Late recurrence of a single gland primary hyperparathyroidism —Atypical parathyroid adenoma or misdiagnosed parathyroid carcinoma
We present a case of a 58-year-old female patient with parathyroid tumor recurrence after parathyroidectomy because of primary hyperparathyroidism. The first tumor was histologically classified as an atypical parathyroid adenoma by a specialized endocrine pathologist. Eleven years after the primary tumor resection a new tumor recurred. Retrospectively, after the tumor recurrence, the primary diagnosis of the atypical adenoma was questioned, and the tumor was temporarily classified to rather be a parathyroid carcinoma. This case aims to raise awareness for the diagnostic challenge of parathyroid carcinomas as a rare cause o...
Source: Clinical Case Reports - January 9, 2024 Category: General Medicine Authors: Jessica Kotliarevskaia,
Udo Siebolts,
Henning Dralle,
Frank Schuppert Tags: CASE REPORT Source Type: research
Chronic Cinacalcet improves skin flap survival in rats: the suggested role of the nitric oxide pathway
Naunyn Schmiedebergs Arch Pharmacol. 2024 Jan 6. doi: 10.1007/s00210-023-02922-7. Online ahead of print.ABSTRACTCinacalcet is a calcimimetic medicine that has been used to treat secondary hyperparathyroidism and parathyroid cancer. Various studies have proposed the positive role of calcium and its receptor in skin wound healing. Furthermore, Cinacalcet interacts with other skin repair-related mechanisms, including inflammation and nitric oxide pathways. The present study evaluated the effect of Cinacalcet on the random-pattern skin flap survival. Eighty-four Wistar male rats were used. Multiple doses of Cinacalcet (30, 3, ...
Source: Cancer Control - January 6, 2024 Category: Cancer & Oncology Authors: Mostafa Akbariani Farahnaz Bidari Zerehpoosh Zohreh Shahabi Amir Shadboorestan Zahra Hami Ehsan Nasiroleslami Sevda Shayesteh Mohsen Chamanara Ahmad Reza Dehpour Source Type: research
Case report: Sagliker syndrome in the patient with recurrent tertiary hyperparathyroidism due to intrathyroidal parathyroid carcinoma
We present a unique clinical case of a patient with classical features of SS, recurrent tertiary hyperparathyroidism (THPT) after total parathyroidectomy due to intrathyroidal parathyroid carcinoma (PC). (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 5, 2024 Category: Endocrinology Source Type: research
Giant functional parathyroid carcinoma: a case report and literature review
ConclusionThe primary approaches for managing parathyroid carcinoma involve precise diagnosis and surgical removal. This case report provides confirmation that the implementation of rigorous treatment measures can yield a substantial improvement in the prognosis. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 5, 2024 Category: Cancer & Oncology Source Type: research
A > 50% Intraoperative Parathyroid Hormone Decrease Into Normal Reference Range Predicts Complete Excision of Malignancy in Patients With Parathyroid Carcinoma
The mainstay of successful treatment for parathyroid carcinoma remains complete surgical excision. Although intraoperative parathyroid hormone (ioPTH) monitoring is a useful adjunct during parathyroidectomy for benign primary hyperparathyroidism, its utility for parathyroid carcinoma remains unclear. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - December 27, 2023 Category: Surgery Authors: Valerie L. Armstrong, Tanaz M. Vaghaiwalla, Cima Saghira, Cheng-Bang Chen, Yujie Wang, Johan Anantharaj, Mehmet Ackin, John I. Lew Source Type: research
Functional and nonfunctional parathyroid carcinoma: two case reports and literature review
AbstractParathyroid carcinoma (PC) is a rare malignant endocrine tumor. It can be divided into functional and non-functional types according to the tumor ’s ability to secrete parathyroid hormone. Herein, we present a case each of functional and nonfunctional PC. Case 1: Functional PC. The main clinical symptoms were high parathyroid hormone and hypercalcemia with bone injury and other complications. The mass was large, capsulated, and showed vascu lar invasion. The tumor was surgically removed, along with a part of the tracheal wall and recurrent laryngeal nerve that were invaded by the tumor. The ipsilateral and isthmu...
Source: Hormones and Cancer - November 29, 2023 Category: Cancer & Oncology Source Type: research
Is there a role for liquid biopsy in the surveillance of parathyroid carcinoma?
This study sought to assess the feasibility and application of liquid biopsy in parathyroid carcinoma and its impact on surveillance. (Source: Surgery)
Source: Surgery - November 21, 2023 Category: Surgery Authors: Thomas Szabo Yamashita, Aditya S. Shirali, Salyna Meas, Vanessa Sarli, Uriel E. Clemente-Gutierrez, Yi-Ju Chiang, Angelica Silva-Figueroa, Danica M. Vodopivec, Michelle Williams, Sarah B. Fisher, Paul H. Graham, Elizabeth G. Grubbs, Anthony Lucci, Naifa B Source Type: research
Discussion
Adam Kabaker (Chicago, IL): Do you think liquid biopsy is better than parathyroid hormone (PTH) in stratifying the risk of disease recurrence or progression for parathyroid carcinoma? Is this additive? Is this going to give us some new information we did not already have? (Source: Surgery)
Source: Surgery - November 21, 2023 Category: Surgery Source Type: research
Management and surgical treatment of parathyroid carcinoma: a 6-year experience of a single centre of endocrine surgery unit
ConclusionPC represents a great challenge in terms of preoperative diagnosis, management and treatment. A surgical approach represents the first best option for PC in referral endocrine surgery units. The early identification of risky patients should be the dominant goal to plan an appropriate therapy and to perform adequate en bloc surgery. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - November 3, 2023 Category: Endocrinology Source Type: research
Comparison of prognosis after partial and total surgical resection for parathyroid carcinoma: an inverse probability of treatment weighting analysis of the SEER database
ConclusionThere was no significant difference in the prognosis of patients who underwent partial and total surgical resection. This finding may provide a useful reference for the treatment of PC. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - October 16, 2023 Category: Endocrinology Source Type: research
A case of asymptomatic giant parathyroid carcinoma
Asian J Surg. 2023 Oct 2:S1015-9584(23)01515-4. doi: 10.1016/j.asjsur.2023.09.098. Online ahead of print.NO ABSTRACTPMID:37793942 | DOI:10.1016/j.asjsur.2023.09.098 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - October 4, 2023 Category: Surgery Authors: Shuo Wang Guangchao Cui Zhongqing Pan Zhiwei Gong Source Type: research
Recurrence hyperparathyroidism caused by synchronous parathyroid carcinoma and parathyromatosis in a patient with long-term hemodialysis
We describe a rare case ... (Source: BMC Nephrology)
Source: BMC Nephrology - October 4, 2023 Category: Urology & Nephrology Authors: Jun Yang, Xili Lu, Pingping Zhou, Hao Liu, Jili Wang and Xinhui Su Tags: Case Report Source Type: research
Delayed diagnosis of parathyroid cancer manifested with pubic bone lesions and chronic kidney failure. Tricks and pitfalls of management
CONCLUSION: The timely diagnosis of PTC is a prerequisite for a good outcome. The best preoperative indicators are serum parathyroid hormone > 4 times above the upper limit, serum calcium > 14 mg/dL, a palpable neck mass, and a local invasion found intraoperatively. The only curative treatment is the complete removal of the tumor with a negative margin.KEY WORDS: Delayed diagnosis, Hyperparathyroidism, Parathyroid cancer, Surgery.PMID:37737657 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - September 22, 2023 Category: Surgery Authors: Georgi Popivanov Ivon Daskalova Borislav Zlatev Elena Piperkova Marina Konaktchieva Stefka Ivanova Mihail Tabakov Kirien Kjosev Ivanka Dimova Ventsislav Mutafchiyski Source Type: research
