Preoperative nomogram for predicting spread through air spaces in clinical-stage IA non-small cell lung cancer using 18F-fluorodeoxyglucose positron emission tomography/computed tomography
ConclusionOur nomogram based on preoperative18F-FDG PET/CT radiological features and SUVmax effectively predicts STAS status in clinical-stage IA NSCLC. Furthermore, our study highlights that metabolic parameters and CT variables associated with STAS differ between solid and part-solid nodular NSCLC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 10, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1457: A Systematic Review and Meta-Analysis of 29 Studies Predicting Diagnostic Accuracy of CT, MRI, PET, and USG in Detecting Extracapsular Spread in Head and Neck Cancers
Conclusion: MRI is the most accurate imaging modality for detecting ECS in head and neck cancers. CT scan is a reasonable alternative, but PET scan may be considered when high specificity is required. USG may not add any further benefit in detecting ECS. (Source: Cancers)
Source: Cancers - April 10, 2024 Category: Cancer & Oncology Authors: Manish Mair Hitesh Singhavi Ameya Pai Mariya Khan Peter Conboy Oladejo Olaleye Rami Salha Phil Ameerally Ram Vaidhyanath Pankaj Chaturvedi Tags: Systematic Review Source Type: research
Viruses, Vol. 16, Pages 583: The Inhibition of Gag-Pol Expression by the Restriction Factor Shiftless Is Dispensable for the Restriction of HIV-1 Infection
fan Pöhlmann
The interferon-induced host cell protein Shiftless (SFL) inhibits −1 programmed ribosomal frameshifting (−1PRF) required for the expression of HIV-1 Gal-Pol and the formation of infectious HIV-1 particles. However, the specific regions in SFL required for antiviral activity and the mechanism by which SFL inhibits −1PRF remain unclear. Employing alanine scanning mutagenesis, we found that basic amino acids in the predicted zinc ribbon motif of SFL are essential for the suppression of Gag-Pol expression but dispensable for anti-HIV-1 activity. We have shown that SFL...
Source: Viruses - April 10, 2024 Category: Virology Authors: Niklas J äger Shreya Ahana Ayyub Frank Peske David Liedtke Jens Bohne Markus Hoffmann Marina V. Rodnina Stefan P öhlmann Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1710: A Novel Cocrystal of Daidzein with Piperazine to Optimize the Solubility, Permeability and Bioavailability of Daidzein
uanhua Du
Yang Lu
It is well known that daidzein has various significant medicinal values and health benefits, such as anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, cholesterol lowering, neuroprotective, cardioprotective and so on. To our disappointment, poor solubility, low permeability and inferior bioavailability seriously limit its clinical application and market development. To optimize the solubility, permeability and bioavailability of daidzein, the cocrystal of daidzein and piperazine was prepared through a scientific and reasonable design, which was thoroughly characterized by single-crystal X...
Source: Molecules - April 10, 2024 Category: Chemistry Authors: Zhipeng Wang Shuang Li Qi Li Wenwen Wang Meiru Liu Shiying Yang Li Zhang Dezhi Yang Guanhua Du Yang Lu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1703: In Situ-Derived N-Doped ZnO from ZIF-8 for Enhanced Ethanol Sensing in ZnO/MEMS Devices
Li
Lei Huang
Microelectromechanical systems (MEMS) gas sensors have numerous advantages such as compact size, low power consumption, ease of integration, etc., while encountering challenges in sensitivity and high resistance because of their low sintering temperature. This work utilizes the in situ growth of Zeolitic Imidazolate Framework-8 (ZIF-8) followed by its conversion to N-doped ZnO. The results obtained from scanning electron microscopy (SEM) and transmission electron microscopy (TEM) indicate that the in situ derivation of ZIF-8 facilitates the adhesion of ZnO particles, forming an island-like structure and...
Source: Molecules - April 10, 2024 Category: Chemistry Authors: Meihua Liang Yong Yan Jiaxuan Yang Xiaodong Liu Rongrong Jia Yuanyuan Ge Zhili Li Lei Huang Tags: Article Source Type: research
