Research a Source Type: research
The role of computed tomography with external rotation and dorsiflexion in decision making for acute isolated non-displaced posterior malleolar fractures Barton íček and Rammelt type II: a prospective study
ConclusionThe conventional computed tomography with external rotation and dorsiflexion represents a reproducible and accurate diagnostic option for detecting syndesmosis instability and fracture instability in acute isolated non-displaced posterior malleolar fractures Barton íček and Rammelt type II.Level of Evidence: Prospective study among consecutive patients (Diagnosis); Level of evidence, 2. (Source: European Journal of Orthopaedic Surgery and Traumatology)
Source: European Journal of Orthopaedic Surgery and Traumatology - April 22, 2024 Category: Orthopaedics Source Type: research
Using an artificial intelligence software improves emergency medicine physician intracranial haemorrhage detection to radiologist levels
Conclusion
The Caire ICH software significantly improved the accuracy and sensitivity of detecting an ICH by the EP to a level comparable to general radiologists. Further prospective research with larger numbers will be needed to understand the impact of Caire ICH on ED logistics and patient outcomes. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - April 22, 2024 Category: Emergency Medicine Authors: Warman, P., Warman, A., Warman, R., Degnan, A., Blickman, J., Smith, D., McHale, P., Coburn, Z., McCormick, S., Chowdhary, V., Dash, D., Sangal, R., Vadhan, J., Bueso, T., Windisch, T., Neves, G. Tags: Original research Source Type: research
Effect of substrate material and abutment geometry on the accuracy of intraoral scanning: An in vitro study
Digital scanning is gradually replacing conventional impression making, but consensus on how tooth preparation influences the accuracy of intraoral scanning is lacking. (Source: Journal of Prosthetic Dentistry)
Source: Journal of Prosthetic Dentistry - April 22, 2024 Category: Dentistry Authors: Ziwei Zhang, Xianqing Ming, Yichen Luo, Wei Zhang Tags: Research and education Source Type: research
